Frontiers in Systems Neuroscience最新文献_第6页

Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex. 在后内侧前额叶皮层中，不重叠的神经元组对不同任务的行为反应决定因素进行编码。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1049062

Muhammad Ali Haider Awan, Hajime Mushiake, Yoshiya Matsuzaka

{"title":"Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex.","authors":"Muhammad Ali Haider Awan, Hajime Mushiake, Yoshiya Matsuzaka","doi":"10.3389/fnsys.2023.1049062","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1049062","url":null,"abstract":"Higher mammals are able to simultaneously learn and perform a wide array of complex behaviors, which raises questions about how the neural representations of multiple tasks coexist within the same neural network. Do neurons play invariant roles across different tasks? Alternatively, do the same neurons play different roles in different tasks? To address these questions, we examined neuronal activity in the posterior medial prefrontal cortex of primates while they were performing two versions of arm-reaching tasks that required the selection of multiple behavioral tactics (i.e., the internal protocol of action selection), a critical requirement for the activation of this area. During the performance of these tasks, neurons in the pmPFC exhibited selective activity for the tactics, visuospatial information, action, or their combination. Surprisingly, in 82% of the tactics-selective neurons, the selective activity appeared in a particular task but not in both. Such task-specific neuronal representation appeared in 72% of the action-selective neurons. In addition, 95% of the neurons representing visuospatial information showed such activity exclusively in one task but not in both. Our findings indicate that the same neurons can play different roles across different tasks even though the tasks require common information, supporting the latter hypothesis.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10793930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher prefrontal activity based on short-term neurofeedback training can prevent working memory decline in acute stroke. 基于短期神经反馈训练的较高前额叶活动可以防止急性中风的工作记忆衰退。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1130272

Masayuki Tetsuka, Takeshi Sakurada, Mayuko Matsumoto, Takeshi Nakajima, Mitsuya Morita, Shigeru Fujimoto, Kensuke Kawai

{"title":"Higher prefrontal activity based on short-term neurofeedback training can prevent working memory decline in acute stroke.","authors":"Masayuki Tetsuka, Takeshi Sakurada, Mayuko Matsumoto, Takeshi Nakajima, Mitsuya Morita, Shigeru Fujimoto, Kensuke Kawai","doi":"10.3389/fnsys.2023.1130272","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1130272","url":null,"abstract":"This study aimed to clarify whether short-term neurofeedback training during the acute stroke phase led to prefrontal activity self-regulation, providing positive efficacy to working memory. A total of 30 patients with acute stroke performed functional near-infrared spectroscopy-based neurofeedback training for a day to increase their prefrontal activity. A randomized, Sham-controlled, double-blind study protocol was used comparing working memory ability before and after neurofeedback training. Working memory was evaluated using a target-searching task requiring spatial information retention. A decline in spatial working memory performance post-intervention was prevented in patients who displayed a higher task-related right prefrontal activity during neurofeedback training compared with the baseline. Neurofeedback training efficacy was not associated with the patient's clinical background such as Fugl-Meyer Assessment score and time since stroke. These findings demonstrated that even short-term neurofeedback training can strengthen prefrontal activity and help maintain cognitive ability in acute stroke patients, at least immediately after training. However, further studies investigating the influence of individual patient clinical background, especially cognitive impairment, on neurofeedback training is needed. Current findings provide an encouraging option for clinicians to design neurorehabilitation programs, including neurofeedback protocols, for acute stroke patients.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9794590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The contralateral organization of the human nervous system as a quantum unfolded, holographic-like, artifactual representation of the underlying dynamics of a fundamentally two-dimensional universe. 人类神经系统的对侧组织，作为一个量子展开的，全息的，基本的二维宇宙的潜在动力学的人工表现。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.987086

Ronald L Zukauskis

{"title":"The contralateral organization of the human nervous system as a quantum unfolded, holographic-like, artifactual representation of the underlying dynamics of a fundamentally two-dimensional universe.","authors":"Ronald L Zukauskis","doi":"10.3389/fnsys.2023.987086","DOIUrl":"https://doi.org/10.3389/fnsys.2023.987086","url":null,"abstract":"A working hypothesis is put forward in this article that the contralateral organization of the human nervous system appears to function like a quantum unfolded holographic apparatus by appearing to invert and reverse quantum unfolded visual and non-visual spatial information. As such, the three-dimensional contralateral organization would be an artifactual representation of the underlying dynamics of a fundamentally two-dimensional universe. According to the holographic principle, nothing that is experienced as three-dimensional could have been processed in a three-dimensional brain. Everything we would experience at a two-dimensional level would appear as a three-dimensional holographic representation, including the architecture of our brains. Various research observations reported elsewhere are reviewed and interpreted here as they may be related in a process that is fundamental to the underlying two-dimensional dynamics of the contralateral organization. The classic holographic method and characteristics of image formation contained by a holograph are described as they relate to the working hypothesis. The double-slit experiment is described and its relevance to the working hypothesis.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10030416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Neuromodulation by digital and analog drugs in consciousness research. 社论:意识研究中数字和模拟药物的神经调节作用。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1238151

Darren F Hight, Anthony G Hudetz, Axel Hutt

引用次数: 0

Testing EEG functional connectivity between sensorimotor and face processing visual regions in individuals with congenital facial palsy. 先天性面瘫患者感觉运动区和面部加工视觉区脑电功能连通性的测试。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1123221

Thomas Quettier, Antonio Maffei, Filippo Gambarota, Pier Francesco Ferrari, Paola Sessa

{"title":"Testing EEG functional connectivity between sensorimotor and face processing visual regions in individuals with congenital facial palsy.","authors":"Thomas Quettier, Antonio Maffei, Filippo Gambarota, Pier Francesco Ferrari, Paola Sessa","doi":"10.3389/fnsys.2023.1123221","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1123221","url":null,"abstract":"Moebius syndrome (MBS) is characterized by the congenital absence or underdevelopment of cranial nerves VII and VI, leading to facial palsy and impaired lateral eye movements. As a result, MBS individuals cannot produce facial expressions and did not develop motor programs for facial expressions. In the latest model of sensorimotor simulation, an iterative communication between somatosensory, motor/premotor cortices, and visual regions has been proposed, which should allow more efficient discriminations among subtle facial expressions. Accordingly, individuals with congenital facial motor disability, specifically with MBS, should exhibit atypical communication within this network. Here, we aimed to test this facet of the sensorimotor simulation models. We estimated the functional connectivity between the visual cortices for face processing and the sensorimotor cortices in healthy and MBS individuals. To this aim, we studied the strength of beta band functional connectivity between these two systems using high-density EEG, combined with a change detection task with facial expressions (and a control condition involving non-face stimuli). The results supported our hypothesis such that when discriminating subtle facial expressions, participants affected by congenital facial palsy (compared to healthy controls) showed reduced connectivity strength between sensorimotor regions and visual regions for face processing. This effect was absent for the condition with non-face stimuli. These findings support sensorimotor simulation models and the communication between sensorimotor and visual areas during subtle facial expression processing.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9509108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum: Making the world behave: A new embodied account on mobile paradigm. 勘误:使世界行为:移动范式的新体现。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1134410

Umay Sen, Gustaf Gredebäck

引用次数: 0

Corrigendum: Image discrimination reversal learning is impaired by sleep deprivation in rats: Cognitive rigidity or fatigue? 勘误:睡眠剥夺会损害大鼠的图像识别逆转学习:认知僵硬还是疲劳?

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1141071

Brian K Strobel, Michelle A Schmidt, Daniel O Harvey, Christopher J Davis

引用次数: 0

Erratum: FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function. 勘误:FABP7:睡眠、昼夜节律、可塑性和代谢功能的神经胶质整合者。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1258687

引用次数: 0

Circadian disruption of memory consolidation in Drosophila. 果蝇记忆巩固的昼夜节律中断。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1129152

Jerry C P Yin, Ethan Cui, Paul E Hardin, Hong Zhou

引用次数: 0

Endocytosis is required for consolidation of pattern-separated memories in the perirhinal cortex. 内吞作用是需要巩固模式分离的记忆在周围皮层。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1043664

Dinka Piromalli Girado, Magdalena Miranda, Marcelo Giachero, Noelia Weisstaub, Pedro Bekinschtein

{"title":"Endocytosis is required for consolidation of pattern-separated memories in the perirhinal cortex.","authors":"Dinka Piromalli Girado, Magdalena Miranda, Marcelo Giachero, Noelia Weisstaub, Pedro Bekinschtein","doi":"10.3389/fnsys.2023.1043664","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1043664","url":null,"abstract":"Introduction: The ability to separate similar experiences into differentiated representations is proposed to be based on a computational process called pattern separation, and it is one of the key characteristics of episodic memory. Although pattern separation has been mainly studied in the dentate gyrus of the hippocampus, this cognitive function if thought to take place also in other regions of the brain. The perirhinal cortex is important for the acquisition and storage of object memories, and in particular for object memory differentiation. The present study was devoted to investigating the importance of the cellular mechanism of endocytosis for object memory differentiation in the perirhinal cortex and its association with brain-derived neurotrophic factor, which was previously shown to be critical for the pattern separation mechanism in this structure.Methods: We used a modified version of the object recognition memory task and intracerebral delivery of a peptide (Tat-P4) into the perirhinal cortex to block endocytosis.Results: We found that endocytosis is necessary for pattern separation in the perirhinal cortex. We also provide evidence from a molecular disconnection experiment that BDNF and endocytosis-related mechanisms interact for memory discrimination in both male and female rats.Discussion: Our experiments suggest that BDNF and endocytosis are essential for consolidation of separate object memories and a part of a time-restricted, protein synthesis-dependent mechanism of memory stabilization in Prh during storage of object representations.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9103059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1