复旦学报(医学版)最新文献

{"title":"Factors related to public COVID-19 vaccine hesitancy based on the \"3Cs\" model: a cross-sectional study","authors":"Xiao Xi Liu, J. Dai, Hao Chen, Xiao Li, Suhong Chen, Yang Yu, Q. Zhao, Ru Wang, Yimeng Mao, H. Fu, Junling Gao, P. Zheng","doi":"10.3969/J.ISSN.1672-8467.2021.03.004","DOIUrl":"https://doi.org/10.3969/J.ISSN.1672-8467.2021.03.004","url":null,"abstract":"Objective: To understand the current situation of the hesitation of COVID-19 vaccines among Chinese residents, analyze the factors of vaccine hesitancy based on the \"3Cs\" model, and to provide reference for population intervention. Methods: From Dec 31, 2020 to Jan 11, 2021, a convenience sampling method was adopted to conduct an online survey of residents in 34 provinces, cities and autonomous regions across the country.The survey content included demographic characteristics, vaccine hesitancy, and the dimensions of the \"3Cs\" (confidence, complacency, and convenience) model.We analyzed the influence of demographic characteristics on vaccine hesitancy by χ2 test.Logistic regression was used to evaluate the effects of \"3Cs\" variables on vaccine hesitancy. Results: A total of 2 531 respondents were surveyed.Their average age was (33.9±8.9) years old, male to female ratio was 1:1.42, and vaccine hesitating respondents accounted for 44.3%.Logistic regression analysis found that gender (ORfemale=1.33, 95%CI: 1.12-1.58), monthly income (compared with 10 000=1.57, 95%CI: 1.25-1.97), healthcare workers(ORno=1.39, 95%CI: 1.12-1.73), and confidence (OR=0.47, 95%CI: 0.40-0.56) and complacency (OR=2.49, 95%CI: 2.10-2.96) in the \"3Cs\" model showed statistically significant impacts on the hesitation of COVID-19 vaccines. Conclusion: The confidence and complacency dimensions in the \"3Cs\" model have an impact on the hesitation of COVID-19 vaccines.Future interventions can focus on improving the public's confidence and reducing complacency associated with COVID-19 vaccines to increase the vaccination rate. © 2021, Editorial Department of Fudan University Journal of Medical Sciences. All right reserved.","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"48 1","pages":"307-312"},"PeriodicalIF":0.0,"publicationDate":"2021-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48677950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public preference and vaccination willingness for COVID-19 vaccine in China","authors":"Y. W. Chen, J. Xu, Yi Wang, H. Yan, J. L. Gao","doi":"10.3969/j.issn.1672-8467.2021.05.002","DOIUrl":"https://doi.org/10.3969/j.issn.1672-8467.2021.05.002","url":null,"abstract":"Objective: To understand public preference and immunization willingness for COVID-19 vaccine in China, and analyze influence factors, provide references for sufficient vaccination coverage. Methods: An online D-efficient discrete choice experiment was conducted from Jan 5, 2021 to Jan 12, 2021, in 1 241 people (with 1066 valid feedbacks), using choice sets with 5 vaccine attributes:protection rate, adverse effect, protection duration, convenience of vaccination, and out-of-pocket cost.Conditional Logit and panel mixed Logit models were used to analyze the effect of vaccine attributes on preferences, while random-effects Logit model was used to analyze the effect of vaccine attributes on vaccination willingness. Results: The COVID-19 vaccine with high protection rate(βefficacy 95%=1.76, P<0.001), low adverse effects(βlow risk=1.93, P<0.001), long protection duration (β5 years=0.59, P<0.001), convenient vaccination process(βconvenient=0.53, P<0.001), and less cost(βcost=0.14, P<0.001) was preferred by the public. Conclusion: Public preference and vaccination willingness for COVID-19 vaccine influenced by all 5 vaccine attributes (protection rate, adverse effect, protection duration, convenience of vaccination, and out-of-pocket cost).The efficacy and safety of the vaccine had the most significant impact. © 2021, Editorial Department of Fudan University Journal of Medical Sciences. All right reserved.","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"48 1","pages":"578-585"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70185025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety status and influencing factors of active psychological counselors in Shanghai under COVID-19 epidemic","authors":"Yiyuan Jiang, W. B. Zhang, Y. Y. Wang, L. Zhu, W. Zhuang, J. Cai, N. Wang","doi":"10.3969/j.issn.1672-8467.2021.05.006","DOIUrl":"https://doi.org/10.3969/j.issn.1672-8467.2021.05.006","url":null,"abstract":"Objective: To evaluate the impact of COVID-19 epidemic on anxiety status of active psychological counselors in Shanghai, China. Methods: We collected the demographic information of participants, cognition and attention to COVID-19, attitude towards the disappearance of COVID-19 and answers to the State-Trait Anxiety Inventory (STAI) on the Shanghai online psychological counseling platform from Feb 4th, 2020 to Mar 11st, 2020.Multiple Logistic regression was used to analyze the associations between COVID-19 epidemic and State-anxiety and Trait-anxiety. Results: Of 704 participants with an average age of 33.24 years (ranging from 18 to 73 years), the mean State-scores and Trait-scores were 44.49±6.31 and 46.19±5.22, respectively.In multivariate Logistic regression analysis, after gender stratification and adjustment of related variables, we found that for males, engaging in relevant prevention and control work was associated with a lower risk for medium or high State-anxiety (OR=0.28, 95%CI:0.09-0.89), and holding a intensively positive attitude was associated with a lower risk for medium or high Trait-anxiety (OR=0.25, 95%CI:0.07-0.87);while for females, those with medical background had a lower risk for State-anxiety (OR=0.17, 95%CI:0.03-0.92), and those paying moderate attention to epidemic had a lower risk for Trait-anxiety (OR=0.22, 95%CI:0.07-0.69). Conclusion: COVID-19 epidemic had different effects on the anxiety status of psychological counselors with different characteristics.Psychological counselors who have poor cognition of the epidemic, excessive attention to the epidemic, low hope for the disappearance of the epidemic, and non-disease prevention and control profession are more susceptible to greater anxiety, which are the key objects of protection in the event of public health emergencies. © 2021, Editorial Department of Fudan University Journal of Medical Sciences. All right reserved.","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"48 1","pages":"603-610"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70185108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional survey on information access through hospital's official account on new media and its association with antenatal care knowledge and health behaviors of pregnant women under COVID-19 epidemic","authors":"X. Li, W. Y. Chen, L. Jin, X. H. Zhang, F. Yang, L. Shen, X. W. Zhang, X. La, N. Abudukelimu, Z. Xie, X. Zhu, L. Wang, H. Jiang","doi":"10.3969/j.issn.1672-8467.2021.04.015","DOIUrl":"https://doi.org/10.3969/j.issn.1672-8467.2021.04.015","url":null,"abstract":"Objective To explore the association between accessing antenatal care information through hospitals' official new media accounts and antenatal care knowledge and individual prevention behavior under COVID-19 epidemic, and to provide evidence for improving the emergency plan for maternity health care services in China under public health emergencies. Methods The online survey was conducted from Feb 5th to Mar 1st, 2020, at the peak of the COVID-19 epidemic in China. Approaches of accessing antenatal care information, COVID-19 related antenatal care knowledge and individual prevention behavior was collected via cross-sectional design. Results A total of 1 936 valid questionnaires were obtained from 21 provinces, autonomous regions and municipalities. Under the COVID-19 epidemic, 75.4% of the pregnant women reported they got institutional service and health education information from hospitals' official new media accounts such as WeChat and Weibo. Multivariate Logistic analysis showed that pregnant women who received information from official accounts of new media had higher scores of COVID-19 relevant antenatal care knowledge (aOR=1.36, 95%CI:1.08-1.71, P<0.01)and individual prevention behaviors(aOR=1.46, 95%CI:1.18-1.82, P<0.01) than those who obtained information from other sources. Conclusion The access to antenatal care knowledge via hospitals' official social media accounts was associated with better antenatal care knowledge and individual prevention behaviors among pregnant women. Under major public health emergency, it is suggested for health institutions to disseminate antenatal health care information via hospitals' official accounts in new media like Wechat and Weibo. Appropriate training should be developed to ensure the quality of health education and service provision in official new media accounts. © 2021, Editorial Department of Fudan University Journal of Medical Sciences. All right reserved.","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"48 1","pages":"520-526"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70184878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognition of the relationship between smoking and COVID-19 and its impact on daily cigarette consumption among smokers","authors":"Yimeng Mao, P. Zheng, Bo Wang, C. Spears, Jidong Huang, M. Eriksen, P. Redmon","doi":"10.3969/J.ISSN.1672-8467.2020.06.005","DOIUrl":"https://doi.org/10.3969/J.ISSN.1672-8467.2020.06.005","url":null,"abstract":"Objective: To explore the cognition of coronavirus disease 2019 (COVID-19) epidemic and its relationship with smoking during the COVID-19 epidemic and provide reference for smoking cessation intervention Methods: A cross-sectional study was conducted among Chinese smokers aged≥18 by an online questionnaire Demographic information, tabacco addiction, daily cigarette consumption during the epidemic, smoking behavior, cognition of COVID-19 epidemic, and other information were collected through Wenjuanxin platform during Mar 19 to Apr 2, 2020 Chi-square tests and multinomial logistic regressions were used for statistical analysis Results: Among 1 388 participants with an average age of 43 91±11 95 years old(ranging 18-75), 95 7% of then were males In all, 1 014 (73 0%) of the participants had not changed their smoking consumption during the epidemic, while 107 (7 7%) smoked more and 267 (19 2%) smoked less Factors contributing to the reduction in smoking included disagreed with the statement that \"Smoking can prevent COVID-19\" (OR=1 56, 95%CI: 1 13-2 15), disagreed with the statement that \"Cigarette smoke is helpful in killing the virus of COVID-19\" (OR=1 63, 95%CI: 1 17-2 26), and agreed that \"Fine particles produced by smoking may increase the spread of virus\" (OR=1 84, 95%CI: 1 32-2 57) Conclusion: It is necessary to clarify the misunderstanding related to smoking and improve the health literacy of smokers through media We should strengthen smoking cessation intervention focusing on respiratory health and the cognition of COVID-19 epidemic in smoking cessation clinics, smoking cessation hotline and other smoking cessation services © 2020, Editorial Department of Fudan University Journal of Medical Sciences All right reserved","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"47 1","pages":"830-836"},"PeriodicalIF":0.0,"publicationDate":"2020-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44135955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public anxiety and its influencing factors in the initial outbreak of COVID-19","authors":"陈苏虹, Chen Su-hong, 戴俊明, Dai Jun-ming, 胡俏, H. Qiao, 陈浩, Chen Hao, 王一, Wang Yi, 高俊岭, Gao Junling, 郑频频, Zheng Pin-pin, 傅华, Fu Hua","doi":"10.3969/J.ISSN.1672-8467.2020.03.012","DOIUrl":"https://doi.org/10.3969/J.ISSN.1672-8467.2020.03.012","url":null,"abstract":"目的探索2019冠状病毒病（COVID-19）暴发疫情下公众的心理状况及影响因素，为心理健康干预提供依据。 方法自2020年1月31日至2月2日采用线上问卷开展横断面调查。以中国各地受疫情影响的成年人为调查对象，问卷包括人口学资料、焦虑情况、心理弹性与自拟压力源量表，并采用χ2检验与Logistic回归分析进行统计分析。 结果共获得4 827份有效问卷，平均年龄（32.3±10.0）岁，女性占67.7%，有湖北暴露史者仅占7.9%，而小区有疑似或确诊病例者占14.8%。GAD-7平均得分为6.29±5.48，中重度焦虑现患率为22.6%。以中重度焦虑为因变量，Logistic回归分析发现对COVID-19有中、高等了解（OR：2.74~7.97，P 结论疫情暴发下对COVID-19信息的过度关注和对传播风险的感知会增加焦虑风险。公众普遍出现焦虑，应当加强心理干预，增加社会支持并提高心理弹性。","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48031399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2019冠状病毒病（COVID-19)疫情期间公众媒体暴露及其与心理健康的关系","authors":"高俊岭 陈浩 毛一蒙 陈苏虹 戴俊明 郑频频 傅华 王一","doi":"10.3969/J.ISSN.1672-8467.2020.02.005","DOIUrl":"https://doi.org/10.3969/J.ISSN.1672-8467.2020.02.005","url":null,"abstract":"目的了解突发公共卫生事件中公众媒体暴露程度与心理健康状态，为健康传播途径和健康教育内容与方向的优化提供依据。 方法采用横断面研究，设计并发放结构化自填电子问卷，于2020年1月31日-2月2日通过网络收集≥ 18岁中国公民的公众媒体暴露、健康行为认知情况、心理健康状态等信息。使用χ2检验和Logistic回归进行统计分析。 结果共收集有效问卷4 827份，其中男性占32.3%，现居湖北者占2.7%，年龄18~85岁，平均（32.32±9.98）岁。疫情信息媒体暴露在每天3 h以上和1 h以下的分别占38.4%和22.7%。焦虑比例为53.3%，重度焦虑比例为9.6%，抑郁比例为48.3%。媒体暴露越高，预防措施越完备（ρ=0.091，P 结论媒体暴露会影响公众心理健康，增加焦虑、抑郁风险，在防控疫情的同时要注重对公众心理健康的疏导。","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"47 1","pages":"173-178"},"PeriodicalIF":0.0,"publicationDate":"2020-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44951544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse phase high-performance liquid chromatography (RP-HPLC) system for analysis of vitamin D3 soft capsules with soybean oil matrix","authors":"Meng-han Li, Xue-mei Ding, Jian Liang","doi":"10.3969/J.ISSN.1672-8467.2019.01.004","DOIUrl":"https://doi.org/10.3969/J.ISSN.1672-8467.2019.01.004","url":null,"abstract":"ObjectiveTo develop a method for the determination and impurity analysis of vitamin D3 soft capsules with soybean oil matrix in reverse phase high performance liquid chromatography (RP-HPLC) system.\u0000\u0000 MethodsRP-HPLC system had Agilent Zorbax Eclipse XDB-C18 column (4.6 mm × 250 mm, 5 μm) with detection wavelength of 265 nm, column temperature of 25 ℃ and flow rate of 1 mL/min. Retention behaviors of vitamin D3 and its 3 isomers were studied by altering the mobile phase. Firstly, acetonitrile was mixed with different proportions of methanol, water and ethanol as the mobile phase to investigate the effects of these 4 mobile phase components on the retention behavior of vitamin D3 and its 3 main related substances (isomers) on a C18 column. Then, a suitable mobile phase was selected for content determination and impurity analysis according to the retention behavior study.\u0000 ResultsThe recovery was only 80.55%-84.37% with 100% acetonitrile as the mobile phase.The addition of ethanol in acetonitrile was found to make remarkably significant improvement. Recovery rate was achieved between 98.07% and 103.23% with V (acetonitrile):V (ethanol)=90:10 as the mobile phase, while improving peak shape. The method showed good linearity [(0.52-5.2)×10-4 μmol/L, R2>0.999] and fine density (RSD < 2.32%) which can be used for determination. For impurities profile, it could be achieved using V (acetonitrile):V (water)=95:5 as the mobile phase which can obviate interference from soybean oil matrix.\u0000\u0000 ConclusionsThe method established in this experiment can easily and accurately determine the content and impurity analysis of vitamin D3 soft capsules with soybean oil matrix in a RP-HPLC system.","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"1 1","pages":"23-31"},"PeriodicalIF":0.0,"publicationDate":"2019-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47411789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision medicine in breast cancer research","authors":"Yi Xiao, Yizhou Jiang, Z. Shao","doi":"10.3969/J.ISSN.1672-8467.2017.06.013","DOIUrl":"https://doi.org/10.3969/J.ISSN.1672-8467.2017.06.013","url":null,"abstract":"","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"44 1","pages":"765-772"},"PeriodicalIF":0.0,"publicationDate":"2017-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47122016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution revolution: advances and prospects of cryo-EM in structural biology","authors":"Zhenguo Chen, Yan Xu","doi":"10.3969/J.ISSN.1672-8467.2017.06.017","DOIUrl":"https://doi.org/10.3969/J.ISSN.1672-8467.2017.06.017","url":null,"abstract":"","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"44 1","pages":"799-805"},"PeriodicalIF":0.0,"publicationDate":"2017-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42176356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}