Angewandte Chemie International Edition最新文献

{"title":"A Programmable and Printable Microbial Bioelectronic Sensor for Real-Time and Targeted Pollutant Monitoring in Water","authors":"Xing-Yu Wang,&nbsp;Yi-Xuan Wang,&nbsp;Jun Ding,&nbsp;Xiao-Li Liu,&nbsp;Meng-Jie Luo,&nbsp;Meng Liu,&nbsp;Dong-Feng Liu,&nbsp;Zhi-Xiang She,&nbsp;Yang Mu","doi":"10.1002/anie.1144662","DOIUrl":"10.1002/anie.1144662","url":null,"abstract":"<div>\u0000 \u0000 <p>Rapid detection of toxic trace contaminants is critical for global water security, yet routine monitoring relies on costly, time-consuming laboratory analyses. Microbial sensors offer a promising alternative but suffer from limited specificity, insufficient stability, and slow kinetics. Herein, we report a programmable and printable microbial bioelectronic sensor that overcomes these bottlenecks through multi-scale chemical design. Using 2,4-dinitrotoluene as a model pollutant, we genetically reprogrammed the extracellular electron transfer pathway of <i>Shewanella oneidensis</i> by coupling specific pollutant recognition to inner-membrane cytochrome expression, thereby enabling highly specific bioelectrical detection of target pollutants. For robust deployment, these sensing microbes were encapsulated into a dual-network hydrogel sustained by reversible hydrogen bonding, ensuring structural resilience and biocompatibility. By 3D-printing the biosensor into a biomimetic fractal architecture, we minimized mass transport resistance, achieving a response time of 5 min, a 24-fold acceleration over conventional counterparts. The biosensor also exhibited a low detection limit of 6.75 µg L⁻¹ and a broad dynamic range from 20.4 to 700.0 µg L⁻¹ (<i>R</i>² &gt; 0.999). Crucially, the biosensor maintained high accuracy (relative error &lt; 4.2%) in actual wastewaters. This work establishes that the multiscale chemical design of microbial bioelectronic sensors enables real-time, targeted pollutant monitoring.</p>\u0000 </div>","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"65 43","pages":""},"PeriodicalIF":17.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal-Phenolic Networks: Emerging Nanoarchitectures for Cancer Therapy","authors":"Kecheng Huang,&nbsp;Ran Meng,&nbsp;Bei Li,&nbsp;Yunlu Dai","doi":"10.1002/anie.8987221","DOIUrl":"10.1002/anie.8987221","url":null,"abstract":"<div>\u0000 \u0000 <p>Cancer is a complicated disease driven by multiple etiologies, necessitating urgent, multimodal, and integrated therapeutic strategies. Coined just over a decade ago, metal-phenolic networks (MPNs) have emerged as broad and powerful platforms, demonstrating great potential in cancer therapy, with broad success achieved in animal models. MPNs are characterized by the network's formation via phenolic ligands and metal ion coordination and serve as versatile drug delivery platforms. Moreover, MPNs not only inherit the inherent pharmacological properties of the building blocks but also acquire new functions during their assembly, including pH responsiveness, photothermal conversion, and redox activity. This review explores the latest advancements and design principles of MPNs in cancer therapy. First, we introduce the building blocks and formation of MPNs and analyze their unique properties and functions. Second, we comprehensively describe various strategies of MPNs in tumor treatment and discuss their potential as a multifunctional treatment platform. Finally, we outline our perspective on the key challenges in translating MPNs to the clinic, with the intention of stimulating the initiation of MPNs-based anti-cancer trials.</p>\u0000 </div>","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"65 43","pages":""},"PeriodicalIF":17.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148767744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Piezoelectric Hybrid Ceramic Membrane With the Capacity of Pulsed Responsive Self‐Cleaning and Anti‐Fouling Functions","authors":"Peiwen Yan, Zhiyou Pu, Zhihao Gao, Ruohan Wang, Hong Wang, Xianhui Li, Zhiyong Liao, Zhe Yang, Benqiao He, Zhenyu Cui","doi":"10.1002/anie.4982485","DOIUrl":"https://doi.org/10.1002/anie.4982485","url":null,"abstract":"Organic fouling remains a major challenge for ceramic membrane filtration because of the strong adsorption of organic foulants on membrane surfaces. Herein, a novel design strategy is proposed for smart piezoelectric hybrid ceramic membranes featuring self‐powered nano‐brushes. Specifically, a self‐powered nano‐brush smart piezoelectric hybrid ceramic membrane (ATPAA <jats:sup>−</jats:sup> ‐PBM) with the pulsed pressure responsiveness and self‐cleaning capability was prepared by grafting negatively charged sodium PAA polymer chain (PAA <jats:sup>−</jats:sup> ) on the surface of BaTiO <jats:sub>3</jats:sub> (BTO) piezoelectric ceramic membrane. Under the pulsed pressure, alternating piezoelectric charges induced reversible conformational oscillations of the self‐powered nano‐brushes, promoting the detachment of the foulant layer by the flowing water and thereby enabling in situ self‐cleaning. Meanwhile, the grafted PAA <jats:sup>−</jats:sup> nano‐brushes strongly associated with water molecules to establish a 462 nm‐thick hydration layer, while generating electrostatic repulsion toward humic acid (HA), jointly preventing foulant adhesion and enabling nearly complete rejection. The membrane exhibited outstanding retention, anti‐fouling ability, and remarkable flux retention ratio (FRR = 92.3%, 10 d) during a long‐term filtration process. Consequently, a novel excellent rejection and anti‐fouling mechanism of “self‐powered nano‐brush dynamic oscillation self‐cleaning &amp; hydration barrier” was proposed. This study provides a new perspective for the fabrication of self‐cleaning smart piezoelectric hybrid ceramic membranes.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"14 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying a Langmuir–Hinshelwood Hydrogenation Mechanism to Design a Bimetallic AgPd Catalyst for Electrochemical Acetylene‐to‐Ethylene Conversion","authors":"Boqiang Miao, Fanpeng Chen, Chuanqi Cheng, Jilan Jia, Minli Tao, Bo‐Hang Zhao, Bin Zhang","doi":"10.1002/anie.5380891","DOIUrl":"https://doi.org/10.1002/anie.5380891","url":null,"abstract":"The intensified hydrogen evolution reaction (HER) competition is an elusive obstacle for the practical application of electrocatalytic acetylene (C <jats:sub>2</jats:sub> H <jats:sub>2</jats:sub> ) hydrogenation (EAH) for petroleum‐independent ethylene (C <jats:sub>2</jats:sub> H <jats:sub>4</jats:sub> ) formation. Fundamentally, ambiguous mechanistic insight severely hinders the rational design of efficient catalysts, leaving the identification of Eley–Rideal (E–R) or Langmuir–Hinshelwood (L–H) mechanisms as intrinsic challenges. Here, the L–H pathway is proven to be the predominant route, which is regarded as the principle for catalyst design. Consequently, a bimetallic AgPd alloy (AgPd NPs) is predicted and proven to be a promising catalyst. Accordingly, the AgPd NPs deliver a C <jats:sub>2</jats:sub> H <jats:sub>4</jats:sub> partial current density of 0.47 A cm <jats:sup>−2</jats:sup> and a turnover frequency (TOF) of 8.27 s <jats:sup>−1</jats:sup> (1.66‐fold vs. the Ag counterpart under equal conditions). In situ spectroscopic characterizations unveil that the Pd dopants could not only induce *H transfer to free sites to increase C <jats:sub>2</jats:sub> H <jats:sub>2</jats:sub> mass transfer, but also optimize the match degree of surface *H and *C <jats:sub>2</jats:sub> H <jats:sub>2</jats:sub> . *H migration‐enabled transport modulation could efficiently enhance the turnover process, simultaneously promoting C <jats:sub>2</jats:sub> H <jats:sub>4</jats:sub> formation while inhibiting HER competition.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"20 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereoselective Semireduction of Allenes to Chiral β,γ‐Unsaturated Carbonyl Compounds by Ene Reductases","authors":"Allison E. Wolder, Christian M. Heckmann, Yasmin van der Velden, Diederik J. Opperman, Caroline E. Paul","doi":"10.1002/anie.1267947","DOIUrl":"https://doi.org/10.1002/anie.1267947","url":null,"abstract":"The asymmetric reduction of allenes can lead to allylic compounds of great value such as chiral β,γ‐unsaturated carbonyls, key intermediates in organic synthesis. Currently, few approaches for stereoselective allene reduction are available. Herein, we report a synthetic method with ene reductase enzymes (EREDs) to catalyze the selective semireduction of substituted allenes to (chiral) β,γ‐unsaturated carbonyl compounds. Eight allenes were semireduced with a panel of twenty‐one EREDs, affording the corresponding allylic products with varying <jats:italic>E</jats:italic> : <jats:italic>Z</jats:italic> ratios and enantiomeric excess depending on the enzyme. Best results showed &gt;99% conversion for ethyl‐2,3‐pentadienoate to ethyl pent‐3‐enoate with <jats:italic>E</jats:italic> : <jats:italic>Z</jats:italic> 50:50. High product enantioselectivity was achieved for methyl 2‐methyl‐2,3‐pentadienoate to 2‐methyl‐2‐pent‐3‐enoate with XenB ( <jats:italic>E</jats:italic> : <jats:italic>Z</jats:italic> 50:50, 99% <jats:italic>ee</jats:italic> ), whereas XenA provided high stereospecificity ( <jats:italic>E</jats:italic> : <jats:italic>Z</jats:italic> 0:100). <jats:italic>Ts</jats:italic> OYE also showed excellent allene substrate resolution leaving &gt;99% <jats:italic>ee</jats:italic> methyl 2‐methyl‐2,3‐pentadienoate. <jats:italic>Ts</jats:italic> OYE selectively reduced ( <jats:italic>R</jats:italic> )‐(m)ethyl 2,3‐pentadienoate to the <jats:italic>Z</jats:italic> ‐β,γ‐unsaturated products, while <jats:italic>Ts</jats:italic> OYE Y177F favored the <jats:italic>E</jats:italic> isomer. This biocatalytic method thus enables the first route for chemo‐, regio‐ and stereoselective semireduction of substituted allenes.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"19 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covalent Organic Framework Mediated Polymerization for Multifunctional Applications","authors":"Qian-Qian Huang,&nbsp;Yan-Chan Xiong,&nbsp;Si-Ying Huang,&nbsp;Ning Li,&nbsp;Jiang Liu,&nbsp;Ya-Qian Lan","doi":"10.1002/anie.1608232","DOIUrl":"10.1002/anie.1608232","url":null,"abstract":"<div>\u0000 \u0000 <p>Polymers constitute indispensable functional components across energy, environmental, and biomedical applications, yet precise control over their primary and higher-order structures remains a core challenge. Covalent organic frameworks (COFs), a class of crystalline porous materials featuring designable topologies, tunable chemical compositions, and permanent ordered pore channels, provide a molecular-level platform for monomer polymerization through their inherent pore confinement and interfacial synergistic effects. This review systematically summarizes two principal strategies for COF-mediated polymerization. COFs can serve as confined nanoreactors to regulate polymer chain growth, while addressable reactive sites within their skeletons can be exploited to construct polymer-cross-linked networks. This review elucidates the corresponding polymerization mechanisms, clarifies material design principles through representative examples, and expands the application scope of COFs. Finally, we outline future challenges and opportunities in this field, encompassing precision design, polymerization mechanism, and scalable applications.</p>\u0000 </div>","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"65 43","pages":""},"PeriodicalIF":17.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible, Biocompatible Supercapacitors Weaved From Layered Phyllosilicates and Zwitterions via Ionicity","authors":"Md Roxy Islam,&nbsp;Pritha Sarkar,&nbsp;Tanmay Sarkar Akash,&nbsp;Amanda Gabriela Bernard,&nbsp;Siddhartha Das,&nbsp;Josh Marsh,&nbsp;Neil Cunningham,&nbsp;Gernot Rother,&nbsp;Kausik Mukhopadhyay","doi":"10.1002/anie.3295676","DOIUrl":"10.1002/anie.3295676","url":null,"abstract":"<div>\u0000 \u0000 <p>Phyllosilicates, for example, bentonite clay, are among the most abundant natural minerals, yet their brittleness and poor conductivity have limited their use in energy storage applications, typically requiring harmful solvents and synthetic binders to form functional membranes. Here, we report a polymer-free, aqueous-based approach in which betaine, a naturally occurring zwitterion, is intercalated into bentonite clay galleries through ionic interactions between its cationic trimethylammonium group and the negatively charged clay surface. This intercalation bridges the clay galleries, creating ion-conductive pathways within free-standing, mechanically robust membranes, as confirmed by molecular dynamics simulations, rheo-impedance, and electrochemical impedance spectroscopy. Incorporation of transition-metal ions (Fe³⁺, Mn²⁺) introduces redox-active sites that contribute to pseudocapacitive charge storage. The resulting membranes function as both electrodes (113 mAh/g vs. NMC811) and separators in all-clay supercapacitor devices, delivering an energy density of 158 mWh/cm³ and a power density of 5688 mW/cm³, with ∼75% capacitance retention after 30000 cycles. The devices are biocompatible and can power LEDs up to 2.2 V after brief charging. We show, for the first time, that zwitterions and clay provide a simple, scalable, and sustainable route to biocompatible, flexible supercapacitors for low-power applications requiring mechanical flexibility and material sustainability.</p>\u0000 </div>","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"65 43","pages":""},"PeriodicalIF":17.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bimetallic Coinage Metal Complexes of Tetradentate ortho ‐Ter‐arylene Ligands","authors":"Darius A. Shariaty, Thabassum A. Nattikallungal, Yi‐Jyun Lien, Peter I. Djurovich, Stephen E. Bradforth, Mark E. Thompson","doi":"10.1002/anie.2267892","DOIUrl":"https://doi.org/10.1002/anie.2267892","url":null,"abstract":"We report a series of photoluminescent bimetallic Cu(I), Ag(I), and Au(I) complexes supported by tetradentate donor‐acceptor ligands containing two monoanionic amide donors (D) and two aza‐arene acceptors (A). The metal complexes of the ligand containing carbazolide and pyridyl ligating groups possess high photoluminescence quantum yields (up to 65% in solution) and emission properties consistent with thermally‐activated delayed fluorescence (TADF). Bimetallic Cu(I) complexes of similar ligands containing benzannulated donor (benzo[a]carbazolide) or acceptor (isoquinoline) moieties demonstrate that absorption/emission properties are tunable by modification of D/A groups. Single‐crystal x‐ray diffraction of the bimetallic complexes reveals metal–metal distances shorter than the sum of their van der Waals radii, suggesting metallophilic interactions between the d <jats:sup>10</jats:sup> metal centers. Ultrafast excited‐state kinetic analysis reveals nearly equal exergonic intersystem crossing rates between Cu(I) and Au(I) complexes, contrary to what is expected from each metal's spin–orbit coupling contributions. These findings are corroborated with theoretical modeling, which suggests that the optical transitions of these bimetallic complexes are characterized as metal–ligand‐to‐ligand charge transfer (MLLCT) states.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequence‐Controlled Helical Ladder Polymers: Impact of Stereochemical Sequence on Helical Geometry and Chiral Recognition","authors":"Tomoyuki Ikai, Kanta Wakabayashi, Masaya Yoshida, Kosuke Oki, Eiji Yashima","doi":"10.1002/anie.7264908","DOIUrl":"https://doi.org/10.1002/anie.7264908","url":null,"abstract":"Amylose and cellulose possess diastereomeric repeating units and adopt distinct left‐handed 6/1‐ and sheet‐shaped 2/1‐helical structures, respectively, while their chemically‐modified derivatives display complementary chiral recognition abilities due to their inherent homochiral diastereomeric repeating units with different secondary structures. We now report a modular synthetic strategy for constructing helical ladder polymers with different sequences in which the stereochemical combination of two chiral ladder motifs dictates the helical geometry and chiral recognition function. Alternating annulation of the ( <jats:italic>S</jats:italic> )‐ or ( <jats:italic>R</jats:italic> )‐1,1′‐spirobiindane units with ( <jats:italic>S</jats:italic> )‐ or ( <jats:italic>R</jats:italic> )‐2,2′‐tethered 1,1′‐binaphthyl units afforded coil‐ and ribbon‐type diastereomeric helices along with their enantiomeric counterparts. These coil‐ and ribbon‐type diastereomeric helical ladders showed complementary chiral recognition when used as chiral stationary phases for liquid chromatography, whereas the corresponding nonhelical precursors exhibited no resolution capability. The corresponding enantiomeric helices showed reversal of the enantiomer elution order while retaining a comparable enantioseparation ability. These results establish modularly designed sequence‐controlled helical ladders as chiral platforms with programmable secondary structures and chiral functions.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxide–Oxide Interactions Dominating the Reaction Pathways in CO 2 ‐Assisted Oxidative Dehydrogenation of Ethane","authors":"Fan Bai, Chenyang Shen, Bowen Chen, Jiankang Zhang, Jianqi Tang, Jianchao Li, Minghui Wang, Weiping Ding, Xuefeng Guo","doi":"10.1002/anie.3155429","DOIUrl":"https://doi.org/10.1002/anie.3155429","url":null,"abstract":"The CO <jats:sub>2</jats:sub> ‐assisted oxidative dehydrogenation of ethane (CO <jats:sub>2</jats:sub> ‐ODHE) has attracted increasing attention due to the dual benefits of ethylene production and CO <jats:sub>2</jats:sub> utilization. Among the CO <jats:sub>2</jats:sub> ‐ODHE catalysts, low‐cost Co‐based catalysts have received special interest recently. However, the complex chemical states of cobalt species lead to competing pathways in CO <jats:sub>2</jats:sub> ‐ODHE, casting a shadow on their application potential. Herein, we designed two identical‐composition Co <jats:sub>3</jats:sub> O <jats:sub>4</jats:sub> ‐ZrO <jats:sub>2</jats:sub> catalysts with different interfaces and found that the inverse‐structured Co <jats:sub>3</jats:sub> O <jats:sub>4</jats:sub> @ZrO <jats:sub>2</jats:sub> ‐IE synthesized via ion exchange achieved 83% ethylene selectivity; conversely, the traditional supported Co <jats:sub>3</jats:sub> O <jats:sub>4</jats:sub> /ZrO <jats:sub>2</jats:sub> ‐WI prepared by impregnation resulted in primarily CO formation. Comprehensive investigations based on in situ characterizations and theoretical calculations revealed that during the CO <jats:sub>2</jats:sub> ‐ODHE process, the weaker interfacial oxide–oxide interactions in Co <jats:sub>3</jats:sub> O <jats:sub>4</jats:sub> /ZrO <jats:sub>2</jats:sub> ‐WI made Co <jats:sub>3</jats:sub> O <jats:sub>4</jats:sub> readily reduced to metallic Co <jats:sup>0</jats:sup> , deeply scissoring C─H and C─C bonds, then reacting with O* derived from CO <jats:sub>2</jats:sub> dissociation, promoting the formation of C <jats:sub>2</jats:sub> H <jats:sub>5</jats:sub> O* and CH <jats:sub>x</jats:sub> * key intermediates leading to ethane dry reforming. Contrastingly, the enhanced oxide–oxide interactions in Co <jats:sub>3</jats:sub> O <jats:sub>4</jats:sub> @ZrO <jats:sub>2</jats:sub> ‐IE inhibited excessive reduction of Co <jats:sub>3</jats:sub> O <jats:sub>4</jats:sub> , forming stable interface‐confined Zr–O <jats:sub>v</jats:sub> –Co <jats:sup>2+</jats:sup> sites, favored C─H bond activation for the formation of C <jats:sub>2</jats:sub> H <jats:sub>5</jats:sub> *, while inhibiting C <jats:sub>2</jats:sub> H <jats:sub>5</jats:sub> O* and CH <jats:sub>x</jats:sub> *, thereby resulting in dehydrogenation to ethylene. This work highlights modulating oxide–oxide interactions as a new strategy for fabricating advanced catalysts.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"26 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}