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Comment on "Efficacy of Surgery on Improvement of Locomotive Syndrome in Older Patients With Lumbar Spinal Stenosis: Comparison With the General Older Population". 《手术治疗老年腰椎管狭窄症患者机车综合征的疗效:与普通老年人群的比较》一文评论。
IF 2.7 4区 医学
Geriatrics & Gerontology International Pub Date : 2026-10-01 DOI: 10.1111/ggi.70787
Safoyev Baqodir Barnoyevich, Boltayev Timur Shavkatovich, Safayev Boburjon Baxodir-o'gli
{"title":"Comment on \"Efficacy of Surgery on Improvement of Locomotive Syndrome in Older Patients With Lumbar Spinal Stenosis: Comparison With the General Older Population\".","authors":"Safoyev Baqodir Barnoyevich, Boltayev Timur Shavkatovich, Safayev Boburjon Baxodir-o'gli","doi":"10.1111/ggi.70787","DOIUrl":"https://doi.org/10.1111/ggi.70787","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 10","pages":"e70787"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between CT-Based Rectal Stool Attenuation and Activities of Daily Living in Hospitalized Older Adults. 基于ct的直肠粪便衰减与住院老年人日常生活活动的关系
IF 2.7 4区 医学
Geriatrics & Gerontology International Pub Date : 2026-10-01 DOI: 10.1111/ggi.70867
Hitoshi Komiya, Kazuhisa Watanabe, Masaaki Nagae, Hirotaka Nakashima, Chisato Fujisawa, Tomihiko Tajima, Yosuke Yamada, Hiroyuki Umegaki
{"title":"Association Between CT-Based Rectal Stool Attenuation and Activities of Daily Living in Hospitalized Older Adults.","authors":"Hitoshi Komiya, Kazuhisa Watanabe, Masaaki Nagae, Hirotaka Nakashima, Chisato Fujisawa, Tomihiko Tajima, Yosuke Yamada, Hiroyuki Umegaki","doi":"10.1111/ggi.70867","DOIUrl":"10.1111/ggi.70867","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the association between rectal stool characteristics measured by computed tomography (CT), particularly stool attenuation, and activities of daily living (ADL) in hospitalized older adults who had previously undergone abdominal CT for clinical reasons.</p><p><strong>Methods: </strong>This single-center exploratory cross-sectional study included adults aged ≥ 65 years admitted to the geriatric ward of Nagoya University Hospital who underwent abdominal CT within 1 month before or during hospitalization. Basic ADL (BADL) and instrumental ADL (IADL) were assessed using the Barthel Index and the Lawton and Brody IADL scale, respectively. Rectal stool attenuation, rectal lumen area, stool area, and gas area were measured on the axial slice with the largest rectal cross-section. High-attenuation stool was defined as > 100 HU, and 10 cm<sup>2</sup> was used as the threshold for rectal area parameters. Correlations between continuous CT parameters were examined using Spearman's rank correlation. Associations between CT findings and ADL were first examined by comparing mean ADL scores between groups defined by CT parameters; multivariable logistic regression was then used to evaluate factors independently associated with high-attenuation stool. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.</p><p><strong>Results: </strong>Among 116 participants (mean age, 85.8 years), 31.0% had high-attenuation stool. High-attenuation stool was associated with significantly lower BADL scores (55.4 ± 38.0 vs. 74.4 ± 27.5) and IADL scores (2.4 ± 2.9 vs. 3.9 ± 2.8). Stool attenuation was positively correlated with stool area (r = 0.34) and negatively correlated with gas area (r = -0.31). In multivariable analysis, lower BADL (OR, 0.983; 95% CI, 0.970-0.997) and lower IADL (OR, 0.840; 95% CI, 0.715-0.986) were independently associated with high-attenuation stool. When analyzed as a continuous variable, stool attenuation was negatively correlated with both BADL (r = -0.224, p = 0.015) and IADL (r = -0.199, p = 0.032).</p><p><strong>Conclusion: </strong>High rectal stool attenuation on CT was significantly associated with lower ADL in hospitalized older adults. These exploratory findings suggest that CT-based rectal stool attenuation may provide supplementary imaging information regarding functional vulnerability in older adults who have previously undergone abdominal CT. However, the cross-sectional design, CT-selected study population, and lack of contemporaneous assessment of constipation symptoms, bowel habits, or stool form preclude conclusions regarding causality or clinical utility.</p>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 10","pages":"e70867"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
B-Type Natriuretic Peptide Is Associated With Sarcopenia in Older Patients Without Symptomatic Heart Failure. b型利钠肽与老年无症状心力衰竭患者肌肉减少症相关
IF 2.7 4区 医学
Geriatrics & Gerontology International Pub Date : 2026-10-01 DOI: 10.1111/ggi.70868
Ayumi Toba, Joji Ishikawa, Yoshiaki Tamura, Atsushi Araki, Kazumasa Harada
{"title":"B-Type Natriuretic Peptide Is Associated With Sarcopenia in Older Patients Without Symptomatic Heart Failure.","authors":"Ayumi Toba, Joji Ishikawa, Yoshiaki Tamura, Atsushi Araki, Kazumasa Harada","doi":"10.1111/ggi.70868","DOIUrl":"https://doi.org/10.1111/ggi.70868","url":null,"abstract":"<p><strong>Aim: </strong>B-type natriuretic peptide (BNP) has been identified as a biomarker of sarcopenia in community-dwelling populations and in patients with heart failure. However, it remains unclear whether BNP is associated with sarcopenia in the pre-heart failure stage in older adults with cardiometabolic diseases.</p><p><strong>Methods: </strong>In this cross-sectional study, BNP was measured in 697 older outpatients with cardiometabolic disease and no history of heart failure or atrial fibrillation. Sarcopenia was assessed using the Asian Working Group for Sarcopenia criteria 2019. The participants were grouped according to whether their BNP level was < 35 pg/mL, 35 ≤ BNP < 100 pg/mL, or ≥ 100 pg/mL in accordance with the Japanese guideline on diagnosis and treatment of heart failure.</p><p><strong>Results: </strong>The mean age was 78.8 ± 6.8 years. Sarcopenia was present in 38% of patients. Natural log-transformed BNP was significantly related to gait speed (B = -0.278, SE = 0.128, p = 0.031) and hand grip strength (B = -0.016, SE = 0.007, p = 0.013) even after adjusting for age, sex, body mass index, estimated glomerular filtration rate, regular alcohol intake, smoking status, diabetes mellitus, dyslipidemia, hypertension, stroke, and antihypertensive medication use. Multivariate logistic regression analysis revealed that those with BNP ≥ 100 pg/mL had an increased risk of sarcopenia (OR 2.33, 95% CI 1.18-4.60), low appendicular skeletal mass index (OR 2.47, 95% CI 1.19-5.15), and low handgrip strength (OR 2.44, 95% CI 1.27-4.68).</p><p><strong>Conclusions: </strong>Increased BNP (≥ 100 pg/mL) was associated with sarcopenia even in individuals with cardiometabolic disease and no history of atrial fibrillation or symptomatic heart failure.</p>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 10","pages":"e70868"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149180929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Application of Machine Learning for Daily-Life Near-Fall Detection in Older Adults. 探索机器学习在老年人日常生活近跌倒检测中的应用。
IF 2.7 4区 医学
Geriatrics & Gerontology International Pub Date : 2026-10-01 DOI: 10.1111/ggi.70862
Nina Marie Schmidt, Tania Zieschang, Lea Feld, Laura Himmelmann, Elisa-Marie Speckmann, Tim Stuckenschneider
{"title":"Exploring the Application of Machine Learning for Daily-Life Near-Fall Detection in Older Adults.","authors":"Nina Marie Schmidt, Tania Zieschang, Lea Feld, Laura Himmelmann, Elisa-Marie Speckmann, Tim Stuckenschneider","doi":"10.1111/ggi.70862","DOIUrl":"10.1111/ggi.70862","url":null,"abstract":"<p><strong>Background: </strong>Falls are a health concern among older adults, and near-falls may serve as an early indicator of future falls, functional decline, and the need for targeted preventive interventions. While previous research has successfully demonstrated near-fall detection using machine learning in controlled laboratory environments, it remains crucial to evaluate the application of such approaches in daily-life settings.</p><p><strong>Aim: </strong>This study examines the application of a pre-trained machine learning algorithm to detect gait perturbations in daily-life and to explore how these classified gait perturbations are associated with participant characteristics.</p><p><strong>Methods: </strong>Data from the SeFallED study was used, which followed up on individuals aged ≥ 60 years who presented to the emergency department following a fall. Daily stepping time was recorded using a thigh-worn accelerometer over 7 days, segmented into windows, and analyzed using a laboratory-based pre-trained one-dimensional convolutional neural network to detect near-falls.</p><p><strong>Results: </strong>A total of 202 participants (median age 75 years) were included in the analysis. On average, 58% of total stepping time windows were classified as gait perturbation windows. Higher age, lower cognitive and functional performance, greater concerns about falling, and higher levels of frailty were associated with a greater proportion of classified gait perturbations.</p><p><strong>Conclusion: </strong>The laboratory-trained algorithm classified a high number of windows as gait perturbations, likely reflecting gait irregularities including misclassifications rather than exclusively near-falls. Although these classifications still meaningfully reflect participant characteristics, further training and validation are required to enhance the algorithm's ability to accurately distinguish and objectively assess gait perturbations and near-falls in daily-life.</p>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 10","pages":"e70862"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149192595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grip Measurement Repetition Changes Low-Strength Classification Under the Asian Working Group for Sarcopenia 2025 Criteria. 握力测量重复改变了亚洲肌少症工作组2025标准下的低强度分类。
IF 2.7 4区 医学
Geriatrics & Gerontology International Pub Date : 2026-10-01 DOI: 10.1111/ggi.70880
Zhangle Zhu
{"title":"Grip Measurement Repetition Changes Low-Strength Classification Under the Asian Working Group for Sarcopenia 2025 Criteria.","authors":"Zhangle Zhu","doi":"10.1111/ggi.70880","DOIUrl":"https://doi.org/10.1111/ggi.70880","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 10","pages":"e70880"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An 11-Protein Plasma Proteomic Signature Associated With Incident Dementia Risk in the UK Biobank 在英国生物库中,与痴呆风险相关的11蛋白血浆蛋白质组学特征
IF 2.7 4区 医学
Geriatrics & Gerontology International Pub Date : 2026-10-01 DOI: 10.1111/ggi.70854
Simin Yang, Zhihong Wang, Yanqi Wu, Hehan Feng, Zongzong Yang, Yuyu Yang
{"title":"An 11-Protein Plasma Proteomic Signature Associated With Incident Dementia Risk in the UK Biobank","authors":"Simin Yang,&nbsp;Zhihong Wang,&nbsp;Yanqi Wu,&nbsp;Hehan Feng,&nbsp;Zongzong Yang,&nbsp;Yuyu Yang","doi":"10.1111/ggi.70854","DOIUrl":"10.1111/ggi.70854","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To derive a compact plasma proteomic signature associated with incident dementia and evaluate the internal performance of the finalized score in UK Biobank.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective cohort study, we screened 2923 baseline Olink assays using Cox models adjusted for age, age squared, sex, and the first 10 genetic principal components. Proteins passing false-discovery-rate control underwent 2- and 5-year landmark analyses, correlation-based redundancy pruning, and repeated stability-based feature selection. The finalized score was evaluated in basic and extended clinical models, a chronological subgroup performance assessment, proportional-hazards testing, and landmark sensitivity analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 36 696 participants (mean age 56.84 years; 591 incident dementia events; median follow-up 15.73 years), the final 11-protein score was associated with incident dementia (hazard ratio per 1-SD increase, 2.645; 95% confidence interval, 2.459–2.845) and increased Harrell's C-index from 0.798 to 0.862. In the extended clinical cohort (23 179 participants; 441 events), C-index increased from 0.792 to 0.861. In the later chronological subset (6954 participants; 97 events), C-index increased from 0.801 to 0.869. Associations persisted in the 2- and 5-year landmark analyses, and no statistically significant score-specific violation of the proportional-hazards assumption was detected (<i>p</i> = 0.105).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A broad plasma proteomic screen yielded a compact 11-protein signature that was strongly associated with incident dementia and showed consistent internal performance after the score had been finalized. Independent external validation is required before clinical use.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149107595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the Rankin Scale: A Patient-Centered Score for Meaningful Recovery After Mechanical Thrombectomy in Older Adults With Pre-Stroke Disability. 超越兰金量表:卒中前残疾老年人机械取栓后有意义恢复的以患者为中心的评分。
IF 2.7 4区 医学
Geriatrics & Gerontology International Pub Date : 2026-10-01 DOI: 10.1111/ggi.70874
Hiroyasu Inoue, Masahiro Oomura, Yoshitaka Nakamura, Yusuke Nishikawa, Yuto Uchida, Shoya Kusui, Atsuhito Taishaku, Yoshiro Nozaki, Tomoyasu Yamanaka, Teishiki Shibata, Yasuhide Inoue, Yoko Taniguchi, Yuta Madokoro, Toyohiro Sato, Teppei Fujioka, Masayuki Mizuno, Shoji Kawashima, Mitsuhito Mase, Noriyuki Matsukawa
{"title":"Beyond the Rankin Scale: A Patient-Centered Score for Meaningful Recovery After Mechanical Thrombectomy in Older Adults With Pre-Stroke Disability.","authors":"Hiroyasu Inoue, Masahiro Oomura, Yoshitaka Nakamura, Yusuke Nishikawa, Yuto Uchida, Shoya Kusui, Atsuhito Taishaku, Yoshiro Nozaki, Tomoyasu Yamanaka, Teishiki Shibata, Yasuhide Inoue, Yoko Taniguchi, Yuta Madokoro, Toyohiro Sato, Teppei Fujioka, Masayuki Mizuno, Shoji Kawashima, Mitsuhito Mase, Noriyuki Matsukawa","doi":"10.1111/ggi.70874","DOIUrl":"10.1111/ggi.70874","url":null,"abstract":"<p><strong>Aim: </strong>The benefit of mechanical thrombectomy (MT) for acute ischemic stroke in patients with pre-stroke moderate-to-severe disability is difficult to evaluate using the modified Rankin Scale (mRS) alone. We developed and evaluated the SMILE-Stroke score as a patient-centered outcome measure.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 31 patients with pre-stroke mRS scores of 3-5 who underwent MT. The 10-point SMILE-Stroke score, comprising Speech, Mobility, Ingestion, Lavatory, and Engagement domains, was assessed at discharge; a score ≥ 4 was prespecified as favorable. Interrater reliability, convergent validity with the Barthel Index, associations with discharge disposition and mRS, and pre-stroke SMILE-Stroke scores were evaluated.</p><p><strong>Results: </strong>Twelve patients (38.7%) achieved a favorable SMILE-Stroke outcome. Interrater reliability was excellent for the total score (single-rater intraclass correlation coefficient = 0.957) and dichotomized outcome (Fleiss' κ = 0.863). The score correlated strongly with the discharge Barthel Index (Spearman's ρ = 0.86, p < 0.001) and showed a graded association with discharge disposition (Kruskal-Wallis p = 0.0012). For distinguishing discharge to home/original residence or rehabilitation hospital from long-term care hospital or death, the SMILE-Stroke score yielded an AUC of 0.82. Notably, 6 of 19 patients (31.6%) with 90-day mRS scores of 4-5 achieved a favorable SMILE-Stroke outcome.</p><p><strong>Conclusions: </strong>The SMILE-Stroke score was feasible, reproducible, and associated with established functional and discharge outcomes in selected MT-treated patients with pre-stroke disability. It may complement the mRS by identifying preserved or regained patient-centered functional domains within poor mRS categories.</p>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 10","pages":"e70874"},"PeriodicalIF":2.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-World Effectiveness of Individualized DASH-Based Nutritional Support on Blood Pressure Trajectories in Elderly Hypertensive Patients: A Retrospective Cohort Study 基于dash的个体化营养支持对老年高血压患者血压轨迹的实际有效性:一项回顾性队列研究。
IF 2.7 4区 医学
Geriatrics & Gerontology International Pub Date : 2026-09-30 DOI: 10.1111/ggi.70849
Qianqian Yang, Na Zhang, Meilan Zheng, Yanli Cheng, Jing Zhou
{"title":"Real-World Effectiveness of Individualized DASH-Based Nutritional Support on Blood Pressure Trajectories in Elderly Hypertensive Patients: A Retrospective Cohort Study","authors":"Qianqian Yang,&nbsp;Na Zhang,&nbsp;Meilan Zheng,&nbsp;Yanli Cheng,&nbsp;Jing Zhou","doi":"10.1111/ggi.70849","DOIUrl":"10.1111/ggi.70849","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hypertension control among Chinese older adults remains suboptimal, and the real-world effectiveness of individualized Dietary Approaches to Stop Hypertension (DASH)-based nutritional support delivered through community nursing is unclear. This study evaluated its association with 6-month blood pressure trajectories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study used electronic health records to compare nurse-delivered individualized DASH-based nutritional support with standard care. Propensity score matching (1:1) was performed. The primary outcome was the 6-month systolic blood pressure (SBP) trajectory, analyzed using linear mixed-effects models with a Group × Time interaction. Secondary outcomes included diastolic blood pressure (DBP), blood pressure control (&lt; 140/90 mmHg), body mass index (BMI), and hypotension.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 366 eligible patients, 210 were matched (105 per group), with all postmatching standardized mean differences &lt; 0.10. SBP trajectories differed significantly between groups (<i>p</i><sub>interaction</sub> &lt; 0.001). At 6 months, the between-group differences were −4.3 mmHg for SBP (95% CI, −6.6 to −2.0; <i>p</i> &lt; 0.001) and −2.7 mmHg for DBP (<i>p</i> &lt; 0.001). Blood pressure control was higher in the intervention group (61.9% vs. 40.0%; <i>p</i> = 0.003). The SBP difference was larger among patients with severe hypertension (−7.5 vs. −3.1 mmHg; <i>p</i><sub>interaction</sub> = 0.012). In the higher-contact subgroup (≥ 3 documented nutritional contacts), the SBP difference was −5.6 mmHg. BMI decreased by 1.2 kg/m<sup>2</sup> (<i>p</i> &lt; 0.001). Hypotension was uncommon and comparable between groups (3.8% vs. 2.9%; <i>p</i> = 1.000).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Individualized community-based DASH nutritional support was associated with more favorable blood pressure trajectories and higher control rates without an observed increase in hypotension. Larger differences were observed among patients with severe baseline hypertension and those with greater documented intervention contact.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149107535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cortical Morphology and Susceptibility to Fall-Related Fractures: A Bidirectional Mendelian Randomization Study 皮质形态与跌倒相关骨折易感性:双向孟德尔随机研究。
IF 2.7 4区 医学
Geriatrics & Gerontology International Pub Date : 2026-09-30 DOI: 10.1111/ggi.70839
Xiao-Ling Yang, Qing-Hua Zhao, Ming-Zhao Xiao, Ying-Zhuo Ma, Yong-Mei Hong
{"title":"Cortical Morphology and Susceptibility to Fall-Related Fractures: A Bidirectional Mendelian Randomization Study","authors":"Xiao-Ling Yang,&nbsp;Qing-Hua Zhao,&nbsp;Ming-Zhao Xiao,&nbsp;Ying-Zhuo Ma,&nbsp;Yong-Mei Hong","doi":"10.1111/ggi.70839","DOIUrl":"10.1111/ggi.70839","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Injurious falls and low-energy fractures after a simple fall cause substantial morbidity in older adults; observational brain-structure associations are vulnerable to confounding and reverse causation. To test whether predicted regional cortical thickness or surface area causally influences falls and fractures after a simple fall, and to evaluate reverse causality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Bidirectional two-sample Mendelian randomization used cortical morphology across 34 regions (&gt; 51 000 Europeans). Outcomes were falls/tendency to fall and simple-fall fractures. Independent genome-wide significant instruments (<i>p</i> &lt; 5 × 10<sup>−8</sup>) were clumped at <i>r</i><sup>2</sup> = 0.001 within a 10 000 kb window, retained if SNP-level <i>F</i> statistics were &gt; 10, and analyzed using inverse-variance weighted MR with sensitivity methods, pleiotropy/directionality checks, and Benjamini–Hochberg FDR correction. Estimated bone mineral density (eBMD) was explored as a potential mediator.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After FDR correction and pleiotropy screening, larger caudal anterior cingulate surface area was associated with lower odds of fracture resulting from a simple fall (OR 0.95, 95% CI 0.92–0.98; pFDR = 0.0159), whereas larger insula surface area was related to higher odds of fracture resulting from a simple fall (OR 1.05, 95% CI 1.02–1.08; pFDR = 0.0037). Associations with the broader falls/tendency-to-fall phenotype were not robust. Reverse MR showed no evidence that falls or simple-fall fractures altered cortical traits, and exploratory eBMD analyses did not support mediation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Genetically predicted surface area in the caudal anterior cingulate and insula was associated with susceptibility to fractures resulting from simple falls. These findings require replication and functional validation before specific neurobiological mechanisms or clinical applications can be inferred.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of AWGS2025 Age-Specific Handgrip Strength Thresholds on AWGC-Defined Cachexia AWGS2025年龄特异性握力阈值对awgc定义的恶病质的影响。
IF 2.7 4区 医学
Geriatrics & Gerontology International Pub Date : 2026-09-29 DOI: 10.1111/ggi.70855
Tatsuma Sakaguchi, Keisuke Maeda, Makoto Yamasaki, Naoharu Mori
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