IF 5 3区化学

Gels Pub Date : 2024-10-17 DOI: 10.3390/gels10100663

Nour Alhuda Alaghawani, Hala Alkhatib, Layla Elmancy, Anis Daou

{"title":"Harmonizing Innovations: An In-Depth Comparative Review on the Formulation, Applications, and Future Perspectives of Aerogels and Hydrogels in Pharmaceutical Sciences.","authors":"Nour Alhuda Alaghawani, Hala Alkhatib, Layla Elmancy, Anis Daou","doi":"10.3390/gels10100663","DOIUrl":"https://doi.org/10.3390/gels10100663","url":null,"abstract":"Gels, specifically hydrogels and aerogels, have emerged as versatile materials with profound implications in pharmaceutical sciences. This comprehensive review looks into detail at hydrogels and aerogels, providing a general introduction to gels as a foundation. The paper is then divided into distinct sections for hydrogels and aerogels, each delving into their unique formulations, advantages, disadvantages, and applications. In the realm of hydrogels, we scrutinize the intricacies of formulation, highlighting the versatile advantages they offer. Conversely, potential limitations are explored, paving the way for a detailed discussion on their applications, with a specific focus on their role in antimicrobial applications. Shifting focus to aerogels, a thorough overview is presented, followed by a detailed explanation of the complex formulation process involving sol-gel chemistry; aging; solvent exchange; and drying techniques, including freeze drying, supercritical drying, and ambient-pressure drying (APD). The intricacies of drug loading and release from aerogels are addressed, providing insights into their pharmaceutical potential. The advantages and disadvantages of aerogels are examined, accompanied by an exploration of their applications, with a specific emphasis on antimicrobial uses. The review culminates in a comparative analysis, juxtaposing the advantages and disadvantages of hydrogels and aerogels. Furthermore, the current research and development trends in the applications of these gels in pharmaceutical sciences are discussed, providing a holistic view of their potential and impact. This review serves as a comprehensive guide for researchers, practitioners, and enthusiasts, seeking a deeper understanding of the distinctive attributes and applications of hydrogels and aerogels in the ever-evolving research concerning pharmaceutical sciences.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"10 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in Hydrogels for Corneal Healing and Tissue Engineering. 用于角膜愈合和组织工程的水凝胶研究进展。

IF 5 3区化学

Gels Pub Date : 2024-10-16 DOI: 10.3390/gels10100662

Kevin Y Wu, Shu Yu Qian, Anne Faucher, Simon D Tran

{"title":"Advancements in Hydrogels for Corneal Healing and Tissue Engineering.","authors":"Kevin Y Wu, Shu Yu Qian, Anne Faucher, Simon D Tran","doi":"10.3390/gels10100662","DOIUrl":"https://doi.org/10.3390/gels10100662","url":null,"abstract":"Hydrogels have garnered significant attention for their versatile applications across various fields, including biomedical engineering. This review delves into the fundamentals of hydrogels, exploring their definition, properties, and classification. Hydrogels, as three-dimensional networks of crosslinked polymers, possess tunable properties such as biocompatibility, mechanical strength, and hydrophilicity, making them ideal for medical applications. Uniquely, this article offers original insights into the application of hydrogels specifically for corneal tissue engineering, bridging a gap in current research. The review further examines the anatomical and functional complexities of the cornea, highlighting the challenges associated with corneal pathologies and the current reliance on donor corneas for transplantation. Considering the global shortage of donor corneas, this review discusses the potential of hydrogel-based materials in corneal tissue engineering. Emphasis is placed on the synthesis processes, including physical and chemical crosslinking, and the integration of bioactive molecules. Stimuli-responsive hydrogels, which react to environmental triggers, are identified as promising tools for drug delivery and tissue repair. Additionally, clinical applications of hydrogels in corneal pathologies are explored, showcasing their efficacy in various trials. Finally, the review addresses the challenges of regulatory approval and the need for further research to fully realize the potential of hydrogels in corneal tissue engineering, offering a promising outlook for future developments in this field.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"10 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and Functional Integration of Hydrogel Composites as Drug Delivery Systems in Contemporary Dentistry. 水凝胶复合材料作为药物输送系统在当代牙科领域的发展和功能整合。

IF 5 3区化学

Gels Pub Date : 2024-10-16 DOI: 10.3390/gels10100661

Dragos Nicolae Fratila, Dragos Ioan Virvescu, Ionut Luchian, Monica Hancianu, Elena Raluca Baciu, Oana Butnaru, Dana Gabriela Budala

{"title":"Advances and Functional Integration of Hydrogel Composites as Drug Delivery Systems in Contemporary Dentistry.","authors":"Dragos Nicolae Fratila, Dragos Ioan Virvescu, Ionut Luchian, Monica Hancianu, Elena Raluca Baciu, Oana Butnaru, Dana Gabriela Budala","doi":"10.3390/gels10100661","DOIUrl":"https://doi.org/10.3390/gels10100661","url":null,"abstract":"This study explores the recent advances of and functional insights into hydrogel composites, materials that have gained significant attention for their versatile applications across various fields, including contemporary dentistry. Hydrogels, known for their high water content and biocompatibility, are inherently soft but often limited by mechanical fragility. Key areas of focus include the customization of hydrogel composites for biomedical applications, such as drug delivery systems, wound dressings, and tissue engineering scaffolds, where improved mechanical properties and bioactivity are critical. In dentistry, hydrogels are utilized for drug delivery systems targeting oral diseases, dental adhesives, and periodontal therapies due to their ability to adhere to the mucosa, provide localized treatment, and support tissue regeneration. Their unique properties, such as mucoadhesion, controlled drug release, and stimuli responsiveness, make them ideal candidates for treating oral conditions. This review highlights both experimental breakthroughs and theoretical insights into the structure-property relationships within hydrogel composites, aiming to guide future developments in the design and application of these multifunctional materials in dentistry. Ultimately, hydrogel composites represent a promising frontier for advancing materials science with far-reaching implications in healthcare, environmental technology, and beyond.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"10 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging Deep Learning and Generative AI for Predicting Rheological Properties and Material Compositions of 3D Printed Polyacrylamide Hydrogels. 利用深度学习和生成式人工智能预测 3D 打印聚丙烯酰胺水凝胶的流变特性和材料成分。

IF 5 3区化学

Gels Pub Date : 2024-10-15 DOI: 10.3390/gels10100660

Sakib Mohammad, Rafee Akand, Kaden M Cook, Sabrina Nilufar, Farhan Chowdhury

{"title":"Leveraging Deep Learning and Generative AI for Predicting Rheological Properties and Material Compositions of 3D Printed Polyacrylamide Hydrogels.","authors":"Sakib Mohammad, Rafee Akand, Kaden M Cook, Sabrina Nilufar, Farhan Chowdhury","doi":"10.3390/gels10100660","DOIUrl":"https://doi.org/10.3390/gels10100660","url":null,"abstract":"Artificial intelligence (AI) has the ability to predict rheological properties and constituent composition of 3D-printed materials with appropriately trained models. However, these models are not currently available for use. In this work, we trained deep learning (DL) models to (1) predict the rheological properties, such as the storage (G') and loss (G\") moduli, of 3D-printed polyacrylamide (PAA) substrates, and (2) predict the composition of materials and associated 3D printing parameters for a desired pair of G' and G\". We employed a multilayer perceptron (MLP) and successfully predicted G' and G\" from seven gel constituent parameters in a multivariate regression process. We used a grid-search algorithm along with 10-fold cross validation to tune the hyperparameters of the MLP, and found the R2 value to be 0.89. Next, we adopted two generative DL models named variational autoencoder (VAE) and conditional variational autoencoder (CVAE) to learn data patterns and generate constituent compositions. With these generative models, we produced synthetic data with the same statistical distribution as the real data of actual hydrogel fabrication, which was then validated using Student's t-test and an autoencoder (AE) anomaly detector. We found that none of the seven generated gel constituents were significantly different from the real data. Our trained DL models were successful in mapping the input-output relationship for the 3D-printed hydrogel substrates, which can predict multiple variables from a handful of input variables and vice versa.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"10 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of κ-Carrageenan on the Freshwater Mussel (Solenaia oleivora) Protein Emulsion Gels: Gel Formation, Stability, and Curcumin Delivery. κ-卡拉胶对淡水贻贝（Solenaia oleivora）蛋白乳液凝胶的影响：凝胶形成、稳定性和姜黄素输送。

IF 5 3区化学

Gels Pub Date : 2024-10-14 DOI: 10.3390/gels10100659

Wanwen Chen, Wu Jin, Xueyan Ma, Haibo Wen, Gangchun Xu, Pao Xu, Hao Cheng

{"title":"Impact of κ-Carrageenan on the Freshwater Mussel (Solenaia oleivora) Protein Emulsion Gels: Gel Formation, Stability, and Curcumin Delivery.","authors":"Wanwen Chen, Wu Jin, Xueyan Ma, Haibo Wen, Gangchun Xu, Pao Xu, Hao Cheng","doi":"10.3390/gels10100659","DOIUrl":"https://doi.org/10.3390/gels10100659","url":null,"abstract":"Protein-based emulsion gels are an ideal delivery system due to their unique structure, remarkable encapsulation efficiency, and tunable digestive behavior. Freshwater mussel (Solenaia oleivora) protein isolate (SoPI), an emerging sustainable protein with high nutritional value, possesses unique value in the development of functional foods. Herein, composite emulsion gels were fabricated with SoPI and κ-carrageenan (κ-CG) for the delivery of curcumin. SoPI/κ-CG stabilized emulsions possessed a high encapsulation efficiency of curcumin with a value of around 95%. The addition of κ-CG above 0.50% facilitated the emulsion gel formation and significantly improved the gel strength with 1326 g. Furthermore, the storage and digestive stability of curcumin were significantly improved as the κ-CG concentration increased. At 1.50% κ-CG, around 80% and 90% curcumin remained after 21-day storage at 45 °C and the 6 h in vitro gastrointestinal digestion, respectively. The addition of 0.50% κ-CG obtained the highest bioaccessibility of curcumin (~60%). This study illustrated the potential of SoPI emulsion gels as a carrier for stabilizing and delivering hydrophobic polyphenols.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"10 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Adhesive Hydrogel Technology for Enhanced Cartilage Repair: A Preliminary Proof of Concept. 增强软骨修复的粘合剂水凝胶技术：概念的初步验证

IF 5 3区化学

Gels Pub Date : 2024-10-14 DOI: 10.3390/gels10100657

Peyman Karami, Robin Martin, Alexis Laurent, Hui Yin Nam, Virginie Philippe, Lee Ann Applegate, Dominique P Pioletti

{"title":"An Adhesive Hydrogel Technology for Enhanced Cartilage Repair: A Preliminary Proof of Concept.","authors":"Peyman Karami, Robin Martin, Alexis Laurent, Hui Yin Nam, Virginie Philippe, Lee Ann Applegate, Dominique P Pioletti","doi":"10.3390/gels10100657","DOIUrl":"https://doi.org/10.3390/gels10100657","url":null,"abstract":"Knee cartilage has limited natural healing capacity, complicating the development of effective treatment plans. Current non-cell-based therapies (e.g., microfracture) result in poor repair cartilage mechanical properties, low durability, and suboptimal tissue integration. Advanced treatments, such as autologous chondrocyte implantation, face challenges including cell leakage and inhomogeneous distribution. Successful cell therapy relies on prolonged retention of therapeutic biologicals at the implantation site, yet the optimal integration of implanted material into the surrounding healthy tissue remains an unmet need. This study evaluated the effectiveness of a newly developed photo-curable adhesive hydrogel for cartilage repair, focusing on adhesion properties, integration performance, and ability to support tissue regeneration. The proposed hydrogel design exhibited significant adhesion strength, outperforming commercial adhesives such as fibrin-based glues. An in vivo goat model was used to evaluate the hydrogels' adhesion properties and long-term integration into full-thickness cartilage defects over six months. Results showed that cell-free hydrogel-treated defects achieved superior integration with surrounding tissue and enhanced cartilage repair, with notable lateral integration. In vitro results further demonstrated high cell viability, robust matrix production, and successful cell encapsulation within the hydrogel matrix. These findings highlight the potential of adhesive hydrogel formulations to improve the efficacy of cell-based therapies, offering a potentially superior treatment for knee cartilage defects.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"10 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Evaluation of the Acaricidal Activity of Xantan Gum-Based Hydrogel and Polymeric Nanoparticles Containing Achyrocline satureioides Extract. 开发和评估基于仙丹胶的水凝胶和含有 Achyrocline satureioides 提取物的聚合物纳米粒子的杀螨活性。

IF 5 3区化学

Gels Pub Date : 2024-10-14 DOI: 10.3390/gels10100658

Rafaela Regina Fantatto, Annelize Rodrigues Gomes, João Vitor Carvalho Constantini, Camila Fernanda Rodero, Marlus Chorilli, Ana Carolina de Souza Chagas, Ana Melero, Rosemeire Cristina Linhari Rodrigues Pietro

{"title":"Development and Evaluation of the Acaricidal Activity of Xantan Gum-Based Hydrogel and Polymeric Nanoparticles Containing Achyrocline satureioides Extract.","authors":"Rafaela Regina Fantatto, Annelize Rodrigues Gomes, João Vitor Carvalho Constantini, Camila Fernanda Rodero, Marlus Chorilli, Ana Carolina de Souza Chagas, Ana Melero, Rosemeire Cristina Linhari Rodrigues Pietro","doi":"10.3390/gels10100658","DOIUrl":"https://doi.org/10.3390/gels10100658","url":null,"abstract":"The Rhipicephalus microplus tick causes enormous economic losses in livestock farming around the world. Despite several promising studies carried out with plant extracts such as Achyrocline satureioides against this ectoparasite, a major obstacle is related to pharmaceutical presentation forms. There is no study showing xantan gum-based hydrogel and polycaprolactone nanoparticles containing A. satureioides extract against R. microplus larvae. The objective of this study was to incorporate A. satureioides extract to develop a nanoformulation (AScn) and a hydrogel (ASlh) and evaluate them against R. microplus larvae with the purpose of increasing the contact time of the extract with the larvae and improve the effectiveness. The ethanolic extracts were incorporated in polycaprolactone nanoparticles and characterized via analysis of the mean hydrodinamic diameter and polidispersity index. The xanthan gum-based hydrogel formulation was prepared with crude extract of A. satureioides 40 mg/mL, 0.25% xanthan gum, and 8% poloxamer, to determine the bioadhesiveness of the formulation in bovine leather and the flow rate of the formulation in the animal. The results in larvae demonstrated that when evaluated in the form of a hydrogel (ASlh), mortality was higher, with 91.48% mortality at a concentration of 20 mg/mL presenting itself as an interesting alternative for controlling this ectoparasite.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"10 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of Aerated Oleogel-Hydrogel Mixtures for 3D Printing of Personalized Cannabis Edibles. 设计充气油凝胶-水凝胶混合物，用于三维打印个性化大麻食品。

IF 5 3区化学

Gels Pub Date : 2024-10-13 DOI: 10.3390/gels10100654

Eleftherios G Andriotis, Adamantini Paraskevopoulou, Dimitrios G Fatouros, Hui Zhang, Christos Ritzoulis

{"title":"Design of Aerated Oleogel-Hydrogel Mixtures for 3D Printing of Personalized Cannabis Edibles.","authors":"Eleftherios G Andriotis, Adamantini Paraskevopoulou, Dimitrios G Fatouros, Hui Zhang, Christos Ritzoulis","doi":"10.3390/gels10100654","DOIUrl":"https://doi.org/10.3390/gels10100654","url":null,"abstract":"Cannabis seed oil oleogel structured with Glycerol Monostearate (20% w/w) was mixed with xanthan gum hydrogel (2% w/w) at different ratios ranging from 0% w/w hydrogel to 75% w/w hydrogel, using a syringe-to-syringe apparatus, for the preparation of 3D-printable food inks. This process enabled the simultaneous blend of oleogel and hydrogel phases and the incorporation of air in a reproducible and accurate manner. The printability of bigel inks with different mass ratios was evaluated by using a conventional benchtop food 3D printer. The printability of the inks was found to be negatively affected by the presence of higher portions of the hydrogel phase, while the printing performance of pure cannabis seed oil oleogel was superior compared to the printing performance of the bigel inks. The physicochemical properties of hybrid gels were investigated with rheological studies, thermophysical studies (Differential Scanning Calorimetry), Polarized Light Microscopy, and Confocal Laser Scanning Microscopy. The microstructure of the aerated inks was affected by the presence of a higher oleogel fraction, in terms of air bubble shape and distribution. The addition of hydrogel at concentrations higher than 50% w/w had a strong negative effect on the mechanical properties of the inks leading to a partial collapse of the printed structures and subsequently to poor printing performance.","PeriodicalId":12506,"journal":{"name":"Gels","volume":"10 10","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuning Antioxidant Function through Dynamic Design of Chitosan-Based Hydrogels. 通过壳聚糖水凝胶的动态设计调节抗氧化功能

IF 5 3区化学

Gels Pub Date : 2024-10-13 DOI: 10.3390/gels10100655

Manuela Maria Iftime, Gabriela Liliana Ailiesei, Daniela Ailincai

引用次数: 0

The Sol-Gel Process, a Green Method Used to Obtain Hybrid Materials Containing Phosphorus and Zirconium. 用于获得含磷和锆混合材料的绿色方法--溶胶-凝胶工艺。

IF 5 3区化学

Gels Pub Date : 2024-10-13 DOI: 10.3390/gels10100656

Petru Merghes, Gheorghe Ilia, Bianca Maranescu, Narcis Varan, Vasile Simulescu

引用次数: 0

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