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The Oxford Handbook of the Neurobiology of Pain最新文献

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Heat Pain and Cold Pain 热痛和冷痛
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2020-06-26 DOI: 10.1093/oxfordhb/9780190860509.013.13
F. Viana, T. Voets
{"title":"Heat Pain and Cold Pain","authors":"F. Viana, T. Voets","doi":"10.1093/oxfordhb/9780190860509.013.13","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190860509.013.13","url":null,"abstract":"Noxious cold and noxious heat have detrimental effects on key biological macromolecules and thus on the integrity of cells, tissues, and organisms. Thanks to the action of a subset of somatosensory neurons, mammals can swiftly detect noxiously cold or hot objects or environments. These temperature-sensitive nociceptor neurons become activated when the temperature at their free endings in the skin or mucosae reaches noxious levels, provoking acute pain and rapid avoidance reflexes. Whereas acute temperature-induced pain is essential to prevent or limit burn injury, pathological conditions such as inflammation or tissue injury can deregulate the thermal sensitivity of the somatosensory system, resulting in painful dysesthesias such as heat and cold hypersensitivity. In recent years, important advances have been made in our understanding of the cellular and molecular mechanisms that underlie the detection of painful heat or cold. These research efforts not only provided key insights into an evolutionary conserved biological alarm system, but also revealed new avenues for the development of novel therapies to treat various forms of persistent pain.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124623117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
A History of Pain Research 疼痛研究的历史
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2020-06-26 DOI: 10.1093/oxfordhb/9780190860509.013.26
F. Cerveró, J. Wood
{"title":"A History of Pain Research","authors":"F. Cerveró, J. Wood","doi":"10.1093/oxfordhb/9780190860509.013.26","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190860509.013.26","url":null,"abstract":"Useful analgesic plant products have been known since antiquity. In recent times, the cell and molecular basis of damage detection and its complex relationship to pain perception have been explored in detail. A range of technical advances have given us considerable new knowledge about both the peripheral aspects of pain pathways and damage transduction as well as central mechanisms of pain modulation. Electrophysiology, imaging, genetic manipulation of animal models of pain, the role of the immune system, and genetic studies of human pain states have all provided new information. Remarkably, despite these advances, we are still uncertain about the locus of pain perception, while the development of new small-molecule analgesic drugs has had almost no success. This article summarizes the history of pain research and discusses present activities together with potential future routes to pain treatment.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127722186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Sensory Signaling Pathways in Inflammatory and Neuropathic Pain 炎性和神经性疼痛的感觉信号通路
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2020-06-26 DOI: 10.1093/OXFORDHB/9780190860509.013.30
H. Willemen, N. Eijkelkamp
{"title":"Sensory Signaling Pathways in Inflammatory and Neuropathic Pain","authors":"H. Willemen, N. Eijkelkamp","doi":"10.1093/OXFORDHB/9780190860509.013.30","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.30","url":null,"abstract":"Sensory neuron sensitivity is modulated by a large variety of mediators that can activate a plethora of signaling cascades. These signaling cascades allow sensory neurons to show remarkable plasticity in response to injury and inflammation. The understanding of intracellular signaling mechanisms that regulate sensory neuron function downstream of receptor–ligand interactions or electrical activity is still at a relatively developing stage. This article highlights what is known about some of the components of classical intracellular signal transduction cascades, such as cyclic adenosine monophosphate (cAMP) and downstream cAMP sensors, mitogen-activated protein kinases, and others in regulating sensory neuron function. How these transduction cascades may contribute to the initiation, maintenance, or even resolution of inflammatory and neuropathic pain is discussed. Moreover, the focus is on how intracellular signaling cascades themselves are subject to plasticity and how this plasticity may underlie the development of chronic pain.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128898569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Neurotrophins, Cytokines, and Pain 神经营养因子，细胞因子和疼痛
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2020-06-26 DOI: 10.1093/OXFORDHB/9780190860509.013.25
S. Sikandar, C. Sommer
{"title":"Neurotrophins, Cytokines, and Pain","authors":"S. Sikandar, C. Sommer","doi":"10.1093/OXFORDHB/9780190860509.013.25","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.25","url":null,"abstract":"The neurotrophin and cytokine families of proteins regulate neuronal functions that affect survival, growth, and differentiation. Because of their extensive expression throughout the nervous system, some neurotrophins and cytokines are widely accepted to modulate synaptic plasticity and nociceptive processing. Among the neurotrophin family are nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3), which all bind to the tyrosine receptor kinases. The potential for BDNF as a therapeutic target is supported by a large body of evidence demonstrating its role in driving plastic changes in nociceptive pathways to initiate and maintain chronic pain. On the other hand, NGF has already proved fruitful as an analgesic target, with efficacy shown for NGF-neutralizing antibodies for pain relief in rheumatic diseases. The cytokine family includes the interleukins, tumor necrosis factors (TNFs), chemokines, interferons (IFNs), and transforming growth factor ß (TGF-ß) family. These bind, often promiscuously, to the heterogeneous group of cytokine receptors, and this cytokine signaling is essential for normal responses of the innate and adaptive immune systems. In pathophysiological states, chronic inflammation enhances the expression of pro-inflammatory cytokines, and many studies support a modulatory role of cytokines in nociceptive processes. At the forefront of anticytokine therapy for analgesia are TNF and IL6 monoclonal antibodies, which are licensed treatments for pain relief in rheumatoid arthritis. This article reviews the pro- and antinociceptive roles of key members of the neurotrophin and cytokine families in the context of chronic pain mechanisms and therapeutic approaches.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133339391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Potassium Channels and Pain 钾通道与疼痛
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2020-06-26 DOI: 10.1093/oxfordhb/9780190860509.013.19
J. Busserolles, X. Gasull, J. Noël
{"title":"Potassium Channels and Pain","authors":"J. Busserolles, X. Gasull, J. Noël","doi":"10.1093/oxfordhb/9780190860509.013.19","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190860509.013.19","url":null,"abstract":"The K+ channel family is one of the most complex families of ion channels. The diversity of this channel family is a real challenge for the study of pain. Potassium channels form the largest family of ion channels in mammals, with more than 80 genes encoding α subunits in humans. Their differences in structures and functions divide them into four families, all of which are expressed in somatosensory neurons and supporting glial cells. The opening of K+ channels hyperpolarizes the plasma membrane, which opposes excitation of the neuron by all other depolarizing channels. K+ channels are very efficient regulators of the electrical activity of sensory neurons and of pain perception. Their potential for the development of antinociceptive pharmacology is immense.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130124307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Neuroimmune Interactions and Pain 神经免疫相互作用和疼痛
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2020-06-26 DOI: 10.1093/oxfordhb/9780190860509.013.29
Jiahe Li, P. Grace
{"title":"Neuroimmune Interactions and Pain","authors":"Jiahe Li, P. Grace","doi":"10.1093/oxfordhb/9780190860509.013.29","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190860509.013.29","url":null,"abstract":"Chronic pain imposes a tremendous burden on the sufferer’s quality of life. Mounting evidence supports a critical role for neuroimmune interactions in the development and maintenance of chronic pain. Nerve injury leads to the activation of glia via sphingosine-1-phosphate, Toll-like receptors, chemokines, neuropeptides, and purinergic receptors. In turn, activated glia influence neuronal activity via interleukin 1β, tumor necrosis factor, brain-derived neurotrophic factor, reactive oxygen species, and excitatory amino acids. Epigenetic mechanisms of neuroimmune communication are also discussed. Investigation of neuroimmune interactions after peripheral nerve injury broadens our understanding of the mechanisms that drive neuropathic pain, and such interactions provide potential therapeutic targets for managing neuropathic pain.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"48 S233","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113954416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Neurobiology of Pain 疼痛的神经生物学
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2019-12-11 DOI: 10.1093/oxfordhb/9780190860509.013.24
M. Fitzgerald, M. Salter
{"title":"The Neurobiology of Pain","authors":"M. Fitzgerald, M. Salter","doi":"10.1093/oxfordhb/9780190860509.013.24","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190860509.013.24","url":null,"abstract":"The influence of development and sex on pain perception has long been recognized but only recently has it become clear that this is due to specific differences in underlying pain neurobiology. This chapter summarizes the evidence for mechanistic differences in male and female pain biology and for functional changes in pain pathways through infancy, adolescence, and adulthood. It describes how both developmental age and sex determine peripheral nociception, spinal and brainstem processing, brain networks, and neuroimmune pathways in pain. Finally, the chapter discusses emerging evidence for interactions between sex and development and the importance of sex in the short- and long-term effects of early life pain.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122731143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Neurobiological Basis of Migraine 偏头痛的神经生物学基础
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2019-12-11 DOI: 10.1093/oxfordhb/9780190860509.013.27
P. Holland, J. Hoffmann, P. Goadsby
{"title":"Neurobiological Basis of Migraine","authors":"P. Holland, J. Hoffmann, P. Goadsby","doi":"10.1093/oxfordhb/9780190860509.013.27","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190860509.013.27","url":null,"abstract":"Migraine is the most common disabling primary headache globally. Attacks often present with unilateral throbbing headache and an array of associated symptoms, including, nausea, multisensory hypersensitivity, and marked fatigue. The diverse symptomatology highlights the complexity of migraine as a whole nervous system disorder involving somatosensory, autonomic, endocrine, and arousal networks. While attempts to describe the entirety of migraine are complex and daunting, this chapter focuses on recent advances in the understanding of its pathophysiology and treatment. The chapter focuses on the underlying neuroanatomical basis for migraine-related headache and associated symptomatology and discusses key clinical and preclinical findings that indicate that migraine likely results from dysfunctional homeostatic mechanisms. Whereby abnormal central nervous system responses to extrinsic and intrinsic cues may lead to increased attack susceptibility. Finally, the chapter considers the recent translational success of targeted calcitonin gene-related peptide and serotonin 1F receptor (5-HT1F) modulation for migraine.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129755545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Transition from Acute to Chronic Pain 从急性疼痛到慢性疼痛的转变
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2019-03-14 DOI: 10.1093/OXFORDHB/9780190860509.013.28
Wei-Hsin Sun, Yu-Shiuan Su, Chih-Cheng Chen
{"title":"The Transition from Acute to Chronic Pain","authors":"Wei-Hsin Sun, Yu-Shiuan Su, Chih-Cheng Chen","doi":"10.1093/OXFORDHB/9780190860509.013.28","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.28","url":null,"abstract":"Chronic pain is not merely a prolonged form of acute pain but rather results from plastic changes that occur along sensory transduction pathways from the peripheral to the central nervous system. Recent studies have revealed that “hyperalgesic priming,” the plastic changes of nociceptors, is essential for the transition from acute to chronic pain. Once challenged, nociceptors may elicit a signal switch to favor pain chronicity in response to future noxious stimuli. This article summarizes the recent progress in research into hyperalgesic priming in different chronic pain models and highlight how the plastic changes of the signal switch varies in different nociceptors. Also discussed is the involvement of proton-sensing receptors in pain chronicity associated with rheumatoid arthritis and fibromyalgia.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133497130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Visceral Pain 发自内心的痛苦
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-10-09 DOI: 10.1093/oxfordhb/9780190860509.013.12
D. Bulmer, C. Roza
{"title":"Visceral Pain","authors":"D. Bulmer, C. Roza","doi":"10.1093/oxfordhb/9780190860509.013.12","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190860509.013.12","url":null,"abstract":"Visceral pain is qualitatively distinct from other pain types; it is poorly localized, difficult to quantify, and accompanied by marked autonomic changes. Acute visceral pain may be an indication of a medical emergency requiring urgent surgical or clinical intervention. However, chronic visceral pain, which contributes significantly to lifelong morbidity, occurs most frequently in the absence of any distinct pathology making it difficult to treat. This article reviews our current understanding of how visceral pain is detected in the periphery, and processed within the spinal cord and central nervous system. It focuses on recent work that has identified pro-nociceptive changes in the bowel of patients with chronic visceral pain and discuss how these findings could lead to the development of novel viscero-specific analgesics. Finally, the article considers how the microbiota can act locally to shape the detection of pain in the periphery and centrally to modulate our perception of visceral pain.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121501319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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