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The Oxford Handbook of the Neurobiology of Pain最新文献

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Opioids and Pain 阿片类药物与疼痛
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/OXFORDHB/9780190860509.013.9
C. Stein, C. Gaveriaux-Ruff
{"title":"Opioids and Pain","authors":"C. Stein, C. Gaveriaux-Ruff","doi":"10.1093/OXFORDHB/9780190860509.013.9","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.9","url":null,"abstract":"This article reviews basic and clinical concepts on pain and mechanisms underlying opioid analgesia. It describes the structure, function, and cellular signaling of opioid receptors; endogenous and exogenous opioid receptor ligands; as well as the central and peripheral sites of opioid actions. The article also presents novel opioid-based therapeutic strategies, developed from recently gained knowledge on opioid receptor structures and signaling, pathological pain situations, and mutant mouse lines, aimed at the reduction of side effects such as respiratory depression, constipation, sedation, tolerance, or opioid-induced hyperalgesia. Lastly, the article addresses clinical problems associated with opioid use, particularly the long-term use of opioid analgesics in chronic pain.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116561271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Measurement of Pain in the Laboratory Rodent 实验啮齿类动物疼痛的测量
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/OXFORDHB/9780190860509.013.21
J. Mogil
{"title":"The Measurement of Pain in the Laboratory Rodent","authors":"J. Mogil","doi":"10.1093/OXFORDHB/9780190860509.013.21","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.21","url":null,"abstract":"The current translational crisis, in which apparently rapidly expanding genetic, molecular, and cellular knowledge has not resulted in novel clinical therapies, has forced preclinical pain researchers to question the algesiometric status quo. One hypothesized cause of poor translation is the limited external validity of the reflexive withdrawals to evoking stimuli that represent the ubiquitous dependent measures of pain at the present time. As a response, new techniques have been developed and are increasingly being incorporated into pain studies. This comprehensive review examines the subjects, assays, and measures used in preclinical pain research, as well as the need for and implementation of newly described measures of spontaneous, ongoing chronic pain.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124662845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
The Sympathetic Nervous System and Pain 交感神经系统与疼痛
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/OXFORDHB/9780190860509.013.6
J. Strong, Jun-Ming Zhang, H. Schaible
{"title":"The Sympathetic Nervous System and Pain","authors":"J. Strong, Jun-Ming Zhang, H. Schaible","doi":"10.1093/OXFORDHB/9780190860509.013.6","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.6","url":null,"abstract":"This article reviews some of the preclinical studies of the sympathetic nervous system’s role in arthritis, inflammatory, and neuropathic pain, in light of the emerging understanding of how the immune system, sensory system, and sympathetic system markedly affect each other’s function, with many mechanisms besides sprouting. Many studies show a pro-inflammatory and pro-nociceptive role for the sympathetic nerves in preclinical models. However, these studies are sometimes conflicting, and the role of the sympathetic nerves can sometimes be anti-inflammatory or anti-nociceptive, particularly at later stages or when systemic effects on immune tissues are considered. The article discusses human correlates of these preclinical studies, as well as some possible reasons for the many conflicting studies in the literature. The article argues that sympathetic-based interventions for chronic pain conditions hold promise despite the conflicting findings in the field, especially if better ways to define appropriate subsets of patients can be developed.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"69 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127810251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Diversity of Neuropathic Pain 神经性疼痛的多样性
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/OXFORDHB/9780190860509.013.22
N. Finnerup, N. Attal
{"title":"The Diversity of Neuropathic Pain","authors":"N. Finnerup, N. Attal","doi":"10.1093/OXFORDHB/9780190860509.013.22","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.22","url":null,"abstract":"This article presents an update of the current classification, diagnosis, assessment, mechanisms, and treatment of neuropathic pain. Neuropathic pain, which is defined as pain associated with a lesion or disease of the somatosensory nervous system, may be caused by a variety of conditions, such as diabetic neuropathy, herpes zoster, surgical trauma, spinal cord injury, and stroke. The diagnostic criteria for neuropathic pain are a history of a nervous system disease or lesion and pain distribution and sensory signs in a neuroanatomically plausible distribution. The treatment of neuropathic pain is often multidisciplinary and involves specific drugs. Recent progress in the diagnosis, assessment, and understanding of its mechanisms offers the perspective of a more rational therapeutic management, which should result in better therapeutic outcome.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126295664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Dorsal Horn Pain Mechanisms 背角疼痛机制
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/OXFORDHB/9780190860509.013.23
H. Zeilhofer, R. Ganley
{"title":"Dorsal Horn Pain Mechanisms","authors":"H. Zeilhofer, R. Ganley","doi":"10.1093/OXFORDHB/9780190860509.013.23","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.23","url":null,"abstract":"The spinal dorsal horn and its equivalent structure in the brainstem constitute the first sites of synaptic integration in the pain pathway. A huge body of literature exists on alterations in spinal nociceptive signal processing that contribute to the generation of exaggerated pain states and hence to what is generally known as “central sensitization.” Such mechanisms include changes in synaptic efficacy or neuronal excitability, which can be evoked by intense nociceptive stimulation or by inflammatory or neuropathic insults. Some of these changes cause alterations in the functional organization of dorsal horn sensory circuits, leading to abnormal pathological pain sensations. This article reviews the present state of this knowledge. It does not cover the contributions of astrocytes and microglia in detail as their functions are the subject of a separate chapter.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124332959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Noxious Mechanosensation 有毒Mechanosensation
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/oxfordhb/9780190860509.013.14
P. Delmas, Sergiy Mikhailovych Korogod, B. Coste
{"title":"Noxious Mechanosensation","authors":"P. Delmas, Sergiy Mikhailovych Korogod, B. Coste","doi":"10.1093/oxfordhb/9780190860509.013.14","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190860509.013.14","url":null,"abstract":"This article introduces a number of critical features of mechanical transduction and neuronal sensory coding, with particular reference to mechanical pain. High threshold mechanoreceptors (HTMRs) in skin are the first relay point for the transduction of noxious mechanical force into the nervous system, and their properties determine how and when nociceptive signal is relayed up to the central nervous system. The article describes the structure and physiology of the mechano-nociceptors and explains the peripheral molecular mechanisms of transduction leading to mechanical pain. In addition, this article also describes a set of computer models of HTMRs and relevant ion channels representing structural and biophysical features of the biological prototype. A better understanding of HTMRs’ function may lead to the development of novel therapeutic pathways in the treatment of chronic mechanical pain.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126646768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Autoantibodies and Neuropathic Pain 自身抗体与神经性疼痛
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/oxfordhb/9780190860509.013.16
J. Dawes, D. Bennett
{"title":"Autoantibodies and Neuropathic Pain","authors":"J. Dawes, D. Bennett","doi":"10.1093/oxfordhb/9780190860509.013.16","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190860509.013.16","url":null,"abstract":"A number of clinical studies indicated an association between autoantibodies and neuropathic pain. This is supported by the observation that immunotherapies that reduce antibody levels alleviate pain in patients and suggests that autoantibodies are not a byproduct of pathology but instead important drivers of neuropathic pain. These autoantibodies can target both neuronal and nonneuronal antigens within the sensory nervous system. Possible pathogenic mechanisms include nerve damage and inflammation as well as disruption of ion channel function. Whether autoantibodies are truly causal to neuropathic pain and exactly what their prevalence is in such pain conditions are important questions that are being addressed with the use of passive transfer in preclinical models and the screening of patient sera. Such studies support the idea that autoantibodies are a mechanism to cause neuropathic pain and provide insight into the molecular components regulating pain sensitivity in a pathological setting. Therefore, this work not only will be applicable to the treatment of patients with autoantibody-mediated pain, but also will facilitate the development of therapies to treat neuropathic pain in the more general context.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132784903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Chloride Channels in Nociceptors 伤害感受器中的氯离子通道
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/OXFORDHB/9780190860509.013.20
U. Oh, Jooyoung Jung
{"title":"Chloride Channels in Nociceptors","authors":"U. Oh, Jooyoung Jung","doi":"10.1093/OXFORDHB/9780190860509.013.20","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.20","url":null,"abstract":"Pain may be induced by activation of various ion channels expressed in primary afferent neurons. These channels function as molecular sensors that detect noxious chemical, temperature, or tactile stimuli and transduce them into nociceptor electrical signals. Transient receptor potential channels are good examples because they are activated by chemicals, heat, cold, and acid in nociceptors. Anion channels were little studied in nociception because of the notion that anion channels might induce hyperpolarization of nociceptors on opening. In contrast, opening of Cl- channels in dorsal root ganglion (DRG) neurons depolarizes sensory neurons, resulting in excitation of nociceptors, thereby inducing pain. Anoctamin 1(ANO1)/TMEM16A is a Ca2+-activated Cl- channel expressed mainly in small DRG neurons, suggesting a nociception role. ANO1 is a heat sensor that detects heat over 44°C. Ano1-deficient mice elicit less nocifensive behaviors to hot temperatures. In addition, mechanical allodynia and hyperalgesia induced by inflammation or nerve injury are alleviated in Ano1\u0000 -/- mice. More important, Ano1 transcripts are increased in chronic pain models. Bestrophin 1 (Best1) is another Ca2+-activated Cl- channel expressed in nociceptors. Best1 is increased in axotomized DRG neurons. The role of Best1 in nociception is not clear. GABAA receptors are in the central process of DRG neurons; GABA depolarizes the primary afferents. This depolarization consists of primary afferent depolarization essential for inhibiting nociceptive input to second-order neurons in the spinal cord, regulating pain signals to the brain. Thus, although Cl- channels in nociceptors are not as numerous as TRP channels, their role in nociception is distinct and significant.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130077826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Proteomics and Metabolomics of Pain 疼痛的蛋白质组学和代谢组学
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/OXFORDHB/9780190860509.013.15
D. Gómez-Varela, Manuela Schmidt
{"title":"The Proteomics and Metabolomics of Pain","authors":"D. Gómez-Varela, Manuela Schmidt","doi":"10.1093/OXFORDHB/9780190860509.013.15","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.15","url":null,"abstract":"This article critically discusses the opportunities and challenges of proteomics and metabolomics in the context of pain research and clinical practice. Painful pathologies are extremely complex and often inadequately managed. In order to significantly improve therapeutic options of pain syndromes, a system-wide analysis of the underlying mechanisms is fundamental. To this end, the article highlights the potential of firmly integrating proteomics and metabolomics into the pain researcher’s toolbox. The article introduces technological aspects of mass spectrometry and also associated stumbling blocks for its standardization in clinical research. Lastly, it outlines the path towards personalized systems pain medicine via the definition of pain phenomes—from multilayered molecular data to phenotypical profiles and integrated analysis of disease networks.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121898732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Cancer and Pain 癌症和疼痛
The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/OXFORDHB/9780190860509.013.32
R. B. Hansen, Sarah Falk
{"title":"Cancer and Pain","authors":"R. B. Hansen, Sarah Falk","doi":"10.1093/OXFORDHB/9780190860509.013.32","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.32","url":null,"abstract":"Pain is a common and feared complication for many cancer patients. Cancer pain covers numerous pain syndromes; since the treatment is complex, it is essential to assess each individual patient with cancer pain thoroughly. Cancer pain includes not only elements of inflammatory and neuropathic pain, but also, importantly, cancer-specific elements. Starting with the clinical aspects of cancer pain and the current knowledge from in vivo models, this article provides an overview of the neurobiology known to drive cancer-induced bone pain as it evolves through the complex interplay between primary afferents, tumor cells, and bone cells. There continue to be many uncertainties and unknown mechanisms involved in cancer pain, and an effort to discover novel therapeutic targets should be emphasized as cancer pain poses an increasing clinical and socioeconomic burden.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114804836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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