The Oxford Handbook of the Neurobiology of Pain最新文献_第3页

Voltage-Gated Calcium Channels 电压门控钙通道

The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/OXFORDHB/9780190860509.013.7

G. Zamponi, M. Gandini, T. Snutch

引用次数: 0

Human Genetics of Pain 人类疼痛遗传学

The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/OXFORDHB/9780190860509.013.1

J. Cox, I. Kurth, C. Woods

引用次数: 3

Central Nervous System Pain Pathways 中枢神经系统疼痛通路

The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/OXFORDHB/9780190860509.013.5

A. Todd, Fan Wang

{"title":"Central Nervous System Pain Pathways","authors":"A. Todd, Fan Wang","doi":"10.1093/OXFORDHB/9780190860509.013.5","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.5","url":null,"abstract":"Nociceptive primary afferents detect stimuli that are normally perceived as painful, and these afferents form synapses in the dorsal horn of the spinal cord and the spinal trigeminal nucleus. Here they are involved in highly complex neuronal circuits involving projection neurons belonging to the anterolateral tract (ALT) and interneurons, which modulate the incoming sensory information. The ALT neurons convey somatosensory information to a variety of brain regions that are involved in the various aspects of the pain experience. A spinothalamic-cortical pathway provides input to several regions of the cerebral cortex, including the first and second somatosensory areas (S1, S2), the insula and the cingluate cortex. These regions are thought be responsible for the sensory-discriminative aspects of pain (S1), pain-related learning (S2), the autonomic and motivational responses (insula), and the negative affect (cingulate). Another ascending system, The spinoparabrachial-limbic pathway targets a variety of brain regions, including the amygdala, and is likely involved in the affective component of pain. A descending system that includes the limbic system, the periaqueductal gray matter of the midbrain, the locus coeruleus, and the rostral ventral medulla, can suppress pain, and this operates partly through the monoamine transmitters noradrenaline and serotonin which are released in the spinal and trigeminal dorsal horn.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127423264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Chemo- and Optogenetic Strategies for the Elucidation of Pain Pathways 阐明疼痛通路的化学和光遗传学策略

The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/oxfordhb/9780190860509.013.33

Sascha R. A. Alles, A. Malfait, Richard J. Miller

{"title":"Chemo- and Optogenetic Strategies for the Elucidation of Pain Pathways","authors":"Sascha R. A. Alles, A. Malfait, Richard J. Miller","doi":"10.1093/oxfordhb/9780190860509.013.33","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190860509.013.33","url":null,"abstract":"Pain is not a simple phenomenon and, beyond its conscious perception, involves circuitry that allows the brain to provide an affective context for nociception, which can influence mood and memory. In the past decade, neurobiological techniques have been developed that allow investigators to elucidate the importance of particular groups of neurons in different aspects of the pain response, something that may have important translational implications for the development of novel therapies. Chemo- and optogenetics represent two of the most important technical advances of recent times for gaining understanding of physiological circuitry underlying complex behaviors. The use of these techniques for teasing out the role of neurons and glia in nociceptive pathways is a rapidly growing area of research. The major findings of studies focused on understanding circuitry involved in different aspects of nociception and pain are highlighted in this article. In addition, attention is drawn to the possibility of modification of chemo- and optogenetic techniques for use as potential therapies for treatment of chronic pain disorders in human patients.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116104459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Dorsal Root Ganglion Neuron Types and Their Functional Specialization 背根神经节神经元类型及其功能特化

The Oxford Handbook of the Neurobiology of Pain Pub Date : 2018-07-10 DOI: 10.1093/OXFORDHB/9780190860509.013.4

E. Emery, P. Ernfors

{"title":"Dorsal Root Ganglion Neuron Types and Their Functional Specialization","authors":"E. Emery, P. Ernfors","doi":"10.1093/OXFORDHB/9780190860509.013.4","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190860509.013.4","url":null,"abstract":"Primary sensory neurons of the dorsal root ganglion (DRG) respond and relay sensations that are felt, such as those for touch, pain, temperature, itch, and more. The ability to discriminate between the various types of stimuli is reflected by the existence of specialized DRG neurons tuned to respond to specific stimuli. Because of this, a comprehensive classification of DRG neurons is critical for determining exactly how somatosensation works and for providing insights into cell types involved during chronic pain. This article reviews the recent advances in unbiased classification of molecular types of DRG neurons in the perspective of known functions as well as predicted functions based on gene expression profiles. The data show that sensory neurons are organized in a basal structure of three cold-sensitive neuron types, five mechano-heat sensitive nociceptor types, four A-Low threshold mechanoreceptor types, five itch-mechano-heat–sensitive nociceptor types and a single C–low-threshold mechanoreceptor type with a strong relation between molecular neuron types and functional types. As a general feature, each neuron type displays a unique and predicable response profile; at the same time, most neuron types convey multiple modalities and intensities. Therefore, sensation is likely determined by the summation of ensembles of active primary afferent types. The new classification scheme will be instructive in determining the exact cellular and molecular mechanisms underlying somatosensation, facilitating the development of rational strategies to identify causes for chronic pain.","PeriodicalId":125057,"journal":{"name":"The Oxford Handbook of the Neurobiology of Pain","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114902708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37