Gene expression最新文献_第2页

Transforming Growth Factor-β1-mediated Regulation of circ_DISP3 and ATF3 in Human Triple-negative Breast Cancer Cells 转化生长因子-β1介导的circ_DISP3和ATF3在人三阴性乳腺癌细胞中的调节作用

Gene expression Pub Date : 2023-10-26 DOI: 10.14218/ge.2023.00101

Sahithya Mohan, Ashok Bharathy, Magesh Induja, Rushil Kolipaka, Suryanarayanan Karthik, Srinidhi Ganesamoorthi, Kumar Sathiya, Iyyappan Saranya, Ravishkumar Lakshmi Akshaya, Nagarajan Selvamurugan

引用次数: 0

Multipotent Stromal Stem Cell Approach in Alleviating Autophagy Beclin-1/XBP-1/STAT5A/PTEN Signaling Pathways in Novodrin-induced Liver Dysfunction 多能间质干细胞途径缓解自噬在诺沃德林诱导的肝功能障碍中的作用Beclin-1/XBP-1/STAT5A/PTEN信号通路

Gene expression Pub Date : 2023-10-13 DOI: 10.14218/ge.2023.00052

Mai O. Kadry, Rehab M. Abdel-Megeed

引用次数: 0

Correlation between IL-27p28 Genetic Polymorphisms and Risk of Allergic Rhinitis IL-27p28基因多态性与变应性鼻炎风险的相关性研究

Gene expression Pub Date : 2023-10-10 DOI: 10.14218/ge.2023.00019

Farzaneh Koohyanizadeh, Sara Falahi, Seyed Hamid Reza Mortazavi, Farhad Salari, Alireza Rezaiemanesh, Ali Gorgin Karaji

引用次数: 0

Moonlighting Effects of Pyruvate Kinase M2 in Chronic Liver Diseases 丙酮酸激酶M2在慢性肝病中的兼职作用

Gene expression Pub Date : 2023-09-28 DOI: 10.14218/ge.2023.00038

Madhav Jadhav, Shailendra Sharma, Vaishnavi Kalmegh, Saumya Kapoor, Amit Shard

引用次数: 0

Titanium-nanostructured and PEGylated Doxorubicin Diminish Chemotherapeutic Resistance in 3-Methylcholanthrene Renal Epithelial Cell Carcinoma via KRAS/FKBP5/P53/JAK2 Signaling 钛纳米结构和聚乙二醇化阿霉素通过KRAS/FKBP5/P53/JAK2信号通路降低3-甲基胆蒽肾上皮细胞癌的化疗耐药

Gene expression Pub Date : 2023-09-28 DOI: 10.14218/ge.2023.00069

Mai O. Kadry, Rehab M. Abdel-Megeed

引用次数: 1

Where To Stop: Occurrence and Evolution of Translational Recoding Signals in RNA Viruses of Eukaryotes 到此为止:真核生物RNA病毒翻译重编码信号的发生和进化

Gene expression Pub Date : 2023-09-28 DOI: 10.14218/ge.2023.00025

Alexey A. Agranovsky

{"title":"Where To Stop: Occurrence and Evolution of Translational Recoding Signals in RNA Viruses of Eukaryotes","authors":"Alexey A. Agranovsky","doi":"10.14218/ge.2023.00025","DOIUrl":"https://doi.org/10.14218/ge.2023.00025","url":null,"abstract":"Many (+)RNA viruses employ translational recoding mechanisms, such as programmed ribosomal readthrough and ribosomal frameshifting, to direct a fraction of translating ribosomes in the infected cell to recode or bypass a stop codon in the zero reading frame and continue translation, thus producing protein isoforms with distinct functions. This creates a means to regulate both the quantity and time of synthesis of canonical and fusion proteins. The viral programmed ribosomal readthrough and ribosomal frameshifting signals are variable, with some being just short RNA sequences encompassing a stop codon, whereas others require elaborate RNA-RNA and RNA-protein interactions. Within virus evolutionary lineages, a given type of recoding signal is not universal, and its presence may be specific to a virus family, species, or even strain. It is possible that the establishment of virus recoding mechanisms and expression patterns occurs after the appearance of extant virus lineages, and these recoding signals might be acquired on multiple occasions during evolution. Recoding signals are the key regulators of gene expression in several clinically important viruses, such as human immunodeficiency viruses 1 and 2, human T-cell lymphotropic retroviruses, and severe acute respiratory syndrome coronavirus 2, as well as in a number of other animal and plant viruses of concern. The knowledge of viral recoding mechanisms is expected to provide new perspectives for the development of antiviral and synthetic biology strategies.","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"2016 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135426613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial Mutations Affect the Cardiovascular System during Aging and Oxidative Stress 线粒体突变在衰老和氧化应激过程中影响心血管系统

Gene expression Pub Date : 2023-09-21 DOI: 10.14218/ge.2023.00039

Anastasia V. Poznyak, Vasily N. Sukhorukov, Mikhail А. Popov, Yegor S Chegodaev, Anton Y. Postnov, Alexander N. Orekhov

引用次数: 1

Host Genetics and COVID-19: Genes Underlying the Patterns of Susceptibility and Prognosis 宿主遗传学和COVID-19:易感性和预后模式的基因

Gene expression Pub Date : 2023-09-21 DOI: 10.14218/ge.2023.00026

Bárbara Ferreira Khouri, Izabella Paulino de Souza Candido, Regina Célia Poli-Frederico, Paulo Roberto Bignardi

{"title":"Host Genetics and COVID-19: Genes Underlying the Patterns of Susceptibility and Prognosis","authors":"Bárbara Ferreira Khouri, Izabella Paulino de Souza Candido, Regina Célia Poli-Frederico, Paulo Roberto Bignardi","doi":"10.14218/ge.2023.00026","DOIUrl":"https://doi.org/10.14218/ge.2023.00026","url":null,"abstract":"Host-specific genetics, such as epigenetic profiles and genetic variants, can contribute to the pathogenesis of infectious diseases. Strong associations have been previously identified in infections by human immunodeficiency virus (HIV), Plasmodium falciparum, norovirus, and influenza A virus. Despite the efforts to characterize the role of host genetics in severe acute respiratory syndrome virus coronavirus 2 (SARS-CoV-2) infection, this comprehension remains incipient. Coronavirus disease 2019 (COVID-19) can evolve with a wide spectrum of manifestations, ranging from asymptomatic and mild cases to severe forms with acute respiratory distress syndrome, multi-organ complications, and even death. Classic clinical risk factors only partially explain this interindividual variability, suggesting that host genetics may contribute to the heterogeneity of courses. Robust evidence has revealed the multiple associations of genes (ABO, PPP1R15A, SLC6A20, IFNAR2, OAS, TYK2, CCR2, CCR5, TLR7, ApoE, TMPRSS2, HLA, ACE2, etc.) with the susceptibility and/or severity of SARS-CoV-2 infection. In addition, the genetics behind the established risk factors have been considered: at least four loci associated with COVID-19 severity (DPP9, FOXP4, SFTPD and MUC5B) have been previously linked to lung fibrosis, interstitial lung disease, lung carcinomas, and/or decreased lung function. In summary, identifying the host-specific genetic factors may improve our knowledge of risk groups for infection and severe outcomes, as well as the biological mechanisms of therapeutic relevance. Therefore, the present literature review aims to understand the genetics underlying the patterns of susceptibility and prognosis of COVID-19.","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136235166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-surgical Treatment Options in Managing Recurrent Hepatocellular Carcinoma 治疗复发性肝癌的非手术治疗选择

Gene expression Pub Date : 2023-09-19 DOI: 10.14218/ge.2023.00010

Walaa Abdelhamed, Mohamed El-Kassas

{"title":"Non-surgical Treatment Options in Managing Recurrent Hepatocellular Carcinoma","authors":"Walaa Abdelhamed, Mohamed El-Kassas","doi":"10.14218/ge.2023.00010","DOIUrl":"https://doi.org/10.14218/ge.2023.00010","url":null,"abstract":"Despite advances in current treatment options, Hepatocellular Carcinoma (HCC) recurrence still presents as a significant clinical challenge. After initial treatment, HCC recurrence occurs in a considerable portion of patients without an available standardized protocol for managing such an incident. Recurrence of advanced liver disease may make surgical treatment options impossible, in which case, locoregional therapy should be considered as an alternative. This review article discusses recurrent HCC after initial treatment and available non-surgical treatment options. Along with systemic therapy, liver-targeted therapies for recurrent HCC including, radiofrequency, microwave ablation, transarterial chemoembolization, and stereotactic body radiation therapy are promising options. Thermal ablation with radiofrequency or microwave ablation is a suitable treatment option for patients who experience smaller tumor recurrences but are not operable because of comorbidities, impaired liver functions, or tumor locality. Transarterial chemoembolization or radioembolization using Yttrium-90 can be used for patients with an incurable disease and have comparatively low adverse effects.","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135011281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagrams Describing the Evolution of Gene Expression, the Emergence of Novel Cell Types During Evolution, and Evo-devo 描述基因表达进化的图表，进化过程中新细胞类型的出现，以及进化-发展

Gene expression Pub Date : 2023-09-01 DOI: 10.14218/ge.2023.00031

Andrei P. Kozlov

引用次数: 0