Correlation between IL-27p28 Genetic Polymorphisms and Risk of Allergic Rhinitis

Q2 Biochemistry, Genetics and Molecular Biology

Gene expression Pub Date : 2023-10-10 DOI:10.14218/ge.2023.00019

Farzaneh Koohyanizadeh, Sara Falahi, Seyed Hamid Reza Mortazavi, Farhad Salari, Alireza Rezaiemanesh, Ali Gorgin Karaji

引用次数: 0

Abstract

Background and objectivesInterleukin 27 (IL-27) is a cytokine consisting of two subunits, p28 and EBI3, and is a key mediator in regulating the differentiation of TCD4 + cells while playing a crucial role in immune-related disorders. This study aims to elucidate the possible association between IL-27p28 single nucleotide polymorphisms (SNPs), IL-27 serum levels, and the risk of allergic rhinitis (AR).

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IL-27p28基因多态性与变应性鼻炎风险的相关性研究

背景与目的白介素27 (interleukin 27, IL-27)是一种由p28和EBI3两个亚基组成的细胞因子，是调节TCD4 +细胞分化的关键介质，同时在免疫相关疾病中发挥重要作用。本研究旨在阐明IL-27p28单核苷酸多态性(snp)、IL-27血清水平与变应性鼻炎(AR)风险之间的可能关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene expression 生物-生物工程与应用微生物

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Gene Expression, The Journal of Liver Research will publish articles in all aspects of hepatology. Hepatology, as a research discipline, has seen unprecedented growth especially in the cellular and molecular mechanisms of hepatic health and disease, which continues to have a major impact on understanding liver development, stem cells, carcinogenesis, tissue engineering, injury, repair, regeneration, immunology, metabolism, fibrosis, and transplantation. Continued research and improved understanding in these areas will have a meaningful impact on liver disease prevention, diagnosis, and treatment. The existing journal Gene Expression has expanded its focus to become Gene Expression, The Journal of Liver Research to meet this growing demand. In its revised and expanded scope, the journal will publish high-impact original articles, reviews, short but complete articles, and special articles (editorials, commentaries, opinions) on all aspects of hepatology, making it a unique and invaluable resource for readers interested in this field. The expanded team, led by an Editor-in-Chief who is uniquely qualified and a renowned expert, along with a dynamic and functional editorial board, is determined to make this a premier journal in the field of hepatology.