Gene expression最新文献

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Acute Myeloid Leukemia with Myelodysplasia-related Cytogenetic/Genetic-defined Abnormalities Masquerades as Acute Undifferentiated Leukemia 急性髓性白血病伴骨髓增生异常相关细胞遗传学/基因定义异常,伪装成急性未分化白血病
Gene expression Pub Date : 2024-05-15 DOI: 10.14218/ge.2024.00034
Zhaodong Xu, Rosemary Mueller
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引用次数: 0
Gene Expression Analysis Reveals Clinically Significant Genes Associated with Familial Hypercholesterolemia and Atherosclerosis 基因表达分析揭示与家族性高胆固醇血症和动脉粥样硬化有关的临床重要基因
Gene expression Pub Date : 2024-05-15 DOI: 10.14218/ge.2023.00184
Kumaran Kasianthan, Janardanan Subramonia Kumar, K. Aruljothi
{"title":"Gene Expression Analysis Reveals Clinically Significant Genes Associated with Familial Hypercholesterolemia and Atherosclerosis","authors":"Kumaran Kasianthan, Janardanan Subramonia Kumar, K. Aruljothi","doi":"10.14218/ge.2023.00184","DOIUrl":"https://doi.org/10.14218/ge.2023.00184","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"16 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential Epigenetic Modifiers Targeting the Alteration of Methylation in Colorectal Cancer 针对结直肠癌甲基化改变的潜在表观遗传修饰剂
Gene expression Pub Date : 2024-05-14 DOI: 10.14218/ge.2023.00039s
Abdeslam Jaafari
{"title":"Potential Epigenetic Modifiers Targeting the Alteration of Methylation in Colorectal Cancer","authors":"Abdeslam Jaafari","doi":"10.14218/ge.2023.00039s","DOIUrl":"https://doi.org/10.14218/ge.2023.00039s","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"106 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
(Epi)genetic Aspects of Metabolic Syndrome Pathogenesis in Relation to Brain-derived Neurotrophic Factor Expression: A Review (与脑源性神经营养因子表达有关的代谢综合征发病机制的(外)遗传学方面:综述
Gene expression Pub Date : 2024-05-08 DOI: 10.14218/ge.2023.00202
N. Todosenko, K. Yurova, O. Khaziakhmatova, M. Vulf, M. Bograya, Pavel Ivanov, Larisa Litvinova
{"title":"(Epi)genetic Aspects of Metabolic Syndrome Pathogenesis in Relation to Brain-derived Neurotrophic Factor Expression: A Review","authors":"N. Todosenko, K. Yurova, O. Khaziakhmatova, M. Vulf, M. Bograya, Pavel Ivanov, Larisa Litvinova","doi":"10.14218/ge.2023.00202","DOIUrl":"https://doi.org/10.14218/ge.2023.00202","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-coding RNA and Atherosclerosis 非编码 RNA 与动脉粥样硬化
Gene expression Pub Date : 2024-02-22 DOI: 10.14218/ge.2023.00117
Aram Adyan, E. Bezsonov, Eugene Grebenshchikov, Alexandr Grinev, Denis Bogomolov
{"title":"Non-coding RNA and Atherosclerosis","authors":"Aram Adyan, E. Bezsonov, Eugene Grebenshchikov, Alexandr Grinev, Denis Bogomolov","doi":"10.14218/ge.2023.00117","DOIUrl":"https://doi.org/10.14218/ge.2023.00117","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"103 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140438143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Group Theory of Messenger RNA Metabolism and Disease 信使 RNA 代谢与疾病的群体理论
Gene expression Pub Date : 2024-01-31 DOI: 10.14218/ge.2023.00079
Michel Planat, M. Amaral, David Chester, F. Fang, Raymond Aschheim, K. Irwin
{"title":"Group Theory of Messenger RNA Metabolism and Disease","authors":"Michel Planat, M. Amaral, David Chester, F. Fang, Raymond Aschheim, K. Irwin","doi":"10.14218/ge.2023.00079","DOIUrl":"https://doi.org/10.14218/ge.2023.00079","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"685 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140479616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Krüppel-like Factor 4, A Potential Therapeutic Agent for Colorectal Cancer: A Bioinformatics Analysis Krüppel样因子4,一种潜在的结直肠癌治疗剂:生物信息学分析
Gene expression Pub Date : 2023-12-18 DOI: 10.14218/ge.2023.00088
Esen Çakmak
{"title":"Krüppel-like Factor 4, A Potential Therapeutic Agent for Colorectal Cancer: A Bioinformatics Analysis","authors":"Esen Çakmak","doi":"10.14218/ge.2023.00088","DOIUrl":"https://doi.org/10.14218/ge.2023.00088","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":" 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138995251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detailed Stability and Unfolding Study of Mycobacterium Global Transcription Regulator Protein 分枝杆菌全球转录调节蛋白的详细稳定性和展开研究
Gene expression Pub Date : 2023-12-14 DOI: 10.14218/ge.2023.00043
Abinit Saha, Devlina Chakravarty, Soumyananda Chakraborti
{"title":"Detailed Stability and Unfolding Study of Mycobacterium Global Transcription Regulator Protein","authors":"Abinit Saha, Devlina Chakravarty, Soumyananda Chakraborti","doi":"10.14218/ge.2023.00043","DOIUrl":"https://doi.org/10.14218/ge.2023.00043","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138973284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Fennel (Foeniculum vulgare) Seed Powder in Increasing Testosterone and IGF1 Gene Expression in the Testis of Lamb 茴香籽粉对增加羔羊睾丸中睾酮和 IGF1 基因表达的作用
Gene expression Pub Date : 2023-12-06 DOI: 10.14218/ge.2023.00020
Seyed Mohammad Hadi Safaei, M. Mohammadabadi, Borhan Moradi, Oleksandr Kalashnyk, N. Klopenko, Olena Babenko, Oleksandr Oleksandrovich Borshch, V. Afanasenko
{"title":"Role of Fennel (Foeniculum vulgare) Seed Powder in Increasing Testosterone and IGF1 Gene Expression in the Testis of Lamb","authors":"Seyed Mohammad Hadi Safaei, M. Mohammadabadi, Borhan Moradi, Oleksandr Kalashnyk, N. Klopenko, Olena Babenko, Oleksandr Oleksandrovich Borshch, V. Afanasenko","doi":"10.14218/ge.2023.00020","DOIUrl":"https://doi.org/10.14218/ge.2023.00020","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"63 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138595493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypoxia-inducible Factor-1α in Diabetic Foot Ulcers: Plain but Not Simple 缺氧诱导因子-1α在糖尿病足溃疡中的作用:简单但不简单
Gene expression Pub Date : 2023-10-27 DOI: 10.14218/ge.2023.00051
Xinmeng Zhou, Daojiang Yu, Xiaodong Sun, Wei Huang, Yong Xu, Changlong Li, Yuanyuan Zhang
{"title":"Hypoxia-inducible Factor-1α in Diabetic Foot Ulcers: Plain but Not Simple","authors":"Xinmeng Zhou, Daojiang Yu, Xiaodong Sun, Wei Huang, Yong Xu, Changlong Li, Yuanyuan Zhang","doi":"10.14218/ge.2023.00051","DOIUrl":"https://doi.org/10.14218/ge.2023.00051","url":null,"abstract":"Hypoxia-inducible factor-1 alpha (HIF-1α) is usually regarded as a core regulator of hypoxic response. Persistent inflammation and impaired wound healing are common manifestations of diabetic foot ulcer (DFU). In normal wounds, HIF-1α and its related regulatory molecules, such as vascular endothelial growth factor and inducible nitric oxide synthase, are activated by hypoxia signals, which in turn promote wound healing. However, abnormal regulation of the HIF-1α signaling pathway by hyperglycemia leads to impaired wound healing in DFU. In this review, we highlight the tissue-specific and stage-specific effects of the HIF-1α signaling pathway in DFU. In the early stage of DFU, HIF-1α in inflammatory cells is over-upregulated by hyperglycemia, causing the activation of nuclear factor-κB and the inducible nitric oxide synthase-mediated pro-inflammatory signaling pathway, leading to sustained inflammation, which is deleterious. In the late stage of DFU, HIF-1α in endothelial cells and keratinocytes is inhibited by hyperglycemia, which leads to the downregulation of vascular endothelial growth factor expression, resulting in insufficient angiogenesis and difficult healing at the wound site. In this review, we discuss recent advances in the knowledge of the HIF-1α signaling pathway and the key targeted molecules in impaired wound healing of DFU. We also summarize the drugs currently in clinical trials that target HIF-1α or its downstream molecules, recapitulate current gaps in our knowledge, and propose rational therapeutic strategies for DFU based on the action characteristics of HIF-1α.","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"44 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136234521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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