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The Emerging Role of (p)ppGpp in DNA Repair and Associated Bacterial Survival against Fluoroquinolones. (p)ppGpp在抗氟喹诺酮类药物的DNA修复和相关细菌存活中的新作用。
Gene expression Pub Date : 2025-04-01 Epub Date: 2024-09-12 DOI: 10.14218/ge.2024.00033
Smitha Sivapragasam
{"title":"The Emerging Role of (p)ppGpp in DNA Repair and Associated Bacterial Survival against Fluoroquinolones.","authors":"Smitha Sivapragasam","doi":"10.14218/ge.2024.00033","DOIUrl":"10.14218/ge.2024.00033","url":null,"abstract":"<p><p>(p)ppGpp binds to RNA polymerase, causing stalling at damaged DNA sites and subsequent backtracking, which facilitates the recognition and removal of damaged DNA by repair proteins. Additionally, (p)ppGpp regulates DNA repair proteins involved in the Save Our Soul response and mutagenic strand break repair pathways, which are crucial for repairing damages induced by Ultraviolet light and other DNA-damaging agents, including antibiotics. Through these repair pathways, (p) ppGpp plays a vital role in mending strand breaks induced by ciprofloxacin, a fluoroquinolone antibiotic. (p)ppGpp mediates bacterial survival by inhibiting the transcription of mismatch repair proteins while simultaneously upregulating error-prone polymerases mediated by stress-induced sigma factors, thereby facilitating mutagenesis. The function of (p)ppGpp in fine-tuning DNA repair proteins to support bacterial survival against antibiotics via stress-induced mutagenesis is an emerging topic in the field of antibiotic resistance research. Currently, limited information is available on how (p)ppGpp interconnects the various DNA repair pathways that directly influence bacterial resistance to antibiotics. (p)ppGpp is also known to promote bacterial persistence against ofloxacin, another fluoroquinolone, by regulating proteins that induce membrane depolarization. The overlapping functions of (p)ppGpp as a master regulator in DNA repair during stress and bacterial persistence are yet to be fully elucidated. This review focuses on recent publications highlighting (p)ppGpp as a potential link connecting DNA repair pathways to bacterial survival strategies against fluoroquinolone antibiotics.</p>","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"24 2","pages":"130-138"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12880726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Myeloid Leukemia with Myelodysplasia-related Cytogenetic/Genetic-defined Abnormalities Masquerades as Acute Undifferentiated Leukemia 急性髓性白血病伴骨髓增生异常相关细胞遗传学/基因定义异常，伪装成急性未分化白血病
Gene expression Pub Date : 2024-05-15 DOI: 10.14218/ge.2024.00034
Zhaodong Xu, Rosemary Mueller
{"title":"Acute Myeloid Leukemia with Myelodysplasia-related Cytogenetic/Genetic-defined Abnormalities Masquerades as Acute Undifferentiated Leukemia","authors":"Zhaodong Xu, Rosemary Mueller","doi":"10.14218/ge.2024.00034","DOIUrl":"https://doi.org/10.14218/ge.2024.00034","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"134 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene Expression Analysis Reveals Clinically Significant Genes Associated with Familial Hypercholesterolemia and Atherosclerosis 基因表达分析揭示与家族性高胆固醇血症和动脉粥样硬化有关的临床重要基因
Gene expression Pub Date : 2024-05-15 DOI: 10.14218/ge.2023.00184
Kumaran Kasianthan, Janardanan Subramonia Kumar, K. Aruljothi
{"title":"Gene Expression Analysis Reveals Clinically Significant Genes Associated with Familial Hypercholesterolemia and Atherosclerosis","authors":"Kumaran Kasianthan, Janardanan Subramonia Kumar, K. Aruljothi","doi":"10.14218/ge.2023.00184","DOIUrl":"https://doi.org/10.14218/ge.2023.00184","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"16 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential Epigenetic Modifiers Targeting the Alteration of Methylation in Colorectal Cancer 针对结直肠癌甲基化改变的潜在表观遗传修饰剂
Gene expression Pub Date : 2024-05-14 DOI: 10.14218/ge.2023.00039s
Abdeslam Jaafari
{"title":"Potential Epigenetic Modifiers Targeting the Alteration of Methylation in Colorectal Cancer","authors":"Abdeslam Jaafari","doi":"10.14218/ge.2023.00039s","DOIUrl":"https://doi.org/10.14218/ge.2023.00039s","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"106 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
(Epi)genetic Aspects of Metabolic Syndrome Pathogenesis in Relation to Brain-derived Neurotrophic Factor Expression: A Review (与脑源性神经营养因子表达有关的代谢综合征发病机制的（外）遗传学方面：综述
Gene expression Pub Date : 2024-05-08 DOI: 10.14218/ge.2023.00202
N. Todosenko, K. Yurova, O. Khaziakhmatova, M. Vulf, M. Bograya, Pavel Ivanov, Larisa Litvinova
{"title":"(Epi)genetic Aspects of Metabolic Syndrome Pathogenesis in Relation to Brain-derived Neurotrophic Factor Expression: A Review","authors":"N. Todosenko, K. Yurova, O. Khaziakhmatova, M. Vulf, M. Bograya, Pavel Ivanov, Larisa Litvinova","doi":"10.14218/ge.2023.00202","DOIUrl":"https://doi.org/10.14218/ge.2023.00202","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-coding RNA and Atherosclerosis 非编码 RNA 与动脉粥样硬化
Gene expression Pub Date : 2024-02-22 DOI: 10.14218/ge.2023.00117
Aram Adyan, E. Bezsonov, Eugene Grebenshchikov, Alexandr Grinev, Denis Bogomolov
{"title":"Non-coding RNA and Atherosclerosis","authors":"Aram Adyan, E. Bezsonov, Eugene Grebenshchikov, Alexandr Grinev, Denis Bogomolov","doi":"10.14218/ge.2023.00117","DOIUrl":"https://doi.org/10.14218/ge.2023.00117","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"103 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140438143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Group Theory of Messenger RNA Metabolism and Disease 信使 RNA 代谢与疾病的群体理论
Gene expression Pub Date : 2024-01-31 DOI: 10.14218/ge.2023.00079
Michel Planat, M. Amaral, David Chester, F. Fang, Raymond Aschheim, K. Irwin
{"title":"Group Theory of Messenger RNA Metabolism and Disease","authors":"Michel Planat, M. Amaral, David Chester, F. Fang, Raymond Aschheim, K. Irwin","doi":"10.14218/ge.2023.00079","DOIUrl":"https://doi.org/10.14218/ge.2023.00079","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"685 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140479616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Krüppel-like Factor 4, A Potential Therapeutic Agent for Colorectal Cancer: A Bioinformatics Analysis Krüppel样因子4，一种潜在的结直肠癌治疗剂：生物信息学分析
Gene expression Pub Date : 2023-12-18 DOI: 10.14218/ge.2023.00088
Esen Çakmak
{"title":"Krüppel-like Factor 4, A Potential Therapeutic Agent for Colorectal Cancer: A Bioinformatics Analysis","authors":"Esen Çakmak","doi":"10.14218/ge.2023.00088","DOIUrl":"https://doi.org/10.14218/ge.2023.00088","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":" 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138995251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detailed Stability and Unfolding Study of Mycobacterium Global Transcription Regulator Protein 分枝杆菌全球转录调节蛋白的详细稳定性和展开研究
Gene expression Pub Date : 2023-12-14 DOI: 10.14218/ge.2023.00043
Abinit Saha, Devlina Chakravarty, Soumyananda Chakraborti
{"title":"Detailed Stability and Unfolding Study of Mycobacterium Global Transcription Regulator Protein","authors":"Abinit Saha, Devlina Chakravarty, Soumyananda Chakraborti","doi":"10.14218/ge.2023.00043","DOIUrl":"https://doi.org/10.14218/ge.2023.00043","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138973284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Fennel (Foeniculum vulgare) Seed Powder in Increasing Testosterone and IGF1 Gene Expression in the Testis of Lamb 茴香籽粉对增加羔羊睾丸中睾酮和 IGF1 基因表达的作用
Gene expression Pub Date : 2023-12-06 DOI: 10.14218/ge.2023.00020
Seyed Mohammad Hadi Safaei, M. Mohammadabadi, Borhan Moradi, Oleksandr Kalashnyk, N. Klopenko, Olena Babenko, Oleksandr Oleksandrovich Borshch, V. Afanasenko
{"title":"Role of Fennel (Foeniculum vulgare) Seed Powder in Increasing Testosterone and IGF1 Gene Expression in the Testis of Lamb","authors":"Seyed Mohammad Hadi Safaei, M. Mohammadabadi, Borhan Moradi, Oleksandr Kalashnyk, N. Klopenko, Olena Babenko, Oleksandr Oleksandrovich Borshch, V. Afanasenko","doi":"10.14218/ge.2023.00020","DOIUrl":"https://doi.org/10.14218/ge.2023.00020","url":null,"abstract":"","PeriodicalId":12502,"journal":{"name":"Gene expression","volume":"63 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138595493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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