Mitochondrial Mutations Affect the Cardiovascular System during Aging and Oxidative Stress

Q2 Biochemistry, Genetics and Molecular Biology

Gene expression Pub Date : 2023-09-21 DOI:10.14218/ge.2023.00039

Anastasia V. Poznyak, Vasily N. Sukhorukov, Mikhail А. Popov, Yegor S Chegodaev, Anton Y. Postnov, Alexander N. Orekhov

引用次数: 1

Abstract

Mitochondria are one of the most crucial components of the cell. Aging has a critical impact on mitochondria. Various studies have shown that the relationship between aging and mitochondria is multifaceted. In this review, we focused on mitochondrial DNA mutations and their impact on the cardiovascular system during aging and oxidative stress. While mitochondria contain their own DNA, part of their proteome is encoded by nuclear DNA, which further complicates the inheritance of mitochondrial diseases, making almost all methods of transmission of various pathologies possible. We provide a discussion on mitochondrial DNA mutagenesis and the most common problems associated with mitochondrial DNA mutations.

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线粒体突变在衰老和氧化应激过程中影响心血管系统

线粒体是细胞中最重要的组成部分之一。衰老对线粒体有重要影响。各种研究表明，衰老和线粒体之间的关系是多方面的。在这篇综述中，我们关注线粒体DNA突变及其在衰老和氧化应激过程中对心血管系统的影响。虽然线粒体含有自己的DNA，但它们的部分蛋白质组是由核DNA编码的，这进一步使线粒体疾病的遗传复杂化，使各种疾病的几乎所有传播方式都成为可能。我们提供了线粒体DNA突变和线粒体DNA突变相关的最常见问题的讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene expression 生物-生物工程与应用微生物

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Gene Expression, The Journal of Liver Research will publish articles in all aspects of hepatology. Hepatology, as a research discipline, has seen unprecedented growth especially in the cellular and molecular mechanisms of hepatic health and disease, which continues to have a major impact on understanding liver development, stem cells, carcinogenesis, tissue engineering, injury, repair, regeneration, immunology, metabolism, fibrosis, and transplantation. Continued research and improved understanding in these areas will have a meaningful impact on liver disease prevention, diagnosis, and treatment. The existing journal Gene Expression has expanded its focus to become Gene Expression, The Journal of Liver Research to meet this growing demand. In its revised and expanded scope, the journal will publish high-impact original articles, reviews, short but complete articles, and special articles (editorials, commentaries, opinions) on all aspects of hepatology, making it a unique and invaluable resource for readers interested in this field. The expanded team, led by an Editor-in-Chief who is uniquely qualified and a renowned expert, along with a dynamic and functional editorial board, is determined to make this a premier journal in the field of hepatology.