Frontiers in Neural Circuits最新文献

{"title":"Developmental trajectories of vocal behaviors in common marmosets as a reference framework for neurobehavioral studies.","authors":"Xincheng Zhao, Takaaki Kaneko, Wanyi Lu, Ken-Ichi Inoue, Masayuki Matsumoto, Masahiko Takada","doi":"10.3389/fncir.2026.1821810","DOIUrl":"10.3389/fncir.2026.1821810","url":null,"abstract":"<p><p>Nonhuman primates are essential model animals for understanding brain development and neurodevelopmental disorders. The common marmoset is becoming a key primate species due to its ease of handling and reproductive efficiency, along with increasing research resources, such as an MRI brain atlas of developing marmosets. The present study aims to further support the use of marmosets by providing a detailed description of the developmental trajectories of vocal behaviors with an automated system to detect and analyze vocalizations. We collected 64,736 vocalizations, classified them into 11 vocal types, and observed significant changes in their vocal behaviors from neonates to 12 weeks of age. Several call types, including Trill, Phee, and Cry, peaked around the sixth week before gradually declining. By contrast, calls such as immature Phee, and Twitter were most frequent at birth but decreased steadily, nearly disappearing by 6-8 weeks. In addition, we provide a platform for automatically detecting these vocalizations using artificial neural networks trained on a dataset applicable across various research contexts. Overall, this study not only describes the developmental trajectories of vocal behaviors in a fixed controlled context across developmental stages, but also serves as a reference framework for analyzing marmoset models of developmental disorders.</p>","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"20 ","pages":"1821810"},"PeriodicalIF":2.9,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fleeing is believing: adaptive behavior under social threat as an inference process.","authors":"Hridai S Khurana, Valeria Mussetto, Leiron Ferrarese, Cornelius T Gross, Rory J Bufacchi","doi":"10.3389/fncir.2026.1812938","DOIUrl":"10.3389/fncir.2026.1812938","url":null,"abstract":"<p><strong>Introduction: </strong>Adverse social experiences profoundly alter animal behavior, yet the processes underlying context-appropriate behavior selection based on prior social interactions remain poorly understood. Existing models capture statistical patterns but are not framed in mechanistic frameworks that explain individual variability and predict behavioral outcomes.</p><p><strong>Methods: </strong>We address this gap by modeling social defeat in mice as a partially observable Markov decision process (POMDP), implementing a heterarchical agent architecture-a structured network of interacting modules balancing exploration and exploitation. Our model successfully reconstructs observed behavioral motifs (e.g., investigation, hesitation, and flights), fits different mouse phenotypes (e.g., susceptible vs. resilient), and mechanistically captures the impact of social defeat as a parameter shift in the animal's internal generative model. Notably, characteristic behavioral motifs including investigation bouts, hesitation, and flight trajectories emerge from the model's inference dynamics, without any trajectory-level fitting. The model additionally reproduces effects of interventions like optogenetic stimulation, and generates testable predictions for future experiments. The model's modular architecture enables natural extension to other behavioral domains including foraging and multi-agent interactions, representing a foundational step toward interpretable models of mouse behavior. By capturing how adverse social experiences reshape decision-making at the computational level, this work offers potential clinical relevance for trauma and anxiety disorders in humans.</p>","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"20 ","pages":"1812938"},"PeriodicalIF":2.9,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13303489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148344661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A modular and flexible pipeline for intraoperative electrode reconstruction and localization in patients with brain lesions.","authors":"Haziq Rabbani, Ipsita Das, Ayan S Mandal, Thomas Nelson, Peter Hadar, Brian Hsueh, Roberto Ciordia, Brian F Coughlin, Emory Peng, Daniel R Cleary, Kelly L Collins, Ahmed M T Raslan, Ziv M Williams, Bryan D Choi, Garth Rees Cosgrove, Shadi A Dayeh, Pamela S Jones, Harmanpreet K Tiwana, Gavin P Dunn, R Mark Richardson, Wenya Linda Bi, Steven Tobochnik, Sydney S Cash, Daniel P Cahill, Angelique C Paulk","doi":"10.3389/fncir.2026.1814667","DOIUrl":"10.3389/fncir.2026.1814667","url":null,"abstract":"<p><p>Intraoperative intracranial electrophysiological recordings provide unique access to human cortical dynamics but remain difficult to translate across patients due to inconsistent localization of transient surface electrodes. Unlike chronic implantations, intraoperative electrodes are placed transiently, rarely visible on imaging, and often inconsistently documented. We present an open-source imaging pipeline, ALIGNER (Advanced Localization and Imaging Guidance for Neurosurgical Electrode Recording), designed to reconstruct intraoperative surface electrode array placements and quantitatively map neural activity to individualized anatomical and pathological substrates. By enabling anatomical localization of these electrodes, this framework supports systematic analysis of spatial gradients in neural activity relative to pathological tissue. We developed a multimodal reconstruction framework integrating pre- and postoperative MRI and CT, cortical surface modeling, semi-automated pathology segmentation, intraoperative photographs or videos when available, and physics-based electrode modeling. To improve robustness in cases with distorted anatomy, artificial intelligence tools such as SynthSR were used to enable reliable cortical surface reconstruction prior to FreeSurfer processing. A monocular depth-estimation network was incorporated to constrain electrode placement in conjunction with Blender cloth-physics simulation when photographic images were available, while atlas- and note-guided inference supported reconstruction otherwise. The pipeline was applied to 38 neurosurgical patients across drug-resistant epilepsy resection (<i>n</i> = 24), malformation (<i>n</i> = 1), brain tumor (<i>n</i> = 11), and deep brain stimulation (<i>n</i> = 2) cases, achieving some type of reconstruction and electrode localization in all participants. By exporting electrode coordinates for quantitative spatial analyses, including distance-based mapping relative to lesions and resection cavities, ALIGNER enables anatomically grounded and reproducible analysis of intraoperative electrophysiology. This open-source framework provides foundational infrastructure for cancer neuroscience studies of tumor-neuron interactions and establishes a scalable platform for future neurostimulation, implantable neurodevice, and brain-computer interface applications requiring precise anatomical localization.</p>","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"20 ","pages":"1814667"},"PeriodicalIF":2.9,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148328337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional implications of atypical action potential generation in the (patho)physiological brain: from developmental program to glioma.","authors":"Tong Tong, Anders Rosendal Korshøj, Wen-Hsien Hou","doi":"10.3389/fncir.2026.1851817","DOIUrl":"10.3389/fncir.2026.1851817","url":null,"abstract":"<p><p>Atypical action potentials (aAPs) are fast depolarizing electrical spikes recorded from the cell body, with a smaller amplitude. Despite varying in the generating mechanisms, aAPs have been reported in various brain cell types, including neurons, oligodendrocyte precursor cells (OPCs), and glioma cells. In this mini-review, we summarize the mechanisms and physiological functions of aAPs and outline their contributions to neurological diseases, particularly in glioma pathology. aAPs have been observed in mature brains, arising from mechanisms such as ectopic depolarizations and gap junction coupling, thereby supporting synaptic integration and network synchrony. It is also a signature of immature neurons in development. Subsets of NG2⁺ OPCs and immature oligodendrocyte-lineage cells exhibit state-, region-dependent excitability, ranging from subthreshold depolarizations to AP-like events, with potential roles in neuron-glial communication, ischemic vulnerability, and myelination. Accumulating human studies have demonstrated that glioma cells generate aAPs, while until recently their molecular profile was characterized by patch-seq. In IDH-mutant glioma, aAP cells exhibit a mixed GABAergic and OPC signature. At the leading edge (LE) of IDH-wild-type gliomas, aAPs are present in both adjacent non-tumor cells and glioblastoma cells (GBCs) across diverse GBC states, yet exhibit reduced proliferation and increased inflammatory signaling. In conclusion, aAPs are a recurrent but context-dependent electrophysiological feature observed in subsets of glioma cells, and may indicate an active role in network integration and active release. Dissecting the differential roles of aAP and no-aAP GBCs through targeted manipulations informed by transcriptomic results may reveal crucial mechanisms underlying multifaceted tumor-neuron crosstalk in glioma progression.</p>","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"20 ","pages":"1851817"},"PeriodicalIF":2.9,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of function of Noggin inhibits glial scar formation and motor function recovery after spinal cord injury.","authors":"Yibo Han, Yuki Wakayama, Shuo Li, Dong Liang, Juntan Li, Yashuang Ping, Hideyuki Arima, Kohji Sato, Yukihiro Matsuyama, Satoru Yamagishi","doi":"10.3389/fncir.2026.1821905","DOIUrl":"10.3389/fncir.2026.1821905","url":null,"abstract":"<p><strong>Introduction: </strong>Noggin is a glycosylated protein that acts as an antagonist of bone morphogenetic proteins and has been implicated in astrogliosis and functional recovery after spinal cord injury (SCI). Although Noggin is known to regulate astrocytic responses, its role in reactive astrogliosis and glial scar formation after SCI remains unclear. Under normal conditions, Noggin is expressed in astrocytes in the white matter of the mouse spinal cord. In this study, we investigated the role of Noggin in reactive astrogliosis and glial scar formation after SCI.</p><p><strong>Methods: </strong>We first examined the expression pattern of Noggin in the mouse spinal cord after SCI. To assess the functional role of Noggin, we used <i>Nestin-Cre; Noggin^flox/flox</i> conditional knockout mice, in which Noggin is conditionally deleted from astrocytes and neurons in the spinal cord. In addition, neutralizing anti-Noggin antibodies were continuously administered to the lesion site using micro-osmotic pumps. GFAP expression and motor function after SCI were then evaluated.</p><p><strong>Results: </strong>As a result, we found that Noggin was upregulated in reactive astrocytes after SCI, suggesting its involvement in the injury response. Conditional deletion of Noggin markedly suppressed glial fibrillary acidic protein (GFAP) expression after SCI. Consistently, local administration of neutralizing anti-Noggin antibodies also reduced GFAP expression around the lesion site. However, anti-Noggin antibody treatment deteriorated motor function after SCI.</p><p><strong>Discussion: </strong>These findings suggest that Noggin is an important regulator of reactive astrogliosis and contributes to glial scar formation after SCI. Although suppression of Noggin reduced GFAP expression and attenuated glial scar formation, it did not improve functional recovery. Rather, motor function was worsened, indicating that reduced glial scar formation may not necessarily be beneficial after SCI. Noggin-mediated astrogliosis may therefore play a protective role in the injured spinal cord.</p>","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"20 ","pages":"1821905"},"PeriodicalIF":2.9,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13253513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148250525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross domain consistency of aesthetic preference-driven social behavior.","authors":"Trung Quang Pham, Junichi Chikazoe","doi":"10.3389/fncir.2026.1793443","DOIUrl":"10.3389/fncir.2026.1793443","url":null,"abstract":"<p><strong>Introduction: </strong>Aesthetic preference is a primary driver of social behavior in the digital era, yet the extent to which these preferences remain consistent across disparate domains remains poorly understood.</p><p><strong>Methods: </strong>We hypothesize that aesthetic judgment is governed by a domain-invariant latent structure, such that individuals who exhibit similar preferences in one category will demonstrate comparable alignment in seemingly unrelated domains. To test this, we recruited 37 participants to evaluate stimuli across three distinct aesthetic domains: art, faces (male and female), and scenes. We developed a novel computational framework that reformulates cross-domain preference as a user-based collaborative filtering problem, encoding individual profiles through inter-subject similarity matrices.</p><p><strong>Results: </strong>Our model successfully predicted participant responses in a target domain based on their similarity to the cohort in a separate source domain. These results demonstrate robust cross-domain consistency, suggesting that aesthetic evaluation is mediated by an abstract, domain-general mechanism rather than being purely stimulus-dependent.</p><p><strong>Discussion: </strong>We propose that this consistency is rooted in a shared neurophysiological pathway, likely involving the orbitofrontal cortex (OFC) and the Default Mode Network (DMN), and discuss how these findings provide a foundation for more sophisticated, cross-modal recommendation systems and the study of individual social identity.</p>","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"20 ","pages":"1793443"},"PeriodicalIF":2.9,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13233533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148198381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.","authors":"Mike Gilbert, Anders Rasmussen","doi":"10.3389/fncir.2026.1815319","DOIUrl":"10.3389/fncir.2026.1815319","url":null,"abstract":"<p><p>We present a summary of ideas that attempt to explain how the locomotor cerebellum may represent and process information. It includes the proposals that (i) the main network computation is a passive and unlearned effect of cell type morphologies and neural architecture; (ii) information has topographically defined spatial dimensions; (iii) it is coded at collective level, at any instant, in any random sample of functionally grouped signals; (iv) topographical organization extends outside the cerebellum and maps to the peripheral nervous system; and (v) learning and memory are at microzone level and in a supplementary role. The aim is to provide competition for traditional learning models and to challenge some common assumptions. We have found that the main resistance to the proposals is in these areas: loyalty to the traditional model; mathematically, the computation is unexpectedly unsophisticated; on the face of it, the mechanism is resource-heavy; we propose that neuroanatomy automates motor coordination and converts feedback into motor output in real time. Some of the ideas are contentious. We argue, nonetheless, that the proposals can explain the evidence.</p>","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"20 ","pages":"1815319"},"PeriodicalIF":2.9,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13201492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular mechanisms underlying social regulation of the posterior tubercular nucleus in zebrafish (<i>Danio rerio</i>).","authors":"Carrie L Adams, Emily M Scott, Fadi A Issa","doi":"10.3389/fncir.2026.1834765","DOIUrl":"10.3389/fncir.2026.1834765","url":null,"abstract":"<p><p>Social status profoundly influences animal behavior through neural plasticity, yet the cellular mechanisms that mediate reconfiguration of neuromodulatory systems remain poorly understood. Here, we investigated status-dependent structural changes in the posterior tubercular nucleus (PTN) of adult zebrafish. Animals were assigned to four social conditions: communal, isolated, dominant, or subordinate. Using markers for cell proliferation (PCNA) and birth-dating (BrdU), we demonstrate that social dominance significantly enhances cell proliferation, leading to an increased population of PTN dopaminergic neurons. In contrast, subordinate and isolated fish exhibited suppressed proliferation and elevated expression of superoxide dismutase 1 (SOD1), suggesting that chronic social stress induces an oxidative burden that may lead to neuronal loss. Furthermore, we identified evidence of neurotransmitter phenotypic plasticity; subordinate fish displayed a significantly higher ratio of glutamatergic (<i>vglut2a</i>) to dopaminergic (<i>dat</i>) expression in PTN neurons compared to dominants, suggesting a status-dependent shift in neuromodulatory identity. Multivariate principal component analysis showed distinct neurobiological profiles that separate social ranks, suggesting that status-dependent plasticity is a coordinated multi-modal response whereby increased BrdU and PCNA expression clustered with the dominant profile while increased expression of cellular stress and shift to glutamate cellular identity clustered with social subordinate and isolate profiles. Collectively, our results improve our understanding of how social experience reshapes the zebrafish brain through integrated changes in cell proliferation, cellular shift in neurotransmitter identity and regulation of cellular viability; thus, providing a potential mechanism for the maintenance of stable behavioral phenotypes in competitive social environments.</p>","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"20 ","pages":"1834765"},"PeriodicalIF":2.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13194128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148014745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Post-ischemic modification of neurogenesis and oligodendrogenesis in rodent models.","authors":"Yoshihide Sehara, Shinya Mochizuki, Reiji Yamazaki","doi":"10.3389/fncir.2026.1863549","DOIUrl":"10.3389/fncir.2026.1863549","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fncir.2026.1803118.].</p>","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"20 ","pages":"1863549"},"PeriodicalIF":2.9,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor imagery affects both cortical and spinal circuitry: a transcranial and trans-spinal magnetic stimulation study.","authors":"Asma Benachour, Nikolay Syrov, Mikhail Lebedev","doi":"10.3389/fncir.2026.1809125","DOIUrl":"10.3389/fncir.2026.1809125","url":null,"abstract":"<p><strong>Introduction: </strong>Motor imagery (MI), the mental rehearsal of movement without physical execution, is a key technique in brain-computer interfaces (BCIs), known for eliciting cortical modulations similar to those exhibited during real movement. Beyond cortical effects, MI could also modulate spinal cord processing, which offers additional potential for neurorehabilitation in conditions like spinal cord injury (SCI) and stroke, where BCIs are used for therapy.</p><p><strong>Material and methods: </strong>To investigate the interactions of MI with both the cortex and the spinal cord, we employed both transcranial magnetic stimulation (TMS) and trans-spinal magnetic stimulation (TSMS) while recording brain and muscle activities.</p><p><strong>Results and conclusion: </strong>With proper coil orientation, TSMS elicited lateralized MEPs in ipsilateral forearm muscles at significantly shorter latencies than M1-evoked MEPs, confirming direct spinal cord activation. Importantly, right-hand kinesthetic MI selectively facilitated TSMS-evoked MEPs in the stimulated ipsilateral side only, providing direct evidence that MI modulates spinal cord excitability. Moreover, TSMS-evoked cortical responses were modulated by imagery, demonstrating that MI increases cortical processing of the ascending spinal volley. This within-group demonstration of MI affecting both cortical and spinal circuitry underscores its potential as a powerful strategy for BCI-driven neurorehabilitation, including pairing MI with spinal magnetic stimulation.</p>","PeriodicalId":12498,"journal":{"name":"Frontiers in Neural Circuits","volume":"20 ","pages":"1809125"},"PeriodicalIF":2.9,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13171853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147963128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}