Fundamental and Clinical Medicine最新文献_第5页

A clinical case of COVID-19 in a patient with Hodgkin lymphoma and brain damage 霍奇金淋巴瘤合并脑损伤患者感染COVID-19临床1例

Fundamental and Clinical Medicine Pub Date : 2023-04-01 DOI: 10.23946/2500-0764-2023-8-1-143-149

G. Zoloev, A. A. Kosovskikh, O. Rudenkova, Zh. V. Pikelgaupt, V. V. Manzhos, K. V. Cherevatenko

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Use of pessary for cervical insufficiency: a discussion 子宫托治疗宫颈功能不全的应用探讨

Fundamental and Clinical Medicine Pub Date : 2023-04-01 DOI: 10.23946/2500-0764-2023-8-1-109-118

K. V. Marochko, Y. Parfenova, N. Artymuk, O. Novikova, D. Beglov

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Short- and long-term results of organ-sparing surgery in patients with severe diffuse adenomyosis at perimenopausal transition 围绝经期重度弥漫性子宫肌病患者保留器官手术的短期和长期结果

Fundamental and Clinical Medicine Pub Date : 2023-04-01 DOI: 10.23946/2500-0764-2023-8-1-93-100

Vitaliy B. Tskhay, Gulnar T. Mikailly, I. I. Tskhay, Krasnoyarsk Partizana Zheleznyaka Street

{"title":"Short- and long-term results of organ-sparing surgery in patients with severe diffuse adenomyosis at perimenopausal transition","authors":"Vitaliy B. Tskhay, Gulnar T. Mikailly, I. I. Tskhay, Krasnoyarsk Partizana Zheleznyaka Street","doi":"10.23946/2500-0764-2023-8-1-93-100","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-93-100","url":null,"abstract":"Aim. To study the short- and long-term results of organ-sparing surgery in patients with severe diffuse adenomyosis who are in the perimenopausal age.Materials and Methods. The study included 18 patients with severe diffuse adenomyosis who underwent fertility-sparing excision of diffuse adenomyosis by means of Osada procedure. Efficiency of surgical treatment and subsequent drug therapy was evaluated at 12 and 24 months of follow-up by pelvic ultrasound examination. The frequency of adenomyosis symptoms and quality of life were assessed using the standard SF-36 questionnaire.Results. Recovery of the menstrual cycle, freedom from pain and anemia, and improved quality of life were documented in all cases (18/18), whereas onset of menopause occurred in half of the cases (9/18). In particular, all scales of the Physical Component Summary from SF-36 questionnaire were significantly improved at both follow-up time points.Conclusion. Organ-sparing excision of diffuse adenomyosis using Osada procedure is the option of choice and might represent an alternative to hysterectomy in women with perimenopausal age, in addition to those of earlier reproductive age.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90308010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 pandemic in low-risk pregnant women in 2020-2022: disease confounders and clinical characteristics 2020-2022年低危孕妇中COVID-19大流行:疾病混杂因素和临床特征

Fundamental and Clinical Medicine Pub Date : 2023-04-01 DOI: 10.23946/2500-0764-2023-8-1-32-42

T. Belokrinitskaya, N. Frolova, K. A. Kargina, E. A. Shametova, M. I. Chuprova, K. Rodionova

{"title":"COVID-19 pandemic in low-risk pregnant women in 2020-2022: disease confounders and clinical characteristics","authors":"T. Belokrinitskaya, N. Frolova, K. A. Kargina, E. A. Shametova, M. I. Chuprova, K. Rodionova","doi":"10.23946/2500-0764-2023-8-1-32-42","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-32-42","url":null,"abstract":"Aim. To identify confounders and clinical symptoms of COVID-19 in low-risk pregnant women during the pandemics from 2020 to 2022.Materials and Methods. The study included pregnant women with COVID-19: 1) those who have been admitted in October-December 2020 (n = 163); 2) those who have been admitted in May-August 2021 (n = 158); 3) those who have been admitted in January-February 2022 (n = 160). Patients in all groups were in the 3st trimester of gestation and were comparable in age (18–35 years), socioeconomic status, parity, body mass index, and had no established risk factors for COVID-19.Results. Iron deficiency anemia, tobacco smoking, and belonging to the East Asian ethnic group were recognized as reliable confounders for COVID-19 in pregnant women. In the 1st year of the pandemic, the most common symptoms were: loss of smell/taste (87.7%), somnolence (68,7%), and shortness of breath (68.1%). In the 2nd pandemic year, SARS-CoV-2 Delta variant more frequently resulted in fever above 38°C (19.6% vs 7.4%), pneumonia (61.4% vs 21.4%), respiratory failure (17.7% vs 4.9%), admission to intensive care unit (11.4% vs 6.4%), and invasive mechanical ventilation (1.89% vs 0). Symptoms of COVID-19 in the 3rd year of the pandemic were similar to those observed in seasonal acute respiratory viral infections: runny nose (66.7%) and cough (54.4%), whereas the cases of pneumonia were rare (3.8%).Conclusion. Among the most reliable confounders of COVID-19 in pregnant women without any risk factors in the 3rd trimester of gestation are iron deficiency anemia, tobacco smoking, and belonging to the East Asian ethnic group. Each SARS-CoV-2 variant provoked vastly different symptoms.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85786986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-ST segment elevation myocardial infarction: results of 2021−2022 非st段抬高型心肌梗死:2021 - 2022年的结果

Fundamental and Clinical Medicine Pub Date : 2023-04-01 DOI: 10.23946/2500-0764-2023-8-1-132-142

O. Barbarash, V. Kashtalap, L. Barbarash

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Statistical analysis of medical data: descriptive statistics and group comparison 医疗资料的统计分析:描述性统计和分组比较

Fundamental and Clinical Medicine Pub Date : 2023-04-01 DOI: 10.23946/2500-0764-2023-8-1-119-131

Zhanna V. Gudinova, Lidia V. Demakova

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Molecular genetic surveillance based on the identification of borrelia in ixodid ticks 蜱中疏螺旋体鉴定的分子遗传监测

Fundamental and Clinical Medicine Pub Date : 2023-04-01 DOI: 10.23946/2500-0764-2023-8-1-63-70

S. Rudakova, O. E. Teslova, N. E. Mutalinova, Yulia F. Kuzmenko, S. V. Strek, N. Penyevskaya, N. Rudakov

{"title":"Molecular genetic surveillance based on the identification of borrelia in ixodid ticks","authors":"S. Rudakova, O. E. Teslova, N. E. Mutalinova, Yulia F. Kuzmenko, S. V. Strek, N. Penyevskaya, N. Rudakov","doi":"10.23946/2500-0764-2023-8-1-63-70","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-63-70","url":null,"abstract":"Aim. To improve emergency diagnostic measures and preventive antimicrobial therapy in patients with ixodid tick bites using molecular genetic techniques for identification of Вorrelia spp.Materials and Methods. Borrelia strains were isolated by inoculation of tick suspension on the BSK-H medium. Molecular genetic screening of Вorrelia spp. was performed by real-time polymerase chain reaction (PCR) and sequencing. In total, we examined 4,276 patients including 272 bitten by Ixodes persulcatus and 3,108 bitten by Dermacentor reticulatus. In addition, we investigated blood of 896 patients for molecular signatures of Borrelia spp.Results. Borrelia spp. was detected by PCR in 30.1% of Ixodes persulcatus and 3.2% of Dermacentor reticulatus suspensions. However, detection of Borrelia spp. in blood was rare, reaching only 1.1% in those bitten by Ixodes persulcatus and two cases of Dermacentor reticulatus bites. Genotyping of Borrelia spp. in 8 tick suspensions showed the presence of Borrelia garinii in 1 sample, Borrelia afzelii in 5 samples, Borrelia bavariensis in 1 sample, and Borrelia miyamotoi in 1 sample.Conclusion. Molecular genetic screening showed the significant proportion of Ixodid ticks bearing Borrelia spp., indicating the need in specific antimicrobial therapy.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77934089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Acute mesenterial ischaemia: a contemporary view 急性肠系膜缺血:当代观点

Fundamental and Clinical Medicine Pub Date : 2023-04-01 DOI: 10.23946/2500-0764-2023-8-1-101-108

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Ceruloplasmin and complement C3 are markers of diminished ovarian reserve in premenopausal women 铜蓝蛋白和补体C3是绝经前妇女卵巢储备减少的标志

Fundamental and Clinical Medicine Pub Date : 2023-03-31 DOI: 10.23946/2500-0764-2023-8-1-8-20

{"title":"Ceruloplasmin and complement C3 are markers of diminished ovarian reserve in premenopausal women","authors":"","doi":"10.23946/2500-0764-2023-8-1-8-20","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-8-20","url":null,"abstract":"Aim. To establish cut-off values for the concentrations of complement C3 and ceruloplasmin, diagnostic markers of reduced antral follicle count (AFC) and anti-Müllerian hormone (AMH) which both indicate diminished ovarian reserve, in women of reproductive age.Materials and Methods. Here we enrolled 864 women (18-40 years of age, average age 31.70 ± 5.14 years) who underwent an annual medical examination in 2017–2019 in the Irkutsk Region and the Republic of Buryatia. Reduced AFC was defined as ≤ 5 antral follicles in each ovary at pelvic ultrasound examination whilst reduced AMH was defined as < 1.2 ng/mL. In total, 112 women had reduced ovarian reserve and 752 were included into the control group. In addition to AMH, we also measured serum prolactin, gonadotropins, inhibin B, estradiol, complement C3, and ceruloplasmin using enzyme-linked immunosorbent assay. The cut-off values were determined by plotting a receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC).Results. The cut-off level of complement C3 was 894 (867; 1355.5) mg/mL [AUC: 0.769 (0.635; 0.904)] in women with reduced AFC (≤ 5) and 981.5 (916.5; 1467.5) mg/mL [AUC: 0.62 (0.493; 0.746)] in women with reduced AMH (< 1.2 ng/mL). The cut-off level of ceruloplasmin was 1.745 (1.625; 1.975) mg/mL [AUC: 0.859 (0.759; 0.96)] in women with reduced AFC (≤ 5) and 1.975 (1.665; 2.15) mg/mL, [AUC: 0.662 (0.542; 0.782)] in women with reduced AMH (< 1.2 ng/mL).Conclusion. We have established the cut-off values for the serum complement C3 and ceruloplasmin in women with reduced AFC and AMH, indicators defining diminished ovarian reserve in women of reproductive age.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91058798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Long-term changes in cognitive status of patients with type 2 diabetes mellitus after coronary artery bypass graft surgery 2型糖尿病患者冠状动脉搭桥术后认知状态的长期变化

Fundamental and Clinical Medicine Pub Date : 2023-03-31 DOI: 10.23946/2500-0764-2023-8-1-21-31

A. Sosnina, I. Tarasova, I. Syrova, O. Maleva, O. Trubnikova, O. Barbarash

{"title":"Long-term changes in cognitive status of patients with type 2 diabetes mellitus after coronary artery bypass graft surgery","authors":"A. Sosnina, I. Tarasova, I. Syrova, O. Maleva, O. Trubnikova, O. Barbarash","doi":"10.23946/2500-0764-2023-8-1-21-31","DOIUrl":"https://doi.org/10.23946/2500-0764-2023-8-1-21-31","url":null,"abstract":"Aim. To study long-term changes (5 to 7 years after coronary artery bypass graft (CABG) surgery) in cognitive status of patients with type 2 diabetes.Materials and Methods. The study included 47 male patients admitted to the Research Institute for Complex Issues of Cardiovascular Diseases for the CABG surgery. Criteria of inclusion were signed informed consent, age from 40 to 75 years, male gender, planned on-pump CABG surgery, and right-handedness. Criteria of exclusion were brain pathology at multislice computed tomography, chronic cerebral ischemia grade II-IV, Beck Depression Inventory score > 16 points, the Mini-Mental State Examination (MMSE) score < 24 points and the Frontal Assessment Battery score < 11 points, arrhythmia, class IIB-IV chronic heart failure stage IIB, chronic obstructive pulmonary disease, cancer, and past medical history of brain injury or stroke. Pre-operative examination of patients classified them into two groups: with (n = 21) and without (n = 26) type 2 diabetes mellitus (DM).Results. 5-7 years after CABG surgery, patients with type 2 DM had a cognitive decline according to MMSE scale as compared to the preoperative level (28,0 [27,0; 29,0] and 27,0 [26,0; 28,0], p = 0.04). In keeping with these findings, odds ratio (OR) of mild cognitive impairment (MCI) in patients with type 2 DM was 1.92 (95% CI = 1.09- 3.37, p = 0.02). Psychomotor and executive functions were reduced in patients with type 2 DM both at baseline and in particular 5-7 years after CABG (p ≤ 0.05). The correlation between glycated hemoglobin (HbA1c) and cognitive parameters were found only in patients with type 2 DM. Higher HbA1c level was also associated with deteriorated executive functions and short-term memory.Conclusion. 5−7 years after CABG surgery, patients with type 2 DM suffer from a cognitive decline and reduced psychomotor and executive functions.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80516786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0