Fundamental and Clinical Medicine最新文献

Uterine Balloon Tamponade in Management of Postpartum Hemorrhage 子宫球囊填塞术在产后出血治疗中的应用

Fundamental and Clinical Medicine Pub Date : 2024-03-29 DOI: 10.23946/2500-0764-2024-9-1-89-101

D. Artymuk, S. Apresyan

{"title":"Uterine Balloon Tamponade in Management of Postpartum Hemorrhage","authors":"D. Artymuk, S. Apresyan","doi":"10.23946/2500-0764-2024-9-1-89-101","DOIUrl":"https://doi.org/10.23946/2500-0764-2024-9-1-89-101","url":null,"abstract":"Aim. To evaluate the efficacy and safety of uterine balloon tamponade for the management of postpartum haemorrhage.Materials and Methods. We have screened the Cochrane Library and PubMed for the following keywords: “intrauterine balloon tamponade”, “controlled balloon tamponade”, “controlled balloon tamponade” AND “postpartum bleeding/haemorrhage” during 5 years (2018-2023). In total, we have identified 358 publications including 3 meta-analyses, 6 systematic reviews, and 13 randomized controlled trials. After checking titles and abstracts to remove duplicates, we selected 38 sources which met the selection criteria.Results. Postpartum haemorrhage remains the leading cause of maternal mortality in both developing and developed countries. In most cases, postpartum haemorrhage occurs due to atony and is controlled by administration of uterotonics. However, if uncurbed, postpartum haemorrhage requires blood transfusion and surgery. Currently, uterine balloon tamponade is considered as one of the most efficient and safe technologies for controlling postpartum haemorrhage and preventing hysterectomy, yet a number of studies have reported negative results. Several investigations showed an advantage of double-balloon tamponade as it provides an additional benefit of vascular compression of the lower uterine segment. Generally, uterine balloon tamponade is an efficient intervention which allows to avoid additional surgeries (uterine artery embolization or hysterectomy) in 87.3 – 100.0% of cases with a relatively low complication rate (< 6.7% – 9.4%).Conclusion. The effectiveness of uterine balloon tamponade and the risk of complications are probably determined by the type of device, the learning curve effect, and the regularity and quality of training of medical personnel. Further in-depth multicenter studies in this direction are required.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"12 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140365836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of Chronic Endometritis with Vague Symptoms in Patients with Endometrial Hyperplasia 治疗子宫内膜增生症患者症状模糊的慢性子宫内膜炎

Fundamental and Clinical Medicine Pub Date : 2024-03-29 DOI: 10.23946/2500-0764-2024-9-1-17-24

N. I. Volotskaya, E. Golubinskaya, E. Zyablitskaya, Р. E. Maksimova

{"title":"Treatment of Chronic Endometritis with Vague Symptoms in Patients with Endometrial Hyperplasia","authors":"N. I. Volotskaya, E. Golubinskaya, E. Zyablitskaya, Р. E. Maksimova","doi":"10.23946/2500-0764-2024-9-1-17-24","DOIUrl":"https://doi.org/10.23946/2500-0764-2024-9-1-17-24","url":null,"abstract":"Aim. To develop new therapeutic approaches for chronic endometritis with vague symptoms, which is frequently diagnosed in patients with endometrial hyperplasia.Materials and Methods. We collected the material from uterine scrapings in patients (age 25-63 years) with endometrial hyperplasia (diagnosed by ultrasound examination) and abnormal uterine bleeding which occurred during hysteroscopic dilation and curettage. Among the exclusion criteria were intraepithelial neoplasia and atypical endometrial hyperplasia, cancer, systemic inflammation, and hormonal therapy. To verify the diagnosis, we employed immunohistochemistry, digital slide scanning, and morphometry.Results. This study confirmed the value of immunohistochemical diagnosis underlying the pathogenetic therapy of endometrial hyperplasia using non-steroidal anti-inflammatory drugs. Inflammatory markers indicating the distribution and quantitative alterations in cell populations had the highest diagnostic value.Conclusion. We developed a molecularly oriented algorithm for the treatment of patients with endometrial hyperplasia. This algorithm improves existing preventive, diagnostic and therapeutic approaches using immunohistochemical techniques. Such molecular testing can help in making correct therapeutic decisions.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"10 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140366791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological Features of Smoking Patients with Multivessel Coronary Artery Disease According to the Frailty Registry 根据虚弱登记数据得出的多支血管冠状动脉疾病吸烟患者的临床病理特征

Fundamental and Clinical Medicine Pub Date : 2024-03-29 DOI: 10.23946/2500-0764-2024-9-1-42-52

O. V. Nakhratova, D. P. Tsygankova, E. Indukaeva, J. M. Center, P. K. Swarovskaya, E. E. Gorbatovskaya, E. Bazdyrev

{"title":"Clinicopathological Features of Smoking Patients with Multivessel Coronary Artery Disease According to the Frailty Registry","authors":"O. V. Nakhratova, D. P. Tsygankova, E. Indukaeva, J. M. Center, P. K. Swarovskaya, E. E. Gorbatovskaya, E. Bazdyrev","doi":"10.23946/2500-0764-2024-9-1-42-52","DOIUrl":"https://doi.org/10.23946/2500-0764-2024-9-1-42-52","url":null,"abstract":"Aim. To analyse clinicopathological features of smoking patients with multivessel coronary artery disease.Material and Methods. We analysed the data from the FRAILTY registry which includes patients with coronary artery disease. In addition to clinical features, we assessed echocardiography data and lipid metabolism levels (total cholesterol, triglycerides, low- and high-density lipoproteins, and high-sensitive C-reactive protein).Results. Of the 381 CAD patients, 178 (46.7%) have smoked at some point (107 (60.1%) current smokers and 71 (39.1%) smoking quitters), whereas 203 (53.3%) patients have never smoked. These groups were comparable in age and cardiovascular disease prevalence. Smokers or smoking quitters’ group had higher proportion of males (78.1 vs. 69%; p = 0.045), higher prevalence of myocardial infarction (61.8 vs. 55.2%; p = 0.047), chronic obstructive pulmonary disease (6.4 vs. 2.3%; p = 0.045), and lower extremity peripheral artery disease (47.8 vs. 31.5%; p = 0.041). There were no differences between the groups regarding the risk of death after cardiac surgery. The level of total cholesterol was 1.8-fold higher in smokers and smoking quitters as compared with patients who never smoked (5.5 (3.7; 6.7) vs. 3.0 (2.2; 4.0) mmol/L; p = 0.01). Similar pattern was discovered regarding to the level of C-reactive protein (5.1 (2.4; 5.3) vs. 3.9 (2.2; 4.2) mg/L in smokers/smoking quitters and never smokers, respectively; p = 0.041). The analysis of echocardiography parameters did not reveal statistically significant differences.Conclusion. Smoking frequently accompanies coronary artery disease. Current smokers and smoking quitters were characterized by higher frequency of myocardial infarction, chronic obstructive pulmonary disease, and lower extremity peripheral artery disease Further, current smokers and smoking quitters had higher serum total cholesterol and C-reactive protein.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"56 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140365243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of the Gut Microbiota in the Development of Colorectal Cancer 肠道微生物群在大肠癌发病中的作用

Fundamental and Clinical Medicine Pub Date : 2024-03-29 DOI: 10.23946/2500-0764-2024-9-1-112-123

V. N. Shumilova, A. E. Goncharov, E. L. Latariya, B. Aslanov

{"title":"The Role of the Gut Microbiota in the Development of Colorectal Cancer","authors":"V. N. Shumilova, A. E. Goncharov, E. L. Latariya, B. Aslanov","doi":"10.23946/2500-0764-2024-9-1-112-123","DOIUrl":"https://doi.org/10.23946/2500-0764-2024-9-1-112-123","url":null,"abstract":"Colorectal cancer (CRC) is one of the most common malignant tumours, which development significantly depends on the role of gut microbiota. Here we discuss the possibilities of using individual microorganisms as biomarkers for CRC screening. During the tumorigenesis, a complex interaction is established between the gut microbiome, the tumor microenvironment and the immune system. The composition of the fecal microbiome in patients with CRC is characterized by reduced numbers of protective microorganisms (Clostridiales, Roseburia, Feacalibacterium) and increased diversity of potentially carcinogenic taxa (Bacteroides, Fusobacterium, Campylobacter, Escherichia, Porphyromonas, Prevotella nigrescens, Thermanaerovibrio acidaminovorans). Recent metagenomic studies of stool samples and tumor biopsies indicate an increased representation of oral pathogenic bacteria in the intestinal microbiome in patients with CRC as compared to the control group, suggesting their potential causative role in CRC. The detection of the abovementioned taxa can be used to differentiate individuals with CRC from healthy individuals. Prospects for further research are associated with the identification of microbial CRC markers in prospective epidemiological studies and their applications for non-invasive screening of CRC.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"63 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140367813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pattern of Circulating Microrna's in Patients with Psoriatic Arthritis 银屑病关节炎患者体内循环微纳的模式

Fundamental and Clinical Medicine Pub Date : 2024-03-29 DOI: 10.23946/2500-0764-2024-9-1-72-88

P. Shesternya, N. A. Shnayder, D. E. Filipenko, E. V. Turchik, А. О. Vasilieva, E. V. Kapustina

{"title":"Pattern of Circulating Microrna's in Patients with Psoriatic Arthritis","authors":"P. Shesternya, N. A. Shnayder, D. E. Filipenko, E. V. Turchik, А. О. Vasilieva, E. V. Kapustina","doi":"10.23946/2500-0764-2024-9-1-72-88","DOIUrl":"https://doi.org/10.23946/2500-0764-2024-9-1-72-88","url":null,"abstract":"Psoriatic arthritis (PsA) is a common rheumatic disease with an extremely variable phenotype. The main domains of PsA are peripheral arthritis, spondylitis, enthesitis and dactylitis. Studying new mechanisms of PsA development can help in finding the key to the development of innovative diagnostic methods and personalized approaches to the treatment of this disease. In recent years, the role of non-coding ribonucleic acids (RNA) in various diseases has been actively discussed, and the highest interest of researchers and clinicians has been focused on microRNAs. The purpose of this review was to search and systematize pre-clinical and clinical studies on the role of circulating microRNAs in the development of PsA and to update knowledge about molecular biomarkers of this disease. The search was conducted in PubMed, Springer, Web of Science, Clinicalkeys, Scopus, OxfordPress, The Cochrane Library, and eLibrary databases using specific keywords and their combinations. We have analysed the publications for 2013-2023, including clinical studies of PsA and psoriasis (PsO). As a result of this descriptive review, miR-10b-5p, miR-126-3p, miR-151a-5p, and miR-130a-3p can be considered as promising molecular biomarkers of PsA and therapeutic response. However, the role of other miRs is debatable and needs further study. In the future, it will be possible to consider previously studied circulating microRNAs with high specificity and sensitivity in PsA as prognostic molecular biomarkers (predictors) of the risk of developing and severity of this disease in patients with PsO.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"39 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140365570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Birth Weight Parameters in Sverdlovsk Region: Preliminary Results 斯维尔德洛夫斯克地区出生体重参数评估：初步结果

Fundamental and Clinical Medicine Pub Date : 2024-03-29 DOI: 10.23946/2500-0764-2024-9-1-25-32

S. R. Belomestnov, T. V. Сhumarnaya, O. Sevostyanova, A. M. Ksenofontov, N. O. Аnkudinov, T. M. Isakova

{"title":"Assessment of Birth Weight Parameters in Sverdlovsk Region: Preliminary Results","authors":"S. R. Belomestnov, T. V. Сhumarnaya, O. Sevostyanova, A. M. Ksenofontov, N. O. Аnkudinov, T. M. Isakova","doi":"10.23946/2500-0764-2024-9-1-25-32","DOIUrl":"https://doi.org/10.23946/2500-0764-2024-9-1-25-32","url":null,"abstract":"Aim. To define median and large-for-gestational-age birth weight in Sverdlovsk Region and to compare them with the results of a population study conducted in Central Europe.Materials and Methods. We conducted a retrospective analysis of 41,745 women. Inclusion criteria were singleton, full-term pregnancy, absence of fetal malformations, and delivery in a licensed medical organization. Exclusion criteria were multiple pregnancy, signs of chromosomal abnormalities during the antenatal development, congenital malformations, and incomplete examination according to the standard used for normal pregnancy. The results were compared with a similar study carried out in Central Europe.Results. The median weight of newborns at 37, 38, 39, 40, and 41 weeks was 3010, 3180, 3350, 3490, and 3600 g, respectively. “Large for gestational age” (above the 90th percentile) weight at 37, 38, 39, 40, and 41 weeks was 3550, 3720, 3900, 4020, and 4150 g, respectively. These parameters were significantly lower than those in Central Europe. Reproductive age, parity, and metabolic disorders were significant population determinants of birth weight.Conclusion. Birth weight parameters in Sverdlovsk Region differ from those in Central Europe, requiring further research. These data might be used for the correct assessment of the newborns and for development of a territorial strategy for the prevention of fetal growth disorders.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"45 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140365938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comorbid Patients with Abdominal Obesity and High Risk of Atrial Fibrillation: Correction of Modifiable Risk Factors as a Strategy of Primary Prevention (Prospective Study) 合并腹部肥胖和心房颤动高风险的患者：将纠正可改变的风险因素作为一级预防策略（前瞻性研究）

Fundamental and Clinical Medicine Pub Date : 2024-03-29 DOI: 10.23946/2500-0764-2024-9-1-53-63

A. I. Olesin, I. V. Konstantinova, N. N. Tyuteleva, V. S. Ivanov

{"title":"Comorbid Patients with Abdominal Obesity and High Risk of Atrial Fibrillation: Correction of Modifiable Risk Factors as a Strategy of Primary Prevention (Prospective Study)","authors":"A. I. Olesin, I. V. Konstantinova, N. N. Tyuteleva, V. S. Ivanov","doi":"10.23946/2500-0764-2024-9-1-53-63","DOIUrl":"https://doi.org/10.23946/2500-0764-2024-9-1-53-63","url":null,"abstract":"Aim. To assess whether correction of modifiable risk factors is efficient to prevent atrial fibrillation (AF) in comorbid patients with abdominal obesity and premature atrial contractions.Materials and Methods. We enrolled 889 comorbid patients with abdominal obesity and premature atrial contractions, aged from 58 to 72 years (average age 66.4 ± 0.7 years). The duration of follow-up was 3 years. All patients underwent correction of potentially modifiable risk factors of AF (normalisation of body weight, blood pressure, blood glucose and lipid levels, cessation of smoking, elimination of physical inactivity) until their target values were achieved. Endpoints included maintenance of sinus rhythm or registration of AF. After the follow-up, all patients could be divided into two groups: 578 (65.02%) patients with incomplete correction of risk factors, 95 (10.69%) patients who achieved target values, and 216 (24.29%) without risk factor correction.Results. Within the first two years of follow-up, the frequency of AF did not differ significantly and was 85.29%, 94.32%, and 93.47% respectively. In patients who achieved target values of potentially modifiable risk factors for > 1 year, the ratio of actual to predicted development of AF during the 2nd and 3rd year of follow-up was 57.58% and 14.29%, respectively.Conclusion. In comorbid patients with abdominal obesity and premature atrial contractions, reduction of AF was observed exclusively in patients with successful correction of all potentially modifiable risk factors for ≥ 2 years.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"40 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140368272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Patient Satisfaction with the Results of Total Hip Replacement 评估患者对全髋关节置换术结果的满意度

Fundamental and Clinical Medicine Pub Date : 2024-03-29 DOI: 10.23946/2500-0764-2024-9-1-64-71

A. D. Botvinkin, V. A. Koryak, I. D. Zarva, N. Tishkov, O. Chernikova, V. Sorokovikov

{"title":"Assessment of Patient Satisfaction with the Results of Total Hip Replacement","authors":"A. D. Botvinkin, V. A. Koryak, I. D. Zarva, N. Tishkov, O. Chernikova, V. Sorokovikov","doi":"10.23946/2500-0764-2024-9-1-64-71","DOIUrl":"https://doi.org/10.23946/2500-0764-2024-9-1-64-71","url":null,"abstract":"Aim. To test a simplified version of assessing the results of total hip replacement based on patient survey data.Materials and Methods. We conducted a cohort retrospective study with historical control. The study included 80 patients interviewed ≥ 1 year after the total hip replacement. Patients were included into the study regardless of gender, age and concomitant pathology. Statistical analysis was performed using EpiInfo software (version 7.2.2.2), Python programming language, and SciPy package version 1.11.4.Results. We developed a compact questionnaire of 33 questions to compare the answers of patients before and after the surgery. After prosthetics, the self-esteem of the patient conditions improved significantly. The results were stratified into 6 blocks of questions by the odds ratio magnitude: emotional state – 49.3 (11.3-215.4); health status – 42.8 (12.4-147.7); ability to move outside the home –14.4 (1.8-113.4); self-care ability at home – 11.7 (5.3-25.7); overall quality of life assessment – 9.3 (3.1-28.4). Such differences before and after surgery were statistically significant for all blocks of questions (p ≤ 0,008). In general, 81.2% (81.2÷81.3) of patients were completely satisfied with the results of the surgery, and 8.8% (8.6÷8.9) were partially satisfied.Conclusion. We tested a study design which allows to evaluate the rate of improvement in selfesteem of patients after the total hip replacement.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"46 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140368024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

General Overview of Endometrial Microbiota 子宫内膜微生物群概况

Fundamental and Clinical Medicine Pub Date : 2024-03-29 DOI: 10.23946/2500-0764-2024-9-1-102-111

E. N. Goloveshkina, T. Skachkova, V. Akimkin

{"title":"General Overview of Endometrial Microbiota","authors":"E. N. Goloveshkina, T. Skachkova, V. Akimkin","doi":"10.23946/2500-0764-2024-9-1-102-111","DOIUrl":"https://doi.org/10.23946/2500-0764-2024-9-1-102-111","url":null,"abstract":"Here, we aimed to summarize the current knowledge describing the endometrial microbiota. The uterine cavity was considered sterile until the second half of the 20th century. The development of molecular biology techniques such as polymerase chain reaction and sequencing enabled many studies to characterise microbial communities inside the uterine cavity. Although the average number of bacteria in the uterus is lower than in the vagina by 2-4 decimal logarithms, their diversity is still remarkable. The physiological core of endometrial microbiome has not been clearly delineated because of technical limitations including possible contamination during sampling, heterogeneity of sequencing techniques, and variations of experimental design. Bacteria might colonise the uterus from vagina, with semen, by translocation through the blood, or during the respective medical procedures. Generally, major alterations of the endometrial microbiota are triggered by gynecological diseases or assisted reproduction. Hitherto, the impact of endometrial microbiota on human health remains controversial. Understanding the relationships between the endometrial microbiota and human diseases can lead to better diagnosis, treatment and prevention of gynecological diseases. To achieve the success, future studies should employ standardized protocols, from sample collection to bioinformatics analysis.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"48 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140365769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Use of Broad-Spectrum Antibiotics in Phthisiology 在咽喉病学中联合使用广谱抗生素

Fundamental and Clinical Medicine Pub Date : 2024-03-29 DOI: 10.23946/2500-0764-2024-9-1-8-16

D. S. Vailenko, T. Tananakina, Yu.G. Pustovoy, V. V. Baranova, V. I. Shmatkov, A. R. Zanin

{"title":"Combined Use of Broad-Spectrum Antibiotics in Phthisiology","authors":"D. S. Vailenko, T. Tananakina, Yu.G. Pustovoy, V. V. Baranova, V. I. Shmatkov, A. R. Zanin","doi":"10.23946/2500-0764-2024-9-1-8-16","DOIUrl":"https://doi.org/10.23946/2500-0764-2024-9-1-8-16","url":null,"abstract":"Aim. To investigate pharmacokinetic and pharmacodynamic interactions of levofloxacin, kanamycin and linezolid in combined chemotherapy of multidrug-resistant tuberculosis.Materials and Methods. We investigated pharmacological interactions between levofloxacin, kanamycin and linezolid using GalaxyWEB GalaxySagittarius – AlphaFold software.Results. We found that levofloxacin can interact through the carboxyl group (–COOH) with compounds containing an amino group, in particular with linezolid and kanamycin, in order to form a carbamide bond -CO-NH-. Levofloxacin is also able to form an azomethine bond via the carbonyl group –C = O with drugs containing the primary amino group (kanamycin and linezolid). 3D models of the drug compounds with plasma proteins were visualized and protein matches of paired intake of drugs were determined: Levofloxacin – Linezolid pair – 181 matches, Levofloxacin – Kanamycin pair – 11 matches, Kanamycin – Linezolid pair – 8 matches. After 1.5-2 hours after the intake of levofloxacin – linezolid - kanamycin, these drugs reached peak concentrations. Levofloxacin and linezolid were primarily metabolized in the liver and kanamycin has not been metabolized at all. All three drugs were excreted by the kidneys.Conclusion. The analysis demonstrated effectiveness of Galaxy Sagittarius – AlphaFold technology and found a significant level of drug-protein complexes. The interaction of linezolid, levofloxacin and kanamycin led to an increase in the effectiveness and safety of pharmacotherapy, underlying their rational combination.","PeriodicalId":12493,"journal":{"name":"Fundamental and Clinical Medicine","volume":"34 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140368298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0