Frontiers in Oncology最新文献

{"title":"Malignant Wolffian adnexal tumor in the ovary: a case report and literature review.","authors":"Cheng Chi, Guoliang Li, Zian Zheng, Xiangyu Wang, Xiangyu Liu","doi":"10.3389/fonc.2025.1526030","DOIUrl":"10.3389/fonc.2025.1526030","url":null,"abstract":"<p><strong>Background: </strong>Wolffian adnexal tumor (WAT) is a rare neoplasm originating from the remnants of the Wolffian duct (mesonephric duct). Malignant WAT occurring in the ovary is exceptionally uncommon. This article presents a case of malignant WAT in the ovary, analyzing and discussing its histological features, diagnostic challenges, biological behavior, and treatment options in conjunction with relevant literature to enhance our understanding of this rare tumor.</p><p><strong>Case presentation: </strong>A 64-year-old woman presented with an 8-month history of persistent abdominal pain and distension. An exploratory laparotomy revealed a small amount of pale-yellow ascites, a slightly atrophic uterus, and a left ovary without significant abnormalities. A solid mass measuring approximately 12 × 10 cm was observed between the left fallopian tube and ovary, displaying extensive dense adhesions to the posterior broad ligament and surrounding bowel. Frozen section pathology indicated a malignant tumor with necrotic areas suggestive of poorly differentiated carcinoma. The patient subsequently underwent a total hysterectomy, bilateral adnexectomy, omentectomy, pelvic lymphadenectomy, and pelvic adhesion release. Adjuvant chemotherapy with four cycles of paclitaxel and carboplatin (TC regimen) was administered, achieving normalization of tumor markers by the second cycle.</p><p><strong>Conclusions: </strong>WAT is a rare entity within the spectrum of female reproductive system tumors, predominantly benign in nature. Due to its extremely low incidence, standardized treatment protocols remain elusive. Further research is warranted to establish effective management strategies and provide a reference for future cases.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1526030"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral retroperitoneal approach for the treatment of a recumbent silkworm-like paravertebral schwannoma in the lumbar spine: a case report.","authors":"Lanming Su, Wei Liu, Yingying Zhang, Feng Li, Yuanqin Liu, Ziyu Wang","doi":"10.3389/fonc.2025.1544175","DOIUrl":"10.3389/fonc.2025.1544175","url":null,"abstract":"<p><strong>Objective: </strong>This case report describes the surgical management of a recumbent silkworm-like paravertebral schwannoma in the lumbar spine resected via the lateral retroperitoneal approach.</p><p><strong>Methods: </strong>A lumbar paravertebral schwannoma resembling a \"recumbent silkworm\" was excised using the lateral retroperitoneal approach. Intraoperative measures included electrophysiological monitoring and insertion of a ureteral D-J stent to protect critical surrounding anatomical structures. Complete tumor resection was achieved without intraoperative complications. Follow-up demonstrated no tumor recurrence or postoperative complications.</p><p><strong>Results: </strong>The duration of surgery was 310 min, with an estimated blood loss of 50mL. The tumor resection rate was 100%. The patient was discharged 11 days after hospitalization. Postoperative histopathological examination confirmed the diagnosis of schwannoma. There were no postoperative complications. The patient ADL (Activities of Daily Living score did not decline compared with the preoperative levels. After one year of follow-up, no signs of tumor recurrence were observed.</p><p><strong>Conclusion: </strong>Paravertebral tumors located in the anterior and lateral aspects of the lumbar spine pose significant surgical challenges because of their complex position and morphology. Complete excision of such tumors via the lateral retroperitoneal approach is an optimal treatment strategy.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1544175"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Integrating health-related quality of life in neuro-oncology.","authors":"Maria Teresa Pedro, Martina Messing-Jünger, Christine Jungk, Peter Hau, Carolin Weiss Lucas","doi":"10.3389/fonc.2025.1573696","DOIUrl":"https://doi.org/10.3389/fonc.2025.1573696","url":null,"abstract":"","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1573696"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anlotinib for the treatment of recurrent and refractory hemangioblastomas: a case report and review of literature.","authors":"Qing Tian, Chaofeng Zhou, Shifan Zhou, Sai Wang, Baorong Feng, Keke Zhang, Yu Zhang, Jieqiong Gao, Xiaoyan Mu, Zhizhong Guo","doi":"10.3389/fonc.2025.1508226","DOIUrl":"10.3389/fonc.2025.1508226","url":null,"abstract":"<p><p>Hemangioblastomas (HBs) are rare, highly vascular tumors that present significant treatment challenges, especially in cases of multiple recurrences. Here we present our experience treating one patient with recurrent and refractory HBs, aiming to provide preliminary data on the use of anlotinib in treating this disease. An 18-year-old woman with recurrent and refractory HBs, treated at the Henan Provincial Hospital of Traditional Chinese Medicine, achieved disease remission through oral anlotinib treatment after recurrence. After being diagnosed with HBs, the patient underwent multiple surgical treatments with some efficacy. After recurrence, additional surgery and radiotherapy were not feasible due to the presence of multiple tumor sites. Oral anlotinib (10mg, qd, q3w) resulted in disease remission and significantly improved the patient's quality of life. Anlotinib may be employed in the management of recurrent and refractory HBs.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1508226"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a predictive model for the risk of endocervical curettage positivity.","authors":"Fang Feng, Hui-Hui Tuo, Jin-Meng Yao, Wei-Hong Wang, Feng-Lan Guo, Rui-Fang An","doi":"10.3389/fonc.2025.1559087","DOIUrl":"10.3389/fonc.2025.1559087","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the clinical characteristics of patients undergoing endocervical curettage (ECC), identify factors influencing ECC positivity, and develop a predictive model to assess the risk of positive ECC results. The goal was to assist clinicians in making ECC decisions and reduce missed diagnoses of cervical lesions.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 953 patients who underwent colposcopically directed biopsy and ECC at the gynecology clinic of the First Affiliated Hospital of Xi'an Jiaotong University between October 2021 and September 2023 due to abnormal screening results. Univariate and multivariate logistic regression analyses were used to identify predictive factors for ECC positivity. An individualized prediction model for ECC positivity risk was developed using R Studio, and the model was subsequently evaluated and validated.</p><p><strong>Results: </strong>Among the 953 women, the ECC positive rate was 31.48% (300/953). Logistic regression analysis identified age (<i>P</i><0.001), human papillomavirus (HPV) status (<i>P</i><0.01), cytology results (<i>P</i><0.05), acetowhite changes (<i>P</i><0.01), Lugol staining (<i>P</i><0.01), and colposcopic impression (<i>P</i><0.01) as independent predictors of ECC positivity. These factors were incorporated into the prediction model for ECC positivity risk. The area under the receiver operating characteristic curve (AUC) of the model was 0.792 (95% CI:0.760-0.824). The Hosmer-Lemeshow test yielded a <i>χ²</i> value of 10.489 (<i>P</i>=0.2324), and the calibration and clinical decision curves demonstrated that the model exhibited satisfactory calibration and clinical utility.</p><p><strong>Conclusions: </strong>The clinical prediction model developed in this study demonstrated good discrimination, calibration, and clinical utility. It can be used to evaluate the risk of ECC positivity in patients undergoing colposcopy, reduce missed diagnoses of cervical lesions, and aid clinicians in making ECC decisions.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1559087"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and clinicopathological value of the controlling nutritional status score in patients with multiple myeloma: a meta-analysis.","authors":"Yin Jin, Wenfei Gu","doi":"10.3389/fonc.2025.1517223","DOIUrl":"10.3389/fonc.2025.1517223","url":null,"abstract":"<p><strong>Background: </strong>The effect of the controlling nutritional status (CONUT) score on forecasting multiple myeloma (MM) prognosis is previously analyzed, whereas the results remained inconsistent. The present meta-analysis focused on identifying the exact function of CONUT in forecasting MM prognosis.</p><p><strong>Methods: </strong>Web of Science, PubMed, Embase, CNKI, and Cochrane Library were comprehensively searched between inception and 1 February 2025. The effect of CONUT on forecasting MM overall survival (OS) and progression-free survival (PFS) was determined by computing pooled hazard ratios (HRs) together with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>There were nine studies with 1,176 patients being recruited into the present work. As indicated by our pooled data, elevated CONUT was related to the dismal OS (HR = 1.87, 95% CI = 1.37-2.54, <i>p</i> < 0.001) of patients with MM. Nonetheless, CONUT was not significantly related to PFS (HR = 1.33, 95% CI = 0.81-2.19, <i>p</i> = 0.254) of MM. Furthermore, higher CONUT score showed a significant relationship to bone marrow plasma cells >30% (OR = 2.30, 95% CI = 1.32-3.99, <i>p</i> = 0.003). On the other hand, CONUT was not markedly correlated with gender (OR = 2.68, 95% CI = 0.81-8.82, <i>p</i> = 0.105), ISS stage (OR = 1.28, 95% CI = 0.94-1.75, <i>p</i> = 0.119), or ECOG PS (OR = 1.30, 95% CI = 0.84-2.01, <i>p</i> = 0.234) of MM.</p><p><strong>Conclusion: </strong>Collectively, according to our results in this meta-analysis, higher CONUT score is markedly related to dismal OS, but not PFS in patients with MM. CONUT score can be used as a candidate marker used to predict MM prognosis in the clinic in the future.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1517223"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of studies that use artificial intelligence on thyroid cancer: a 20-year bibliometric analysis.","authors":"YingZheng Gao, JiaHao Chen, Tao Fu, Yi Gu, WeiDong Du","doi":"10.3389/fonc.2025.1525650","DOIUrl":"10.3389/fonc.2025.1525650","url":null,"abstract":"<p><p>In recent years, with the rapid advancement of computer science, artificial intelligence has found extensive applications and has been the subject of significant research within the healthcare industry, particularly in areas such as medical imaging, diagnostics, biomedical engineering, and health data analytics. Artificial intelligence has also made considerable inroads in the diagnosis and treatment of thyroid cancer. This study aims to evaluate the progress, current hotspots, and potential future directions of research on artificial intelligence in the field of thyroid cancer through a bibliometric analysis. This study retrieved literature on the application of artificial intelligence in thyroid cancer from 2004 to 2024 from the Web of Science Core Collection (WoSCC) database. A retrospective bibliometric analysis and visualization study of the filtered data were conducted using VOSviewer, CiteSpace, and the Bibliometrix package in R software. A total of 956 articles from 70 countries/regions were included. China had the highest number of publications, with Shanghai Jiao Tong University (China) being the most prolific research institution. The most prolific author was Wei, X. (n=14), while Haugen, B. R. was the most co-cited author (n=297). The Frontiers in Oncology (35 articles, IF=3.5, Q1) was the most frequently publishing journal, and Thyroid (cited 1,705 times) was the most co-cited journal. Keywords such as 'ultrasound,' 'deep learning,' and 'diagnosis' indicate research hotspots in this field. This study provides a comprehensive exposition of the current advancements, emerging trends, and future directions of artificial intelligence in thyroid cancer research. It serves as a valuable resource for clinicians and researchers, offering a systematic understanding of key focal areas in the field, thereby assisting in the identification and determination of future research trajectories.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1525650"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial genomics reveals cholesterol metabolism as a key factor in colorectal cancer immunotherapy resistance.","authors":"Andrew J Kavran, Yulong Bai, Brian Rabe, Anna Kreshock, Andrew Fisher, Yelena Cheng, Anne Lewin, Chao Dai, Matthew J Meyer, Konstantinos J Mavrakis, Anna Lyubetskaya, Eugene Drokhlyansky","doi":"10.3389/fonc.2025.1549237","DOIUrl":"10.3389/fonc.2025.1549237","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape across multiple cancer types achieving durable responses for a significant number of patients. Despite their success, many patients still fail to respond to ICIs or develop resistance soon after treatment. We sought to identify early treatment features associated with ICI outcome. We leveraged the MC38 syngeneic tumor model because it has variable response to ICI therapy driven by tumor intrinsic heterogeneity. ICI response was assessed based on the level of immune cell infiltration into the tumor - a well-established clinical hallmark of ICI response. We generated a spatial atlas of 48,636 transcriptome-wide spots across 16 tumors using spatial transcriptomics; given the tumors were difficult to profile, we developed an enhanced transcriptome capture protocol yielding high quality spatial data. In total, we identified 8 tumor cell subsets (<i>e.g.</i>, proliferative, inflamed, and vascularized) and 4 stroma subsets (<i>e.g.</i>, immune and fibroblast). Each tumor had orthogonal histology and bulk-RNA sequencing data, which served to validate and benchmark observations from the spatial data. Our spatial atlas revealed that increased tumor cell cholesterol regulation, synthesis, and transport were associated with a lack of ICI response. Conversely, inflammation and T cell infiltration were associated with response. We further leveraged spatially aware gene expression analysis, to demonstrate that high cholesterol synthesis by tumor cells was associated with cytotoxic CD8 T cell exclusion. Finally, we demonstrate that bulk RNA-sequencing was able to detect immune correlates of response but lacked the sensitivity to detect cholesterol synthesis as a feature of resistance.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1549237"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: The synergistic effects of pyrotinib combined with adriamycin on HER2-positive breast cancer.","authors":"Chaokun Wang, Shuzhen Deng, Jing Chen, Xiangyun Xu, Xiaochen Hu, Dejiu Kong, Gaofeng Liang, Xiang Yuan, Yuanpei Li, Xinshuai Wang","doi":"10.3389/fonc.2025.1536374","DOIUrl":"https://doi.org/10.3389/fonc.2025.1536374","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fonc.2021.616443.].</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1536374"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering the heterogeneity of NK cells on the prognosis of HCC by integrating bulk and single-cell RNA-seq data.","authors":"Jiashuo Li, Zhenyi Liu, Gongming Zhang, Xue Yin, Xiaoxue Yuan, Wen Xie, Xiaoyan Ding","doi":"10.3389/fonc.2025.1570647","DOIUrl":"10.3389/fonc.2025.1570647","url":null,"abstract":"<p><strong>Background: </strong>The tumor microenvironment (TME) plays a critical role in the development, progression, and clinical outcomes of hepatocellular carcinoma (HCC). Despite the critical role of natural killer (NK) cells in tumor immunity, there is limited research on their status within the tumor microenvironment of HCC. In this study, single-cell RNA sequencing (scRNA-seq) analysis of HCC datasets was performed to identify potential biomarkers and investigate the involvement of natural killer (NK) cells in the TME.</p><p><strong>Methods: </strong>Single-cell RNA sequencing (scRNA-seq) data were extracted from the GSE149614 dataset and processed for quality control using the \"Seurat\" package. HCC subtypes from the TCGA dataset were classified through consensus clustering based on differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) was employed to construct co-expression networks. Furthermore, univariate and multivariate Cox regression analyses were conducted to identify variables linked to overall survival. The single-sample gene set enrichment analysis (ssGSEA) was used to analyze immune cells and the screened genes.</p><p><strong>Result: </strong>A total of 715 DEGs from GSE149614 and 864 DEGs from TCGA were identified, with 25 overlapping DEGs found between the two datasets. A prognostic risk score model based on two genes was then established. Significant differences in immune cell infiltration were observed between high-risk and low-risk groups. Immunohistochemistry showed that HRG expression was decreased in HCC compared to normal tissues, whereas TUBA1B expression was elevated in HCC.</p><p><strong>Conclusion: </strong>Our study identified a two-gene prognostic signature based on NK cell markers and highlighted their role in the TME, which may offer novel insights in immunotherapy strategies. Additionally, we developed an accurate and reliable prognostic model, combining clinical factors to aid clinicians in decision-making.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1570647"},"PeriodicalIF":3.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}