Frontiers in Oncology最新文献

{"title":"A cross-sectional study exploring the perception of exercise oncology in the Italian population.","authors":"Anita Borsati, Diana Giannarelli, Giampaolo Pase, Christian Ciurnelli, Linda Toniolo, Ilaria Trestini, Daniela Tregnago, Lorenzo Belluomini, Marco Sposito, Jessica Insolda, Michele Milella, Federico Schena, Sara Pilotto, Alice Avancini","doi":"10.3389/fonc.2024.1430083","DOIUrl":"10.3389/fonc.2024.1430083","url":null,"abstract":"<p><strong>Introduction: </strong>We aim to examine the population's perception of physical exercise in patients with cancer.</p><p><strong>Materials and methods: </strong>An anonymous survey was conducted to reach a sample of Italian adults. The questionnaire investigated sociodemographic factors, physical exercise levels, and perceptions about the importance, benefits, and safety of exercise, the support from oncologists and family/friends, as well as the capability and ease of patients of exercise.</p><p><strong>Results: </strong>Overall, 838 persons participated in this survey. The majority of respondents agree that exercise is important (60.5%) and beneficial (61.5%) for patients with cancer during anticancer treatments, whereas 40.2% believed in its safety. Forty-two percent and 51.9% of participants expressed a positive opinion regarding the advice of oncologists and the encouragement of family/friends to exercise, respectively. Only 27.2% of respondents feel that patients are capable of exercising, and 9.0% agree that it is easy for them.</p><p><strong>Conclusion: </strong>Although the population has a favorable perception of the importance and benefits of physical exercise, they do not still believe that patients are capable of performing it. Increasing awareness of the feasibility of a physical exercise intervention in the context of cancer is crucial to supporting patients.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"14 ","pages":"1430083"},"PeriodicalIF":3.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Endolymphatic sac tumor with blurred vision.","authors":"Ke Yuan, Weijian Luo, Jia Chen, Quanzhou Peng, Xiaoguang Tong, Jiliang Hu","doi":"10.3389/fonc.2024.1463526","DOIUrl":"10.3389/fonc.2024.1463526","url":null,"abstract":"<p><strong>Introduction: </strong>Endolymphatic sac tumor (ELST) is a rare neoplasm that exhibits aggressive growth primarily in the endolymphatic capsule and can potentially affect nearby neurovascular structures. The diagnosis of ELST poses challenges due to its low prevalence, gradual progression, and nonspecific symptomatology. It is currently believed that prompt surgical intervention is recommended for endolymphatic sac tumors upon diagnosis. In cases where the lesion is complex or in close proximity to vital blood vessels and nerves, making complete resection challenging, adjuvant therapy may be employed postoperatively. This approach aims to enhance treatment outcomes.</p><p><strong>Case presentation: </strong>A case of a 53-year-old male was admitted to the Department of Neurosurgery of Shenzhen People's Hospital with the main cause of dizziness and blurred vision, and was found to have an occupation in the pontocerebellar angle for about 20 days. Preoperative cranial CT suggested that the temporal bone mastoid was widely damaged with worm-like bone, and some of them showed honeycomb changes. MRI suggested that shadow was seen in the posterior part of the left internal auditory canal, temporal bone mastoid and jugular foramen, with a size of about 28x21x27mm.The T1-weighted image showed low and equal signals, and the T2-weighted image showed equal and slightly low signals in the center with multicompartmental cystic high signals in the margin. The center of the mass strengthened significantly after enhancement. The patient had no other clinical manifestations and no family history. The clinical diagnosis was left-sided pontocerebellar angle occupation - nature to be determined. The occupation was resected microscopically using the distal lateral combined anterior approach to the sigmoid sinus. Due to the extremely rich blood supply of the tumor, the tumor was embedded in the petrous humerus, which was soft and tough, and the surrounding structures were not clearly displayed, making surgical resection extremely difficult. postoperative pathology and immunohistochemistry confirmed that this lesion was an endolymphatic cystic tumor. After surgery, most of the tumor was successfully resected while preserving neurological function well, and the residual tumor was treated with adjuvant gamma knife with good results.</p><p><strong>Conclusion: </strong>ELST is a rare, low-grade, locally aggressive tumor that is difficult to diagnose early. During the surgery, it was observed that the tumor had a significant blood supply, which made its removal challenging. Preoperative embolization of the tumor's blood supply artery would facilitate surgical resection and help avoid massive intraoperative bleeding. Complete surgical resection is the treatment of choice, and any remaining tumor remnants can be managed with adjuvant radiotherapy post-surgery, necessitating long-term follow-up to monitor any developments.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"14 ","pages":"1463526"},"PeriodicalIF":3.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: A rare case of delayed drug-induced hyponatremia in recurrent upper tract urothelial carcinoma following GC and Tislelizumab treatment.","authors":"Zhi-Jie Wang, Ying-Fang Nie, Shi-Bing Liang, Jing Zhou, Shu-Lan Hao, Li-Kun Liu","doi":"10.3389/fonc.2024.1528237","DOIUrl":"10.3389/fonc.2024.1528237","url":null,"abstract":"<p><p>Drug-induced hyponatremia is an adverse reaction with accelerated electrolyte disturbance. This study reported a rare case of delayed hyponatremia in a 68year-old female with recurrent upper tract urothelial carcinoma after Gemcitabine plus Cisplatin (GC) and Tislelizumab treatment. She had left ureter surgery, recurrence a year later with mildly abnormal kidney function (glomerular filtration rate (GFR) was 54.9 ml/min). After the first cycle of GC plus Tislelizumab, severe hyponatremia leading to life-threatening conditions occurred eight days later. Hypothesizing Cisplatin as the cause, its usage was modified in the second cycle (40mg/day for three days). No severe hyponatremia followed. CT showed partial remission. From the third cycle, due to grade IV bone marrow suppression, she had Tislelizumab alone. Now, she is on 21-day Tislelizumab maintenance with a stable tumor status. Low-dose continuous Cisplatin may suit patients with borderline or mildly abnormal renal function (GFR: 40-60mL/min) better than single full-dose use. Tislelizumab alone for maintenance may be an option for those intolerant of chemotherapy. But Na⁺ decrease may be related to Tirelizumab or Gemcitabine, needing more clinical observation and experiments.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"14 ","pages":"1528237"},"PeriodicalIF":3.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Camrelizumab-induced immune-related toxic epidermal necrolysis in lung adenocarcinoma: a case report and literature review.","authors":"Man Sun, Huan Zhou, Dan Zang, Chen-Guang Liu, Jun Chen","doi":"10.3389/fonc.2024.1417936","DOIUrl":"10.3389/fonc.2024.1417936","url":null,"abstract":"<p><p>Toxic epidermal necrolysis (TEN) is a rare and serious skin reaction. This study reports a case of a patient with lung adenocarcinoma (LUAD) who developed severe TEN after 8 days of treatment with Camrelizumab monotherapy. The patient's condition was effectively relieved with high-dose corticosteroids and intravenous immunoglobulin therapy. The diagnosis and treatment of immune-related TEN are challenging. This is a rare and severe case of TEN associated with the use of Camrelizumab. Additionally, we provide an in-depth understanding of immune-related TEN, summarizing its characteristics and treatment progress through a literature review, aiming to provide reference for the clinical safe application of immune checkpoint inhibitors (ICIs).</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"14 ","pages":"1417936"},"PeriodicalIF":3.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Innovative approach to esophageal cancer with right aortic arch: neoadjuvant immunotherapy and 3D reconstruction.","authors":"Chengwen Luo, Zhilin Luo","doi":"10.3389/fonc.2024.1496265","DOIUrl":"10.3389/fonc.2024.1496265","url":null,"abstract":"<p><strong>Background: </strong>We report a rare case of locally advanced esophageal cancer with a right aortic arch (RAA), successfully treated with neoadjuvant immunotherapy and minimally invasive esophagectomy, guided by three-dimensional (3D) reconstruction.</p><p><strong>Case presentation: </strong>A 50-year-old male with stage III esophageal squamous cell carcinoma (cT3N0M0) and RAA underwent four cycles of neoadjuvant immunotherapy with sintilimab, resulting in significant tumor regression. Minimally invasive esophagectomy was performed with the aid of preoperative 3D reconstruction, which was critical in navigating the complex vascular anatomy and ensuring surgical precision.</p><p><strong>Conclusion: </strong>This case demonstrates the efficacy of neoadjuvant immunotherapy combined with 3D reconstruction in managing esophageal cancer complicated by vascular anomalies. This approach offers a promising alternative for complex cases where conventional treatments pose higher risks.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"14 ","pages":"1496265"},"PeriodicalIF":3.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing machine learning to predict prostate cancer survival: a review.","authors":"Sungun Bang, Young Jin Ahn, Kyo Chul Koo","doi":"10.3389/fonc.2024.1502629","DOIUrl":"10.3389/fonc.2024.1502629","url":null,"abstract":"<p><p>The prediction of survival outcomes is a key factor in making decisions for prostate cancer (PCa) treatment. Advances in computer-based technologies have increased the role of machine learning (ML) methods in predicting cancer prognosis. Due to the various effective treatments available for each non-linear landscape of PCa, the integration of ML can help offer tailored treatment strategies and precision medicine approaches, thus improving survival in patients with PCa. There has been an upsurge of studies utilizing ML to predict the survival of these patients using complex datasets, including patient and tumor features, radiographic data, and population-based databases. This review aims to explore the evolving role of ML in predicting survival outcomes associated with PCa. Specifically, we will focus on the applications of ML in forecasting biochemical recurrence-free, progression to castration-resistance-free, metastasis-free, and overall survivals. Additionally, we will suggest areas in need of further research in the future to enhance the utility of ML for a more clinically-utilizable PCa prognosis prediction and treatment optimization.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"14 ","pages":"1502629"},"PeriodicalIF":3.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: DYNLT3 overexpression induces apoptosis and inhibits cell growth and migration <i>via</i> inhibition of the Wnt pathway and EMT in cervical cancer.","authors":"Jianan Zhang, Qi Shen, Lu Xia, Xueqiong Zhu, Xuejie Zhu","doi":"10.3389/fonc.2024.1545180","DOIUrl":"10.3389/fonc.2024.1545180","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fonc.2022.889238.].</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"14 ","pages":"1545180"},"PeriodicalIF":3.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A stacking ensemble system for identifying the presence of histological variants in bladder carcinoma: a multicenter study.","authors":"Canjie Peng, Quanhao He, Fajin Lv, Qing Jiang, Yong Chen, Zongjie Wei, Yingjie Xv, Fangtong Liao, Mingzhao Xiao","doi":"10.3389/fonc.2024.1469427","DOIUrl":"10.3389/fonc.2024.1469427","url":null,"abstract":"<p><strong>Purpose: </strong>To create a system to enable the identification of histological variants of bladder cancer in a simple, efficient, and noninvasive manner.</p><p><strong>Material and methods: </strong>In this multicenter diagnostic study, we retrospectively collected basic information and CT images about the patients concerned from three hospitals. An interactive deep learning-based bladder cancer image segmentation framework was constructed using the Swin UNETR algorithm for further features extraction. Radiomic features and deep learning features were extracted for further stacking ensemble system construction. The segmentation model' performance was assessed by using Dice Similarity (Dice) metrics, Intersection Over Union (IOU), Sensitivity (SEN) and Specificity (SPE). To evaluate the system's performance, we used the Receiver Operating Characteristics (ROC) curve, the Accuracy Score (ACC) and Decision Curve Analysis (DCA).</p><p><strong>Results: </strong>410 patients from one hospital were included in the training set, while 60 patients from two other hospitals were included in the test set. A total of 50 features comprising 46 radiomic features and 4 deep learning features were finally retained for further stacking ensemble model building. The interactive segmentation model and system exhibited excellent performance in both training (Dice = 0.78, IOU = 0.65, SEN = 0.83, SPE = 1.00, AUC = 0.940, ACC = 0.868) and testing datasets (Dice = 0.80, IOU = 0.67, SEN = 0.89, SPE = 1.00, AUC = 0.905, ACC = 0.900).</p><p><strong>Conclusion: </strong>We successfully constructed a stacking ensemble machine learning model for early, non-invasive identification of histological variants in bladder cancer which will help urologists make clinical decisions.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"14 ","pages":"1469427"},"PeriodicalIF":3.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EIF4A3-induced circ_0022382 promotes breast cancer cell progression through the let-7a-5p/PI3K/AKT/mTOR signaling pathway and SLC7A11 axis.","authors":"Wei Liu, Jun Zhang, Jiawen Zhang, Yu Ye, Jianqin Zhu, Qiwen Yu, Tao Li, Xiaochun Sun, Huabiao Chen","doi":"10.3389/fonc.2024.1476731","DOIUrl":"10.3389/fonc.2024.1476731","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer is one of the most common cancers in women and poses a serious threat to women's health. Circular RNAs (circRNAs) have been found to be specifically expressed in cancers and regulate the growth and death of tumor cells. The role of circRNAs in breast cancer remain unknown. In this study, we explored the impacts of circRNAs on the progression of breast cancer cells.</p><p><strong>Methods: </strong>Using bioinformatics analysis, we screened out one up-regulated circRNA in breast cancer, and its function and regulatory mechanisms were confirmed by quantitative real-time PCR, cell counting kit-8 experiment, migration assay, dual luciferase reporter assay, Kyoto Encyclopedia of Genes and Genomes enrichment analysis, cell immunofluorescence, clone formation assay, scratch wound healing experiment, RNA immunoprecipitation and subcutaneous tumor-bearing experiments.</p><p><strong>Results: </strong>Circ_0022382 was highly expressed in breast cancer cell lines MDA-MB-231, MCF-7 as well as breast cancer tissues, and promoted the proliferative and migratory capacity of breast cancer cells. In terms of regulatory mechanisms, circ_0022382 activated PI3K/AKT/mTOR signaling pathway and SLC7A11 by sponging let-7a-5p, while knockdown of circ_0022382 contributed to the occurrence of disulfidptosis. In addition, EIF4A3 promoted the expression of circ_0022382 in MDA-MB-231 and MCF-7. Consistently, knockdown of circ_0022382 inhibited the growth of breast cancer cells <i>in vivo</i>.</p><p><strong>Discussion: </strong>Circ_0022382 and its related molecules may be effective targets for diagnosis or targeted therapy of breast cancer.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"14 ","pages":"1476731"},"PeriodicalIF":3.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Intradural-extramedullary cervical spine clear cell meningioma mimicking a schwannoma in a child.","authors":"Xiang Yang, Chongxi Xu, Seidu A Richard, Yongliang Jiang, Jiaxi Wang, Bin Xu, Jianguo Xu, Hao Li","doi":"10.3389/fonc.2024.1505141","DOIUrl":"10.3389/fonc.2024.1505141","url":null,"abstract":"<p><p>Clear cell meningioma (CCM) is an exceedingly rare subtype of meningioma, with spinal occurrences being even more uncommon. It predominantly affects children and is characterized by a high recurrence rate and poor prognosis, posing significant challenges for clinical treatment. Currently, gross total resection (GTR) is the best approach to reduce recurrence and improve prognosis in these patients. However, detailed descriptions of intraoperative findings, particularly for intraspinal cervical CCM, are scarce in the literature. Here, we report a rare case in which the upper cervical spinal CCM mimicked a schwannoma, detailing the surgical treatment strategy and prognosis. Additionally, we analyzed all previously reported cases of spinal CCM to investigate the clinical characteristics, optimal treatment strategies, and prognostic factors, which may be of particular interest to neurosurgeons.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"14 ","pages":"1505141"},"PeriodicalIF":3.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}