Geburtshilfe Und Frauenheilkunde最新文献

{"title":"Subjective Birth Experience and Person-Centred Care in Obstetrics: Study Protocol of the Prospective Mixed-Methods Research Project RESPECT.","authors":"Bianka Vollert, Nina Schurig, Vanessa Zieß, Victoria Weise, Lara Seefeld, Ariane Göbel, Cahit Birdir, Pauline Wimberger, Susan Garthus-Niegel","doi":"10.1055/a-2551-3705","DOIUrl":"10.1055/a-2551-3705","url":null,"abstract":"<p><strong>Background: </strong>The interdisciplinary research project <b>RESPECT</b> (A Prospective Mixed-Methods- <b>RE</b> search Project on <b>S</b> ubjective Birth Experience and <b>PE</b> rson-centred <b>C</b> are in Paren <b>T</b> s and Obstetric Health Care Staff) aims to investigate the subjective birth experience of (expectant) parents in Germany and associated factors before, during, and after childbirth, including care-related aspects such as person-centred care and mistreatment during childbirth. In addition, the perspective of obstetric health care staff regarding their role in parents' subjective birth experience and person-centred care in obstetrics are explored.</p><p><strong>Methods: </strong>RESPECT _PARENTS is a prospective cohort study targeting a community sample of expectant parents in the Dresden area with four assessment points from pregnancy to 24 months postpartum using online questionnaires and a structured telephone interview. Applying a mixed-methods approach, the main study is complemented by a sub-study with parents (RESPECT _PARENTS-TALK ) and an additional study branch with obstetric health care staff (RESPECT _STAFF ), both using qualitative interviews.</p><p><strong>Results: </strong>In this study protocol, the theoretical background, methods, and first results regarding sociodemographic and birth-related variables of the sample (N = 2424 participants including n = 1693 expectant mothers/birthing parents and n = 731 partners) are presented and discussed.</p><p><strong>Conclusion: </strong>The data will provide meaningful insights into parents' subjective birth experience and health-related effects over time, considering the perspectives of both parents and the obstetric health care staff. The findings can contribute to the development of strategies to improve obstetric health care according to the latest WHO recommendations and the German national health goal \"Health around childbirth\", and thus to prevent traumatic birth experiences.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 11","pages":"1169-1194"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12591835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertensive Disorders in Pregnancy (HDP): Diagnostics and Therapy. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/018, June 2024).","authors":"Ulrich Pecks, Marc Baumann, Julia Binder, Christine Contini, Anne Dathan-Stumpf, Ralf Dechend, Birgit Enna-Kirchmair, Thorsten Fischer, Thierry Girard, Susanne Greve, Tanja Groten, Andreas Hartung, Sven Kehl, Maria Koch, Andrea Köbke, Peter Kranke, Olav Lapaire, Silke Mader, Lars Christian Rump, Alexandra Sperling, Holger Stepan, Sylvia Stracke, Stefan Verlohren, Frauke von Versen-Höynck, Karl Winkler, Michael Zemlin, Dietmar Schlembach","doi":"10.1055/a-2522-2347","DOIUrl":"https://doi.org/10.1055/a-2522-2347","url":null,"abstract":"<p><p><b>Aim</b> This S2k guideline of the German Society of Gynecology and Obstetrics (DGGG) contains consensus-based recommendations for the care and treatment of women with hypertension in pregnancy. It aims to serve as a guide for all professions involved in the care of pregnant women and to improve interprofessional and interdisciplinary cooperation. A new focus was placed on patients' long-term health beyond the postpartum period. <b>Methods</b> The existing S2k guideline was revised and the relevant literature reviewed. Where new questions arose, they were formulated and developed in PICO format. A targeted systematic literature search was carried out using PubMed. Other international guidelines were also consulted. After summarizing and presenting the available data, recommendations and statements were developed, discussed, and agreed on by the guideline group. <b>Recommendations</b> The recommendations cover prediction, prevention, diagnosis, and treatment from the moment hypertensive disease is detected in pregnancy as well as postpartum, in the puerperium, and during breastfeeding. A major change from the previous version of the guideline is the reduction in blood pressure levels that should be achieved during pregnancy. Suggestions are made on how to proceed with regards to the long-term health of mother and child, which the guideline group believes is currently regulated inadequately in the German healthcare system.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 8","pages":"810-850"},"PeriodicalIF":1.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12324857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Adjuvant Targeted Treatment of Early Hormone Receptor-positive HER2-negative Breast Cancer: Olaparib, Abemaciclib or Ribociclib - Which One, How and For Whom?","authors":"Stefan Lukac, Kerstin Pfister, Henning Schäffler, Elena Leinert, Angelina Fink, Brigitte Rack, Visnja Fink, Wolfgang Janni, Sabine Heublein","doi":"10.1055/a-2617-2084","DOIUrl":"https://doi.org/10.1055/a-2617-2084","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1055/a-2562-8469.].</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 6","pages":"e2"},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Nuchal Cord Based on Specific CTG Patterns Intrapartum - A Myth?","authors":"Lars Brodowski, Roza Röchte-Christoforatou, Ismini Staboulidou, Constantin Sylvius von Kaisenberg, Elna Kühnle","doi":"10.1055/a-2561-6555","DOIUrl":"10.1055/a-2561-6555","url":null,"abstract":"<p><strong>Background: </strong>Nuchal cord, the situation when the umbilical cord is wrapped around the neck of the fetus, is a common occurrence during pregnancy and intrapartum. Abnormal cardiotocography patterns (CTG patterns) during nuchal cord are usually not associated with increased perinatal morbidity. This retrospective data analysis aimed to investigate the occurrence of specific CTG patterns with nuchal cord.</p><p><strong>Methods: </strong>150 CTGs with and 150 CTGs without nuchal cord at 60 and 30 minutes prior to delivery were randomly selected from the obstetric database of Hanover Medical School out of a total cohort of 7573 births (spontaneous delivery, vaginal-operative delivery, secondary caesarean section) between 2014 and 2017. After anonymization in accordance with the 2015 FIGO criteria, CTG patterns were interpreted by three physicians with varying levels of professional experience. The physicians were also asked to assess whether nuchal cord was present or not. The interrater variability between investigators regarding the interpretation of the CTG patterns was also investigated using proportion of agreement and kappa statistics.</p><p><strong>Results: </strong>Nuchal cord was present in 11% of the total cohort. The study cohort and the total cohort were equivalent in terms of patient characteristics. No significant differences were found in the assessments of the three physicians with regard to CTGs with and without nuchal cord. Likewise, logistic regression analysis was unable to identify a specific CTG pattern in cases with nuchal cord intrapartum. High interpretation variability between physicians was found regarding CTG interpretations (PoA > 0.5).</p><p><strong>Conclusion: </strong>CTG interpretation just before delivery of the infant is not useful to detect nuchal cord. Moreover, despite the existence of defined criteria, the variability between the CTG interpretations of the three physicians was high.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 10","pages":"1073-1080"},"PeriodicalIF":1.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Certification of a Rural Endometriosis Clinic Leads to Improvement in the Diagnosis and Treatment of Endometriosis - a Retrospective Analysis.","authors":"Cynthia Kohl, Jana Kager, Raul Donutiu, Michael Gerken, Thomas Papathemelis","doi":"10.1055/a-2593-0666","DOIUrl":"10.1055/a-2593-0666","url":null,"abstract":"<p><strong>Introduction: </strong>Endometriosis is a very common benign condition in women. In recent years certification of health care institutions has led to a more standardized care for endometriosis patients, aiming at improving the quality of diagnosis and treatment. The introduction of a common classification system facilitates quantification of disease extent. This study investigated whether certification of a rural endometriosis clinic ameliorated care in endometriosis patients.</p><p><strong>Methods and material: </strong>A single-center retrospective data analysis was performed of all endometriosis patients that underwent surgery at the investigated institution, certified in 2019, for the years 2018-2022.</p><p><strong>Results: </strong>Between 2018 and 2022, a total of 812 surgeries were performed, with certification significantly improving diagnostic and surgical outcomes. Post-certification, there was an increase in ultrasound utilization (47.7% vs. 35.6%, p = 0.007), greater recognition of adenomyosis (65.8% vs. 57.0%, p = 0.035), and higher rates of complete lesion removal (92.5% vs. 87.8%, p = 0.011). Pain outcomes also improved, with more patients achieving pain relief 12 months postoperatively (40.5% vs. 34.5%, p = 0.196 vs. < 0.001). Additionally, certification enhanced follow-up assessments (64.1% vs. 40.7%, p < 0.001) and documentation of rectal lesions in patients with dyschezia (p < 0.001), indicating a positive impact on overall care quality.</p><p><strong>Conclusion: </strong>This study shows that certification significantly improved care for endometriosis patients. Certification enhanced diagnostic precision, increased the use of ultrasound, improved surgical outcomes, and enabled more nuanced application of the #Enzian scoring system. Follow-up assessments became more consistent, reflecting stronger quality control. Despite remaining challenges, certification elevated the clinic's standard of care and emphasized patient-centered management.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 9","pages":"941-950"},"PeriodicalIF":2.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of SARS-CoV-2 Infection on the Course of Pregnancy and Birth After Assisted Reproduction.","authors":"Violet Eckstein, Katrin Glaß, Jessica Schaar, Pauline Wimberger, Maren Goeckenjan","doi":"10.1055/a-2524-2474","DOIUrl":"10.1055/a-2524-2474","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this single center cohort study was to examine the possible effects of SARS-CoV-2 infection, especially the Omicron variant, on outcome of pregnancy and birth after infertility treatment with assisted reproduction.</p><p><strong>Material and methods: </strong>A total of 51 pregnancies and births after assisted reproduction were investigated in the period from 01/2022 to 12/2022 in a university fertility center with regards to SARS-CoV-2 infections and vaccination status. Eight multiple pregnancies were assessed separately. 20 women with singleton pregnancy had a confirmed SARS-CoV-2 infection in the six months prior to or during the pregnancy. This group was compared to 23 singleton pregnancies without SARS-CoV-2 infection or with infection had occurred more than six months before assisted reproduction.</p><p><strong>Results: </strong>The comparison of single pregnancy with or without SARS-CoV-2 showed no differences considering age or body mass index. Complications of pregnancy such as preeclampsia, pregnancy-induced hypertension, placenta previa, placental insufficiency, and preterm labor were also comparable for both groups. There were no significant differences between the two groups with regards to gestational age at delivery, birth weight, birth mode, and APGAR scores. A comparison of the course of pregnancy in women with and women without basic immunization also showed no significant differences.</p><p><strong>Conclusion: </strong>In the study period of 2022, infection with SARS-CoV-2, in most cases with the Omicron variant, during or up to six months prior to a pregnancy following assisted reproduction did not significantly affect the risk of maternal and fetal complications of pregnancy from the 2nd trimester of pregnancy or the fetoneonatal outcome.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 10","pages":"1081-1089"},"PeriodicalIF":1.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12517771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Surgery in Endometrial Cancer: Superior for Low-Risk and Comparable for High-Risk Cases in a 20-Year Cohort Study.","authors":"Valentina Auletta, Maya Ehab Hassan, Angela Kather, Nikolaus Gaßler, Davit Bokhua, Ingo B Runnebaum","doi":"10.1055/a-2589-0498","DOIUrl":"10.1055/a-2589-0498","url":null,"abstract":"<p><strong>Objective: </strong>Minimally invasive surgery (MIS) to treat endometrial cancer offers advantages over laparotomy, although concerns about its oncological safety for high-risk tumors and feasibility in patients with significant comorbidities remain. This study evaluates perioperative and long-term outcomes of MIS versus open surgery in a tertiary referral center cohort, using FIGO 2010 and 2023 classifications.</p><p><strong>Methods: </strong>This is a retrospective analysis of perioperative outcomes, recurrence rates, and survival after endometrial cancer surgery (2000-2021) at an ESGO training center and tertiary referral center in Germany. 760 patients underwent hysterectomy, and adequate data for risk classification (without molecular diagnostics) was available for 330 of them.</p><p><strong>Results: </strong>More than one third of the patients were aged 70 years or older and approximately half of the patients were obese. A high proportion presented with comorbidities such as hypertension or diabetes. MIS demonstrated favorable perioperative results in both low-risk and high-risk patients. Survival analysis showed a superior outcome with MIS for low-risk (5-year RFS rate: 79.8% vs. 59.2%, p = 0.035; OS rate: 83.8% vs. 58.0%, p = 0.010) and FIGO 2023 stage I disease (OS: p = 0.014). The oncological safety of MIS was equivalent to that of open surgery for high-risk tumors (5-year RFS rate: 60.5% vs. 54.3%, p = 0.506; OS rate: 67.5% vs. 58.3%, p = 0.416) and FIGO 2023 stages II (RFS, p = 0.453; OS, p = 0.378) and III (RFS, p = 0.419; OS, p = 0.850).</p><p><strong>Conclusion: </strong>MIS was found to have superior outcomes for low-risk endometrial cancer and a comparable safety for high-risk patients, including those with older age or significant comorbidities. These findings support the use of MIS approaches as viable options across diverse risk groups, in line with FIGO 2023.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 7","pages":"724-735"},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Baseline Characteristics and Therapeutic Management Strategies in Metastatic Cervical Cancer in Germany: A Multicentric Retrospective Longitudinal Observational Study: A Quality Assurance Initiative of the AGO-Study Group and AGO-OK Uterus.","authors":"Dominik Denschlag, Bastian Czogalla, Florian Heitz, Markus Kerkmann, Laura-Christin Fangmann, Philip H Klecker, Frederik A Stuebs, Linn Wölber, Julia Radosa, Pia C Lodde, Stephan Seitz, Christian George, Pawel Mach, Angelina Fink, Davit Bokhua, Nikolaus deGregorio, Björn Lampe, Franziska Hemptenmacher, Verena Friebe, Markus Fleisch, Pauline Wimberger, Anna Jaeger, Andreas Schnelzer, Suzana Mittelstadt, Dominik Ratiu, Michael Eichbaum, Adriana Haus, Matthias Kalder, Beyhan Ataseven, Willibald Schröder, Holger Bronger, Jens Kosse, Uwe Andreas Ulrich, Gabriele Elser, Philipp Harter","doi":"10.1055/a-2520-5736","DOIUrl":"10.1055/a-2520-5736","url":null,"abstract":"<p><strong>Introduction: </strong>Real-world data on treatment patterns and outcomes in recurrent or metastatic cervical cancer (r/mCC) are lacking.</p><p><strong>Methods: </strong>This first national quality assurance initiative was a retrospective analysis of patients with r/mCC diagnosed between 2018 and 2022, who were identified from medical records of 31 gynecologic cancer centers in Germany. Patient demographic and clinical characteristics, treatment patterns, and clinical outcomes were assessed descriptively. Progression-free (PFS) and overall survival (OS) were calculated using Kaplan-Meier analysis.</p><p><strong>Results: </strong>A total of 503 eligible patients (median age 55 years) were analyzed for r/mCC. 276/503 patients (55%) received first-line (1L) chemotherapy (platinum combination: 247/276; 79%) followed by targeted antibody therapy with bevacizumab (177/247; 72%), immunotherapy (19/247; 8%), or both combined (50/247; 20%). 111/503 (22%) received chemotherapy only (platinum combination: 64/111; 58%, platinum mono: 35/111; 31%, or platinum-free: 12/111; 11%), and 110/503 (22%) did not receive any systemic treatment (the remaining 6/503 patients received immunotherapy only). For these subgroups after a median follow-up of 16 months, the PFS was 12 months (95% CI 11-14), 8.8 months (95% CI 7.1-11), and 3 months (95% CI 2.3-4.8), and OS was 25 months (95% CI 21-31), 17 months (95% CI 14-22), and 3.6 months (95% CI 2.8-5.3), respectively. 176/283 (62%) patients who developed progressive disease (PD) were treated with second-line (2L) therapy.</p><p><strong>Conclusion: </strong>Only half of the patients with r/mCC were treated 1L with platinum-combination therapy including antibody therapy according to national guidelines. Moreover, 22% at initial diagnosis and 38% of patients at PD were not treated with systemic therapy at all. This might reflect poor general performance status, patients' preference, and/or lack of effective therapies especially in 2L treatment.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 5","pages":"520-532"},"PeriodicalIF":2.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update Breast Cancer 2024 Part 3 - Patients with Advanced Stage Breast Cancer.","authors":"Diana Lüftner, Hans-Christian Kolberg, Andreas D Hartkopf, Tanja N Fehm, Manfred Welslau, Volkmar Müller, Florian Schütz, Peter A Fasching, Christian Jackisch, Frederik Marme, Katharina Keller, Manuel Hörner, Chloë Goossens, Erik Belleville, Michael Untch, Marc Thill, Hans Tesch, Nina Ditsch, Julia C Radosa, Maggie Banys-Paluchowski, Achim Wöckel, Nadia Harbeck, Elmar Stickeler, Rupert Bartsch, Bahriye Aktas, Andreas Schneeweiss, Johannes Ettl, Florin-Andrei Taran, Wolfgang Janni, Rachel Würstlein, Michael P Lux","doi":"10.1055/a-2515-2366","DOIUrl":"10.1055/a-2515-2366","url":null,"abstract":"<p><p>The use of CDK4/6 inhibitors, the new PI3K/AKT-kinase inhibitors, selective estrogen receptor-degraders (SERDs), antibody-drug conjugates, immune therapies and PARP inhibitors in recent years has resulted in a marked change in the therapy landscape for patients with advanced stage breast cancer. CDK4/6 inhibitors, trastuzumab deruxtecan, and sacituzumab govitecan have all been shown to provide significant overall survival benefits compared to conventional chemotherapy. Other substances are also showing promising results and hold out the hope that further analysis of the overall survival benefits will be available in the near future. The speed at which studies are now being carried out has markedly increased, and conferences and specialist journals are now constant sources of new information. This review summarizes the most recent publications and conference presentations on the treatment of patients with advanced stage breast cancer.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 5","pages":"507-519"},"PeriodicalIF":2.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Analysis of the Incidence of Serous Tubal Intraepithelial Carcinoma (STIC) in Germany - Evaluation of the Cancer Registry of the Federal State of Rhineland-Palatinate from 2016 to 2023.","authors":"Valerie Catherine Linz, Alina Breuer, Philipp Leppert, Nils Herm-Stapelberg, Katja Schwarzer, Annette Hasenburg","doi":"10.1055/a-2555-4602","DOIUrl":"10.1055/a-2555-4602","url":null,"abstract":"<p><strong>Introduction: </strong>Serous tubal intraepithelial carcinomas (STIC) are classified as precursor lesions of high-grade serous carcinomas (HGSC) in women. STIC are rare and their incidence, prognosis and therapy remain unclear. Since 2021, all cases of isolated STIC in Germany must be reported, which means that all STICs in the German federal state of the Rhineland-Palatine (RLP) are available for evaluation.</p><p><strong>Material and methods: </strong>A systematic search of the pathology reports in the RLP cancer registry was carried out for the period 01/2016-12/2023 using keywords related to STIC, and the results of the search were evaluated.</p><p><strong>Results: </strong>382 pathology reports were identified as relevant and screened. A total of seven patients with isolated STIC were reported to the RLP registry in the years 2020-2022. This corresponds to 0.014% of all reported cases of cancer in women in RLP in this period. Six patients had a diagnosis of isolated STIC, identified during risk-reducing salpingo-oophorectomy (RRSO). The mean patient age at the time of RRSO was 60.29 (± 7.09) years. RRSO was carried out on average 9.38 (± 6.75) years after a primary diagnosis of breast cancer/DCIS in five patients. No HGSC was reported for any of the patients with isolated STIC in the follow-up period until 01/2024. 43 synchronous STICs were reported for the period from 01/2016 to 12/2023.</p><p><strong>Conclusion: </strong>2-3 diagnoses of isolated STIC were recorded annually in RLP in the years 2020-2022. To date, there have been no reports of HGSC in these patients. In the future, the systematic recording of STICs will be expanded to include the cancer registries of other federal states of Germany and it will be possible to obtain valid data on the incidence of STIC in Germany. The collected data will also provide the basic information for a national STIC registry.</p>","PeriodicalId":12481,"journal":{"name":"Geburtshilfe Und Frauenheilkunde","volume":"85 5","pages":"541-547"},"PeriodicalIF":2.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}