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Chitosan-sulfonic acid-catalyzed green synthesis of naphthalene-based azines as potential anticancer agents. 壳聚糖-磺酸催化的萘醌类潜在抗癌剂的绿色合成。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-04-01 Epub Date: 2024-02-22 DOI: 10.4155/fmc-2023-0351
Abdullah Ya Alzahrani, Sobhi M Gomha, Magdi Ea Zaki, Basant Farag, Fathy E Abdelgawad, Mahmoud A Mohamed
{"title":"Chitosan-sulfonic acid-catalyzed green synthesis of naphthalene-based azines as potential anticancer agents.","authors":"Abdullah Ya Alzahrani, Sobhi M Gomha, Magdi Ea Zaki, Basant Farag, Fathy E Abdelgawad, Mahmoud A Mohamed","doi":"10.4155/fmc-2023-0351","DOIUrl":"10.4155/fmc-2023-0351","url":null,"abstract":"<p><p><b>Aim:</b> This study focuses on advancing green chemistry in anticancer drug discovery, particularly through the synthesis of azine derivatives with a naphthalene core using CS-SO<sub>3</sub>H as a catalyst. <b>Methods:</b> Novel benzaldazine and ketazine derivatives were synthesized using (<i>E</i>)-(naphthalen-1-ylmethylene)hydrazine and various carbonyl compounds. The methods employed included thermal and grinding techniques, utilizing CS-SO<sub>3</sub>H as an eco-friendly and cost-effective catalyst. <b>Results:</b> The approach resulted in high yields, short reaction times and demonstrated catalyst reusability. Cytotoxicity tests highlighted compounds <b>3b, 11</b> and <b>13</b> as potent against the HEPG2-1. <b>Conclusion:</b> This study successfully aligns with the objectives of eco-conscious drug development in organic chemistry. Molecular docking and <i>in silico</i> studies further indicate the potential of these ligands as antitumor medicines, with favorable oral bioavailability properties.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"647-663"},"PeriodicalIF":4.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and molecular docking studies of 5-trifluoromethoxy-2-indolinones as cholinesterase dual inhibitors. 作为胆碱酯酶双重抑制剂的 5-三氟甲氧基-2-吲哚啉酮的合成和分子对接研究。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-04-01 Epub Date: 2024-03-05 DOI: 10.4155/fmc-2023-0281
Özge Soylu-Eter, Nurten Özsoy, Nilgün Karalı
{"title":"Synthesis and molecular docking studies of 5-trifluoromethoxy-2-indolinones as cholinesterase dual inhibitors.","authors":"Özge Soylu-Eter, Nurten Özsoy, Nilgün Karalı","doi":"10.4155/fmc-2023-0281","DOIUrl":"10.4155/fmc-2023-0281","url":null,"abstract":"<p><p><b>Background:</b> In Alzheimer's disease, butyrylcholinesterase (BuChE) activity gradually increases, while acetylcholinesterase (AChE) activity decreases or remains unchanged. Dual inhibitors have important roles in regulation of synaptic acetylcholine levels and progression of Alzheimer's disease. <b>Methods:</b> 1-(Thiomorpholin-4-ylmethyl)/benzyl-5-trifluoromethoxy-2-indolinones (<b>6-7</b>) were synthesized. AChE and BuChE inhibitory effects were investigated with Ellman's method. Molecular docking studies were performed for analyzing the possible binding interactions at active sites. <b>Results:</b> Compound <b>6g</b> was the strongest inhibitor against both AChE (<i>K</i><sub>i</sub> = 0.35 μM) and BuChE (<i>K</i><sub>i</sub> = 0.53 μM). It showed higher inhibitory effects than both donepezil and galantamine. Moreover, compound <b>7m</b> had a higher inhibitory effect than galantamine and the effect was comparable to that of donepezil against both AChE (<i>K</i><sub>i</sub> = 0.69 μM) and BuChE (<i>K</i><sub>i</sub> = 0.95 μM). <b>Conclusion:</b> The benzyl substitution compared with 1-(thiomorpholin-4-ylmethyl) group significantly increased both AChE and BuChE inhibitory effects.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":"16 7","pages":"623-645"},"PeriodicalIF":4.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of novel covalent inhibitors of DJ-1 through hybrid virtual screening. 通过混合虚拟筛选发现新型 DJ-1 共价抑制剂。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-04-01 Epub Date: 2024-02-23 DOI: 10.4155/fmc-2023-0301
Yanyu Ma, Yidan Song, Junyi Wang, Xiayu Shi, Zhen Yuan, Shuang Li, Honglin Li, Zhuo Chen, Shiliang Li
{"title":"Discovery of novel covalent inhibitors of DJ-1 through hybrid virtual screening.","authors":"Yanyu Ma, Yidan Song, Junyi Wang, Xiayu Shi, Zhen Yuan, Shuang Li, Honglin Li, Zhuo Chen, Shiliang Li","doi":"10.4155/fmc-2023-0301","DOIUrl":"10.4155/fmc-2023-0301","url":null,"abstract":"<p><p><b>Background:</b> DJ-1 is a ubiquitously expressed protein with multiple functions. Its overexpression has been associated with the occurrence of several cancers, positioning DJ-1 as a promising therapeutic target for cancer treatment. <b>Methods:</b> To find novel inhibitors of DJ-1, we employed a hybrid virtual screening strategy that combines structure-based and ligand-based virtual screening on a comprehensive compound library. <b>Results:</b> <i>In silico</i> study identified six hit compounds as potential DJ-1 inhibitors that were assessed <i>in vitro</i> at the cellular level. Compound 797780-71-3 exhibited antiproliferation activity in ACHN cells with an IC<sub>50</sub> value of 12.18 μM and was able to inhibit the Wnt signaling pathway. This study discovers a novel covalent inhibitor for DJ-1 and paves the way for further optimization.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"665-677"},"PeriodicalIF":4.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis and mechanistic study of new dual targeting HDAC/tubulin inhibitors. 新型双靶向 HDAC/tubulin 抑制剂的设计、合成和机理研究。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-04-01 Epub Date: 2024-03-04 DOI: 10.4155/fmc-2023-0336
Mona S El-Zoghbi, Amr Ka Bass, Gamal El-Din A Abuo-Rahma, Mamdouh Fa Mohamed, Mohamed Badr, Hanan A Al-Ghulikah, El-Shimaa Mn Abdelhafez
{"title":"Design, synthesis and mechanistic study of new dual targeting HDAC/tubulin inhibitors.","authors":"Mona S El-Zoghbi, Amr Ka Bass, Gamal El-Din A Abuo-Rahma, Mamdouh Fa Mohamed, Mohamed Badr, Hanan A Al-Ghulikah, El-Shimaa Mn Abdelhafez","doi":"10.4155/fmc-2023-0336","DOIUrl":"10.4155/fmc-2023-0336","url":null,"abstract":"<p><p><b>Aim:</b> The purpose of this work is to create and synthesize a new class of chemicals: 3-cyano-2-substituted pyridine compounds with expected multitarget inhibition of histone deacetylase (HDAC) and tubulin. <b>Materials & methods:</b> The target compounds (<b>3a-c, 4a-c</b> and <b>5a-c</b>) were synthesized utilizing 6-(4-methoxyphenyl)-2-oxo-4-(3,4,5-trimethoxyphenyl)-3-cyanopyridine, with various linkers and zinc-binding groups (ZBGs). <b>Results:</b> Most of the tested compounds showed promising growth inhibition, and hydroxamic acid-containing hybrids possessed higher HDAC inhibition than other ZBGs. Compound <b>4b</b> possessed the highest potency; however, it showed the most tubulin polymerization inhibition. Docking studies displayed good binding into HDAC1 and six pockets and tubulin polymerization protein. <b>Conclusion:</b> Compound <b>4b</b> could be considered a good antitumor candidate to go further into <i>in vivo</i> and clinical studies.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"601-622"},"PeriodicalIF":4.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel sulfonamide derivatives as a tool to combat methicillin-resistant Staphylococcus aureus. 作为抗耐甲氧西林金黄色葡萄球菌工具的新型磺酰胺衍生物。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-03-01 Epub Date: 2024-02-13 DOI: 10.4155/fmc-2023-0116
Martin Krátký
{"title":"Novel sulfonamide derivatives as a tool to combat methicillin-resistant <i>Staphylococcus aureus</i>.","authors":"Martin Krátký","doi":"10.4155/fmc-2023-0116","DOIUrl":"10.4155/fmc-2023-0116","url":null,"abstract":"<p><p>Increasing resistance in <i>Staphylococcus aureus</i> has created a critical need for new drugs, especially those effective against methicillin-resistant strains (methicillin-resistant <i>Staphylococcus aureus</i> [MRSA]). Sulfonamides are a privileged scaffold for the development of novel antistaphylococcal agents. This review covers recent advances in sulfonamides active against MRSA. Based on the substitution patterns of sulfonamide moieties, its derivatives can be tuned for desired properties and biological activity. Contrary to the traditional view, not only <i>N</i>-monosubstituted 4-aminobenzenesulfonamides are effective. Novel sulfonamides have various mechanisms of action, not only 'classical' inhibition of the folate biosynthetic pathway. Some of them can overcome resistance to classical sulfa drugs and cotrimoxazole, are bactericidal and active <i>in vivo</i>. Hybrid compounds with distinct bioactive scaffolds are particularly advantageous.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"545-562"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
19 Schiff bases as antimycobacterial agents: synthesis, molecular docking and a plausible mechanism of action. 19 作为抗霉菌剂的希夫碱：合成、分子对接和合理的作用机制。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-03-01 Epub Date: 2024-02-05 DOI: 10.4155/fmc-2023-0305
Yu-Xiang Cai, Jun-Xian Chen, Hong-Mei Dong, Zai-Chang Yang
{"title":"19 Schiff bases as antimycobacterial agents: synthesis, molecular docking and a plausible mechanism of action.","authors":"Yu-Xiang Cai, Jun-Xian Chen, Hong-Mei Dong, Zai-Chang Yang","doi":"10.4155/fmc-2023-0305","DOIUrl":"10.4155/fmc-2023-0305","url":null,"abstract":"<p><p><b>Aim:</b> To discover novel anti-<i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) drugs, 19 compounds were synthesized; their anti-<i>Mtb</i> effects were evaluated and mechanisms of action were preliminarily explored. <b>Materials & methods:</b> The compounds were synthesized and their anti-<i>Mtb</i> activity was elucidated using resazurin microtiter assays. The plausible target of the potential compound was investigated by microimaging techniques, gas chromatography-mass spectrometry analysis and molecular docking. <b>Results:</b> 19 compounds inhibited <i>Mtb</i> growth with minimum inhibitory concentrations ranging from 1 to 32 μg/ml. Compounds <b>1</b>-<b>17</b> showed inhibition of <i>Mtb</i> KatG enzyme. Compound <b>19</b>, the most potent, might be an inhibitor of Pks13 polyketide synthase. <b>Conclusion:</b> This study suggests that 2-((6-fluoropyridin-3-yl)methylene) hydrazine-1-carbothioamide (<b>19</b>) is a potential anti-<i>Mtb</i> lead compound with a novel mechanism of action.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"453-467"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139682313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging synthetic strategies and pharmacological insights of 1,3,4-thiadiazole derivatives: a comprehensive review. 1,3,4-噻二唑衍生物的新合成策略和药理学见解：综述。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-03-01 Epub Date: 2024-02-14 DOI: 10.4155/fmc-2023-0203
Davinder Kumar, Navidha Aggarwal, Virender Kumar, Hitesh Chopra, Rakesh Kumar Marwaha, Rohit Sharma
{"title":"Emerging synthetic strategies and pharmacological insights of 1,3,4-thiadiazole derivatives: a comprehensive review.","authors":"Davinder Kumar, Navidha Aggarwal, Virender Kumar, Hitesh Chopra, Rakesh Kumar Marwaha, Rohit Sharma","doi":"10.4155/fmc-2023-0203","DOIUrl":"10.4155/fmc-2023-0203","url":null,"abstract":"<p><p>This review meticulously examines the synthesis techniques for 1,3,4-thiadiazole derivatives, focusing on cyclization, condensation reactions and functional group transformations. It enhances the understanding of these chemical methods that re crucial for tailoring derivative properties and functionalities. This study is considered to be vital for researchers, detailing established effects such as antioxidant, antimicrobial and anticancer activities, and revealing emerging pharmacological potentials such as neuroprotective, antiviral and antidiabetic properties. It also discusses the molecular mechanisms underlying these effects. In addition, this article covers structure-activity relationship studies and computational modelling that are essential for designing potent, selective 1,3,4-thiadiazole compounds. This work lays a foundation for future research and targeted therapeutic development.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"563-581"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NeuroClick: software for mimicking click reaction to generate drug-like molecules permeating the blood-brain barrier. NeuroClick：模仿点击反应生成可渗透血脑屏障的类药物分子的软件。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-03-01 Epub Date: 2024-02-19 DOI: 10.4155/fmc-2023-0017
Anastasiia M Isakova, Alexander A Kovalenko, Ekaterina V Skorb, Sergey Shityakov
{"title":"NeuroClick: software for mimicking click reaction to generate drug-like molecules permeating the blood-brain barrier.","authors":"Anastasiia M Isakova, Alexander A Kovalenko, Ekaterina V Skorb, Sergey Shityakov","doi":"10.4155/fmc-2023-0017","DOIUrl":"10.4155/fmc-2023-0017","url":null,"abstract":"<p><p><b>Background:</b> Traditional methods for chemical library generation in virtual screening often impose limitations on the accessible chemical space or produce synthetically irrelevant structures. Incorporating common chemical reactions into generative algorithms could offer significant benefits. <b>Materials & methods:</b> In this study, we developed NeuroClick, a graphical user interface software designed to perform in silico azide-alkyne cycloaddition, a widely utilized synthetic approach in modern medicinal chemistry. <b>Results & conclusion:</b> NeuroClick facilitates the generation and filtering of large combinatorial libraries at a remarkable rate of 10,000 molecules per minute. Moreover, the generated products can be filtered to identify subsets of pharmaceutically relevant compounds based on Lipinski's rule of five and blood-brain barrier permeability prediction. We demonstrate the utility of NeuroClick by generating and filtering several thousand molecules for dopamine D3 receptor ligand screening.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"389-398"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The discovery of a novel IκB kinase β inhibitor based on pharmacophore modeling, virtual screening and biological evaluation. 基于药效学建模、虚拟筛选和生物学评价发现新型 IκB 激酶 β 抑制剂。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-03-01 Epub Date: 2024-02-22 DOI: 10.4155/fmc-2023-0261
Luyao Li, Shouping Gong
{"title":"The discovery of a novel IκB kinase β inhibitor based on pharmacophore modeling, virtual screening and biological evaluation.","authors":"Luyao Li, Shouping Gong","doi":"10.4155/fmc-2023-0261","DOIUrl":"10.4155/fmc-2023-0261","url":null,"abstract":"<p><p><b>Background:</b> IκB kinase β (IKKβ) plays a pivotal role in the NF-κB signaling pathway and is considered a promising therapeutic target for various diseases. <b>Materials & methods:</b> The authors developed and validated a 3D pharmacophore model of IKKβ inhibitors via the HypoGen algorithm in Discovery Studio 2019, then performed virtual screening, molecular docking and kinase assays to identify hit compounds from the ChemDiv database. The compound with the highest inhibitory activity was further evaluated in adjuvant-induced arthritis rat models. <b>Results:</b> Among the four hit compounds, Hit 4 had the highest IKKβ inhibitory activity (IC<sub>50</sub> = 30.4 ± 3.8), and it could significantly ameliorate joint inflammation and damage <i>in vivo</i>. <b>Conclusion:</b> The identified compound, Hit 4, can be optimized as a therapeutic agent for inflammatory diseases.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"531-544"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139930687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, synthesis and evaluation of aminothiazole derivatives as potential anti-Alzheimer's candidates. 设计、合成和评估氨基噻唑衍生物作为潜在的抗阿尔茨海默氏症候选药物。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-03-01 Epub Date: 2024-02-20 DOI: 10.4155/fmc-2023-0290
Arti Soni, Ashwani Kumar, Vivek Kumar, Ravi Rawat, Volkan Eyupoglu
{"title":"Design, synthesis and evaluation of aminothiazole derivatives as potential anti-Alzheimer's candidates.","authors":"Arti Soni, Ashwani Kumar, Vivek Kumar, Ravi Rawat, Volkan Eyupoglu","doi":"10.4155/fmc-2023-0290","DOIUrl":"10.4155/fmc-2023-0290","url":null,"abstract":"<p><p><b>Aim:</b> The objective of the present study was to design, synthesize and evaluate diverse Schiff bases and thiazolidin-4-one derivatives of aminothiazole as key pharmacophores possessing acetylcholinesterase inhibitory activity. <b>Materials & methods:</b> Two series of compounds (13 each) were synthesized and evaluated for their acetylcholinesterase inhibition and antioxidant activity. Molecular docking of all compounds was performed to provide an insight into their binding interactions. <b>Results:</b> Compounds <b>2j</b> (IC<sub>50</sub> = 0.03 μM) and <b>3e</b> (IC<sub>50</sub> = 1.58 μM) were found to be the best acetylcholinesterase inhibitors among compounds of their respective series. Molecular docking analysis supported the results of <i>in vitro</i> activity by displaying good docking scores with the binding pocket of human acetylcholinesterase (Protein Data Bank ID: 4EY7). <b>Conclusion:</b> Compound <b>2j</b> emerged as a potential lead compound with excellent acetylcholinesterase inhibition, antioxidant and chelation activity.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"513-529"},"PeriodicalIF":4.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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