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Future medicinal chemistry最新文献

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Synthesis, anticancer activity, docking and computational studies of new pyridyl-glycosyl hybrids and acyclic analogs. 新型吡啶基-糖基杂交化合物和无环类似物的合成、抗癌活性、对接和计算研究。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-09-12 DOI: 10.1080/17568919.2024.2389768
Mohamed N El-Bayaa,Eman R Kotb,Sabri Messaoudi,Hanem M Awad,Mahmoud G Saleh,Hanan A Soliman
{"title":"Synthesis, anticancer activity, docking and computational studies of new pyridyl-glycosyl hybrids and acyclic analogs.","authors":"Mohamed N El-Bayaa,Eman R Kotb,Sabri Messaoudi,Hanem M Awad,Mahmoud G Saleh,Hanan A Soliman","doi":"10.1080/17568919.2024.2389768","DOIUrl":"https://doi.org/10.1080/17568919.2024.2389768","url":null,"abstract":"New pyridine-O-glycosides and their acyclic nucleoside analogues were prepared by heterocyclization and glycosylation. The anticancer activity against HCT-116, HepG2 and MCF-7 human cancer cells and BJ-1 cell revealed that the galacto- and xylopyranosyl glycosides possessing 4-bromophenyl have superior cytotoxic activities against HepG2 cell while glycosides 7-9 resulted in superior cytotoxic activities regarding MCF-7 breast cell. In case of HCT-116 colorectal carcinoma cells, two products and the derived glycosides and acyclic analogues showed potent activities. The most potent compounds were investigated for their possible binding affinities to the active site of CDK2 enzyme via in silico molecular docking simulation in addition to computational studies. The results support the antiproliferative effect and elucidate the interactions of 3a and 8 with catalytic sites.","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":"167 1","pages":"1-15"},"PeriodicalIF":4.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein-protein interactions in cGAS-STING pathway: a medicinal chemistry perspective. cGAS-STING 通路中蛋白质与蛋白质之间的相互作用：药物化学的视角。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-09-12 DOI: 10.1080/17568919.2024.2383164
Shi-Duo Zhang,Hui Li,Ye-Ling Zhou,Xue-Chun Liu,De-Chang Li,Chuan-Feng Hao,Qi-Dong You,Xiao-Li Xu
{"title":"Protein-protein interactions in cGAS-STING pathway: a medicinal chemistry perspective.","authors":"Shi-Duo Zhang,Hui Li,Ye-Ling Zhou,Xue-Chun Liu,De-Chang Li,Chuan-Feng Hao,Qi-Dong You,Xiao-Li Xu","doi":"10.1080/17568919.2024.2383164","DOIUrl":"https://doi.org/10.1080/17568919.2024.2383164","url":null,"abstract":"Protein-protein interactions (PPIs) play pivotal roles in biological processes and are closely linked with human diseases. Research on small molecule inhibitors targeting PPIs provides valuable insights and guidance for novel drug development. The cGAS-STING pathway plays a crucial role in regulating human innate immunity and is implicated in various pathological conditions. Therefore, modulators of the cGAS-STING pathway have garnered extensive attention. Given that this pathway involves multiple PPIs, modulating PPIs associated with the cGAS-STING pathway has emerged as a promising strategy for modulating this pathway. In this review, we summarize an overview of recent advancements in medicinal chemistry insights into cGAS-STING PPI-based modulators and propose alternative strategies for further drug discovery based on the cGAS-STING pathway.","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":"40 1","pages":"1-20"},"PeriodicalIF":4.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, crystal structure, biological and docking studies of 5-hydroxy-2-{[(2-methylpropyl)iminio]methyl}phenolate. 5-hydroxy-2-{[(2-methylpropyl)iminio]methyl}phenolate 的合成、晶体结构、生物学和对接研究。
IF 4.2 4区 医学
Future medicinal chemistry Pub Date : 2024-09-11 DOI: 10.1080/17568919.2024.2389763
Arjunan Ayyappan,Sebastian Arockiasamy
{"title":"Synthesis, crystal structure, biological and docking studies of 5-hydroxy-2-{[(2-methylpropyl)iminio]methyl}phenolate.","authors":"Arjunan Ayyappan,Sebastian Arockiasamy","doi":"10.1080/17568919.2024.2389763","DOIUrl":"https://doi.org/10.1080/17568919.2024.2389763","url":null,"abstract":"Background: Schiff base compounds are potential drugs.Results: A Schiff base compound prepared by condensing 2,4-dihydroxy benzaldehyde and isobutylamine was characterized for structure, thermal, physicochemical and biological properties. The keto-enol tautomerism and azomethine functionality enhances electron delocaliZation and biological activity. The compound showed good antibacterial and antifungal activity at 40 μg/ml against bacteria such as Escherichia coli and Staphylococcus aureus and fungi like Candida albicans and Candida tropicalis. The docking study exhibits a moderate binding affinity for the GyrB protein in E. coli with a binding energy of -4.26 kcal/mol.Conclusion: The compound exhibits enhanced biological activity and suppression of cell growth at concentrations as low as 30 μg/ml. The IC50 for MFC-7 was found to be 41.5 μg/ml.","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":"42 1","pages":"1-16"},"PeriodicalIF":4.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New pyridopyrimidine derivatives as dual EGFR and CDK4/cyclin D1 inhibitors: synthesis, biological screening and molecular modeling. 作为表皮生长因子受体和 CDK4/ 环素 D1 双重抑制剂的新型吡啶嘧啶衍生物：合成、生物筛选和分子建模。
IF 3.2 4区 医学
Future medicinal chemistry Pub Date : 2024-08-17 Epub Date: 2024-07-18 DOI: 10.1080/17568919.2024.2366147
Fatma Ma Krakisha, Dina Ia Othman, Walaa M El Husseiny, Magda Na Nasr
{"title":"New pyridopyrimidine derivatives as dual EGFR and CDK4/cyclin D1 inhibitors: synthesis, biological screening and molecular modeling.","authors":"Fatma Ma Krakisha, Dina Ia Othman, Walaa M El Husseiny, Magda Na Nasr","doi":"10.1080/17568919.2024.2366147","DOIUrl":"10.1080/17568919.2024.2366147","url":null,"abstract":"<p><p><b>Aim:</b> A series of pyridopyrimidine derivatives <b>5-20</b> was designed, synthesized and examined for antitumor activity using four types of malignant cells.<b>Materials & methods:</b> Cervical cancer (HeLa), hepatic cancer (HepG-2), breast cancer (MCF-7) and colon cancer (HCT-166) cells, as well as normal human lung fibroblast cells (WI-38) were used to determine the cytotoxicity.<b>Results:</b> Pyrazol-1-<i>yl</i> pyridopyrimidine derivative <b>5</b> was found to be the most active compound against three malignant cells Hela, MCF-7 and HepG-2 with IC<sub>50</sub> values of 9.27, 7.69 and 5.91 μM, respectively, related to standard Doxorubicin. Moreover, compounds <b>5</b> and <b>10</b> showed good inhibition against cyclin dependent kinase (CDK4/cyclin D1) and epidermal growth factor (EGFR) enzymes.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"1633-1648"},"PeriodicalIF":3.2,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, characterization and biological evaluation of aurones as potential neuroprotective agents. 作为潜在神经保护剂的醛酮的合成、表征和生物学评估。
IF 3.2 4区 医学
Future medicinal chemistry Pub Date : 2024-08-17 Epub Date: 2024-06-28 DOI: 10.1080/17568919.2024.2363713
Muhammad Ayaz, Syed Wadood Ali Shah, Mohammad Shoaib, Fawad Ali Shah, Fawad Ahmed
{"title":"Synthesis, characterization and biological evaluation of aurones as potential neuroprotective agents.","authors":"Muhammad Ayaz, Syed Wadood Ali Shah, Mohammad Shoaib, Fawad Ali Shah, Fawad Ahmed","doi":"10.1080/17568919.2024.2363713","DOIUrl":"10.1080/17568919.2024.2363713","url":null,"abstract":"<p><p><b>Aim:</b> To synthesize aurone (Ar) derivatives and to demonstrate their effects against diabetes mellitus (DM) and neurodegeneration.<b>Materials & methods:</b> Five Ar (<b>A-E</b>) derivatives were synthesized, characterized by proton NMR and screened for antioxidant, anti-diabetic and anti-cholinesterase activities. They were further evaluated for neuroprotective effects in streptozotocin (STZ)-induced neurodegenerative model.<b>Results:</b> Among the aurone derivatives ArE demonstrated significant reversal of cognitive impairment, oxidative stress and neuroinflammation. Biochemical analysis revealed anti-diabetic and neuroprotective effects, possibly through downregulation of inflammatory markers and upregulation of antioxidant enzymes.<b>Conclusion:</b> Synthesized Ar (<b>A-E</b>) exhibits promising therapeutic potential against STZ-induced neurodegeneration and DM by modulating inflammatory and oxidative pathways, suggesting a novel avenue for disease management.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"1649-1663"},"PeriodicalIF":3.2,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An overview of pyridazin-3(2H)-one: a core for developing bioactive agents targeting cardiovascular diseases and cancer. 哒嗪-3(2H)-酮概述：开发针对心血管疾病和癌症的生物活性制剂的核心。
IF 3.2 4区 医学
Future medicinal chemistry Pub Date : 2024-08-17 Epub Date: 2024-08-06 DOI: 10.1080/17568919.2024.2379234
Zeinab S Abd-Rabo, Aya M Serry, Riham F George
{"title":"An overview of pyridazin-3(2<i>H</i>)-one: a core for developing bioactive agents targeting cardiovascular diseases and cancer.","authors":"Zeinab S Abd-Rabo, Aya M Serry, Riham F George","doi":"10.1080/17568919.2024.2379234","DOIUrl":"10.1080/17568919.2024.2379234","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) and cancer are the top two leading causes of death globally. Vasodilators are commonly used to treat various CVDs. In cancer treatment, targeted anticancer agents have been developed to minimize side effects compared with traditional chemotherapy. Many hypertension patients are more prone to cancer, a case known as reverse cardio-oncology. This leads to the search for drugs with dual activity or repurposing strategy to discover new therapeutic uses for known drugs. Recently, medicinal chemists have shown great interest in synthesizing pyridazinone derivatives due to their significant biological activities in tackling these critical health challenges. This review will concentrate on pyridazin-3(2<i>H</i>)-one-containing compounds as vasodilators and anticancer agents, along with a brief overview of various methods for their synthesis.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"1685-1703"},"PeriodicalIF":3.2,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety. 含有 2-硫代海因分子的混合肉桂酸衍生物的体外抗乳腺癌研究。
IF 3.2 4区 医学
Future medicinal chemistry Pub Date : 2024-08-17 Epub Date: 2024-07-01 DOI: 10.1080/17568919.2024.2366694
Dalal Nasser Binjawhar, Fawziah A Al-Salmi, Maha Ali Alghamdi, Ola A Abu Ali, Eman Fayad, Youstina William Rizzk, Nourhan M Ali, Ibrahim Mohey El-Deen, Elsayed H Eltamany
{"title":"<i>In vitro</i> anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety.","authors":"Dalal Nasser Binjawhar, Fawziah A Al-Salmi, Maha Ali Alghamdi, Ola A Abu Ali, Eman Fayad, Youstina William Rizzk, Nourhan M Ali, Ibrahim Mohey El-Deen, Elsayed H Eltamany","doi":"10.1080/17568919.2024.2366694","DOIUrl":"10.1080/17568919.2024.2366694","url":null,"abstract":"<p><p><b>Aim</b>: To synthesize new hybrid cinnamic acids (<b>10a</b>, <b>10b</b> and <b>11</b>) and ester derivatives (<b>7</b>, <b>8</b> and <b>9</b>) and investigate their anti-breast cancer activities.<b>Materials & methods:</b> Compounds <b>7-11</b> were evaluated (<i>in vitro</i>) for their cytotoxic activities against the MCF-7 cell line. A flow cytometry examination was performed. Protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2), topoisomerase II and caspase-9 were measured by qRT-PCR. Molecular docking studies were conducted.<b>Results</b>: Several components were discovered to be active, mainly component <b>11</b>, which induced arrest in the cell cycle at phase S, greatly decreased the expression of Nrf2 and topoisomerase II; and upregulated the expression of caspase-9.<b>Conclusion:</b> The newly thiohydantoin-cinnamic acid hybrids can contribute to creating promising candidates for cancer drugs.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"1665-1684"},"PeriodicalIF":3.2,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of novel benzothiazole-thiadiazole-based thiazolidinone derivative: in vitro and in silico approaches to develop promising anti-Alzheimer's agents. 鉴定新型苯并噻唑-噻二唑基噻唑烷酮衍生物：开发有前景的抗阿尔茨海默氏症药物的体外和硅学方法。
IF 3.2 4区 医学
Future medicinal chemistry Pub Date : 2024-08-17 Epub Date: 2024-06-28 DOI: 10.1080/17568919.2024.2366159
Shoaib Khan, Rafaqat Hussain, Tayyiaba Iqbal, Yousaf Khan, Urooj Jamal, Hany W Darwish, Muhammad Adnan
{"title":"Identification of novel benzothiazole-thiadiazole-based thiazolidinone derivative: <i>in vitro</i> and <i>in silico</i> approaches to develop promising anti-Alzheimer's agents.","authors":"Shoaib Khan, Rafaqat Hussain, Tayyiaba Iqbal, Yousaf Khan, Urooj Jamal, Hany W Darwish, Muhammad Adnan","doi":"10.1080/17568919.2024.2366159","DOIUrl":"10.1080/17568919.2024.2366159","url":null,"abstract":"<p><p><b>Aim:</b> The present study describes benzothiazole derived thiazolidinone based thiadiazole derivatives (<b>1-16</b>) as anti-Alzheimer agents.<b>Materials & methods:</b> Synthesis of benzothiazole derived thiazolidinone based thiadiazole derivatives was achieved using the benzothiazole bearing 2-amine moiety. These synthesized compounds were confirmed via spectroscopic techniques (<sup>1</sup>H NMR, <sup>13</sup>C NMR and HREI-MS). These compounds were biologically evaluated for their anti-Alzheimer potential. Binding interactions with proteins and drug likeness of the analogs were explored through molecular docking and ADMET analysis, respectively. In the novel series, compound-<b>3</b> emerged as the most potent inhibitor when compared with other derivatives of the series.<b>Conclusion:</b> The present study provides potent anti-Alzheimer's agents that can be further optimized to discover novel anti-Alzheimer's drugs.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"1601-1613"},"PeriodicalIF":3.2,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Barbiturate-sulfonate hybrids as potent cholinesterase inhibitors: design, synthesis and molecular modeling studies. 作为强效胆碱酯酶抑制剂的巴比妥酸-磺酸盐杂化物：设计、合成和分子模型研究。
IF 3.2 4区 医学
Future medicinal chemistry Pub Date : 2024-08-17 Epub Date: 2024-07-16 DOI: 10.1080/17568919.2024.2366158
Asmaa F Kassem, Mohamed A Omar, Ahmed Temirak, Riham A El-Shiekh, Aladdin M Srour
{"title":"Barbiturate-sulfonate hybrids as potent cholinesterase inhibitors: design, synthesis and molecular modeling studies.","authors":"Asmaa F Kassem, Mohamed A Omar, Ahmed Temirak, Riham A El-Shiekh, Aladdin M Srour","doi":"10.1080/17568919.2024.2366158","DOIUrl":"10.1080/17568919.2024.2366158","url":null,"abstract":"<p><p><b>Aim:</b> Design and synthesis of a series of 5-benzylidene(thio)barbiturates <b>3a-r</b>.<b>Methodology:</b> Evaluation of the inhibitory activity of the new chemical entities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) using Donepezil as the standard reference.<b>Results & Conclusion:</b> Compound <b>3r</b> emerged as the most potent AChE inhibitor (IC<sub>50</sub> = 9.12 μM), while compound <b>3q</b> exhibited the highest inhibitory activity against BChE (IC<sub>50</sub> = 19.43 μM). Toxicological bioassays confirmed the absence of cytotoxicity for the most potent compounds at the tested doses. Molecular docking analysis demonstrated that the tested derivatives effectively bind to the active sites of both enzymes. Overall, this study sheds light on the potential of barbiturate-sulfonate conjugates as promising drug candidates.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"1615-1631"},"PeriodicalIF":3.2,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medicinal chemistry aspects of fat mass and obesity associated protein: structure, function and inhibitors. 脂肪量和肥胖相关蛋白的药物化学方面：结构、功能和抑制剂。
IF 3.2 4区 医学
Future medicinal chemistry Pub Date : 2024-08-17 Epub Date: 2024-08-05 DOI: 10.1080/17568919.2024.2380245
Changyu Ren, Zhi Cao, Yang Liu, Rui Wang, Congcong Lin, Zishu Wang
{"title":"Medicinal chemistry aspects of fat mass and obesity associated protein: structure, function and inhibitors.","authors":"Changyu Ren, Zhi Cao, Yang Liu, Rui Wang, Congcong Lin, Zishu Wang","doi":"10.1080/17568919.2024.2380245","DOIUrl":"10.1080/17568919.2024.2380245","url":null,"abstract":"<p><p>Adiposity and obesity-related proteins (FTO), the earliest identified mRNA <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) demethylases, are known to play crucial roles in several biological processes. Therefore, FTO is a promising target for anticancer treatment. Understanding the biological functions and regulatory mechanisms of FTO targets can serve as guidelines for drug development. Despite significant efforts to develop FTO inhibitors, no specific small-molecule inhibitors have entered clinical trials so far. In this manuscript, we review the relationship between FTO and various cancers, the small-molecule inhibitors developed against FTO targets from the perspective of medicinal chemistry and other fields, and describe their structural optimization process and structure-activity relationship, providing clues for their future development direction.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"1705-1726"},"PeriodicalIF":3.2,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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