PROBLEMS of Infectious and Parasitic Diseases最新文献

{"title":"RARE CASE OF ASCARIASIS DETECTED BY COLONOSCOPY ON THE BACKGROUND OF ELEVATED LEVELS OF FECAL CALPROTECTIN","authors":"R. Harizanov, I. Kaftandjiev, I. Rainova, N. Tsvetkova","doi":"10.58395/7x6e3005","DOIUrl":"https://doi.org/10.58395/7x6e3005","url":null,"abstract":"Introduction: The causative agents of ascariasis in humans are two species: Ascaris lumbricoides and Ascaris suum. For diagnosis, a fecal sample is most often examined. In some cases, the parasite can be identified when coming out with the intestinal passage, and very rarely up on colonoscopy.\u0000Aim to present a rare case of ascariasis where the diagnosis was made by colonoscopy on the background of elevated levels of fecal calprotectin (f-CP).\u0000Case presentation: A colonoscopy was performed on a 52-year-old female patient due to elevated f-CP. The patient had no complaints. The colonoscopy did not detect pathological changes of the intestinal mucosa, but documented larval stages of Ascaris spp. freely moving in the lumen of the large intestine. The patient was treated with albendazole. Subsequent parasitological examinations of fecal samples were negative.\u0000Discussion: In developed countries, the transmission of Ascaris lumbricoides is greatly reduced. On the background of a very limited transmission of Ascaris lumbricoides, many authors consider that most of the sporadic cases of ascariasis are due to Ascaris suum. In the case described by us, the f-CP levels normalized after the treatment, and for this reason, we cannot categorically reject the relationship between Ascaris infection and elevated f-CP levels.\u0000Conclusion: The presented clinical case is of interest due to the unusual way of diagnosi ascariasis. In the absence of clinical symptoms, and pathological changes of blood and biochemical parameters, except for elevated fecal calprotectin, inflammatory colon disease was suspected and was colonoscopy performed on this occasion.","PeriodicalId":124630,"journal":{"name":"PROBLEMS of Infectious and Parasitic Diseases","volume":"14 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139596140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DECODING MICROBIOME DYSBIOSIS THROUGH METAGENOMIC ALPHA DIVERSITY","authors":"Y. Hodzhev, B. Tsafarova, V. Tolchkov, Vania Youroukova, S. Ivanova, D. Kostadinov, Nikolay Yanev, S. Panaiotov","doi":"10.58395/fmx7px98","DOIUrl":"https://doi.org/10.58395/fmx7px98","url":null,"abstract":"Background: Sarcoidosis is a chronic inflammatory disease that can affect multiple organs. The aetiology of sarcoidosis is not fully understood, but there is increasing evidence that the microbiome may play a role. The blood microbiome is a collection of microorganisms that live in the bloodstream. It is a complex and dynamic community that is influenced by a variety of factors, including the host’s lifestyle and pathology. Recent studies have shown that people with sarcoidosis have alterations in their blood microbiome. These alterations include changes in the diversity, richness, and evenness of the microbial community. The abundance measures by which the blood microbiome diversity may detect instances of dysbiosis related to sarcoidosis aetiology. It should be clearly distinguished from microbiome changes related to unspecific inflammation or sepsis. However, the available evidence suggests that the microbiome may be a promising target for therapeutic interventions.\u0000Aim: The primary goal of this review was to assess and compare the existing metrics of microbiome composition and diversity as established by metagenomic analyses. Additionally, we aim to elucidate the potential causal relationship between these measures, the phenomenon of blood microbiome dysbiosis and the pathogenesis of sarcoidosis.\u0000Conclusion: In the present review, we investigated alpha diversity measures as characteristics of microbiome communities, examining their potential as indicators of dysbiosis, and the probablemechanisms of microbiome participation. A descriptive qualitative comparison was conducted between lung microbiome data of sarcoidosis patients and blood microbiome data of healthy adults. This comparison elucidates common taxa between the two microbiomes and identifies taxa potentially involved in sarcoidosis.","PeriodicalId":124630,"journal":{"name":"PROBLEMS of Infectious and Parasitic Diseases","volume":"32 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139597019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL CASE REPORT: PERTUSSIS INFECTION FOLLOWED BY A PARAPERTUSSIS INFECTION IN THE SAME CHILD","authors":"N. Brankova, Victoria Levterova, M. Ivanova, I. Simeonovski, Мariya Malcheva","doi":"10.58395/faq0fx14","DOIUrl":"https://doi.org/10.58395/faq0fx14","url":null,"abstract":"Whooping cough is a vaccine-preventable, acute respiratory disease caused by the gram-negative bacterium Bordetella pertussis. In recent years there has been a worldwide reccurrence of pertussis infection. The most vulnerable group in society are infants under one year of age, they are at the greatest risk of severe complications or even death. Whooping cough is usually associated with infection caused by B. pertussis, but Bordetella parapertussis can also cause pertussis-like symptoms. The disease is known as parapertussisл Clinical data alone are not sufficient to differentiate between  the two infections. Modern, fast and reliable diagnostic is .needed. Bordetella holmesii, viral infections caused by RSV, adenovirus, etc. can present with pertussis-like symptoms and should be diagnosed and treated accordingly.\u0000The aim of this study is to present a clinical case of a child with pertussis infection followed by parapertussis infection. To diagnose and differentiate the two infections, a real-time PCR molecular genetic method was used to detect the genes specific for the causative agents.\u0000Pertussis vaccination does not protect against B. parapertussis infections, and cross-immunity between the two bacteria has not been observed. Therefore, in the presence of pertussis-like symptoms (paroxysms of persistent cough, vomiting after coughing), it is advisable to differentiate between B. pertussis and B.parapertussis infection, especially in populations with high pertussis vaccination coverage.","PeriodicalId":124630,"journal":{"name":"PROBLEMS of Infectious and Parasitic Diseases","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139625055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REGULATORY MECHANISMS OF ANGIOTENSIN-CONVERTING ENZYME 2 AND THEIR SIGNIFICANCE IN THE DEVELOPMENT OF SEVERE COVID-19","authors":"Mina Pencheva, Neshka A. Manchorova-Veleva","doi":"10.58395/cvkyan65","DOIUrl":"https://doi.org/10.58395/cvkyan65","url":null,"abstract":"From 2019 to the present day, the coronavirus infection COVID-19 continues to be a serious health problem. Scientists and clinicians from all over the world have joined efforts in studying the molecular interaction mechanisms between SARS-CoV-2 and ACE2, including virus-induced changes in ACE2 transcription, expression, and functionalities leading to disruption of basic regulatory pathways for vascular homeostasis, and reprogramming of key proteases, co-receptors and adhesion molecules.\u0000Here, we aimed to clarify the mechanisms and signals that would restore the virus-induced imbalance between destructive and protective effects of ACE2.\u0000Understanding why only certain individuals are predisposed to infection with SARS-CoV-2, and development of severe pathology is at the center of scientific interest, and the strategies for prevention and therapy.","PeriodicalId":124630,"journal":{"name":"PROBLEMS of Infectious and Parasitic Diseases","volume":" 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139623693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NONTUBERCULOUS MYCOBACTERIA - CURRENT RISK IN BULGARIA","authors":"Yuliana Atanasova, Stanislava P Yordanova, Ana Baykova, E. Bachiyska","doi":"10.58395/gnmhxb78","DOIUrl":"https://doi.org/10.58395/gnmhxb78","url":null,"abstract":"Background: Nontuberculous mycobacteria (NTM) are generally free-living and have a potential to cause opportunistic infection. More than 190 species of NTM have been identified (http://www.bacterio.net/mycobacterium.html), up to 60 species of them are pathogenic. The distribution is geographically specific for some species and others are cosmopolitan. Understanding their diversity has practical value for the treatment and management of NTM disease. Except for isolated reports, there is no accurate information about NTM spread among Bulgarian patients.\u0000Material and Methods: We retrospectively analysed the data on the NTM isolated from patients throughout the country for the period from January 2010 to December 2017. Identification to the species level was done by Line Probe Assay (LPA).\u0000Results: 586 NTM strains were identified. We calculated the rate of NTM isolation in Bulgaria and NTM disease incidence by applying microbiological criteria defined by the American Thoracic Society (ATS). As a result, the laboratory isolation rate amounted to 1/100 000 people for the period, and when applying only the ATS criteria, the prevalence of NTM disease was 0,23 per 100 000 people. In both cases, we reported that NTM   disease incidence remains low as compared to tuberculosis, though with an increasing  trend. The prevalence of NTM varied significantly between northern and southern Bulgaria, as well as between the capital and the rest of the country's regions.\u0000Conclusions: Slow growing NTM species predominate in Bulgaria but rapidly growing ones have isolation levels higher than the average for Europe and closer to that of Asian countries. Given the demographic situation in Bulgaria and the changing climatic factors, NTM infections need special attention.","PeriodicalId":124630,"journal":{"name":"PROBLEMS of Infectious and Parasitic Diseases","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139624756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION OF CLINICAL PRESENTATION WITH SEVERITY AND OUTCOME OF COVID-19","authors":"Mariana Stoycheva, Mariela Geneva-Popova, P. Vasilev, Tania Velyanova, P. Argirova, Ivan Baltadjiev","doi":"10.58395/b7vrdc10","DOIUrl":"https://doi.org/10.58395/b7vrdc10","url":null,"abstract":"Background. The world continues to struggle with the 2019 coronavirus disease (COVID-19). The pandemic is under control, but the disease exists and it is extremely important to have algorithms for early diagnostic and prognostic guidance. The aim of the study is to find correlations between the spectrum of clinical symptoms with the disease severity and the outcome of COVID-19, aiming to maximally early diagnosis and establishing early predictors for severity and fatal outcome.\u0000Materials and methods. The study included 169 adults hospitalized at the University Hospital St. George, Plovdiv, between September 2021 and December 2022 with a PCR verified diagnosis of COVID-19. The methods of clinical analysis (history and clinical examination) and assessment of oxygen saturation were used. For the purposes of the study, patients were distributed into groups according to age (below and over 60 years); disease severity (moderate or severe/critical clinical course), and outcome (survived or died).\u0000Results. According to analysed data, 92 patients (54.43%) were men, and 69 (40.82%) were under 60 years; 126 patients (74.5%) had a moderate and 43 (25.4%)-  severe clinical course. The disease has a gradual onset in 149 (88.1 %). The most frequent initial symptoms were fever and fatigue (60.4 %), followed by fatigue with arthro-myalgias (26.2%). Co-morbidities were documented for 140 patients (82.8%). COVID-19 was severe/critical in 14.3% of patients under 60 years and 34.1% of patients ≥ 60 years (p < 0.01), with case fatality rate 7.4% vs.  25% respectively (p < 0.001). Conclusion. Our data highlight the importance of advanced age (over 60 years) and comorbidities ( arterial hypertension, diabetes mellitus, cirrhosis hepatis) as high-risk factors for severe course and fatal outcome of COVID-19","PeriodicalId":124630,"journal":{"name":"PROBLEMS of Infectious and Parasitic Diseases","volume":" 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139625082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANNUAL ANALYSIS OF PARASITIC INFECTIONS IN BULGARIA IN 2022","authors":"R. Harizanov, Mihaela Videnova, Ognyan Mikov, I. Kaftandjiev, A. Ivanova, E. Kaneva, R. Borisova, N. Tsvetkova, I. Rainova, Violeta Yakimova","doi":"10.58395/5hpwmk26","DOIUrl":"https://doi.org/10.58395/5hpwmk26","url":null,"abstract":"INTRODUCTION: Infections caused by parasites still represent an important global health problem. Although parasitic infections are responsible for significant morbidity and mortality in developing countries, they are also prevalent in developed countries. This study aims to establish the dynamics of the parasitic infections registered in the country (local and imported) and to analyze the situation, based on data from the previous years.\u0000METHODS: We used the annual reports of regional health inspectorates, diagnostic laboratories, medical universities, and data from the National center of infectious and parasitic diseases about all individuals infected with parasitic diseases in the country.\u0000RESULTS: A total of 635,522 persons were examined in 2022, of whom 1.82% were diagnosed with various parasitic infections. In the local helminthic zoonoses such as echinococcosis and trichinellosis, a significant decrease in morbidity was observed,1.3%₀₀₀ (n = 89) for cystic echinococcosis and 0.16%₀₀₀ (n = 9) for trichinellosis. For soil-transmitted helminthiases (ascariasis and trichuriasis), the incidence was 6.7%₀₀₀ and 0.5%₀₀₀, respectively. Data on enterobiasis does not show any particular dynamics in 2022 either. The registered prevalence for the country was 1.48%, and for children from various childcare facilities - 2.45%. During the year, seven cases of vector-borne parasitic diseases were registered in the country: imported malaria was diagnosed in 5 patients (4 Bulgarian citizens and one foreigner), and autochthonous visceral leishmaniasis - in two persons.\u0000CONCLUSIONS: The analysis shows that, in spite of a trend of   declining   morbidityfor some socially significant protozoan and helminth infections, human parasitic diseases still represent a significant problem with social and medical consequences for the population of our country. Therefore, it is necessary to preserve and strengthen the surveillance and control network  by including new personnel in the medical parasitology structures.","PeriodicalId":124630,"journal":{"name":"PROBLEMS of Infectious and Parasitic Diseases","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139624421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADVERSE EVENTS FOLLOWING VACCINATION WITH A VIRAL VECTOR-BASED VACCINE - A CROSS-SECTIONAL STUDY","authors":"V. Rangelova, Zhivka Getsova","doi":"10.58395/dvaah470","DOIUrl":"https://doi.org/10.58395/dvaah470","url":null,"abstract":"Background: The effectiveness and safety of recently implemented COVID-19 vaccine platforms are often compared since the launch of the mass vaccination campaign worldwide. The aim of the present study is to assess the prevalence of adverse events (AEs) occurring after vaccination with the two viral vector-based vaccines authorized in the European Union to prevent COVID-19. \u0000Materials and methods: A survey was carried out among adults who have completed vaccination with either of the viral vector-based vaccine approved for use in Bulgaria ChAdOx1-S nCoV-19 vaccine (commonly known as Astra Zeneca or Vaxzevria) or Ad26.COV2S vaccine (commonly known as Janssen or JCOVDEN). For the data analysis, standard descriptive statistics was used. Quantitative variables are presented by the mean and standard deviation (mean ± SD) or median (25th percentile; 75th percentile). Qualitative variables are presented as numbers absolute/relative frequencies totals and percentages. The Kolmogorov-Smirnov test was used to obtain information regarding the distribution of the sampled patients. The chi-square test for independence was used to determine whether differences between observed and theoretical distributions existed. \u0000Results: In total 314 respondents took part in the study. Of them, 273 (86.9%) reported at least one local AE after the first dose of a vaccine, and the prevalence among the ChAdOx1-S vaccine group was significantly higher (88.5%) than in the Ad26.COV2.S vaccine group (59.2%) (Pearson χ2 test=19.942, p=0.000). The most common systemic AEs after administration of a viral vector-based vaccine were chills (77.3% for ChAdOx1-S and 25.9% for Ad26. COV2.S.) fatigue (76.3% for ChAdOx1-S and 25.9% for Ad26.COV2.S.), and headache (62.3% for ChAdOx1-S and 25.9% for Ad26.COV2.S.). Those adverse events appeared significantly more often in participants vaccinated with the ChAdOx1-S vaccine. \u0000Conclusion: The analysis of the collected data proves that although common, AEs following vaccination with vector-based products are classified as mild and usually resolve within 48 hours of dose administration.","PeriodicalId":124630,"journal":{"name":"PROBLEMS of Infectious and Parasitic Diseases","volume":"44 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123202798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CLINICAL CASE OF PULMONARY NOCARDIOSIS IN AN IMMUNOCOMPROMISED PATIENT","authors":"L. Boyanova, Z. Ivanova","doi":"10.58395/xqn34m62","DOIUrl":"https://doi.org/10.58395/xqn34m62","url":null,"abstract":"Nocardia microorganisms are saprophytes, either non-pathogenic or pathogenic, causing nocardiosis. The clinically significant disease  occurs in immunocompromised people, most often as pneumonia with cough, dyspnea, and fever. Antibiotic therapy, which is longer in time, is necessary. The main treatment is with sulfonamides, but the sensitivity of these bacteria varies. Therefore, the antibiotic susceptibility of the respective strain is important to apply combined therapy if needed. The risk of death without treatment is high, especially if the infection disseminates and the brain is involved. Antibacterial prophylaxis is therefore recommended in patients at high risk of nocardiosis. Our clinical case concerns an immunocompromised patient with isolated Nocardia from bronchoalveolar lavage (BAL).","PeriodicalId":124630,"journal":{"name":"PROBLEMS of Infectious and Parasitic Diseases","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128928110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEVELOPMENT AND PILOT VALIDATION OF A NOVEL PCR-BASED REPLICON TYPING SCHEME FOR PLASMID FAMILIES ASSOCIATED WITH ANTIBIOTIC RESISTANCE IN PSEUDOMONAS SPP.","authors":"Ivan Stoikov, I. Ivanov, E. Dobreva, Deyan Donchev, S. Sabtcheva, R. Hristova","doi":"10.58395/f06f4r51","DOIUrl":"https://doi.org/10.58395/f06f4r51","url":null,"abstract":"Background. Pseudomonas species are ubiquitous environmental Gram-negative bacteria increasingly associated with difficult to treat healthcare-associated infections. Along with their substantial intrinsic antimicrobial resistance, the ability to acquire additional resistance and pathogenicity determinants contributes to increased morbidity and mortality. Plasmids represent the major vehicles of gene transfer among hospital strains. Accumulation and dissemination of resistance genes through horizontal gene transfer is exceptionally problematic since it leads to the emergence of multi-resistant and stable phenotypes highlighting the importance of novel tools for studying plasmid epidemiology.\u0000Materials and Methods. In this study we introduce a novel PCR-based replicon typing (PBRT) scheme for differentiation of various Pseudomonas spp. plasmid families requiring only two multiplex PCR (mPCR) assays. mPCR 1 is composed of previously published primer sets for IncP-1, IncP-7, IncP-9, IncQ, A/C, N, W, IncU. Primers for multiplex PCR 2 were designed after an in-depth in-silico bioinformatic analysis of the repA gene of more than 50 reference IncP-2, IncP-6, IncP-10, pKLC102-like and pMOS94-like plasmids some of which studied for the first time as a group.\u0000Results. The scheme was tested on a set of 90 previously genotyped multi-resistant clinical Pseudomonas spp. isolates. The detection rate of the target plasmid families was low in our strain collection. Replicons were registered in only 3/90 isolates from the IncP-7 (n=1), IncP-10 (n=1), and pMOS94-like (n=1) families. This pilot study demonstrates a novel PBRT scheme applicable to Pseudomonas spp. targeting plasmids of incompatibility groups known to harbour genes associated with antibiotic resistance.","PeriodicalId":124630,"journal":{"name":"PROBLEMS of Infectious and Parasitic Diseases","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125314276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}