{"title":"血管紧张素转换酶 2 的调控机制及其在严重并发症-19 中的意义","authors":"Mina Pencheva, Neshka A. Manchorova-Veleva","doi":"10.58395/cvkyan65","DOIUrl":null,"url":null,"abstract":"From 2019 to the present day, the coronavirus infection COVID-19 continues to be a serious health problem. Scientists and clinicians from all over the world have joined efforts in studying the molecular interaction mechanisms between SARS-CoV-2 and ACE2, including virus-induced changes in ACE2 transcription, expression, and functionalities leading to disruption of basic regulatory pathways for vascular homeostasis, and reprogramming of key proteases, co-receptors and adhesion molecules.\nHere, we aimed to clarify the mechanisms and signals that would restore the virus-induced imbalance between destructive and protective effects of ACE2.\nUnderstanding why only certain individuals are predisposed to infection with SARS-CoV-2, and development of severe pathology is at the center of scientific interest, and the strategies for prevention and therapy.","PeriodicalId":124630,"journal":{"name":"PROBLEMS of Infectious and Parasitic Diseases","volume":" 32","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"REGULATORY MECHANISMS OF ANGIOTENSIN-CONVERTING ENZYME 2 AND THEIR SIGNIFICANCE IN THE DEVELOPMENT OF SEVERE COVID-19\",\"authors\":\"Mina Pencheva, Neshka A. Manchorova-Veleva\",\"doi\":\"10.58395/cvkyan65\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"From 2019 to the present day, the coronavirus infection COVID-19 continues to be a serious health problem. Scientists and clinicians from all over the world have joined efforts in studying the molecular interaction mechanisms between SARS-CoV-2 and ACE2, including virus-induced changes in ACE2 transcription, expression, and functionalities leading to disruption of basic regulatory pathways for vascular homeostasis, and reprogramming of key proteases, co-receptors and adhesion molecules.\\nHere, we aimed to clarify the mechanisms and signals that would restore the virus-induced imbalance between destructive and protective effects of ACE2.\\nUnderstanding why only certain individuals are predisposed to infection with SARS-CoV-2, and development of severe pathology is at the center of scientific interest, and the strategies for prevention and therapy.\",\"PeriodicalId\":124630,\"journal\":{\"name\":\"PROBLEMS of Infectious and Parasitic Diseases\",\"volume\":\" 32\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"PROBLEMS of Infectious and Parasitic Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.58395/cvkyan65\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"PROBLEMS of Infectious and Parasitic Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.58395/cvkyan65","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
REGULATORY MECHANISMS OF ANGIOTENSIN-CONVERTING ENZYME 2 AND THEIR SIGNIFICANCE IN THE DEVELOPMENT OF SEVERE COVID-19
From 2019 to the present day, the coronavirus infection COVID-19 continues to be a serious health problem. Scientists and clinicians from all over the world have joined efforts in studying the molecular interaction mechanisms between SARS-CoV-2 and ACE2, including virus-induced changes in ACE2 transcription, expression, and functionalities leading to disruption of basic regulatory pathways for vascular homeostasis, and reprogramming of key proteases, co-receptors and adhesion molecules.
Here, we aimed to clarify the mechanisms and signals that would restore the virus-induced imbalance between destructive and protective effects of ACE2.
Understanding why only certain individuals are predisposed to infection with SARS-CoV-2, and development of severe pathology is at the center of scientific interest, and the strategies for prevention and therapy.