血管紧张素转换酶 2 的调控机制及其在严重并发症-19 中的意义

Mina Pencheva, Neshka A. Manchorova-Veleva
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引用次数: 0

摘要

从2019年至今,冠状病毒感染COVID-19仍是一个严重的健康问题。来自世界各地的科学家和临床医生共同致力于研究SARS-CoV-2与ACE2之间的分子相互作用机制,包括病毒诱导的ACE2转录、表达和功能变化导致血管稳态基本调控通路的破坏,以及关键蛋白酶、共受体和粘附分子的重编程。在这里,我们的目标是阐明能恢复由病毒引起的 ACE2 破坏作用和保护作用之间失衡的机制和信号。了解为什么只有某些人才容易感染 SARS-CoV-2 并发展成严重病症是科学界关注的焦点,也是预防和治疗策略的核心。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
REGULATORY MECHANISMS OF ANGIOTENSIN-CONVERTING ENZYME 2 AND THEIR SIGNIFICANCE IN THE DEVELOPMENT OF SEVERE COVID-19
From 2019 to the present day, the coronavirus infection COVID-19 continues to be a serious health problem. Scientists and clinicians from all over the world have joined efforts in studying the molecular interaction mechanisms between SARS-CoV-2 and ACE2, including virus-induced changes in ACE2 transcription, expression, and functionalities leading to disruption of basic regulatory pathways for vascular homeostasis, and reprogramming of key proteases, co-receptors and adhesion molecules. Here, we aimed to clarify the mechanisms and signals that would restore the virus-induced imbalance between destructive and protective effects of ACE2. Understanding why only certain individuals are predisposed to infection with SARS-CoV-2, and development of severe pathology is at the center of scientific interest, and the strategies for prevention and therapy.
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