Gastroenterology Research最新文献_第9页

Primary Non-Function of Hepatic Allograft With Preexisting Microvesicular Steatosis/Foamy Degeneration and Mild Large-Droplet Macrovesicular Steatosis. 肝脏异体移植物原发性无功能，伴有原有的微泡性脂肪变性/泡沫变性和轻度大滴大泡性脂肪变性。

IF 1.5

Gastroenterology Research Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI: 10.14740/gr1687

Melissa E Limia, Xiu Li Liu, Jennifer Yu, Kathleen Byrnes

{"title":"Primary Non-Function of Hepatic Allograft With Preexisting Microvesicular Steatosis/Foamy Degeneration and Mild Large-Droplet Macrovesicular Steatosis.","authors":"Melissa E Limia, Xiu Li Liu, Jennifer Yu, Kathleen Byrnes","doi":"10.14740/gr1687","DOIUrl":"10.14740/gr1687","url":null,"abstract":"It has been established that more than mild large-droplet macrovesicular steatosis (LD-MAS) is associated with increased risk of graft non-function. In contrast, even severe small-droplet macrovesicular steatosis (SD-MAS) has been found to be less prognostically significant. It remains unclear if a donor liver with diffuse microvesicular steatosis is associated with an increased risk of graft dysfunction. A 56-year-old male with alcoholic cirrhosis was transplanted with a liver from a 42-year-old overweight male donor after brain death. The frozen section of the donor liver biopsy taken at harvest showed diffusely enlarged clear/foamy hepatocytes and mild LD-MAS (about 5-10% of total tissue). The reperfusion liver biopsy taken at time 0 of transplantation showed hemorrhage, pale and enlarged hepatocytes, and mild LD-MAS (about 10% of total tissue) with lipopeliosis. The graft became non-functional, and the patient was re-transplanted 24 h after the initial transplantation. Histologic examination of the failed liver allograft showed extensive hemorrhagic necrosis, neutrophilic inflammation, diffuse microvesicular steatosis, and large extracellular fat droplets (about 20% of total tissue). This case demonstrates that precautions are needed to avoid using livers with diffuse and severe microvesicular steatosis.","PeriodicalId":12461,"journal":{"name":"Gastroenterology Research","volume":"17 1","pages":"37-40"},"PeriodicalIF":1.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre- and Post-Implant Endoscopy in Left Ventricular Assist Device Recipients: A Single-Center Experience. 左心室辅助装置受术者植入前后的内窥镜检查：单中心经验。

IF 1.5

Gastroenterology Research Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI: 10.14740/gr1661

Wael T Mohamed, Vinay Jahagirdar, Fouad Jaber, Mohamed K Ahmed, Hassan M Ghoz, Brett W Sperry, Wendell K Clarkston

{"title":"Pre- and Post-Implant Endoscopy in Left Ventricular Assist Device Recipients: A Single-Center Experience.","authors":"Wael T Mohamed, Vinay Jahagirdar, Fouad Jaber, Mohamed K Ahmed, Hassan M Ghoz, Brett W Sperry, Wendell K Clarkston","doi":"10.14740/gr1661","DOIUrl":"10.14740/gr1661","url":null,"abstract":"Background: Gastrointestinal bleeding (GIB) is common in left ventricular assist devices (LVADs) patients, but the optimal screening approach before LVAD implantation is still unclear. The aim of the study was to describe our experience with pre- and post-LVAD implantation endoscopic screening and subsequent GI bleeding in this cohort.Methods: A retrospective review was conducted among all patients who underwent LVAD implantation at Saint Luke's Hospital, between 2010 and 2020. The data were reviewed to determine the yield and safety of endoscopic procedures performed within 1 month before LVAD placement and the incidence of GIB within 1 year after implantation.Results: A total of 167 LVAD patients met the inclusion criteria, and 23 underwent pre-implantation endoscopic evaluation. Angiodysplasia had a significantly higher odds ratio (OR) of 9.41 (95% confidence interval (CI): 2.01 - 44.09) in post-LVAD endoscopy, while there was no significant difference in bleeding from other sources such as peptic ulcer disease or diverticular bleeding. There was no difference in the incidence of GIB in patients who underwent endoscopic evaluation pre-LVAD compared to post-LVAD GIB (32.6% vs. 39.1%, P = 0.64). Endoscopy was well-tolerated in this cohort, and argon plasma coagulation was the most commonly used intervention to achieve hemostasis.Conclusions: According to our results, we recommend against routine pre-LVAD endoscopic screening. Instead, we suggest an individualized approach, where decisions are made on a case-by-case basis.","PeriodicalId":12461,"journal":{"name":"Gastroenterology Research","volume":"17 1","pages":"1-9"},"PeriodicalIF":1.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Activin A Is a Novel Biomarker of Endoscopic Activity in Ulcerative Colitis 血清活化素 A 是溃疡性结肠炎内镜活动的新型生物标记物

IF 1.5

Gastroenterology Research Pub Date : 2023-12-01 DOI: 10.14740/gr1677

Ryohei Ogihara, Hiroki Kurumi, Tsutomu Kanda, Kazuo Yashima, Hajime Isomoto, N. Yamaguchi

引用次数: 0

Comparing the Efficacy and Safety of Adalimumab and Vedolizumab in Treating Moderate to Severe Crohn’s Disease and Ulcerative Colitis 比较阿达木单抗和维多珠单抗治疗中重度克罗恩病和溃疡性结肠炎的疗效和安全性

IF 1.5

Gastroenterology Research Pub Date : 2023-12-01 DOI: 10.14740/gr1664

Nooraldin Merza, Yusuf Nawras, Omar Saab, D. Dahiya, Zohaib Ahmed, Meghana Ranabothu, Safa Boujemaa, Mona Hassan, Abdallah A. Kobeissy, Kirthi Lilley

引用次数: 0

Identifying Key Genes to the Early Diagnosis of Inflammatory Bowel Disease by Integrating Analysis at the Blood and Tissue Levels 通过整合血液和组织水平的分析鉴定炎症性肠病早期诊断的关键基因

IF 1.5

Gastroenterology Research Pub Date : 2023-12-01 DOI: 10.14740/gr1683

Xin Yu Wang, Dan Zhang

引用次数: 0

Timing and Outcomes of Percutaneous Endoscopic Gastrostomy After Ischemic Stroke 缺血性脑卒中后经皮内镜胃造瘘术的时机和疗效

IF 1.5

Gastroenterology Research Pub Date : 2023-12-01 DOI: 10.14740/gr1653

Shoma Bommena, Pooja Rangan, Joyce lee-Iannotti, W. Wassef, Rakesh Nanda

引用次数: 0

Marital Status Is a Prognostic Factor for Cardiovascular Mortality but Not a Prognostic Factor for Cancer Mortality in Siewert Type II Adenocarcinoma of the Esophagogastric Junction 婚姻状况是食管胃交界处 Siewert II 型腺癌心血管死亡率的预后因素，但不是癌症死亡率的预后因素

IF 1.5

Gastroenterology Research Pub Date : 2023-12-01 DOI: 10.14740/gr1670

Zhong Qiang Zheng, Xuan Zi Sun

引用次数: 0

The Impact of COVID-19 on Outcomes of Ischemic Colitis: A Nationwide Retrospective Analysis. 新冠肺炎对缺血性结肠炎预后的影响：全国回顾性分析。

IF 1.5

Gastroenterology Research Pub Date : 2023-10-01 Epub Date: 2023-10-21 DOI: 10.14740/gr1660

Humzah Iqbal, Rakahn Haddadin, Patrick Zhang, Hasib Haidary, Devang Prajapati

{"title":"The Impact of COVID-19 on Outcomes of Ischemic Colitis: A Nationwide Retrospective Analysis.","authors":"Humzah Iqbal, Rakahn Haddadin, Patrick Zhang, Hasib Haidary, Devang Prajapati","doi":"10.14740/gr1660","DOIUrl":"10.14740/gr1660","url":null,"abstract":"Background: Ischemic colitis is the most common presentation of mesenteric ischemia and is associated with significant morbidity and mortality. Coagulopathy has been associated with the development of ischemic colitis. Coronavirus disease 2019 (COVID-19) infection can lead to a variety of pathology and physiological derangements, including coagulopathy. Some case reports have described severe ischemic colitis in patients with COVID-19 infection. Our study aimed to elucidate the impact of COVID-19 infection on ischemic colitis outcomes.Methods: Patients with a diagnosis of ischemic colitis were identified using the 2020 Nationwide Inpatient Sample (NIS). Patients were stratified based on the presence of COVID-19 infection. Data were collected regarding mortality, shock, blood transfusion, length of stay, hospital charges, age, gender, race, primary insurance, median income, hospital region, hospital bed size, and comorbidities. The relationship between COVID-19 and outcomes was analyzed using multivariate regression analysis.Results: A total of 67,685 patients were included in the final analysis. COVID-19 was associated with an increased risk of in-hospital mortality (adjusted odds ratio (aOR): 4.006, P < 0.001), shock (aOR: 1.62, P = 0.002), and blood transfusion (aOR: 1.49, P = 0.007). COVID-19 was also associated with an increased length of stay (16.2 days vs. 8.7 days) and higher total hospital charges ($268,884.1 vs. $145,805.9).Conclusions: Among hospitalized patients with ischemic colitis, COVID-19 infection was associated with worse outcomes and higher resource utilization. Further studies are needed to investigate the mechanisms underlying this association.","PeriodicalId":12461,"journal":{"name":"Gastroenterology Research","volume":"16 5","pages":"270-275"},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71480108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 Outcomes in Inflammatory Bowel Disease Hospitalized Patients: A Comprehensive Analysis Using the National Inpatient Sample. 炎症性肠病住院患者的新冠肺炎结局：使用全国住院患者样本的综合分析。

IF 1.5

Gastroenterology Research Pub Date : 2023-10-01 Epub Date: 2023-10-21 DOI: 10.14740/gr1657

Justin M Joseph, Anum Akhlaq, Rehmat Ullah Awan, Saleha Aziz, Moon Ryu, Asif Farooq, Karthik Gangu, Ehizogie Edigin, Abu Baker Sheikh

{"title":"COVID-19 Outcomes in Inflammatory Bowel Disease Hospitalized Patients: A Comprehensive Analysis Using the National Inpatient Sample.","authors":"Justin M Joseph, Anum Akhlaq, Rehmat Ullah Awan, Saleha Aziz, Moon Ryu, Asif Farooq, Karthik Gangu, Ehizogie Edigin, Abu Baker Sheikh","doi":"10.14740/gr1657","DOIUrl":"10.14740/gr1657","url":null,"abstract":"Background: There is no uniformity in the available literature concerning the effects of coronavirus disease 2019 (COVID-19) viral illness on people with inflammatory bowel disease (IBD).Methods: We conducted an analysis using the 2020 National Inpatient Sample (NIS) database to compare the outcomes of COVID-19 hospitalized patients with and without IBD.Results: Of 1,050,040 patients admitted with COVID-19, 5,750 (0.5%) also had IBD. The group with COVID-19 and IBD had higher percentages of females and White individuals and a greater prevalence of chronic lung disease, peripheral vascular disease, and liver disease. However, after accounting for confounding variables, there was no significant difference in mortality rates, length of hospital stays, or hospitalization costs between the two groups.Conclusion: According to our findings, the presence of IBD does not appear to elevate the risk of COVID-19 complications.","PeriodicalId":12461,"journal":{"name":"Gastroenterology Research","volume":"16 5","pages":"262-269"},"PeriodicalIF":1.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71480104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal Mucormycosis: A Clinical Review. 胃肠道毛霉菌病：临床综述。

IF 1.5

Gastroenterology Research Pub Date : 2023-10-01 Epub Date: 2023-10-21 DOI: 10.14740/gr1662

Yazan Addasi, Anny H Nguyen, Ahmed Sabri, Faran Ahmad, Rajani Rangray, Manasa Velagapudi

引用次数: 0