Frontiers in Biology最新文献_第9页

Comparative analysis of metabolic network of pathogens 病原菌代谢网络的比较分析

Frontiers in Biology Pub Date : 2017-04-14 DOI: 10.1007/s11515-017-1440-8

K. Gaurav, Y. Hasija

引用次数: 1

Crosstalk between catecholamines and erythropoiesis 儿茶酚胺与红细胞生成的串扰

Frontiers in Biology Pub Date : 2017-04-14 DOI: 10.1007/s11515-017-1428-4

Fakhredin Saba, N. Saki, E. Khodadi, M. Soleimani

引用次数: 8

Antioxidative properties of phenolic compounds isolated from the fungal endophytes of Zingiber nimmonii (J. Graham) Dalzell. 从姜内生真菌中分离的酚类化合物的抗氧化特性。

Frontiers in Biology Pub Date : 2017-04-14 DOI: 10.1007/s11515-016-1441-z

M. Das, H. Prakash, M. Nalini

引用次数: 8

Intestinal organoid as an in vitro model in studying host-microbial interactions. 肠道类器官作为研究宿主-微生物相互作用的体外模型。

Frontiers in Biology Pub Date : 2017-04-01 Epub Date: 2017-03-07 DOI: 10.1007/s11515-017-1444-4

Jun Sun

{"title":"Intestinal organoid as an in vitro model in studying host-microbial interactions.","authors":"Jun Sun","doi":"10.1007/s11515-017-1444-4","DOIUrl":"https://doi.org/10.1007/s11515-017-1444-4","url":null,"abstract":"Background: Organoid is an in vitro three-dimensional organ-bud that shows realistic microanatomy and physiologic relevance. The progress in generating organoids that faithfully recapitulate human in vivo tissue composition has extended organoid applications from being just a basic research tool to a translational platform with a wide range of uses. Study of host-microbial interactions relies on model systems to mimic the in vivo infection. Researchers have developed various experimental models in vitro and in vivo to examine the dynamic host-microbial interactions. For some infectious pathogens, model systems are lacking whereas some of the used systems are far from optimal.Objective: In the present work, we will review the brief history and recent findings using organoids for studying host-microbial interactions.Methods: A systematic literature search was performed using the PubMed search engine. We also shared our data and research contribution to the field.Results: we summarize the brief history of 3D organoids. We discuss the feasibility of using organoids in studying host-microbial interactions, focusing on the development of intestinal organoids and gastric organoids. We highlight the advantage and challenges of the new experimental models. Further, we discuss the future direction in using organoids in studying host-microbial interactions and its potential application in biomedical studies.Conclusion: In combination with genetic, transcriptome and proteomic profiling, both murine- and human-derived organoids have revealed crucial aspects of development, homeostasis and diseases. Specifically, human organoids from susceptible host will be used to test their responses to pathogens, probiotics, and drugs. Organoid system is an exciting tool for studying infectious disease, microbiome, and therapy.","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"12 2","pages":"94-102"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-017-1444-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37052150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The radial organization of neuronal primary cilia is acutely disrupted by seizure and ischemic brain injury. 神经元初级纤毛的放射状组织会因癫痫发作和缺血性脑损伤而受到急性破坏。

Frontiers in Biology Pub Date : 2017-04-01 Epub Date: 2017-03-08 DOI: 10.1007/s11515-017-1447-1

Gregory W Kirschen, Hanxiao Liu, Tracy Lang, Xuelin Liang, Shaoyu Ge, Qiaojie Xiong

{"title":"The radial organization of neuronal primary cilia is acutely disrupted by seizure and ischemic brain injury.","authors":"Gregory W Kirschen, Hanxiao Liu, Tracy Lang, Xuelin Liang, Shaoyu Ge, Qiaojie Xiong","doi":"10.1007/s11515-017-1447-1","DOIUrl":"10.1007/s11515-017-1447-1","url":null,"abstract":"Background: Neuronal primary cilia are sensory organelles that are critically involved in the proper growth, development, and function of the central nervous system (CNS). Recent work also suggests that they signal in the context of CNS injury, and that abnormal ciliary signaling may be implicated in neurological diseases.Methods: We quantified the distribution of neuronal primary cilia alignment throughout the normal adult mouse brain by immunohistochemical staining for the primary cilia marker adenylyl cyclase III (ACIII) and measuring the angles of primary cilia with respect to global and local coordinate planes. We then introduced two different models of acute brain insult-temporal lobe seizure and cerebral ischemia, and re-examined neuronal primary cilia distribution, as well as ciliary lengths and the proportion of neurons harboring cilia.Results: Under basal conditions, cortical cilia align themselves radially with respect to the cortical surface, while cilia in the dentate gyrus align themselves radially with respect to the granule cell layer. Cilia of neurons in the striatum and thalamus, by contrast, exhibit a wide distribution of ciliary arrangements. In both cases of acute brain insult, primary cilia alignment was significantly disrupted in a region-specific manner, with areas affected by the insult preferentially disrupted. Further, the two models promoted differential effects on ciliary lengths, while only the ischemia model decreased the proportion of ciliated cells.Conclusions: These findings provide evidence for the regional anatomical organization of neuronal primary cilia in the adult brain and suggest that various brain insults may disrupt this organization.","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"12 2","pages":"124-138"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412953/pdf/nihms860631.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34969575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete mitochondrial genome of Ampittia dioscorides (Lepidoptera: Hesperiidae) and its phylogenetic analysis 薯蓣Ampittia dioscorides线粒体全基因组及其系统发育分析

Frontiers in Biology Pub Date : 2017-02-28 DOI: 10.1007/s11515-016-1434-y

Xin-Min Qin, Xiao-wen Yang, li-xia hou, Hui-min Li

引用次数: 2

Association between microRNA-21, microRNA-150, and micro-RNA-451 expression and clinical outcome of patients with acute lymphoblastic leukemia 微小RNA-21、微小RNA-150和微小-RNA-451表达与急性淋巴细胞白血病患者临床转归的关系

Frontiers in Biology Pub Date : 2017-02-28 DOI: 10.1007/s11515-016-1437-8

A. Asnafi, E. Khodadi, N. Golchin, Arash Alghasi, Y. Tavakolifar, N. Saki

引用次数: 7

Mechanisms of genome instability in Hutchinson-Gilford progeria Hutchinson-Gilford早衰症基因组不稳定的机制

Frontiers in Biology Pub Date : 2017-02-28 DOI: 10.1007/s11515-016-1435-x

Haoyue Zhang, Kan Cao

引用次数: 0

Intracellular organelle networks: Understanding their organization and communication through systems-level modeling and analysis 胞内细胞器网络:通过系统级建模和分析来理解它们的组织和交流

Frontiers in Biology Pub Date : 2017-02-28 DOI: 10.1007/s11515-016-1436-9

Qinle Ba, Ge Yang

引用次数: 6

Molecular and genetic insights into an infantile epileptic encephalopathy - CDKL5 disorder. 婴儿癫痫性脑病- CDKL5紊乱的分子和遗传学见解。

Frontiers in Biology Pub Date : 2017-02-01 Epub Date: 2017-01-23 DOI: 10.1007/s11515-016-1438-7

Ailing Zhou, Song Han, Zhaolan Joe Zhou

{"title":"Molecular and genetic insights into an infantile epileptic encephalopathy - CDKL5 disorder.","authors":"Ailing Zhou, Song Han, Zhaolan Joe Zhou","doi":"10.1007/s11515-016-1438-7","DOIUrl":"https://doi.org/10.1007/s11515-016-1438-7","url":null,"abstract":"Background: The discovery that mutations in cyclin-dependent kinase-like 5 (CDKL5) gene are associated with infantile epileptic encephalopathy has stimulated world-wide research effort to understand the molecular and genetic basis of CDKL5 disorder. Given the large number of literature published thus far, this review aims to summarize current genetic studies, draw a consensus on proposed molecular functions, and point to gaps of knowledge in CDKL5 research.Methods: A systematic review process was conducted using the PubMed search engine focusing on CDKL5 studies in the recent ten years. We analyzed these publications and summarized the findings into four sections: genetic studies, CDKL5 expression patterns, molecular functions, and animal models. We also discussed challenges and future directions in each section.Results: On the clinical side, CDKL5 disorder is characterized by early onset epileptic seizures, intellectual disability, and stereotypical behaviors. On the research side, a series of molecular and genetic studies in human patients, cell cultures and animal models have established the causality of CDKL5 to the infantile epileptic encephalopathy, and pointed to a key role for CDKL5 in regulating neuronal function in the brain. Mouse models of CDKL5 disorder have also been developed, and notably, manifest behavioral phenotypes, mimicking numerous clinical symptoms of CDKL5 disorder and advancing CDKL5 research to the preclinical stage.Conclusions: Given what we have learned thus far, future identification of robust, quantitative, and sensitive outcome measures would be the key in animal model studies, particularly in heterozygous females. In the meantime, molecular and cellular studies of CDKL5 should focus on mechanism-based investigation and aim to uncover druggable targets that offer the potential to rescue or ameliorate CDKL5 disorder-related phenotypes.","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"12 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-016-1438-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35058490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18