Frontiers in Biology最新文献

{"title":"Putting it all together: intrinsic and extrinsic mechanisms governing proteasome biogenesis","authors":"Lauren A Howell, R. Tomko, A. Kusmierczyk","doi":"10.1007/s11515-017-1439-1","DOIUrl":"https://doi.org/10.1007/s11515-017-1439-1","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"12 1","pages":"19-48"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-017-1439-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47195092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhizoplane microbiota of superior wheat varieties possess enhanced plant growth-promoting abilities","authors":"A. Siddiqa, Y. Rehman, S. Hasnain","doi":"10.1007/s11515-016-1426-y","DOIUrl":"https://doi.org/10.1007/s11515-016-1426-y","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"11 1","pages":"481-487"},"PeriodicalIF":0.0,"publicationDate":"2016-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-016-1426-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53096790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcription factor Pitx3 mutant mice as a model for Parkinson’s disease","authors":"F. Zhou, Li Li, Juming Yue, J. Dani","doi":"10.1007/s11515-016-1429-8","DOIUrl":"https://doi.org/10.1007/s11515-016-1429-8","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"11 1","pages":"427-438"},"PeriodicalIF":0.0,"publicationDate":"2016-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-016-1429-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53096863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the bioactive potential of Serriatia marcescens VITAPI (Acc: 1933637) isolated from soil","authors":"A. Muthukumar, P. Pradeep, Isha Thigale, V. Mohanasrinivasan, Naine S. Jemimah, C. Subathra Devi","doi":"10.1007/s11515-016-1430-2","DOIUrl":"https://doi.org/10.1007/s11515-016-1430-2","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"11 1","pages":"476-480"},"PeriodicalIF":0.0,"publicationDate":"2016-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-016-1430-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53096919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor XIII Val34Leu polymorphism and risk of recurrent pregnancy loss in Iranian population: a case control study","authors":"Seyed Mehdi Sajjadi, A. Khosravi, Jalil Pakravesh, Z. Soheili, S. Samiei, S. Mohammadi, Mohammad Ali Jalali Far","doi":"10.1007/s11515-016-1419-x","DOIUrl":"https://doi.org/10.1007/s11515-016-1419-x","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"11 1","pages":"471-475"},"PeriodicalIF":0.0,"publicationDate":"2016-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-016-1419-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53096503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronal activity controls the development of interneurons in the somatosensory cortex.","authors":"Rachel Babij, Natalia De Marco Garcia","doi":"10.1007/s11515-016-1427-x","DOIUrl":"10.1007/s11515-016-1427-x","url":null,"abstract":"<p><strong>Background: </strong>Neuronal activity in cortical areas regulates neurodevelopment by interacting with defined genetic programs to shape the mature central nervous system. Electrical activity is conveyed to sensory cortical areas via intracortical and thalamocortical neurons, and includes oscillatory patterns that have been measured across cortical regions.</p><p><strong>Objective: </strong>In this work, we review the most recent findings about how electrical activity shapes the developmental assembly of functional circuitry in the somatosensory cortex, with an emphasis on interneuron maturation and integration. We include studies on the effect of various neurotransmitters and on the influence of thalamocortical afferent activity on circuit development. We additionally reviewed studies describing network activity patterns.</p><p><strong>Methods: </strong>We conducted an extensive literature search using both the PubMed and Google Scholar search engines. The following keywords were used in various iterations: \"interneuron\", \"somatosensory\", \"development\", \"activity\", \"network patterns\", \"thalamocortical\", \"NMDA receptor\", \"plasticity\". We additionally selected papers known to us from past reading, and those recommended to us by reviewers and members of our lab.</p><p><strong>Results: </strong>We reviewed a total of 132 articles that focused on the role of activity in interneuronal migration, maturation, and circuit development, as well as the source of electrical inputs and patterns of cortical activity in the somatosensory cortex. 79 of these papers included in this timely review were written between 2007 and 2016.</p><p><strong>Conclusions: </strong>Neuronal activity shapes the developmental assembly of functional circuitry in the somatosensory cortical interneurons. This activity impacts nearly every aspect of development and acquisition of mature neuronal characteristics, and may contribute to changing phenotypes, altered transmitter expression, and plasticity in the adult. Progressively changing oscillatory network patterns contribute to this activity in the early postnatal period, although a direct requirement for specific patterns and origins of activity remains to be demonstrated.</p>","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"11 1","pages":"459-470"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53096819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular, physiological and pathological aspects of the long non-coding RNA NEAT1.","authors":"Pang-Kuo Lo, Benjamin Wolfson, Qun Zhou","doi":"10.1007/s11515-016-1433-z","DOIUrl":"10.1007/s11515-016-1433-z","url":null,"abstract":"<p><strong>Background: </strong>The majority of mammalian genomes have been found to be transcribed into non-coding RNAs. One category of non-coding RNAs is classified as long non-coding RNAs (lncRNAs) based on their transcript sizes larger than 200 nucleotides. Growing evidence has shown that lncRNAs are not junk transcripts and play regulatory roles in multiple aspects of biological processes. Dysregulation of lncRNA expression has also been linked to diseases, in particular cancer. Therefore, studies of lncRNAs have attracted significant interest in the field of medical research. Nuclear enriched abundant transcript 1 (NEAT1), a nuclear lncRNA, has recently emerged as a key regulator involved in various cellular processes, physiological responses, developmental processes, and disease development and progression.</p><p><strong>Objective: </strong>This review will summarize and discuss the most recent findings with regard to the roles of NEAT1 in the function of the nuclear paraspeckle, cellular pathways, and physiological responses and processes. Particularly, the most recently reported studies regarding the pathological roles of deregulated NEAT1 in cancer are highlighted in this review.</p><p><strong>Methods: </strong>We performed a systematic literature search using the Pubmed search engine. Studies published over the last 8 years (between January 2009 and August 2016) were the sources of literature review. The following keywords were used: \"Nuclear enriched abundant transcript 1\", \"NEAT1\", and \"paraspeckles\".</p><p><strong>Results: </strong>The Pubmed search identified 34 articles related to the topic of the review. Among the identified literature, thirteen articles report findings related to cellular functions of NEAT1 and eight articles are the investigations of physiological functions of NEAT1. The remaining thirteen articles are studies of the roles of NEAT1 in cancers.</p><p><strong>Conclusion: </strong>Recent advances in NEAT1 studies reveal the multifunctional roles of NEAT1 in various biological processes, which are beyond its role in nuclear paraspeckles. Recent studies also indicate that dysregulation of NEAT1 function contributes to the development and progression of various cancers. More investigations will be needed to address the detailed mechanisms regarding how NEAT1 executes its cellular and physiological functions and how NEAT1 dysregulation results in tumorigenesis, and to explore the potential of NEAT1 as a target in cancer diagnosis, prognosis and therapy.</p>","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"11 6","pages":"413-426"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637405/pdf/nihms867247.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35511007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling axonal defects in hereditary spastic paraplegia with human pluripotent stem cells","authors":"Kyle R. Denton, Chongchong Xu, Harsh N. Shah, Xue-Jun Li","doi":"10.1007/s11515-016-1416-0","DOIUrl":"https://doi.org/10.1007/s11515-016-1416-0","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"11 1","pages":"339-354"},"PeriodicalIF":0.0,"publicationDate":"2016-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-016-1416-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53096468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver regeneration is associated with lipid reorganization in membranes of the endoplasmic reticulum","authors":"A. I. Bozhkov, N. Menzyanova, V. Davydov, N. Kurguzova, V. I. Sidorov, A. S. Vasilieva","doi":"10.1007/s11515-016-1420-4","DOIUrl":"https://doi.org/10.1007/s11515-016-1420-4","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"11 1","pages":"396-403"},"PeriodicalIF":0.0,"publicationDate":"2016-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-016-1420-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53096539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finding neoepitopes in mouse models of personalized cancer immunotherapy","authors":"Sahar Al Seesi, Alok Das Mohapatra, Arpita Pawashe, I. Măndoiu, F. Duan","doi":"10.1007/s11515-016-1422-2","DOIUrl":"https://doi.org/10.1007/s11515-016-1422-2","url":null,"abstract":"","PeriodicalId":12454,"journal":{"name":"Frontiers in Biology","volume":"11 1","pages":"366-375"},"PeriodicalIF":0.0,"publicationDate":"2016-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11515-016-1422-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53096681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}