Forensic Science, Medicine and Pathology最新文献_第9页

The micro CT evaluation of crown and root pulp volume versus dentin thickness in teeth in postmortem interval (PMI). 对死后间隔期（PMI）牙冠和牙根牙髓体积与牙本质厚度的显微 CT 评估。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-03-21 DOI: 10.1007/s12024-024-00805-8

Selcuk Cetin, Nihat Akbulut, Kaan Orhan, Burak Bilecenoglu, Mert Ocak, Emre Bayram, Ahmet Altan, Bulent Eren, Serkan Silsupur, Bedirhan Sezer Oner

{"title":"The micro CT evaluation of crown and root pulp volume versus dentin thickness in teeth in postmortem interval (PMI).","authors":"Selcuk Cetin, Nihat Akbulut, Kaan Orhan, Burak Bilecenoglu, Mert Ocak, Emre Bayram, Ahmet Altan, Bulent Eren, Serkan Silsupur, Bedirhan Sezer Oner","doi":"10.1007/s12024-024-00805-8","DOIUrl":"10.1007/s12024-024-00805-8","url":null,"abstract":"Determining the postmortem interval (PMI) is one of the main study subjects of forensic sciences. The main purpose of this prospective in vitro study that was the Micro-CT evaluation of teeth crown and root pulp volume versus dentin thickness in terms of PMI determination. The study involved 60 female Wistar rats, with weights ranging from 270 to 320 g. These rats were grouped into six different post-mortem period categories. Following the animals' sacrifice, they were subjected to a natural putrefaction period, with a control group, in the grounds of a sheltered garden. Hemi-mandible samples were then extracted and placed in glass tubes for Micro-CT evaluations, following the progression of putrefaction processes. The pulp volume and dentin thickness were assessed using Micro-CT, and the gathered data underwent statistical analysis. Micro-CT was employed to analyze sixty right mandibular second molar teeth in the hemi-mandible. The crown pulp volume exhibited a reduction in group 6, with a value of 0.239 mm3 after a three-month period of natural putrefaction (p < 0.001). There is statistically differences among groups in case of pairwise comparison (p < 0.05). However, the root pulp volume and dentin thickness variables did not display any statistically significant changes. Despite certain limitations associated with this study, the Micro-CT findings concerning teeth pulp volume can serve as an objective parameter, especially for late postmortem investigations and the estimation of time of death.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"71-79"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical trauma in children and adolescents in Berlin. 柏林儿童和青少年的机械创伤。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-04-16 DOI: 10.1007/s12024-024-00814-7

Christine Eimer, Claas Buschmann, Jonas Deeken, Thoralf Kerner

{"title":"Mechanical trauma in children and adolescents in Berlin.","authors":"Christine Eimer, Claas Buschmann, Jonas Deeken, Thoralf Kerner","doi":"10.1007/s12024-024-00814-7","DOIUrl":"10.1007/s12024-024-00814-7","url":null,"abstract":"Management of severe pediatric trauma remains challenging. Injury patterns vary according to patient age and trauma mechanism. This study analyzes trauma mechanisms in deceased pediatric patients. Fatal pediatric trauma cases aged 0-18 years who underwent forensic autopsy in the Federal State of Berlin, Germany, between 2008 until 2018 were enrolled in this retrospective study. Autopsy protocols were analyzed regarding demographic characteristics, trauma mechanisms, injury patterns, resuscitation measures, survival times as well as place, and cause of death. 71 patients (73% male) were included. Traffic accidents (40%) were the leading cause of trauma, followed by falls from height > 3 m (32%), railway accidents (13%), third party violence (11%) and other causes (4%). While children under 14 years of age died mostly due to traumatic brain injury (59%), polytrauma was the leading cause of death in patients > 14 years (55%). Other causes of death were hemorrhage (9%), thoracic trauma (1%) or other (10%). A suicidal background was proven in 24%. In the age group of > 14 years, 40% of all mortalities were suicides. Cardiopulmonary resuscitation was carried out in 39% of all patients. 42% of the patients died at the scene. Children between 0 and 14 years of age died most frequently from traumatic brain injury. In adolescents between 14 and 18 years of age, polytrauma was mostly the cause of death with a high coincidence of suicidal deaths. The frequency of fatal traffic accidents and suicides shows the need to improve accident and suicide prevention for children and adolescents.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"115-122"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tension hydrothorax complicating syringopleural shunt for post-traumatic syringomyelia. 外伤后鞘膜积液分流术并发的张力性水胸。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-07-26 DOI: 10.1007/s12024-024-00827-2

Michael Duffy, Yeliena Baber, Chris O'Donnell

引用次数: 0

The application of vibrational spectroscopy in forensic analysis of biological evidence. 振动光谱法在生物证据法医分析中的应用。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-08-24 DOI: 10.1007/s12024-024-00866-9

Zehua Fan, Ji Zhang, Chunling Ma, Bin Cong, Ping Huang

{"title":"The application of vibrational spectroscopy in forensic analysis of biological evidence.","authors":"Zehua Fan, Ji Zhang, Chunling Ma, Bin Cong, Ping Huang","doi":"10.1007/s12024-024-00866-9","DOIUrl":"10.1007/s12024-024-00866-9","url":null,"abstract":"Vibrational spectroscopy is a powerful analytical domain, within which Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy stand as exemplars, offering high chemical specificity and sensitivity. These methodologies have been instrumental in the characterization of chemical compounds for an extensive period. They are particularly adept at the identification and analysis of minute sample quantities. Both FTIR and Raman spectroscopy are proficient in elucidating small liquid samples and detecting nuanced molecular alterations. The application of chemometrics further augments their analytical prowess. Currently, these techniques are in the research phase within forensic medicine and have yet to be broadly implemented in examination and identification processes. Nonetheless, studies have indicated that a combined classification model utilizing FTIR and Raman spectroscopy yields exceptional results for the identification of biological fluid-related information and the determination of causes of death. The objective of this review is to delineate the current research trajectory and potential applications of these two vibrational spectroscopic techniques in the detection of body fluids and the ascertainment of causes of death within the context of forensic medicine.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"406-416"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hereditary thrombophilia as a possible risk factor for severe disease in COVID-19: a case series. 遗传性血栓性疾病可能是 COVID-19 严重疾病的危险因素：病例系列。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-09-27 DOI: 10.1007/s12024-024-00879-4

Jonathan Tse, Julita Gongolli, Joseph A Prahlow

{"title":"Hereditary thrombophilia as a possible risk factor for severe disease in COVID-19: a case series.","authors":"Jonathan Tse, Julita Gongolli, Joseph A Prahlow","doi":"10.1007/s12024-024-00879-4","DOIUrl":"10.1007/s12024-024-00879-4","url":null,"abstract":"Purpose: The risk factors that modulate one's susceptibility for severe COVID-19 have been well documented. Despite this, hypercoagulability remains an often overlooked risk factor for severe disease for COVID-19. Because COVID-19 infection is a risk factor for hypercoagulability, a reasonable presumption/hypothesis is that patients with hereditary thrombophilia would be at a higher risk of thrombotic complications associated with COVID-19 infection.Methods: This case report details two cases where previously unknown hereditary thrombophilias likely contributed to the mortality of COVID-19 patients.Results: The first COVID-19 patient's cause of death was pulmonary thromboemboli from deep vein thrombosis due to heterozygous MTHFR C667T and heterozygous PAI-1 4G/5G mutations. The second COVID-19 patient's cause of death was an acute myocardial infarct due to a coronary artery thrombosis in the setting of heterozygous MTHFR A1298C and homozygous PAI-1 4G/5G mutations. In each case, COVID-19 infection was also considered contributory to death.Conclusion: The occurrence of these fatal thrombotic events in COVID-19 patients with hereditary thrombophilias raises questions as to whether this combination of thrombotic risk factors for hypercoagulability may have placed patients at a significant enough risk to experience these fatal thrombotic complications. Thus, while not sufficient alone to prove that SARS-CoV-2 patients with hereditary thrombophilias are at increased risk for thrombotic complications, these two cases indicate that further investigation is warranted into elucidating the relationship between thrombotic risk factors as it may identify an additional high-risk medical condition for COVID-19 and have important diagnostic and therapeutic ramifications.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"260-266"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Death in a bathtub of an adolescent with neurofibromatosis type 2 exhibiting meningioangiomatosis with white matter involvement. 一名患有神经纤维瘤病 2 型、脑膜血管瘤病并累及白质的青少年在浴缸中死亡。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-08-24 DOI: 10.1007/s12024-024-00867-8

Kentaro Sakai, Kino Hayashi

{"title":"Death in a bathtub of an adolescent with neurofibromatosis type 2 exhibiting meningioangiomatosis with white matter involvement.","authors":"Kentaro Sakai, Kino Hayashi","doi":"10.1007/s12024-024-00867-8","DOIUrl":"10.1007/s12024-024-00867-8","url":null,"abstract":"Neurofibromatosis type 2 (NF2) is a neurocutaneous syndrome characterized by the development of multiple benign tumors, including vestibular schwannomas and meningiomas, in the nervous system. Seizures are rarely associated with NF2, and the lethality of this condition typically stems from tumor growth and related complications, leaving the incidence of sudden death largely unreported. This report discribes a 16-year-old girl with a history of NF2 and occasional seizures who died unexpectedly in a bathtub. Postmortem examination revealed multiple tumors in the cranial nerves (schwannoma), under the dura mater (meningioma), and in the upper cervical cord (neurofibroma). Typical signs of drowning, such as foam in the airways, were not present. Upon histological examination, meningioangiomatosis (MA) was observed in the cerebellum and the cerebral cortex, specifically in the frontal lobe, temporal lobe, and insula. The MA extended into the white matter, exhibiting severe perivascular fibrosis and cystic dilatation of perivascular spaces in the frontal lobe and cerebellum. Additionally, glial microhamartomas were detected both around and separate from the MA. These autopsy findings suggest that sudden unexpected death in epilepsy (SUDEP) was the cause of death rather than drowning. Moreover, while NF2-associated MA is typically asymptomatic, unlike sporadic MA, which commonly presents with seizures, the spread of MA into the white matter is unusual in an NF2 patient. Therefore, MA with the white matter involvement could have been a factor causing the seizures and the occurrence of SUDEP in this NF2 patient.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"283-289"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Death following cylindrical battery ingestion associated with toxic manganese levels. 摄入圆柱形电池后死亡，与有毒锰含量有关。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-06-29 DOI: 10.1007/s12024-024-00854-z

Eulalie Pefferkorn, Bruno Clément, Agathe Bascou, Céline Guilbeau-Frugier, Norbert Telmon, Frédéric Savall, Fabrice Dedouit

{"title":"Death following cylindrical battery ingestion associated with toxic manganese levels.","authors":"Eulalie Pefferkorn, Bruno Clément, Agathe Bascou, Céline Guilbeau-Frugier, Norbert Telmon, Frédéric Savall, Fabrice Dedouit","doi":"10.1007/s12024-024-00854-z","DOIUrl":"10.1007/s12024-024-00854-z","url":null,"abstract":"Cases of battery ingestion are well documented in the scientific literature, especially concerning button cell battery ingestion in children. In this instance, the authors present an atypical case of a young man who voluntarily ingested a cylindrical alkaline battery containing manganese. The patient died approximately a week later, despite not exhibiting any specific symptoms. The battery was found in the cecum during the autopsy, showing deterioration at its positive pole. The cecal mucosa exhibited two ulcerations without perforation. Histological analysis revealed intestinal ischemia in the cecum, with no microscopic lesions in other organs. Toxicology reports indicated high levels of manganese in both cardiac and peripheral blood. Considering all the results from the additional analyses, the experts concluded that the death was likely of multifactorial origin, associated with a toxic blood concentration of manganese. To the best of our knowledge, this is the first recorded death following the ingestion of a cylindrical battery, and the first instance of manganese intoxication resulting from the ingestion of an alkaline battery. The authors will present the case and provide a literature review to assess the extent to which the presence of manganese may have contributed to the fatality.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"295-301"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasive aspergillosis leading to fatal cerebral hemorrhage: a case report and comprehensive literature review.

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-02-25 DOI: 10.1007/s12024-025-00966-0

Nicole Pasin, Matteo Lorenzoni, Erika Velotta, Giulio Riva, Raffaella Scotto Opipari, Mara Di Pietro, Roberta Tamiozzo, Umberto Nardi

{"title":"Invasive aspergillosis leading to fatal cerebral hemorrhage: a case report and comprehensive literature review.","authors":"Nicole Pasin, Matteo Lorenzoni, Erika Velotta, Giulio Riva, Raffaella Scotto Opipari, Mara Di Pietro, Roberta Tamiozzo, Umberto Nardi","doi":"10.1007/s12024-025-00966-0","DOIUrl":"https://doi.org/10.1007/s12024-025-00966-0","url":null,"abstract":"Aspergillus fumigatus significantly threatens immunocompromised individuals by causing potentially fatal diseases, primarily invasive aspergillosis (IA). IA, mostly affecting the lungs, can disseminate to other organs, including the central nervous system (CNS), leading to high mortality rates. We present the case of an 84-year-old immunocompetent male with a history of significant comorbidities, who developed a lethal subarachnoid and tetraventricular hemorrhage. Initial symptoms included paroxysmal neuralgic pain and ophthalmic manifestations. Despite diagnostic efforts, the infection was confirmed only after a positive Aspergillus galactomannan antigen test on cerebrospinal fluid, post-mortem microbiological culture, and mass spectrometry (MS) authentication. The patient exhibited rapid deterioration and succumbed due to the erosion of a mycotic cerebral aneurysm of the left internal carotid artery. Diagnosing IA, particularly isolated CNS IA in immunocompetent patients, is challenging due to its nonspecific symptoms and difficulty detecting the pathogen in standard diagnostic tests. This article emphasizes the pivotal role of pathological examination to obtain a definitive diagnosis, assess fungal infiltration of brain vessels, and thus clarify the accurate source of fatal brain hemorrhages.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exsanguination from an arteriovenous dialysis fistula: accident, suicide or medical malpractice?

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-02-24 DOI: 10.1007/s12024-025-00955-3

S Schof, J Hertzberg, A Jahnke, Christoph G Birngruber

{"title":"Exsanguination from an arteriovenous dialysis fistula: accident, suicide or medical malpractice?","authors":"S Schof, J Hertzberg, A Jahnke, Christoph G Birngruber","doi":"10.1007/s12024-025-00955-3","DOIUrl":"https://doi.org/10.1007/s12024-025-00955-3","url":null,"abstract":"A female senior dialysis patient was found dead in her apartment, covered in blood. Bloodstains were observed in different rooms of the apartment. During the post-mortem examination on site, a small, roundish opening of the skin was observed on the flexor side of the upper arm, within a longitudinal scar, from which blood was draining. Throughout police investigation, the possibility of an accident, a suicidal act, or medical malpractice during dialysis care was considered. An autopsy was ordered for further clarification. The autopsy identified exsanguination from a fistula on the flexor side of the left upper arm as the cause of death. The fistula could be traced into an arteriovenous shunt vessel that had been created a long time ago for dialysis. Upon projection onto the shunt vessel, punctiform crusts with underlying hemorrhages in the subcutaneous fatty tissue were identified in the skin. Histological examinations of the fistula and its surrounding tissue revealed no evidence of vasculitis or perivascular inflammatory changes, but puncture sites of varying ages with connective tissue texture disruption of the vessel wall and the adjacent subcutaneous tissue. Forensic medical examination concluded that death was caused by bleeding from an arteriovenous dialysis shunt vessel as a complication of hemodialysis. This case illustrates the relevance of comprehensive forensic medical case processing as the basis for a well-founded assessment.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A singular case of complex suicide by hanging with hesitation marks by axe.

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-02-20 DOI: 10.1007/s12024-025-00964-2

Annachiara Vinci, Laura Laura Ambrosi, Marcello Benevento, Davide Ferorelli, Biagio Solarino

引用次数: 0