Forensic Science, Medicine and Pathology最新文献_第9页

Prominent black esophagus, Wischnewsky spots, and black duodenum in a fatal hypothermia case with an underlying diabetic ketoacidosis. 在一个伴有糖尿病酮症酸中毒的致命低体温病例中，出现了明显的黑色食管、Wischnewsky斑点和黑色十二指肠。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-06-13 DOI: 10.1007/s12024-024-00837-0

Shojiro Takasu, Sari Matsumoto, Kimiharu Iwadate

{"title":"Prominent black esophagus, Wischnewsky spots, and black duodenum in a fatal hypothermia case with an underlying diabetic ketoacidosis.","authors":"Shojiro Takasu, Sari Matsumoto, Kimiharu Iwadate","doi":"10.1007/s12024-024-00837-0","DOIUrl":"10.1007/s12024-024-00837-0","url":null,"abstract":"Hypothermia can occur in patients with diabetic ketoacidosis (DKA), and these two conditions can exacerbate each other. Fatal hypothermia and DKA have overlapping features and findings such as Wischnewsky spots (WS), black esophagus, basal subnuclear vacuolization in the renal tubule, dehydration, and increased acetone levels. Therefore, it may be challenging to differentiate or clarify the context of these two conditions. Herein, we report a case of a 49-year-old man with type 1 diabetes who was found lying in his house in mid-winter. He experienced cardiopulmonary arrest 10 h after the initial discovery and died at the hospital. On autopsy, florid left cardiac blood was observed. Black discoloration of the distal part of the esophageal mucosa, widespread WS in the gastric mucosa, and black discoloration of the duodenal mucosa were observed. Histologically, neutrophil infiltration in the esophageal mucosa, neutrophil infiltration and bleeding in the gastric mucosa, basal subnuclear vacuolization and Armanni-Ebstein lesion in the renal tubule epithelium in the kidney, and hyalinization of the islets of Langerhans were observed in the pancreas. Blood acetone and β-hydroxybutyrate levels were 538 µg/mL and 8947 µmol/L, respectively. Glycated hemoglobin A1c and glucose levels were 16.2% and 883 mg/dL, respectively, while C-reactive protein level was 3.64 mg/dL. In conclusion, obnubilation due to DKA was assumed to be the underlying cause of hypothermia, and the combination of these two conditions led to the outcome of death. The concurrent presence of these conditions likely contributed to the conspicuous mucosal findings in the upper gastrointestinal tract.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"307-313"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective evaluation of neonates with fatal congenital lung malformation: A single center 15-year forensic autopsy experience. 对患有致命先天性肺畸形的新生儿进行回顾性评估：单中心 15 年法医尸检经验。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-06-20 DOI: 10.1007/s12024-024-00853-0

Tingting Wang, Yishu Liu, Yadong Guo, Changquan Zhang, Jifeng Cai

{"title":"Retrospective evaluation of neonates with fatal congenital lung malformation: A single center 15-year forensic autopsy experience.","authors":"Tingting Wang, Yishu Liu, Yadong Guo, Changquan Zhang, Jifeng Cai","doi":"10.1007/s12024-024-00853-0","DOIUrl":"10.1007/s12024-024-00853-0","url":null,"abstract":"Congenital lung malformation (CLM) is a leading cause of infant mortality. Clinical methods for diagnosing CLM mainly rely on computed tomography, magnetic resonance imaging, ultrasonography, and Doppler. However, forensic identification of the cause of death in neonates is challenging. Unequivocal classification criteria for CLM are missing as its forensic identification is ambiguous. Therefore, we aimed to analyze neonatal death cases at our center to assist in identifying those with congenital lung malformation. This retrospective study identified and classified the causes of deaths of neonates autopsied between January 2008 and April 2023. All cases born alive and died within 28 days with a clear time of death were selected, and forensic experts reviewed their records. The manner, cause of death, and other characteristics were noted and discussed. This retrospective study reveals a steady increase in autopsy cases from 2008 to 2015, attributed to improved parental consent, heightened awareness of autopsy importance, and enhanced medical resources. However, a subsequent decline post-2015 is observed, potentially influenced by advancements in medical technology and prenatal examination protocols. The top causes of neonatal mortality include respiratory diseases, asphyxia, congenital dysplasia, and fetal distress. Congenital lung malformations, particularly bronchopulmonary malformations, constitute a significant portion of congenital anomalies. This study underscores the importance of standardized autopsies and histopathological examinations in diagnosing and understanding CLM. Future research should focus on expanding case collections and elucidating the genetic basis of CLM to improve forensic management and outcomes.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"183-192"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sudden cardiac death due to an obstructive large right atrial myxoma. 阻塞性巨大右心房肌瘤导致心脏猝死。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-07-23 DOI: 10.1007/s12024-024-00817-4

Joshua Nelson, David Waters, Lorenzo Gitto

引用次数: 0

Thymicolymphatic status as a cause of death in eclampsia - forensic history of "unexplained" death. 作为子痫死因的胸淋巴状态--"不明原因 "死亡的法医史。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-05-02 DOI: 10.1007/s12024-024-00822-7

Dubravko Habek, Jasna Čerkez Habek

引用次数: 0

A case of a lidocaine intoxication of a 12 week old boy due to a circumcision in a domestic setting - clinical, toxicological and forensic aspects. 一例在家庭环境中因包皮环切术导致 12 周大男婴利多卡因中毒的病例--临床、毒理学和法医学方面。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-08-01 DOI: 10.1007/s12024-024-00859-8

Noelle Dyballa, Julian Alexander Härtel, Julian Prangenberg, Hilke Andresen-Streichert

引用次数: 0

Suicide by ligature strangulation and/or hanging inside a motor vehicle: a comprehensive review. 汽车内勒死和/或上吊自杀：综合评述。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-05-18 DOI: 10.1007/s12024-024-00828-1

Carlo Pietro Campobasso, Mariavictoria De Simone, Antonietta Porzio, Edoardo Mazzini, Anna Carfora, Alessandro Feola

{"title":"Suicide by ligature strangulation and/or hanging inside a motor vehicle: a comprehensive review.","authors":"Carlo Pietro Campobasso, Mariavictoria De Simone, Antonietta Porzio, Edoardo Mazzini, Anna Carfora, Alessandro Feola","doi":"10.1007/s12024-024-00828-1","DOIUrl":"10.1007/s12024-024-00828-1","url":null,"abstract":"Suicide by ligature strangulation/hanging inside vehicles is uncommon, and only few cases have been reported in the literature. This study aimed to conduct a comprehensive review of reported cases of suicide by ligature strangulation/hanging inside vehicles, analyzing the features of the death scene, of the ligature and furrow, autopsy findings, and causes of death. The comprehensive review was performed following the PRISMA guidelines by using the most common scientific databases. According to inclusion criteria, a total of 20 cases of vehicle-assisted strangulation/hanging were reviewed: 13 cases were assessed as ligature strangulation resulting in 7 complete decapitations and 7 other cases as hanging. All victims were young or adult males, except for one 48-year-old female. Death was assessed as suicide in all cases, except for a possible accidental autoerotic death. In 8 cases, a history of depression or other psychiatric disorders was reported. Toxicological analysis were positive in 7 cases. Hard ligature materials (nylon, steel, plastic, hemp ropes) were used in most cases, but only 13 cases had a well-demarcated furrow. In 2 cases, no internal findings of asphyxia were found. An additional case of ligature strangulation inside a motor vehicle off is also presented, where no autopsy findings of asphyxia were observed, except for a broad pale furrow and monolateral conjunctival petechiae. This study highlights the challenges in classifying suicidal hanging and ligature strangulation in motor vehicles.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"443-457"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Air embolism during unsuccessful transcatheter closure of secundum atrial septal defect in a patient with an undetected left-sided inferior vena cava. 一名未检测到左侧下腔静脉的患者在经导管关闭房间隔缺损不成功的过程中发生空气栓塞。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-10-17 DOI: 10.1007/s12024-024-00902-8

Silvia Farkašová Iannaccone, Alžbeta Ginelliová, Janka Vecanová, Daniel Farkaš

{"title":"Air embolism during unsuccessful transcatheter closure of secundum atrial septal defect in a patient with an undetected left-sided inferior vena cava.","authors":"Silvia Farkašová Iannaccone, Alžbeta Ginelliová, Janka Vecanová, Daniel Farkaš","doi":"10.1007/s12024-024-00902-8","DOIUrl":"10.1007/s12024-024-00902-8","url":null,"abstract":"A 46-year-old man with a history of secundum atrial septal defect and interstitial lung disease was admitted to the hospital for a planned transcatheter closure of the atrial septal defect. Following multiple failed attempts to place a right femoral vein catheter, the procedure was aborted. Another attempt was made to the left femoral vein, but that attempt was complicated by an unfamiliar resistance. Even though resistance was met during insertion, the catheter was further inserted until a position in the inferior vena cava above the liver was obtained at fluoroscopy. Simultaneously, the patient became unresponsive. The procedure was immediately aborted and the atrial septal defect closure was not completed. Air embolism to the heart and brain was detected using echocardiography and computed tomography. The patient died 15 days after the procedure. Death was attributed to severe cerebral edema due to air embolism. The autopsy revealed a left-sided inferior vena cava. This case report demonstrates that unexpected congenital vascular anomalies complicating a routine transcatheter closure of the atrial septal defect can result in a fatal outcome.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"345-351"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution of methamphetamine and insulin to the death of a woman suffering from type I diabetes - which played the greater role? 甲基苯丙胺和胰岛素对一名 I 型糖尿病妇女死亡的影响--哪个作用更大？

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-07-04 DOI: 10.1007/s12024-024-00855-y

Klára Handlosová, Pavel Šištík, Matěj Uvíra, Kateřina Andelova, Petr Handlos, David Stejskal

{"title":"Contribution of methamphetamine and insulin to the death of a woman suffering from type I diabetes - which played the greater role?","authors":"Klára Handlosová, Pavel Šištík, Matěj Uvíra, Kateřina Andelova, Petr Handlos, David Stejskal","doi":"10.1007/s12024-024-00855-y","DOIUrl":"10.1007/s12024-024-00855-y","url":null,"abstract":"This report presents a fatal case of a young female Type I diabetic patient who developed convulsions and loss of consciousness after taking methamphetamine and spending some time in a dance club. During the convulsions, she was given sugar and when no response occurred, her boyfriend who was not experienced in the use of insulin administered a dose of insulin to her. The woman lost consciousness and died despite the efforts of the emergency service. A biochemical analysis revealed a high level of insulin (196.67 mU/L) and low levels of glucose (2.96 mmol/L) and C-peptide (26 pmol/L). Toxicological analysis revealed a methamphetamine concentration of 389 ng/mL and an amphetamine concentration of 19 ng/mL. The forensic perspective of the difficult determination of the contribution of each of the factors to the death, i.e., the pre-existing medical condition (Type I diabetes), the use of methamphetamine, the physical exertion at the dance club, and, finally, the non-indicated administration of insulin, is discussed. The ruling of the court is also reported.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"502-506"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of suicide secondary to diethylene glycol intentional ingestion. 一例二甘醇蓄意吞食后自杀的病例。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2024-05-22 DOI: 10.1007/s12024-024-00832-5

Stanley de Almeida Araújo, Isabela Stefanon, David Campos Wanderley, Rodrigo Zamprogna, Rafaele Zampier, Ana Cristina Simões-E-Silva

{"title":"A case of suicide secondary to diethylene glycol intentional ingestion.","authors":"Stanley de Almeida Araújo, Isabela Stefanon, David Campos Wanderley, Rodrigo Zamprogna, Rafaele Zampier, Ana Cristina Simões-E-Silva","doi":"10.1007/s12024-024-00832-5","DOIUrl":"10.1007/s12024-024-00832-5","url":null,"abstract":"We aimed to describe a case of acute kidney injury (AKI) with an uncommon case. We described a previously health 24 years old male that presented acute kidney injury associated with neurological and respiratory symptoms. He was initially admitted at the hospital with nausea, vomiting, blurred vision, and reduced urine output. The patient's condition got worse approximately in one week. Laboratory tests revealed high levels of nitrogenous waste, hyponatremia, metabolic acidosis with an increased anion gap, and the presence of proteinuria and hematuria. The patient experienced paresthesia, seizures, respiratory alterations, and altered consciousness. The initial diagnostic hypothesis of rapidly progressive glomerulonephritis was not confirmed. A deeper investigation of the case exposed that it could have occurred an intentional exogenous poisoning with diethylene glycol (DEG). Renal biopsy unveil findings suggestive of poison-induced nephrotoxicity, which corroborated the suspicion. Despite therapeutic efforts, the patient died due to pulmonary complications. This case report shows the need to consider DEG poisoning as a etiology of AKI, especially in patients with neurological symptoms. Laboratory and histopathological analysis were crucial for the diagnosis.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":"290-294"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of pathologists in increasing knowledge of safe sleep practices for infants. 病理学家在增加婴儿安全睡眠知识方面的作用。

IF 1.5 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-03-01 Epub Date: 2023-12-22 DOI: 10.1007/s12024-023-00764-6

Roger W Byard

引用次数: 0