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Immediate implant placement with guided bone regeneration following dentoalveolar trauma - a case report. 牙槽外伤后即刻种植体植入引导骨再生1例报告。
Folia medica Pub Date : 2026-04-03 DOI: 10.3897/folmed.68.e152126
Varvara-Velika G Rogova, Desislava A Konstantinova, Tihomir D Georgiev
{"title":"Immediate implant placement with guided bone regeneration following dentoalveolar trauma - a case report.","authors":"Varvara-Velika G Rogova, Desislava A Konstantinova, Tihomir D Georgiev","doi":"10.3897/folmed.68.e152126","DOIUrl":"10.3897/folmed.68.e152126","url":null,"abstract":"<p><p>Dentoalveolar trauma is a common cause of tooth loss, especially in the anterior region of the maxilla. The restoration of teeth in this area is invariably challenging due to aesthetic considerations. A variety of treatment modalities are available for clinicians to select from. These include tooth-supported solutions, such as fixed (dental bridges) or removable (partial dentures) prosthodontics, as well as implant-supported restorations. Implant dentistry is an evolving field with expanding indications. The case under consideration is that of head trauma, accompanied by injuries to the soft intra- and extraoral tissues, as well as fractures to teeth #11, #12, and #13. The patient underwent a surgical procedure involving the immediate placement of two implants, accompanied by simultaneous guided bone regeneration. A provisional removable partial denture was fabricated. The placement of the implants occurred six months prior to the subsequent extraction of the teeth. The dentition was subsequently restored with an implant-supported metal-ceramic bridge.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posterior self-expanding stand-alone cage: outcomes in degenerative disc disease. 后路自我扩张独立式cage：退行性椎间盘疾病的预后。
Folia medica Pub Date : 2026-04-03 DOI: 10.3897/folmed.68.e170420
Nia Atanasova Gecheva, Petar Lyubomirov Ilkov, Konstantin Alexandrov Uzunov
{"title":"Posterior self-expanding stand-alone cage: outcomes in degenerative disc disease.","authors":"Nia Atanasova Gecheva, Petar Lyubomirov Ilkov, Konstantin Alexandrov Uzunov","doi":"10.3897/folmed.68.e170420","DOIUrl":"10.3897/folmed.68.e170420","url":null,"abstract":"<p><strong>Introduction: </strong>Degenerative disc disease (DDD) and lumbar facet joint pathology are leading causes of chronic back pain, predominantly affecting older adults due to cumulative spinal degeneration. Lumbar spondylosis, a key manifestation of DDD, contributes to mechanical instability, radiculopathy, and neurogenic claudication, significantly impairing mobility and quality of life.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Micro RNAs in septic acute kidney injury: pathophysiology, biomarkers and therapeutic targets. 脓毒性急性肾损伤中的微rna：病理生理学、生物标志物和治疗靶点。
Folia medica Pub Date : 2026-04-03 DOI: 10.3897/folmed.68.e166581
Georgi Nikolov, Dimitar Nikolov, Mladen Naydenov, Chavdar Stefanov
{"title":"Micro RNAs in septic acute kidney injury: pathophysiology, biomarkers and therapeutic targets.","authors":"Georgi Nikolov, Dimitar Nikolov, Mladen Naydenov, Chavdar Stefanov","doi":"10.3897/folmed.68.e166581","DOIUrl":"https://doi.org/10.3897/folmed.68.e166581","url":null,"abstract":"<p><strong>Introduction: </strong>Septic acute kidney injury (S-AKI) is a life-threatening complication of sepsis with high mortality and limited treatment options. Emerging evidence highlights the role of microRNAs (miRNAs) as critical regulators of the key pathogenic pathways involved in S-AKI, including inflammation, apoptosis, oxidative stress, and microvascular dysfunction.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for visceral metastases in cutaneous melanoma: insights from a clinical cohort. 皮肤黑色素瘤内脏转移的危险因素：来自临床队列的见解。
Folia medica Pub Date : 2026-04-03 DOI: 10.3897/folmed.68.e167983
Luiz-Sorin Vasiu, Razvan Danciu, Laura Raducu, Cristian Radu Jecan
{"title":"Risk factors for visceral metastases in cutaneous melanoma: insights from a clinical cohort.","authors":"Luiz-Sorin Vasiu, Razvan Danciu, Laura Raducu, Cristian Radu Jecan","doi":"10.3897/folmed.68.e167983","DOIUrl":"https://doi.org/10.3897/folmed.68.e167983","url":null,"abstract":"<p><strong>Introduction: </strong>Cutaneous melanoma, a malignancy originating from melanocytes, is characterized by a high propensity for metastatic spread. It commonly affects the lungs, liver, brain, lymph nodes, and skin.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Customized chin cup: enhancing pediatric compliance in Class III orthodontic treatment - a case report. 定制下巴杯：提高小儿III类正畸治疗依从性一例报告。
Folia medica Pub Date : 2026-03-19 DOI: 10.3897/folmed.68.e147880
Prema Anbarasu, Saravana Kumar Subramanian, M Gokilla Priya, Dhanush Sakthivel, Harini Saravanan, R Pravin
{"title":"Customized chin cup: enhancing pediatric compliance in Class III orthodontic treatment - a case report.","authors":"Prema Anbarasu, Saravana Kumar Subramanian, M Gokilla Priya, Dhanush Sakthivel, Harini Saravanan, R Pravin","doi":"10.3897/folmed.68.e147880","DOIUrl":"10.3897/folmed.68.e147880","url":null,"abstract":"<p><p>This case report emphasizes the role of a customized chin cup in the management of Class III malocclusion in pediatric patients, emphasizing its contribution to improved compliance and treatment outcomes. Class III malocclusion, often characterized by maxillary retrusion and mandibular prognathism, presents unique challenges in orthodontics, particularly in young patients. Reverse pull facemask therapy is a well-established method to correct maxillary retrusion, but the success of this approach heavily depends on patient compliance. Prefabricated chin cups, commonly used in facemasks, frequently lead to discomfort and irritation, negatively affecting adherence. In this report, we present a simple, cost-effective technique to customize chin cups using polyvinyl siloxane (PVS) for enhanced comfort, stability, and compliance. By improving the fit of the chin cup, this method addresses a critical barrier to successful Class III treatment in pediatric cases.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term management of a child with aortopulmonary septal defect and Eisenmenger syndrome: a 6-year follow-up case study. 儿童肺动脉间隔缺损和艾森曼格综合征的长期治疗：6年随访病例研究。
Folia medica Pub Date : 2026-03-19 DOI: 10.3897/folmed.68.e149000
Daniela Milanova-Ilieva, Kostadin Ketev, Ivanka Karavelikova, Lyubov Chochkova-Bukova, Elisaveta Levunlieva, Anna Kaneva-Nencheva
{"title":"Long-term management of a child with aortopulmonary septal defect and Eisenmenger syndrome: a 6-year follow-up case study.","authors":"Daniela Milanova-Ilieva, Kostadin Ketev, Ivanka Karavelikova, Lyubov Chochkova-Bukova, Elisaveta Levunlieva, Anna Kaneva-Nencheva","doi":"10.3897/folmed.68.e149000","DOIUrl":"https://doi.org/10.3897/folmed.68.e149000","url":null,"abstract":"<p><p>We report the case of a boy diagnosed at age 9 with a large aortopulmonary septal defect and Eisenmenger syndrome, highlighting the challenges of late diagnosis and management of fixed pulmonary hypertension. Over the course of six years (2018-2024), the patient underwent several follow-ups, including invasive hemodynamic assessments and echocardiography, revealing progressive pulmonary vascular disease. Despite the administration of medical therapy with sildenafil, bosentan, and antiplatelets, the patient's condition remained unfavorable due to fixed pulmonary vascular obstructive disease. This case underscores the importance of early diagnosis and the complexities of managing advanced pulmonary hypertension in congenital heart defects.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermatosurgical rounds: double opposing rotational advancement (Ying-Yang) flap for reconstruction of primary defects following skin cancer excisions in the medial foot ankle and preauricular regions. 皮肤外科轮次：双对向旋转推进（阴阳）皮瓣用于重建内侧足、踝关节和耳前区域皮肤癌切除后的原发性缺损。
Folia medica Pub Date : 2026-03-19 DOI: 10.3897/folmed.68.e168322
Simona Kordeva, Konstantin Georgiev Tchernev, Georgi Tchernev
{"title":"Dermatosurgical rounds: double opposing rotational advancement (Ying-Yang) flap for reconstruction of primary defects following skin cancer excisions in the medial foot ankle and preauricular regions.","authors":"Simona Kordeva, Konstantin Georgiev Tchernev, Georgi Tchernev","doi":"10.3897/folmed.68.e168322","DOIUrl":"10.3897/folmed.68.e168322","url":null,"abstract":"<p><p>Surgical reconstructive techniques continue to evolve as dermatosurgeons combine clinical expertise, technical skill, and innovation. In some cases, such innovation can result in better outcomes in terms of tension management, vascular supply preservation, and esthetic appearance.\u0000\u0000The double-opposing rotation advancement flap, also known as the Ying-Yang flap due to its yin-yang mode of action, is often applied in the scalp region, where it provides excellent results with minimal complications. However, data supporting its application in less conventional anatomical sites remains limited.\u0000\u0000We present two independent cases involving primary defects resulting from skin tumor excisions, successfully reconstructed with the Ying-Yang flap in atypical locations: the medial foot ankle and preauricular regions. Tension-free closure was achieved in both cases, and follow-up at two months demonstrated great wound healing.\u0000\u0000While surgical excision remains the gold standard for treating skin cancer, these cases highlight the double-opposing rotation advancement flap as a versatile and effective reconstructive option beyond its standard indications.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periorbital cholesterol granulomas/cysts - two clinical cases presentation. 眼眶周围胆固醇肉芽肿/囊肿- 2例临床报告。
Folia medica Pub Date : 2026-03-19 DOI: 10.3897/folmed.68.e149538
Karen Dzhambazov, Stoyan Markov, Aleksandrina Topalova-Shishmanova, Georgi Georgiev, Konstantin Giritliev, Elizabet Dzhambazova
{"title":"Periorbital cholesterol granulomas/cysts - two clinical cases presentation.","authors":"Karen Dzhambazov, Stoyan Markov, Aleksandrina Topalova-Shishmanova, Georgi Georgiev, Konstantin Giritliev, Elizabet Dzhambazova","doi":"10.3897/folmed.68.e149538","DOIUrl":"10.3897/folmed.68.e149538","url":null,"abstract":"<p><p>Cholesterol granulomas and cysts represent uncommon pathological findings in the paranasal cavities; however, they have also been documented in other areas, including the orbit, the petrous part of the temporal bone, and the nasal septum, among others. Histologically, they are composed of granulation tissue and a significant quantity of cholesterol crystals. The etiology of the disease is primarily associated with microtraumas in the affected structures, which result in the rupture of small blood vessels. This phenomenon leads to the accumulation of formed elements and cholesterol in the affected regions, resulting in the formation of a foreign-body-type granuloma that gradually increases in size. The process is both expansive and destructive, characterized by gradual and painless development.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound-guided perineural tibial nerve dextrose injection for plantar fasciitis: a case series highlighting safety and efficacy. 超声引导下胫神经周围注射葡萄糖治疗足底筋膜炎：一个强调安全性和有效性的病例系列。
Folia medica Pub Date : 2026-03-19 DOI: 10.3897/folmed.68.e164066
Guntur Darmawan, Alif Noeriyanto Rahman, Stanley King Hei Lam, Faisal Parlindungan, Laniyati Hamijoyo, Tolga Ergonenc
{"title":"Ultrasound-guided perineural tibial nerve dextrose injection for plantar fasciitis: a case series highlighting safety and efficacy.","authors":"Guntur Darmawan, Alif Noeriyanto Rahman, Stanley King Hei Lam, Faisal Parlindungan, Laniyati Hamijoyo, Tolga Ergonenc","doi":"10.3897/folmed.68.e164066","DOIUrl":"10.3897/folmed.68.e164066","url":null,"abstract":"<p><p>Treatments for plantar fasciitis are often unsatisfactory. Dextrose exerts an analgesic effect through inhibiting transient receptor potential vanilloid receptor 1 (TRPV1)-mediated neuroinflammation. We reported the effectiveness of ultrasound-guided perineural tibial nerve (TN) 5% dextrose water (D5W) injection using the hydrodissection technique in treating plantar fasciitis.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydatid disease of the ribs: a diagnostic challenge with an endless differential diagnosis - a case report. 肋骨包虫病：诊断挑战与无尽的鉴别诊断-一个病例报告。
Folia medica Pub Date : 2026-02-26 DOI: 10.3897/folmed.68.e146872
Dimcho Argirov, Vladimir Aleksiev, Boyko Yavorov
{"title":"Hydatid disease of the ribs: a diagnostic challenge with an endless differential diagnosis - a case report.","authors":"Dimcho Argirov, Vladimir Aleksiev, Boyko Yavorov","doi":"10.3897/folmed.68.e146872","DOIUrl":"10.3897/folmed.68.e146872","url":null,"abstract":"<p><p>Hydatid disease is a parasitic infection in humans caused by Echinococcusgranulosus and can lead to tissue cyst formation anywhere in the body. The most common sites for the development of parasitic cysts are the liver (75%) and lungs (15%). Skeletal involvement in echinococcal infection is relatively rare, occurring in only 1%-4% of cases. Few reports in the available medical literature describe rib hydatidosis, which clinically mimics benign or malignant cystic tumors.</p>","PeriodicalId":12415,"journal":{"name":"Folia medica","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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