Frontiers in Cardiovascular Medicine最新文献

{"title":"Risk analysis of cardiovascular mortality after gastric cancer diagnosis: a large population-based study.","authors":"Qiang Zhao, Qiaohong Zhou, Jiayue Dong, Qiang Tong","doi":"10.3389/fcvm.2025.1459151","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1459151","url":null,"abstract":"<p><strong>Background: </strong>The increasing prevalence of cardiovascular mortality is becoming a significant worry for individuals who have survived cancer. The aim of this study is to investigate the dynamic trend of cardiovascular death in patients with gastric cancer (GC) and identify the risk factors associated with cardiovascular disease (CVD)-specific mortality in non-metastatic GC patients.</p><p><strong>Methods: </strong>In the present study, 29,324 eligible patients diagnosed with primary GC were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Standardized mortality ratios (SMRs) adjusted by age, gender, calendar year, and race were calculated. Fine-Gray's competing risk models were taken to identify the prognostic factors of cardiovascular death in GC patients.</p><p><strong>Results: </strong>There were 1083 (5.2%) cardiovascular deaths among 20,857 patients with local/regional GC, and 76 (0.9%) cardiovascular deaths among 8,467 patients with metastatic GC. The SMRs of CVD-specific mortality continuously increased since the 1975s throughout the 2015s. The competing risk models showed that age (>75 years vs. 0-50 years, HR: 6.602, 95% CI: 4.356-10.006), T stage (T4 vs. T1, HR:0.524, 95% CI: 0.370-0.741), N stage (N3 vs. N0, HR: 0.557, 95% CI: 0.343-0.903), surgery (Yes vs. No, HR: 0.551, 95% CI: 0.461-0.659), and radiotherapy (Yes vs. No, HR: 1.011, 95% CI: 1.011-1.437) were predictive of CVD-specific mortality. Furthermore, based on the results of the competing risk analyses, a nomogram was constructed to predict the probability of CVD-specific mortality for local/regional GC patients.</p><p><strong>Conclusion: </strong>Our study demonstrated the dynamic trend of cardiovascular death in GC patients, and identified prognostic risk predictors, highlighting the importance cardio-oncology teams in offering comprehensive care and long-term follow-up for GC patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1459151"},"PeriodicalIF":2.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular repair of abdominal aortic aneurysm-related type II endoleak: a multicenter study on the possibility of further intervention.","authors":"E Erdemutu, Chongbin Zhou, Ming Ma, Liqiang Hu, Jisiguleng Wu, Xiangchen Dai, Zhanfeng Gao","doi":"10.3389/fcvm.2025.1450942","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1450942","url":null,"abstract":"<p><strong>Background: </strong>We aimed to analyze the risk factors associated with Type II endoleak (T2EL) requiring reintervention after endovascular aneurysm repair (EVAR) for multicenter abdominal aortic aneurysms.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on data from 614 patients with abdominal aortic aneurysms who underwent elective EVAR at three centers (Tianjin Medical University General Hospital, Affiliated Hospital of Inner Mongolia Medical University, Shanxi Provincial People's Hospital) from January 2017 to December 2021. After applying exclusion criteria, 375 patients were included in the study, with 50 patients in the T2EL-related reintervention group and 325 patients in the non-T2EL group. Single-factor and multiple-factor logistic analyses were used to identify high-risk factors, and ROC curve analysis was performed to determine the risk thresholds for mesenteric artery diameter, number of lumbar arteries, maximum aneurysm diameter, and proportion of intraluminal thrombus volume.</p><p><strong>Results: </strong>The rate of T2EL-related reintervention among the 375 patients was 13.33% (50/375). Single-factor analysis indicated that age, hypertension, maximum aneurysm diameter, proportion of intraluminal thrombus, diameter of inferior mesenteric artery (IMA), and number of patent lumbar arteries (LA) were risk factors for T2EL-related reintervention. Multiple-factor logistic analysis identified maximum aneurysm diameter, proportion of thrombus, IMA diameter, and number of patent LA as the main influencing factors for T2EL-related reintervention after EVAR. Significant risk factors for reintervention were maximum aneurysm diameter (OR = 1.043, 95% CI 1.015-1.072, <i>P</i> = 0.002), IMA diameter (OR = 3.901, 95% CI 1.116-13.632, <i>P</i> = 0.033), and number of LA (OR = 2.584, 95% CI 1.722-3.769, <i>P</i> < 0.001). A significant protective factor for reintervention was thrombus proportion (OR = 0.895, 95% CI 0.864-0.927, <i>P</i> < 0.001). ROC curve analysis showed that the risk thresholds for reintervention were an IMA diameter of 2.95 mm, intraluminal thrombus volume proportion <42.5%, number of LA ≤5.5, and aneurysm diameter of 53.55 mm.</p><p><strong>Conclusion: </strong>Cases with identified risk factors are considered to have a higher risk of T2EL-related reintervention after EVAR. Exceeding the new risk thresholds may indicate a higher likelihood of T2EL-related reintervention after EVAR.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1450942"},"PeriodicalIF":2.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the hidden burden: prevalence and factors linked to left ventricular hypertrophy in hypertensive patients receiving care in Harari region, Ethiopia.","authors":"Ashenafi Tadesse, Zerihun Abera Ayele, Megnot Hailu Mekonnen, Sinetibeb Mesfin, Dawit Abebe","doi":"10.3389/fcvm.2025.1533707","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1533707","url":null,"abstract":"<p><strong>Background: </strong>Left ventricular hypertrophy (LVH) is often a complication of hypertension and an independent risk factor for cardiovascular events. In Ethiopia, there is a scarcity of data on the prevalence and associated factors of left ventricular hypertrophy among hypertensive adults. This study aimed to assess the prevalence and associated factors of left ventricular hypertrophy among adult patients with hypertension attending treatment at two public hospitals in Harar, Eastern Ethiopia from 20 December 2021 to 20 December 2023.</p><p><strong>Method: </strong>A hospital-based cross-sectional study was conducted on 264 hypertensive patients from 20 December 2021 to 20 December 2023. A pretested structured questionnaire and checklist were used to collect data from participants and their clinical records. The data were collected by trained residents and interns. Data were analyzed using SPSS version 29. Left ventricular mass was measured by transthoracic echocardiography. Associations between categorical variables were assessed using a chi-square test and odds ratio with 95% confidence interval. A logistic regression model was used to identify risk factors of LVH. <i>p</i>-values of <0.05 were considered as statistically significant.</p><p><strong>Results: </strong>The study included 264 adults with hypertension, with a mean age of 58.4 years, and the majority (54.5%) were male. The prevalence of echocardiographically confirmed left ventricular hypertrophy (LVH) was 30.7% (95% CI: 25.1%-36.3%), with mild LVH being the most common type (51%). Significant predictors of LVH included age over 60 years [adjusted odds ratio (AOR) = 5.981, CI = 1.832-19.522, <i>p</i> = 0.003], khat chewing (AOR = 2.676, CI = 1.786-9.109, <i>p</i> = 0.001), diabetes (AOR = 10.430, CI = 2.904-37.454, <i>p</i> < 0.001), poor medication adherence (AOR = 4.132, CI = 1.208-14.141, <i>p</i> = 0.024), uncontrolled systolic blood pressure (AOR = 8.340, CI = 2.280-30.512, <i>p</i> = 0.001), lack of home blood pressure monitoring (AOR = 5.591, CI = 1.041-30.012, <i>p</i> = 0.045), and longer hypertension duration (AOR = 8.766, CI = 2.101-36.584, <i>p</i> = 0.003). These findings emphasize the need to address modifiable risk factors in managing hypertension to reduce the burden of LVH.</p><p><strong>Conclusions: </strong>The echocardiographic prevalence of LVH was 30.7% in the study population. These results highlight the importance of addressing modifiable risks to reduce LVH burden.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1533707"},"PeriodicalIF":2.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between polychlorinated biphenyls and hypertension risk: a systematic review and meta-analysis.","authors":"Seyedeh Fatemeh Hamzavi, Iman Elahi Vahed, Ali Samadi Shams, Fateme Nozari, Baroukh Gamzeh Latava, Saman Mardukhi, Behnoosh Sabaghi, Zakieh Sadat Hosseini, Zohre Masoumi Shahr-E Babak, Sahar Ahrari, Ali Keshavarzian, Mohammad Rahmanian","doi":"10.3389/fcvm.2025.1529431","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1529431","url":null,"abstract":"<p><strong>Background and aim: </strong>Hypertension (HTN) is a widespread global health challenge, and its increasing prevalence is attributed to individual and environmental risk factors. Persistent organic pollutants (POPs), especially polychlorinated biphenyls (PCBs), contribute to cardiovascular risk by accumulating in fatty tissues, which leads to oxidative stress and vascular inflammation. This review and meta-analysis aimed to investigate the association between PCB exposure and hypertension.</p><p><strong>Methods: </strong>Adhering to the PRISMA 2020 guidelines, data sources such as PubMed, Scopus, Web of Science, and Google Scholar were systematically searched up to July 2024 to find observational studies on the link between PCBs and hypertension risk. Studies were reviewed and chosen according to established inclusion and exclusion criteria, focusing on observational studies examining PCB exposure and hypertension risk. Independent reviewers conducted data extraction, and the quality of studies was evaluated using the JBI critical appraisal tool. A meta-analysis with a random-effects model was conducted to determine combined odds ratios (ORs) for hypertension linked to total PCB exposure and specific PCB types.</p><p><strong>Results: </strong>Of the 494 records identified, 21 studies met the inclusion criteria, comprising 5 cohort studies, 15 cross-sectional studies, and one case-control study, totaling 51,514 participants. Exposure to total PCBs correlated with an elevated risk of hypertension (OR = 1.78, 95% CI: 1.30-2.44). Dioxin-like PCBs were also associated with a heightened risk (OR = 1.54, 95% CI: 1.24-1.90), while non-dioxin-like PCBs were not significantly linked (OR = 1.16, 95% CI: 0.81-1.66). Among individual congeners, PCB-74, PCB-118, PCB-105, and PCB-153 were significantly related to higher hypertension risk.</p><p><strong>Conclusion: </strong>These findings indicate a positive correlation between PCB exposure and hypertension, particularly with dioxin-like PCBs and certain PCB congeners. Additional research is necessary to clarify the mechanisms involved and to promote measures for reducing PCB exposure, particularly in high-risk populations.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024595223, PROSPERO (CRD42024595223).</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1529431"},"PeriodicalIF":2.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in the study of the mechanism of ferroptosis in coronary heart disease and clinical intervention strategies.","authors":"Yingzhi Liu, Zixuan Yu, Yuwen Lu, Yue Liu, Lingli Chen, Jie Li","doi":"10.3389/fcvm.2025.1545231","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1545231","url":null,"abstract":"<p><p>Coronary heart disease (CHD), a serious cardiovascular condition with complex and diverse pathogenesis, has recently seen increased attention to the role of ferroptosis-a novel iron-dependent form of programmed cell death. This review synthesizes current research on ferroptosis mechanisms in CHD and emerging clinical intervention strategies. Ferroptosis is characterized by dysregulated iron metabolism, lipid peroxidation, and reactive oxygen species (ROS) accumulation, processes intimately linked to CHD pathophysiology. Under ischemic and hypoxic conditions commonly seen in coronary artery disease (CAD), cardiomyocytes become particularly susceptible to ferroptosis, resulting in cellular dysfunction and diminished cardiac performance. Mechanistic studies have revealed that altered expression of iron metabolism-related proteins (including GPX4, FTH1, TfR1, and HO-1), accumulation of lipid peroxidation products, and disruption of antioxidant defense systems (particularly the Nrf2/GPX4 pathway) are central to ferroptosis progression in cardiac tissue. Clinically, both specific ferroptosis inhibitors (such as Ferrostatin-1) and traditional medicine components (such as Puerarin) have emerged as promising therapeutic candidates, showing cardioprotective effects in experimental models. However, research into ferroptosis mechanisms in CHD remains in its early stages, with significant questions regarding its relationship with other cell death pathways and the clinical efficacy of ferroptosis-targeting interventions requiring further investigation. Future research directions should include in-depth mechanistic exploration and the development of more effective, safer clinical interventions targeting the ferroptosis pathway in cardiovascular disease.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1545231"},"PeriodicalIF":2.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter tricuspid valve replacement: will it prevail?","authors":"Xiling Zhang, Nina Sophie Pommert, David Meier, Stephanie L Sellers, Hatim Seoudy, Oliver J Müller, Derk Frank, Tim Attmann, Rouven Berndt, Gregor Warnecke, Thomas Puehler, Georg Lutter","doi":"10.3389/fcvm.2025.1562658","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1562658","url":null,"abstract":"<p><p>Severe tricuspid regurgitation (TR) is a prevalent and challenging condition associated with poor survival outcomes and significant morbidity. Medical therapy alone often fails to provide adequate symptom relief, and stand-alone surgical intervention is linked to high mortality rates, making it a less favorable option unless combined with left-sided valve surgery. The advent of transcatheter tricuspid interventions has provided new therapeutic possibilities, particularly for high-risk patients who are ineligible for conventional surgery. However, many patients are still unsuited for transcatheter tricuspid repair or have only limited benefits from such procedures. In this context, Transcatheter tricuspid valve replacement (TTVR) has rapidly emerged as a promising alternative, offering the potential for more effective treatment outcomes. This review explores the latest advancements in TTVR devices, highlights key clinical findings, and discusses the challenges and limitations of this evolving strategy. Additionally, we address patient selection criteria, procedural outcomes, and future directions in the field, emphasizing the potential of TTVR to transform the management of severe TR.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1562658"},"PeriodicalIF":2.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical study into the impact of brief aerobic exercise on the cardiopulmonary function of patients diagnosed with hyperlipidemia.","authors":"Hua Zhang, Ya-Ru Ge, Li Feng, Jing Zhang, Ning Wang, Xiao-Yan Zhang, Cong Liu","doi":"10.3389/fcvm.2025.1484693","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1484693","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine the effectiveness of brief aerobic exercise on patients diagnosed with hyperlipidemia.</p><p><strong>Methods: </strong>Seventy patients diagnosed with hyperlipidemia were enrolled from community health centers between May 2023 and October 2023. They were randomly assigned into two groups: test and control group, each consisting of 35 patients. The test group received personalized exercise recommendations along with routine medication, while the control group only received routine medication. The effectiveness of the intervention was assessed after 3 months. Various indicators including blood pressure, lipid levels, changes in cardiopulmonary function, 6-minute walk distance (6MWD) test results, the percentage of 6MWD relative to the predicted value (6MWD%Pred), copeptin (CPP), and fibroblast growth factor 21 (FGF21) were compared, before and after the intervention within each group and between the two groups.</p><p><strong>Results: </strong>After 3 months of personalized exercise, the test group showed significantly higher levels in three indicators compared to the control group. Specifically, the test group exhibited higher metabolic equivalent (MET) values [( <math> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> </math>  ± SD<i>,</i> 4.6 ± 0.27 METs) vs. ( <math> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> </math>  ± SD, 3.8 ± 1.06 METs); <i>P</i> < 0.05], longer 6-minute walk distance (6MWD) [( <math> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> </math>  ± SD, 488.08 ± 40.59 meters) vs. ( <math> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> </math>  ± SD, 366.76 ± 160.49 meters); <i>P</i> < 0.05], and a higher percentage of 6MWD relative to the predicted value (6MWD %Pred) [( <math> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> </math>  ± SD, 92.8 ± 14.05) vs. ( <math> <mrow><mover><mi>x</mi> <mo>¯</mo></mover> </mrow> </math>  ± SD, 71.3 ± 30.69); <i>P</i> < 0.05]. Additionally, within the test group, there was a significant increase in MET, 6MWD, and 6MWD%Pred compared to baseline (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Short-term aerobic exercise shows significant improvement in the cardiopulmonary function of patients with hyperlipidemia. However, it did not exhibit significant efficacy in managing hyperlipidemia.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1484693"},"PeriodicalIF":2.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the COVID-19 pandemic on ST-segment elevation myocardial infarction treatment strategy and outcomes.","authors":"Jakub Bychowski, Tomasz Michalski, Wojciech Sobiczewski, Miłosz Jaguszewski, Marcin Gruchała","doi":"10.3389/fcvm.2025.1522661","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1522661","url":null,"abstract":"<p><strong>Background: </strong>The most reliable care quality indicators for STEMI patients undergoing primary percutaneous coronary intervention (pPCI) include onset-to-door time (OTDT), time from admission to wire crossing and in-hospital mortality.</p><p><strong>Aims: </strong>Our study aimed to evaluate the impact of the COVID-19 pandemic on these selected care quality indicators in pre-pandemic and pandemic groups of STEMI patients.</p><p><strong>Methods: </strong>This single-centre, retrospective study, enrolled 480 STEMI patients, aged 63.59 ± 12.44 years treated with pPCI across two time frames: pre-pandemic (<i>n</i> = 331) and pandemic (<i>n</i> = 149). The evaluation criteria included OTDT, time from admission to PCI-mediated reperfusion, in-hospital mortality, and predictors of time delays.</p><p><strong>Results: </strong>Our study revealed a significant increases in OTDT (median 3 h; IQR 1.5-12.0 vs. median 5 h; IQR 2.0-24.0, <i>p</i> = 0.011) and time from admission to wire crossing (median 92 min; IQR 65.0-187.0 vs. median 115.0; IQR 73.0-233.0, <i>p</i> = 0.025), in the COVID-19 pandemic group of STEMI patients, compared to the pre-pandemic subset. We also observed an increase in in-hospital mortality (7.85% vs. 14.09%, <i>p</i> = 0.033) and incidence of cardiogenic shock/cardiac arrest (16.62% vs. 26.85%, <i>p</i> = 0.009). Additionally, the proportion of patients with prolonged OTDT (24.45% vs. 35.71%, <i>p</i> = 0.019) and extended time from admission to PCI-mediated reperfusion (51.96% vs. 65.77%, <i>p</i> = 0.005) increased during the pandemic period.</p><p><strong>Conclusions: </strong>The study's results indicated prolonged OTDT and admission-to-wire crossing times, increased in-hospital mortality, and the higher frequency of cardiogenic shock/cardiac arrest during the COVID-19 pandemic. These findings demonstrate the negative impact of the pandemic on treatment times and outcomes for patients diagnosed with STEMI.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1522661"},"PeriodicalIF":2.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating bacterial DNA in cardiovascular disease.","authors":"Sarah Appleby, Rachel Purcell","doi":"10.3389/fcvm.2025.1476165","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1476165","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) remains a global health burden despite advances in prevention and treatment. Conventional biomarkers, while effective for a number of patient groups, fail to provide personalized diagnosis and prognosis, necessitating the exploration of novel markers. Advancements in sequencing technology have unveiled the role of cell-free DNA (cfDNA) as a reservoir of genetic information from all cells within the body, and associations between elevated cfDNA levels and CVD risk factors and status have been reported. Recent attention has turned to a subset of cfDNA, circulating bacterial DNA (cbDNA), derived from gut microbiota, as a potential biomarker. Investigations into microbial translocation from the gut, particularly the phenomenon of 'leaky gut,' reveal its association with CVD and provide a potential source for cbDNA. Here, we review the existing literature on cbDNA in CVD, highlighting its potential diagnostic and prognostic value. Current studies have largely been carried out in small, disparate cohorts, using different sample types and a range of methodologies. While cbDNA shows potential as a diagnostic and prognostic biomarker, the lack of consensus in methodologies and populations studied calls for standardized approaches and large cohorts to establish cbDNA as a reliable CVD biomarker. Future research should focus on identifying the source of cbDNA and its pathological relevance, utilizing advanced sequencing techniques and standardized cohorts for conclusive findings.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1476165"},"PeriodicalIF":2.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effects of coffee consumption on the structure and function of the heart from multiple perspectives.","authors":"Xiong-Bin Ma, Yan-Lin Lv, Lin Qian, Jing-Fen Yang, Qian Song, Yong-Ming Liu","doi":"10.3389/fcvm.2025.1453106","DOIUrl":"https://doi.org/10.3389/fcvm.2025.1453106","url":null,"abstract":"<p><strong>Objective: </strong>To assess the causal relationship between coffee consumption and cardiac structure and function in elderly European populations using multiple genetic methodologies.</p><p><strong>Methods: </strong>Leveraging genome-wide association study (GWAS) data from elderly European populations, we conducted linkage disequilibrium score regression (LDSC), two-step Mendelian randomization (MR), and colocalization analyses to investigate genetic associations, causal relationships, and mediating effects among these factors. Robustness of findings was verified through comprehensive sensitivity analyses.</p><p><strong>Results: </strong>LDSC regression analysis revealed positive genetic correlations between coffee consumption and cardiac parameters, excluding left ventricular (LV) ejection fraction and right ventricular (RV) ejection fraction. MR results demonstrated favorable associations between increased coffee consumption and cardiac parameters. After applying the Bonferroni adjustment to IVW analysis, as coffee consumption increased by each 1-cup/day, LV end-diastolic volume increased (<i>β</i> = 0.128; 95% CI: 0.043-0.212; <i>P</i> = 0.002), an increase in LV end-systolic volume (<i>β</i> = 0.143; 95% CI: 0.053-0.232; <i>P</i> = 0.001), an increase in RV end-diastolic volume (<i>β</i> = 0.200; 95% CI: 0.095-0.305; <i>P</i> < 0.001), and an increase in RV stroke volume (<i>β</i> = 0.209; 95% CI: 0.104-0.313; <i>P</i> < 0.001). Mediation analyses indicated that each 1-cup/day increase in coffee consumption significantly correlated with reduced diastolic blood pressure (DBP) and elevated body mass index (BMI). Notably, higher DBP exhibited inverse associations with ventricular systolic/diastolic functional parameters, whereas increased BMI demonstrated positive associations with these parameters, collectively mitigating age-related ventricular volume loss. No U-shaped associations were detected in linear MR frameworks. Colocalization analyses confirmed shared causal genetic variants between coffee intake and cardiac remodeling phenotypes.</p><p><strong>Conclusions: </strong>Genetically predicted coffee consumption may counteract age-associated ventricular volume loss in elderly Europeans through dual mediation pathways involving DBP reduction and BMI elevation. These structural adaptations suggest potential cardioprotective mechanisms against senile cardiac atrophy. Future studies should prioritize the integration of coffee consumption into cardiovascular risk assessment frameworks and develop personalized recommendations based on individual health profiles.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1453106"},"PeriodicalIF":2.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}