Frontiers in Cardiovascular Medicine最新文献

{"title":"Influence of remnant lipoprotein particle cholesterol on non-target lesions progression in patients undergoing percutaneous coronary intervention.","authors":"Jing Liu, Tian-Qi Teng, Zheng Li, Feng-Wang Hu, Wei-Wei Sha, Chang-Xian Shen, Yong Xia, Yao-Jun Zhang, Li Liang","doi":"10.3389/fcvm.2024.1471479","DOIUrl":"10.3389/fcvm.2024.1471479","url":null,"abstract":"<p><strong>Background: </strong>Low-Density Lipoprotein Cholesterol (LDL-C) is the primary lipid therapy target for coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI). However, progression of coronary atherosclerosis occurs even LDL-C controlled well, some potentially important factors have been overlooked.</p><p><strong>Objective: </strong>This study aims to elucidate the relationship between remnant lipoprotein particle cholesterol (RLP-C) and the progression of non-target lesions (NTLs) in patients with well-controlled lipid levels after PCI.</p><p><strong>Methods: </strong>This retrospective study included 769 CAD patients who underwent PCI and followed up angiography within 6-24 months thereafter. Employing Multivariate Cox regression analysis, we assessed the correlation between RLP-C and NTLs progression. Based on the receiver operating characteristic curve analysis, we identified the optimal cutoff point for RLP-C, following which the patients were divided into two groups. Propensity score matching balanced confounding factors between groups, and Log-rank tests compared Kaplan-Meier curves for overall follow-up to assess NTLs progression.</p><p><strong>Results: </strong>Multivariate Cox analysis revealed an independent association between RLP-C and NTLs progression when LDL-C was well-controlled. Additionally, the RLP-C level of 0.555 mmol/L was determined to be the best value for predicting NTLs progression. Following propensity score matching, Kaplan-Meier curves illustrated a significantly higher cumulative rate of NTLs progression in patients with RLP-C levels ≥0.555 mmol/L compared to the others (Log-rank <i>P</i> = 0.002). Elevated RLP-C levels were associated with high triglyceride concentrations, diabetes mellitus, and increased risk of revascularization.</p><p><strong>Conclusions: </strong>This study illustrated the atherogenic impact of RLP-C in CAD patients. High RLP-C levels increased the risk of revascularization.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1471479"},"PeriodicalIF":2.8,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrotendinous xanthomatosis: a literature review and case study.","authors":"Anthony Matta, Fabienne Ory Magne, Thierry Levade, Fabrice Bonneville, Jean Ferrières","doi":"10.3389/fcvm.2024.1496442","DOIUrl":"10.3389/fcvm.2024.1496442","url":null,"abstract":"<p><p>Cerebrotendinous xanthomatosis (CTX) is a rare but treatable inherited neurometabolic disorder that can lead to severe sequelae if left untreated. Chenodeoxycholic acid is a safe and effective treatment for CTX. Early diagnosis is essential to improve patient outcomes. Neurological disturbances, cataracts, and intractable diarrhea are key features to raise diagnostic suspicion and differentiate CTX from other metabolic disorders in patients with dyslipidemia and xanthomas. The diagnosis of CTX depends on high cholestanol plasma levels, undetectable plasma bile acids, neuroradiological findings, and CYP27A1 gene analysis. This review provides a stepwise approach to diagnosing patients with CTX, aims to improve physician awareness of CTX, and highlights the effectiveness of chenodeoxycholic acid as the standard of care. In addition, we report a unique case of CTX with major premature cardiovascular events, initially misdiagnosed as heterozygous familial hypercholesterolemia. This review also provides evidence to establish the c.470T>C (p. Leu157Pro) variant of the CYP27A1 gene as a likely pathologic variant.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1496442"},"PeriodicalIF":2.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 inhibitors for alleviating heart failure through non-hypoglycemic mechanisms.","authors":"Ya-Ru Chen, Fang-Yuan Zhu, Rong Zhou","doi":"10.3389/fcvm.2024.1494882","DOIUrl":"10.3389/fcvm.2024.1494882","url":null,"abstract":"<p><p>Sodium-glucose cotransporter-2 (SGLT2) inhibitors afford significant cardiovascular benefits to patients with diabetes mellitus and heart failure. Three large randomized clinical trials (EMPAREG-Outcomes, DECLARE-TIMI58, and DAPA-HF) have shown that SGLT2 inhibitors prevent cardiovascular events and reduce the risk of death and hospital admission resulting from heart failure. Patients without type 2 diabetes mellitus (T2DM) also experience a similar degree of cardiovascular benefit as those with T2DM do. SGLT2 inhibitors could improve cardiac function through potential non-hypoglycemic mechanisms, including the reduction of the circulatory volume load, regulation of energy metabolism, maintenance of ion homeostasis, alleviation of inflammation and oxidative stress, and direct inhibition of cardiac SGLT1 receptors and antimyocardial fibrosis. This article reviews the mechanism through which SGLT2 inhibitors prevent/alleviate heart failure through non-hypoglycemic pathways, to support their use for the treatment of heart failure in non-T2DM patients.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1494882"},"PeriodicalIF":2.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JN. 1 and cardiac-related clinical manifestations: a current public health concern.","authors":"Sangeeta Chhotaray, Pralaya Kumar Sahoo, Suman Kumar Mekap, Soumya Jal, Gurudutta Pattnaik","doi":"10.3389/fcvm.2024.1488226","DOIUrl":"10.3389/fcvm.2024.1488226","url":null,"abstract":"","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1488226"},"PeriodicalIF":2.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Concurrent transcatheter aortic and mitral valve replacement for symptomatic concomitant aortic and mitral valve stenoses.","authors":"Benjamin Mothibe Bussmann, Sam Dawkins, James Newton, Thomas Cahill","doi":"10.3389/fcvm.2024.1487061","DOIUrl":"10.3389/fcvm.2024.1487061","url":null,"abstract":"<p><p>In patients undergoing transcatheter aortic valve implantation (TAVI), multi-valve disease is common and associated with worse outcomes. Despite multiple emerging transcatheter valve treatment options, no guidelines exist for the transcatheter treatment of multi-valve disease. We present a case of a 76-year-old patient with concomitant severe aortic valve stenosis and severe mitral valve stenosis who underwent concurrent TAVI and transcatheter mitral valve replacement. In this case report, we demonstrate the feasibility of concurrent double-valve transcatheter intervention to treat patients with multi-valve disease. We also highlight the role of the heart valve team to guide individual patient treatment strategies in the absence of clinical guidelines and the importance of multi-modality imaging to plan and execute the procedure.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1487061"},"PeriodicalIF":2.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between waist-to-hip ratio and risk of myocardial infarction: a systematic evaluation and meta-analysis.","authors":"Xiaojuan Zhang, Liu Yang, Cong Xiao, Jiacong Li, Tao Hu, Linfeng Li","doi":"10.3389/fcvm.2024.1438817","DOIUrl":"10.3389/fcvm.2024.1438817","url":null,"abstract":"<p><strong>Background: </strong>Myocardial infarction(MI) is one of the most serious health threats. Despite the increasing number of clinical methods used to predict the onset of MI, the prediction of MI is still unsatisfactory and necessitates new methods.</p><p><strong>Objective: </strong>To systematically review observational studies from the past two decades on the association between waist-to-hip ratio (WHR) and MI risk.</p><p><strong>Methods: </strong>Original literature on the correlation between WHR and MI was searched in PubMed, Embase, Web of Science, Cochrane Library, Science Direct, CNKI, and Wanfang up to January 31, 2024. Two researchers independently screened, extracted data, and assessed quality using the Newcastle-Ottawa Scale (NOS) and Revman5.3. Meta-analysis with Stata 16.0 calculated the combined Odd ratio (OR) for WHR and MI risk. Heterogeneity was assessed with the <i>I</i> ² statistic to select the appropriate effects model. Subgroup analysis, meta-regression, sensitivity analysis, and funnel plots tested for heterogeneity and publication bias.</p><p><strong>Results: </strong>A total of 22 observational studies were included, involving 709,093 participants. The meta-analysis showed that an elevated WHR was significantly associated with an increased risk of MI, with a pooled odds ratio (OR) of 1.98 [95% Confidence interval (CI): 1.75-2.24] and high heterogeneity (<i>I</i> ² = 91.5%, <i>P</i> < 0.0001). Subgroup analysis revealed a stronger association between WHR and MI in women (OR: 1.99, 95% CI: 1.43-2.77) compared to men (OR: 1.74, 95% CI: 1.36-2.22). Regional analysis indicated that the association between WHR and MI risk was highest in Asian populations (OR: 2.93 95% CI: 1.61-5.33), followed by American (OR: 1.73, 95% CI: 1.45-2.08) and European populations (OR: 2.19, 95% CI: 1.49-3.22). Sensitivity analysis demonstrated that the results remained stable after excluding one study.</p><p><strong>Conclusion: </strong>In the general adult population, a higher WHR is a potentially significant association for MI and has predictive value for MI.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1438817"},"PeriodicalIF":2.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cardiovascular-kidney-metabolic index with all-cause mortality during hospitalization in critically ill patients: a retrospective cohort study from MIMIC IV2.2.","authors":"Xiaolong Qu, Yuping Liu, Peng Nie, Lei Huang","doi":"10.3389/fcvm.2024.1513212","DOIUrl":"10.3389/fcvm.2024.1513212","url":null,"abstract":"<p><strong>Background: </strong>The cardiovascular-kidney-metabolic index (CKMI), a novel functional indicator proposed in this study, aims to accurately reflect the functional status of the heart, kidneys, and metabolism. However, its ability to predict mortality risk in critically ill patients during their stay in the intensive care unit (ICU) remains uncertain. Therefore, this study aims to validate the correlation between the CKMI during hospitalization and all-cause mortality.</p><p><strong>Methods: </strong>The study utilized the Medical Information Mart for Intensive Care IV 2.2 (MIMIC-IV) dataset for a retrospective analysis of cohorts. The cohorts were divided into quartiles based on CKMI index levels. The primary endpoint was all-cause mortality during ICU and hospital stay, while secondary endpoints included the duration of ICU stay and overall hospitalization period. We established Cox proportional hazards models and employed multivariable Cox regression analysis and restricted cubic spline (RCS) regression analysis to explore the relationship between CKMI index and all-cause mortality during hospitalization in critically ill patients. Additionally, subgroup analyses were conducted based on different subgroups.</p><p><strong>Results: </strong>The study enrolled 1,576 patients (male 60.79%). In-patient and ICU mortality was 11.55% and 6.73%. Multivariate COX regression analysis demonstrated a significant negative correlation between CKMI index and the risk of hospital death [HR, 0.26 (95% CI 0.07-0.93), <i>P</i> = 0.038] and ICU mortality [HR, 0.13 (95% CI 0.03-0.67), <i>P</i> = 0.014].RCS regression model revealed that in-hospital mortality (<i>P</i>-value =0.015, P-Nonlinear =0.459) and ICU mortality (<i>P</i>-value =0.029, P-Nonlinear =0.432) increased linearly with increasing CKMI index. Subgroup analysis confirmed consistent effect size and direction across different subgroups, ensuring stable results.</p><p><strong>Conclusion: </strong>Our research findings suggest that a higher CKMI index is associated with a significant reduction in both in-hospital and ICU mortality among critically ill patients. Therefore, CKMI index emerges as a highly valuable prognostic indicator for predicting the risk of in-hospital death in this population. However, to strengthen the validity of these results, further validation through larger-scale prospective studies is imperative.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1513212"},"PeriodicalIF":2.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between self-reported sleep duration and incident cardiovascular diseases in a nationwide prospective cohort study of Chinese middle-aged and older adults.","authors":"Qing Zhao, Yuan Zhu, Yu Zhang, Huanyuan Luo, Yantao Ma, Xiaoshan Chen, Jiaming Gu, Lizhi Wang","doi":"10.3389/fcvm.2024.1474426","DOIUrl":"10.3389/fcvm.2024.1474426","url":null,"abstract":"<p><strong>Purpose: </strong>This study explores the correlation between sleep duration and cardiovascular disease (CVD) among middle-aged and older adults in China. Furthermore, we aim to investigate the association between sleep duration and incident CVD in this population, while assessing potential variations across different age and gender subgroups.</p><p><strong>Methods: </strong>Utilizing data from the nationwide prospective survey of the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2011, 2013, 2015, and 2018, involving 17,596 participants aged 45 years and above, we employed Cox proportional hazards regression models. These models were used to examine the impact of baseline sleep duration on CVD, considering age (middle-aged/elderly) and gender (male/female) groups.</p><p><strong>Results: </strong>Over the 8-year follow-up, 2,359 CVD events were recorded. Compared to individuals sleeping 6-8 h per day, a short sleep duration (≤6 h/day) was significantly associated with an increased risk of CVD (HR: 1.17, 95% CI: 1.03-1.33). Subgroup analysis revealed a more pronounced relationship in participants aged ≥60 years, where both short sleep duration (≤6 h/day) (HR: 1.17, 95% CI: 1.02-1.35) and long sleep duration (>8 h/day) (HR: 1.20, 95% CI: 1.02-1.41) were significantly associated with an elevated risk of CVD. Specifically, among female participants, short sleep durations (≤6 h/day) was significantly associated with CVD (HR: 1.24, 95% CI: 1.05-1.47).</p><p><strong>Conclusion: </strong>Short sleep durations can serve as predictive factors for CVD in China's population aged 45 and above, particularly among elderly female participants. Our study underscores the importance of considering sleep health as a critical aspect when formulating strategies for enhancing CVD prevention.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1474426"},"PeriodicalIF":2.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular intravascular intervention for central venous stenosis in maintenance hemodialysis patients: a retrospective observational study.","authors":"Yiming Tao, Jianyun Wang, Jianchao Ma, Siqi Peng, Boxi Chen, Shuting Deng, Ye Yuan, Nan Jiang, Sichun Wen, Bohou Li, Qiong Wu, Lixia Xu, Sijia Li, Ting Lin, Feng Wen, Lei Fu, Zhuo Li, Renwei Huang, Chaosheng He, Wenjian Wang, Zhiming Ye, Wei Shi, Zhonglin Feng, Shuangxin Liu","doi":"10.3389/fcvm.2024.1405606","DOIUrl":"10.3389/fcvm.2024.1405606","url":null,"abstract":"<p><strong>Background: </strong>The number of people undergoing maintenance hemodialysis is increasing rapidly worldwide. Central vein stenosis (CVS) is a common vascular complication in undergoing hemodialysis, especially those with a history of catheterization. This study aimed to investigate the characteristics of CVS and the clinical effectiveness of percutaneous transluminal angioplasty (PTA) alone and sequential percutaneous transluminal stenting (PTS) in hemodialysis patients with CVS.</p><p><strong>Methods: </strong>A retrospective analysis of 26 cases of endovascular intervention for CVS using PTA alone or sequential PTS was performed. The characteristics of CVS and the clinical effectiveness of these procedures were evaluated.</p><p><strong>Results: </strong>This study included 26 hemodialysis patients who presented with symptomatic CVS. Of these 26 patients, 53.85% were male, and their mean age was approximately 54.96 years. All the patients had a history of catheter placement or pacemaker implantation. The incidence of brachiocephalic vein stenosis was significantly higher than that of subclavian vein stenosis (46.16% vs. 26.92%). Based on the degree of stenosis and elastic retraction, these patients were administered PTA alone or sequential PTS. There was no difference in patient age, hemodialysis time, catheter retention time, or stenosis length between the PTA alone and sequential PTS groups. However, the degree of venous stenosis in the PTS group was more severe than that in the PTA alone group. The primary patency rates in the sequential PTS and PTA alone groups were 94.12% and 100% at 3 months; 88.24% and 88.89% at 6 months; 75.00% and 85.71% at 9 months; and 66.67% and 71.43% at 12 months, respectively. It is worth noting that for 7 patients with complete occlusion of the brachiocephalic vein, we used sharp recanalization technology and stenting placement, with patency rates of 85.71% and 71.43% at 6 and 12 months, respectively.</p><p><strong>Conclusions: </strong>PTA alone is recommended for patients with less than 50% central venous elastic retraction, while sequential PTS is recommended for patients with ≥ 50% central venous elastic retraction. PTA and PTS are safe and effective methods for the treatment of CVS in patients undergoing hemodialysis.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1405606"},"PeriodicalIF":2.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in sepsis-associated cardiovascular disease mortality in the United States, 1999 to 2022.","authors":"Malik Salman, Jack Cicin, Ali Bin Abdul Jabbar, Ahmed El-Shaer, Abubakar Tauseef, Noureen Asghar, Mohsin Mirza, Ahmed Aboeata","doi":"10.3389/fcvm.2024.1505905","DOIUrl":"10.3389/fcvm.2024.1505905","url":null,"abstract":"<p><strong>Purpose: </strong>Cardiovascular disease (CVD) is the leading cause of death in the United States, and sepsis significantly contributes to hospitalization and mortality. This study aims to assess the trends of sepsis-associated CVD mortality rates and variations in mortality based on demographics and regions in the US.</p><p><strong>Methods: </strong>The Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database was used to identify CVD and sepsis-related deaths from 1999 to 2022. Data on gender, race and ethnicity, age groups, region, and state classification were statistically analyzed to obtain crude and age-adjusted mortality rates (AAMR). The Joinpoint Regression Program was used to determine trends in mortality within the study period.</p><p><strong>Results: </strong>During the study period, there were a total of 1,842,641 deaths with both CVD and sepsis listed as a cause of death. Sepsis-associated CVD mortality decreased between 1999 and 2013, from AAMR of 65.7 in 1999 to 58.8 in 2013 (APC -1.06*%, 95% CI: -2.12% to -0.26%), then rose to 74.3 in 2022 (APC 3.23*%, 95% CI: 2.18%-5.40%). Throughout the study period, mortality rates were highest in men, NH Black adults, and elderly adults (65+ years old). The Northeast region, which had the highest mortality rate in the initial part of the study period, was the only region to see a decline in mortality, while the Northwest, Midwest, and Southern regions experienced significant increases in mortality rates.</p><p><strong>Conclusion: </strong>Sepsis-associated CVD mortality has increased in the US over the past decade, and both this general trend and the demographic disparities have worsened since the onset of the COVID-19 pandemic.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"11 ","pages":"1505905"},"PeriodicalIF":2.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}