Frontiers in Behavioral Neuroscience最新文献

{"title":"Regional prefrontal and hippocampal differences in gray matter volume are linked to the propensity for renewal in extinction learning.","authors":"Silke Lissek, Martin Tegenthoff","doi":"10.3389/fnbeh.2025.1592929","DOIUrl":"10.3389/fnbeh.2025.1592929","url":null,"abstract":"<p><strong>Introduction: </strong>The renewal effect of extinction describes the reoccurrence of an extinguished response if recall is performed in a context that is not the same as the extinction context. This learning phenomenon is clinically relevant, since it potentially interferes with therapy success for anxiety disorders or phobias. The propensity to show the renewal effect appears to be a stable processing strategy in context-related extinction, associated with higher BOLD activation in hippocampus, ventromedial PFC (vmPFC) and inferior frontal gyrus (IFG) in individuals who show renewal (REN) compared to those who do not (NoREN). However, evidence on a potential relationship between structural properties such as gray matter volume (GMV) in these regions and the propensity to show renewal is lacking.</p><p><strong>Methods: </strong>In this study, we applied voxel-based morphometry (VBM) to investigate whether individuals with and without a propensity for renewal differ regarding their GMV in extinction-related brain regions, and whether such a difference is linked to the renewal level.</p><p><strong>Results: </strong>Results revealed differential GMV in REN and NoREN in adjacent subregions of IFG and vmPFC, respectively. Higher GMV in REN was located predominantly in orbital IFG and in BA10 of vmPFC. Higher GMV in NoREN was located predominantly in triangular IFG and in BA 11 of vmPFC. In bilateral anterior cingulate cortex (ACC) and anterior hippocampus, GMV was overall higher in NoREN. In the complete sample, higher GMV in IFG BA 47, vmPFC BA11, bilateral ACC and bilateral anterior hippocampus was associated with less renewal, and partially with a higher error level in extinction learning in a novel context.</p><p><strong>Discussion: </strong>The findings suggest that higher GMV in several regions active during extinction learning may support a more thorough processing of extinction trials which in turn could be conducive to an extinction recall solely based on recent extinction memory, disregarding context information. In summary, this study provides first-time evidence for a relationship of GMV in of extinction- and renewal-relevant brain regions with behavioral performance during extinction learning and the propensity to show the renewal effect.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1592929"},"PeriodicalIF":2.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic 17β-estradiol treatment improves negative valence, anhedonic profile, and social interactions in ovariectomized, middle-aged female rats.","authors":"Cheryl D Conrad, Dylan N Peay, Sara Sladkova, Jinah L Kim, Megan E Donnay, Amanda M Acuña, Kennedy E Whittaker","doi":"10.3389/fnbeh.2025.1553501","DOIUrl":"10.3389/fnbeh.2025.1553501","url":null,"abstract":"<p><p>Women experience depression at nearly 2-fold higher rates than men, with middle-age during the menopausal transition being particularly vulnerable. Preclinical studies commonly focus on young adult or aged subjects and/or rely upon a few behavioral tasks. Given the highly variable and heterogenous nature of depression, the current study implemented a behavioral battery to assess whether estradiol (E2, endogenously expressed in women and rats) would improve depressive measures using the Research Domain Criteria (RDoC) for negative valence, anhedonia, sociability, and anxiety in early middle-aged, ovariectomized (OVX) female rats. F344-cdf rats were OVX and injected daily with E2 (3 μg/ml, or oil). Behavioral testing began after 14 days of injections, which continued throughout the study. E2 improved the depressive profile when using a composite metric for negative valence (immobility on the forced swim task, FST), anhedonia (duration to initiate grooming following sucrose splash and latency to initiate grooming with sucrose), sociability (time interacting toward a novel conspecific), and novelty-induced anxiety (time spent investigating marbles). Interestingly, FST immobility significantly and positively correlated with sucrose preference to show they were opposingly related: higher immobility on FST corresponded to more sucrose ingested. Also, time spent in a chamber with a novel conspecific was less informative than time directed at the conspecific. Other tasks, such as the marble bury test showed some hoarding behavior. These nuances revealed difficulties in assessing behaviors within and across studies, but overall showed that E2 improved the depressive-like syndrome (DLS) in middle-aged females based upon the RDoC.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1553501"},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory state moderates response to cannabis on negative affect and sleep quality in individuals with anxiety.","authors":"Jonathon K Lisano, Carillon J Skrzynski, Gregory Giordano, Angela D Bryan, L Cinnamon Bidwell","doi":"10.3389/fnbeh.2025.1549311","DOIUrl":"10.3389/fnbeh.2025.1549311","url":null,"abstract":"<p><strong>Introduction: </strong>Inflammation has been implicated as an underlying pathology in negative affect and sleep disruption. Cannabinoids like delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) have demonstrated anti-inflammatory properties. This study aimed to assess if cannabis use altered cytokine concentration and whether inflammatory status moderated the influence of 4 weeks of cannabis use on negative affect and sleep quality in anxious individuals.</p><p><strong>Methods: </strong>Participants with mild or greater anxiety (<i>n</i> = 147) were assigned to one of three cannabis chemovars (THC + CBD, THC, CBD), asked to consume their products <i>ad libitum</i> for 4 weeks, and were compared to a group of participants with anxiety who did not use cannabis (<i>n</i> = 24). Measures of negative affect (Depression Anxiety and Stress Scale-21: DASS-21), sleep quality (Pittsburgh Sleep Quality Index: PSQI), and plasma cytokine concentrations were measured at Baseline and Week-4. Multilevel modeling assessed if there were group-dependent changes in cytokine concentrations over time, and whether baseline inflammation moderated the association between cannabis use and both negative affect and sleep quality.</p><p><strong>Results: </strong>There were no group-dependent changes in cytokine concentrations throughout the study (<i>p</i> = 0.12). It was observed that baseline inflammatory state moderated the group-by-time relationship for DASS-21 (<i>p</i> < 0.001) and PSQI (<i>p</i> = 0.04). In both models, chemovars higher in CBD produced more consistent improvements, while THC-associated improvements varied by baseline inflammatory state.</p><p><strong>Conclusion: </strong>These novel findings suggest that baseline inflammatory status influences the relationship between cannabis use, negative affect, and sleep quality in people with anxiety.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1549311"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theta-gamma coupling: nonlinearity as a universal cross-frequency coupling mechanism.","authors":"Alex Sheremet, Yu Qin","doi":"10.3389/fnbeh.2025.1553000","DOIUrl":"10.3389/fnbeh.2025.1553000","url":null,"abstract":"<p><p>The Cross Frequency Coupling (CFC) phenomenon is defined as a statistical correlation between characteristic parameters neural oscillations. This study demonstrates and analyzes the nonlinear mechanism of the CFC, with a focus on the coupling between slow and fast oscillations, as a model for theta-gamma coupling. We first discuss the usage of the spectrum/bispectrum CFC measure using experimental data. As a physical paradigm, we propose the concept of a Class II neural population at low activity: neurons fire intermittently, and the time spent in the subthreshold regime is much larger that the duration of an action potential. We verify the emergence of fast oscillations (gamma) using a direct numerical simulations (DNS) of a population of Hodgkin-Huxley neurons forced by a slow theta oscillation. To deconstruct the mechanism, we derive a mean field approximation based on a reduction of the Hodgkin-Huxley model to a two-equation leaky-integrate-and-fire (LIF) model. Under theta forcing, mean field model generates gamma oscillations; the solutions exhibit spectrum/bispectrum CFC patterns that agree qualitatively with both the DNS model and experimental data. For the theta-gamma coupling problem, the mean field model may be linearized using an asymptotic expansion. The analytical solution of the linear system describes theta-gamma interaction as a gamma stabilization/destabilization cycle and provides explicit expressions of the gamma amplitude and frequency modulation by theta. The results demonstrate that nonlinearity as a universal/unifying mechanism of all CFC types.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1553000"},"PeriodicalIF":2.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Noninvasive brain stimulation: a promising approach to study and improve emotion regulation.","authors":"Masaru Tanaka, Zhenhong He, Shangfeng Han, Simone Battaglia","doi":"10.3389/fnbeh.2025.1633936","DOIUrl":"10.3389/fnbeh.2025.1633936","url":null,"abstract":"","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1633936"},"PeriodicalIF":2.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying social distance using deep learning-based video analysis: results from the BTBR mouse model of autism.","authors":"Tausif Khan, Kostiantyn Cherkas, Nikolas A Francis","doi":"10.3389/fnbeh.2025.1602205","DOIUrl":"10.3389/fnbeh.2025.1602205","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is characterized by challenges in social communication, difficulties in understanding social cues, a tendency to perform repetitive behaviors, and restricted interests. BTBR T⁺ Itpr3^tf/J (BTBR) mice exhibit ASD-like behavior and are often used to study the biological basis of ASD. Social behavior in BTBR mice is typically scored manually by experimenters, which limits the precision and accuracy of behavioral quantification. Recent advancements in deep learning-based tools for machine vision, such as DeepLabCut (DLC), enable automated tracking of individual mice housed in social groups. Here, we used DLC to measure locomotion and social distance in pairs of familiar mice. We quantified social distance by finding the Euclidean distance between pairs of tracked mice. BTBR mice showed hyperlocomotion and greater social distance than CBA control mice. BTBR social distance was consistently greater than CBA control mice across the duration of a 60-min experiment. Despite exhibiting greater social distance, BTBR mice showed comparable socio-spatial arrangements of heads, bodies, and tails compared to CBA control mice. We also found that age, sex, and body size may affect social distance. Our findings demonstrate that DeepLabCut facilitates the quantification of social distance in BTBR mice, providing a complementary tool for existing behavioral assays.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1602205"},"PeriodicalIF":2.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To chew or not to chew? Exploring the influence of scented chew toys on puppy chewing.","authors":"Rituparna Sonowal, Nathaniel J Hall, Anastasia C Stellato","doi":"10.3389/fnbeh.2025.1602063","DOIUrl":"10.3389/fnbeh.2025.1602063","url":null,"abstract":"<p><strong>Introduction: </strong>Chewing and mouthing are natural oral behaviors in dogs, particularly during puppyhood, yet owners report these as nuisance behaviors. The provision of appropriate enrichment items, such as scented chew toys, are often recommended to reduce these undesirable behaviors. Nevertheless, the influence of providing scented chew toys on chewing and mouthing behavior in puppies has not been investigated.</p><p><strong>Methods: </strong>We collected data on engagement levels in dogs (<i>N</i> = 29) with commercially available rubber chew toys during two 5-min sessions in an observation room, with each dog interacting with both toy types (non-scented, peanut butter-scented with squeaker) on separate days. Following the sessions, dogs were randomly assigned to be provided with either the non-scented (<i>N</i> = 15; control) and scented squeaker toy (<i>N</i> = 14) for 1 week in their household. Before and after the 1-week period, owners filled out an online questionnaire detailing how often their dog engaged in chewing and mouthing behaviors at home and they rated their agreement with various statements about their dog's chewing behavior.</p><p><strong>Results: </strong>During observation sessions, puppies spent more time interacting with (<i>p</i> = 0.02) and sniffing (<i>p</i> < 0.0001) the peanut butter-scented squeaker toy in comparison to the non-scented toy. The frequency of owner's prompting the dog to engage with the toy during the observation sessions was higher for the non-scented toy than the peanut butter-scented squeaker toy (<i>p</i> < 0.0001). Descriptive statistics reveal that owners in the non-scented group were more likely to agree that their dog's mouthing or nipping was problematic in the second survey (61.5%, + 16%) compared to the initial survey (45.5%), while owners in the scented group were less likely to agree (41.6%, -28.4%) compared to the initial survey (70%). Owner reports suggest no changes in the frequency of dogs chewing on undesired items and mouthing or nipping on body parts during the 1-week period for either toy type.</p><p><strong>Discussion: </strong>The findings suggest that scent can enhance engagement with chew toys, and although chew toys did not influence owner perceptions, future research should evaluate the use of structured owner-implemented training strategies on mitigating unwanted chewing or mouthing behavior in dogs.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1602063"},"PeriodicalIF":2.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Gut-brain axis correlates, mediators, and moderators of stress resilience or vulnerability.","authors":"Annelise A Madison, Silvia Turroni, Audrey F Duff, Jeff D Galley, Amy R Mackos, Avinash Veerappa","doi":"10.3389/fnbeh.2025.1629472","DOIUrl":"10.3389/fnbeh.2025.1629472","url":null,"abstract":"","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1629472"},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Brain reward and aversion circuits: progress review on current and future breakthroughs.","authors":"Dan P Covey, Keith B J Franklin","doi":"10.3389/fnbeh.2025.1632916","DOIUrl":"https://doi.org/10.3389/fnbeh.2025.1632916","url":null,"abstract":"","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1632916"},"PeriodicalIF":2.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ants engaged in cooperative food transport show anticipatory and nest-oriented clearing of the obstacles surrounding the food: goal-directed behavior emerging from collective cognition.","authors":"Ehud Fonio, Danielle Mersch, Ofer Feinerman","doi":"10.3389/fnbeh.2025.1533372","DOIUrl":"10.3389/fnbeh.2025.1533372","url":null,"abstract":"<p><p>One of the hallmarks of higher cognition is the ability to anticipate near-future events and effectively react to them. This requires perceiving events in a dynamic environment and adjusting the actions accordingly to suit the expected outcomes. Social insects exhibit various forms of emergent collective cognition; however, it is not clear whether such preplanning is one of them. We discovered that when longhorn crazy ants cooperatively carry a large food item to the nest, some ants clear the path ahead of the moving load from small debris. The obstacle clearing is nest-oriented, as it creates a clear path connecting the food load with the nest. We show that this anticipatory obstacle-clearing behavior is context specific and that it is functional in reducing the time needed to deliver the large food load to the nest. Importantly, we found that no personal knowledge of the food load is required for the ants to start clearing the obstacles. Individual ant tracking revealed that clearing is instead triggered by social cues in the form of freshly laid pheromone markings. Indeed, we observed that obstacle clearing was performed by ants that had never experienced the big food load and even in cases where no such load was present at all, in response to the pheromone marks alone. These results provide strong evidence that individual ants do not possess an internal representation of the final goal of obstacle clearing. On the other hand, the goal-directedness of obtacle clearing appears to emerge at the ant group level from collective cognition.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1533372"},"PeriodicalIF":2.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}