Frontiers in Behavioral Neuroscience最新文献

{"title":"Higher levels of D2R and D3R in the frontal-striatal regions are associated with reduced perseverative reward seeking after opioid abstinence.","authors":"Yingying Li, Xigeng Zheng, Cong Gao, Shao Li, Zhengkui Liu, Meixuan Lv, Fei Xiao, Yunjing Bai","doi":"10.3389/fnbeh.2025.1552055","DOIUrl":"https://doi.org/10.3389/fnbeh.2025.1552055","url":null,"abstract":"<p><strong>Introduction: </strong>The lower levels of dopamine D2 receptor (D2R) in the striatum and the heightened levels of dopamine D2 receptor (D3R) in the midbrain have been linked to impulsive behavior and risky decision-making associated with drug dependence. While D3R has been considered a potential target for treating drug dependence, the connection between D3R in the prefrontal-striatal regions and maladaptive drug-related behaviors remains poorly understood.</p><p><strong>Methods: </strong>This study utilized two high-cost tasks to investigate perseverative reward seeking, specifically conflict-based approaching behavior and persistent responding behavior under a progesterone receptor (PR) procedure. Additionally, D2R and D3R levels in the medial prefrontal cortex (mPFC) and striatum were examined through Western blotting.</p><p><strong>Results: </strong>After each task, male rats were divided into two subpopulations: high-approaching vs. low-approaching and high-responding vs. low-responding. Rats treated with morphine (MOR) exhibited a 3 fold increase in the likelihood of developing high-approaching or high-responding behaviors compared to drug-naïve rats. D2R expression was higher in the ventral striatum of morphine-treated, low-approaching rats than high-approaching rats, negatively correlating with approaching behaviors within the morphine-exposed group. After six consecutive PR sessions, D3R levels in the dorsal striatum differed significantly between morphine-treated, low-responding rats and morphine-treated, high-responding rats, negatively correlating with responding behaviors within the morphine-exposed group. An intriguing finding was the non-linear relationships, resembling an inverted U shape, observed between the level of D3R in the mPFC and reward-seeking behaviors, as revealed by both tasks.</p><p><strong>Discussion: </strong>The elevated or relatively higher levels of D2R and D3R in the frontal-striatal regions may serve as protective factors for individuals abstaining from opioids, enabling them to control their reward-seeking behavior better.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1552055"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of propofol on the cognition and hippocampal N-methyl-D-aspartate subunits expression in an MPTP-induced Parkinson's disease rat model.","authors":"Ping Zhu, Yongyan Zhang, Hua Xu, Yu Ren","doi":"10.3389/fnbeh.2025.1607421","DOIUrl":"https://doi.org/10.3389/fnbeh.2025.1607421","url":null,"abstract":"<p><strong>Introduction: </strong>Parkinson's disease (PD) is associated with higher risk of cognitive impairment. Until now, little is known about the effect of anesthetics on cognitive function in PD patients. The imbalance of hippocampal N-methyl-D-aspartate (NMDA) receptors NR2A/NR2B subunit ratio is reported to be associated with memory dysfunction in PD rats. The current study investigated the effects of propofol on the cognitive function and hippocampal NR2A/NR2B ratio in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD rat model.</p><p><strong>Methods: </strong>MPTP was stereotaxically injected into the substantia nigra pars compacta of male Wistar rats. Next day (day 2), the rats in the chronic intervention groups were injected daily with either propofol (80 mg/kg/day, i.p.) or fat emulsion for 7 days (day 2-8). The rats in the acute intervention groups received propofol or fat emulsion only on day 8. Then, all the rats underwent an open field test and an inhibitory avoidance (IA) test. At last, the rats were killed for histological analysis and hippocampal NR2A and NR2B proteins and mRNA level quantification.</p><p><strong>Results: </strong>Neither acute nor chronic treatment with propofol can significantly change the impairment of locomotor activity and dopaminergic denervation of the striatum in MPTP-lesioned rats. MPTP lesioning caused IA memory impairment, which was aggravated by chronic treatment with propofol. Furthermore, chronic treatment with propofol also aggravated the imbalance of hippocampal NR2A/NR2B ratio in MPTP-lesioned rats.</p><p><strong>Discussion: </strong>The current findings indicate that chronic propofol treatment exacerbated MPTP-induced inhibitory avoidance (IA) memory impairment and aggravated the imbalance of hippocampal NR2A/NR2B ratio in MPTP-lesioned rats. Our current data demonstrate a correlation, not direct causation, between NR2A/NR2B dysregulation and cognitive impairment. Future studies should probe whether this imbalance is a driver or consequence of synaptic dysfunction.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1607421"},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of online games on creativity and the role of imagination.","authors":"Yung-Hsun Cheng","doi":"10.3389/fnbeh.2025.1561548","DOIUrl":"10.3389/fnbeh.2025.1561548","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background study: &lt;/strong&gt;The rapid growth of online gaming has sparked interest in its potential effects on cognitive abilities such as creativity. Previous research indicates that interactive digital environments may enhance creative skills through immersive gameplay. However, the role of imagination as a mediator in the relationship between gaming and creativity remains under-explored. This study investigates how playing online games influences creativity and examines the mediating effect of imagination in this relationship.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;The primary objectives of this research are to: (1) evaluate the direct impact of online gaming: investigate how participation in online gaming affects players' imagination and creativity levels, measuring specific outcomes through qualitative and quantitative assessments. (2) explore the mediating role of imagination: analyze the relationship between players' motivation for gaming and their creative output, focusing on how imagination serves as a mediating factor in this dynamic. (3) differentiate game types and their effects: assess how various genres of online games, specifically role-playing games (RPGs) and sandbox games, uniquely influence players' imaginative capabilities and creative expressions, using comparative analyses to highlight differences in outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study employed a mixed-method approach, combining survey questionnaires and experimental procedures. The survey collected responses from 202 participants, gathering insights into their gaming behaviors, motivations, and perceived creativity. For the experimental segment, 12 participants (6 males, 6 females) were divided equally into experimental and control groups. Participants were assigned to either play &lt;i&gt;Genshin Impact&lt;/i&gt; (a RPG) or &lt;i&gt;Roblox&lt;/i&gt; (a sandbox game) to observe differences in creativity and imagination lasting for four weeks. Data were analyzed to determine the relationship between gaming motivation, imagination, and creativity. However, the goal of this work was to investigate whether exclusive play of either Roblox or Genshin Impact over a four-week period would differentially influence player motivation, creativity, and imagination.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Results from the survey and experimental data indicate a significant relationship between players' motivation and post-game imagination. Notably, gaming motivation also had a significant impact on creativity, particularly in &lt;i&gt;Genshin Impact&lt;/i&gt; and &lt;i&gt;Roblox&lt;/i&gt;. The findings confirmed that imagination acts as a mediator between motivation and creativity, suggesting that players who are more motivated display enhanced creative abilities, partly due to increased imaginative engagement during gameplay.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The study concludes that online gaming can positively influence creativity, especially when imagination mediates the relationship between gaming motivation and c","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1561548"},"PeriodicalIF":2.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12137278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deletion of <i>Mex3c</i> gene leads to autistic-like behavior in mice by inhibiting AMPK signal pathway.","authors":"Hui Cai, Chengping Zhang, Haonan Zhang, Yong Du, Kai Wang","doi":"10.3389/fnbeh.2025.1551440","DOIUrl":"10.3389/fnbeh.2025.1551440","url":null,"abstract":"<p><strong>Introduction: </strong>Autism Spectrum Disorder (ASD) is a hereditary neurodevelopmental condition influenced by genetic alterations, particularly in genes regulating neural development and synaptic plasticity. Emerging evidence suggests that the <i>Mex3c</i> gene plays a role in energy metabolism and neuronal development, indicating its potential relevance to ASD pathogenesis.</p><p><strong>Methods: </strong>To investigate the role of <i>Mex3c</i> in ASD, we generated <i>Mex3c</i> knockout (KO) mice and conducted a series of behavioral tests, histological analyses, and molecular assays. Behavioral phenotyping included elevated plus maze, open-field test, and three-chamber social interaction test. Histological assessments included Nissl staining, Golgi-Cox staining, and transmission electron microscopy. Molecular evaluations included Western blotting and analysis of the AMPK/SIRT1/PGC1α signaling pathway.</p><p><strong>Results: </strong><i>Mex3c</i> KO mice exhibited autistic-like behaviors, including social deficits and anxiety-like traits. These behavioral abnormalities were accompanied by reduced neuronal number, decreased dendritic spine density, and impaired synaptic protein expression in the hippocampus. Mitochondrial structural damage and dysfunction were observed, alongside suppression of the AMPK/SIRT1/PGC1α signaling pathway.</p><p><strong>Conclusion: </strong>Our findings suggest that <i>Mex3c</i> gene deletion induces ASD-like phenotypes in mice, potentially through disruption of mitochondrial function and synaptic integrity via the AMPK/SIRT1/PGC1? pathway. These results support the candidacy of <i>Mex3c</i> as a susceptibility gene for ASD and highlight mitochondrial signaling pathways as potential therapeutic targets.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1551440"},"PeriodicalIF":2.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in anxiety and depression: insights from adult rodent models of chronic stress and neural plasticity.","authors":"Rachel Bowman, Maya Frankfurt, Victoria Luine","doi":"10.3389/fnbeh.2025.1591973","DOIUrl":"10.3389/fnbeh.2025.1591973","url":null,"abstract":"<p><p>The often co-morbid conditions of depression and anxiety are the most common mental illnesses and are more prevalent among females than males. Chronic stress paradigms in rodents serve as valuable preclinical models for investigating the factors contributing to these disorders and their neural underpinnings. A variety of chronic stressors are associated with the development of sexually differentiated effects on anxiety- and depressive-like responses in rodents. This review summarizes and discusses common behavioral tasks used to assess anxiety-like (e.g., elevated plus maze, open field) and depressive-like (e.g., sucrose preference, forced swim) behaviors in rodents and discusses evidence of sex differences in these responses. Preclinical chronic stress models also aid in identifying potential mechanisms underlying behavioral changes, including dendritic synaptic alterations in neural circuits affected by stress. Robust sex differences have been observed in stress-responsive brain regions such as the prefrontal cortex, hippocampus, and amygdala. Therefore, applying chronic stress paradigms and assessing their neural effects in rodents may provide crucial insights into the biological basis of sexually differentiated mental illnesses in humans.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1591973"},"PeriodicalIF":2.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical period plasticity is associated with resilience to short unpredictable stress.","authors":"Robert Williams, Charlie Van Den Oord, Erica N Lee, Samuel C Fedde, Gia L Oscherwitz, Adema Ribic","doi":"10.3389/fnbeh.2025.1584240","DOIUrl":"10.3389/fnbeh.2025.1584240","url":null,"abstract":"<p><p>Low resilience to stressful events can increase the risk of anxiety and depression. Resilience decreases with age, parallel to drastic changes in the quality of brain plasticity from juvenile to old age, suggesting that the type of plasticity found in the maturing brain promotes resilience. To indirectly test this, we administered short unpredictable stress to adult male and female wild type (WT) C57BL/6 mice, as well as to two groups of mice characterized by heightened cortical plasticity: adolescent C57BL/6 WT mice and adult mice that lack SynCAM 1 (Synaptic Cell Adhesion Molecule 1), a critical plasticity brake in the mature brain. We found that short unpredictable stress robustly increased core body temperature in all groups of mice, indicative of stress-induced hyperthermia (SIH) and confirming the efficacy of the stress paradigm. However, depressive-like behavior as measured though tail suspension test was increased in adult WT mice only, supporting that the type of plasticity found in the immature brains of adolescent WT and adult SynCAM 1 knockout (KO) mice promotes resilience to stress. All three groups of mice showed a mild increase in locomotor activity after stress, suggesting that the quality of plasticity does not correlate with resilience to anxiety-like phenotypes. Our study hence provides indirect evidence for the protective role of developmental plasticity during stress and points to new mechanisms that promote resilience to stress-induced depression.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1584240"},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resilience phenotypes derived from an active inference account of allostasis.","authors":"Laura A Harrison, Antonio J Gracias, Karl J Friston, J Galen Buckwalter","doi":"10.3389/fnbeh.2025.1524722","DOIUrl":"10.3389/fnbeh.2025.1524722","url":null,"abstract":"<p><p>Within a theoretical framework of enactive allostasis, we explore active inference strategies for minimizing surprise to achieve resilience in dynamic environments. While individual differences and extrinsic protective factors traditionally account for variability in resilience trajectories following stressor exposure, the enactive model emphasizes the importance of the physical and social environment, specifically the \"enactive niche,\" which is both shaped by and impacts organisms living in it, accounting for variable success in allostatic prediction and accommodation. Enactive allostasis infers or predicts states of the world to minimize surprise and maintain regulation after surprise, i.e., resilience. Action policies are selected in accordance with the inferred state of a dynamic environment; those actions concurrently shape one's environment, buffering against current and potential stressors. Through such inferential construction, multiple potential solutions exist for achieving stability within one's enactive niche. Spanning a range of adaptive resilience strategies, we propose four phenotypes-fragile, durable, resilient, and pro-entropic (PE)-each characterized by a constellation of genetic, epigenetic, developmental, experiential, and environmental factors. Biological regulatory outcomes range from allostatic (over)load in the fragile and durable phenotypes, to allostatic recovery in resilience, and theoretically to increasing allostatic accommodation or \"growth\" in the proposed PE phenotype. Awareness distinguishes phenotypes by minimizing allostatically demanding surprise and engenders the cognitive and behavioral flexibility empirically associated with resilience. We further propose a role for awareness in proactively shaping one's enactive niche to further minimize surprise. We conclude by exploring the mechanisms of phenotypic plasticity which may bolster individual resilience.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1524722"},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of maladaptive pain in dogs referred for behavioral complaints: challenges and opportunities.","authors":"Jenthe Kwik, Tiny De Keuster, Tim Bosmans, José Mottet","doi":"10.3389/fnbeh.2025.1569351","DOIUrl":"10.3389/fnbeh.2025.1569351","url":null,"abstract":"<p><strong>Introduction: </strong>Diagnosing maladaptive pain in dogs with behavioral complaints is challenging, as clinical signs are often non-specific and may be absent during examination. This paper supports veterinary teams in distinguishing behavioral changes that stem from a behavioral disorder, maladaptive pain, or both.</p><p><strong>Methods: </strong>The medical records of ten client-owned dogs referred to the authors' behavioral practice were selected to identify challenges in recognizing maladaptive pain and to highlight diagnostic tools. A Toolbox approach was used for assessment, integrating caregiver questionnaires, medical history, home video analysis, clinical observation, and a timeline. Behavioral signs were categorized as green (adaptive) or red (maladaptive) flags to facilitate differential diagnosis and guide treatment decisions.</p><p><strong>Results: </strong>All dogs (<i>n</i> = 10) were diagnosed with altered socioemotional functioning. In 7/10 cases, the Toolbox approach indicated maladaptive pain, confirmed by medical imaging in 3/7 cases. Multimodal treatment led to recovery in 6/7 dogs. In 3/10 dogs with behavioral histories, an acute worsening of signs suggested maladaptive pain, confirmed by imaging in all cases. Treatment led to partial recovery in 2/3 dogs, while one was euthanized due to neoplasia. Diagnostic challenges fell into three categories: bias in observation, clinical examination, and interpretation of behavioral signs.</p><p><strong>Conclusion: </strong>Diagnosing maladaptive pain in dogs with behavioral problems requires a comprehensive approach. Recognizing red flags, using targeted diagnostic tools, and implementing multimodal treatment strategies can improve quality of life, reduce suffering, and enhance case management.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1569351"},"PeriodicalIF":2.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term memory retrieval enhances brain functional connectivity.","authors":"Fanglei Duan, Xiangyu Yan, Jing Wang, Zhenhua Wu, Yixin Zhang, QiCheng Shu, Fangfang Liu, Fan Xu, Qin Han","doi":"10.3389/fnbeh.2025.1578415","DOIUrl":"https://doi.org/10.3389/fnbeh.2025.1578415","url":null,"abstract":"<p><strong>Introduction: </strong>Short-term memory poses a significant challenge, involving complex processes of image perception, memory formation, and execution. However, the mechanisms underlying the formation, storage, and execution of short-term memory remain poorly understood.</p><p><strong>Methods: </strong>In this study, 41 healthy college students participated in a memory challenge test designed to investigate these processes. Functional near-infrared spectroscopy (fNIRS) was employed to measure dynamic changes in hemoglobin concentrations in specific cortical regions, while facial expressions and vital signs were recorded in real-time during the tests.</p><p><strong>Results: </strong>The results revealed heightened activity in the inferior prefrontal gyrus, visual association cortex, pre-motor cortex, and supplementary motor cortex. Functional connectivity between these regions was significantly enhanced during the tasks, and inter-group differences decreased over time. Participants with superior short-term memory exhibited lower levels of negative emotional expressions and higher heart rates compared to those with weaker memory performance. These findings suggest that cortical interconnectivity and adequate cerebral blood oxygenation play critical roles in enhancing short-term memory capacity. This has important implications for education, as it highlights strategies for cultivating attention, training memory skills, and improving memory integration abilities.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1578415"},"PeriodicalIF":2.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coadministration antagonist dopamine receptor D4 with CB2 receptor agonist decreases binge-like intake of palatable food in mice.","authors":"Luis Miguel Rodríguez-Serrano, Ana Paola López-Castillo, María Cristina Cabrera-Mejía, Ana Sofía Cedillo-Figueroa, Nyahn Zepeda-Ortigosa, Carolina Carregha-Lozano, María Elena Chávez-Hernández","doi":"10.3389/fnbeh.2025.1572374","DOIUrl":"10.3389/fnbeh.2025.1572374","url":null,"abstract":"<p><strong>Introduction: </strong>Food intake is regulated by two systems: homeostatic and hedonic. An imbalance between these systems can induce overconsumption, such as binge eating disorder (BED), and is associated with dysregulation of the dopamine reward system. The cannabinoid type 2 receptor (CB2R) has been identified in dopamine neurons and may play an important role in motivated behaviors, including food intake. Nevertheless, the interaction between the dopamine D4 (DRD4) receptor and CB2R in binge-like intake has not yet been identified. Therefore, the present study aims to evaluate the effects of intraperitoneal administration of DRD4 antagonist (L-745870), as well as the coadministration of DRD4 antagonist with either CB2R agonist (HU308) or antagonist (AM630), on binge-like intake of palatable food (PF) in adult male mice.</p><p><strong>Methods: </strong>We used adult male 34 C57BL6/J mice. All animals were housed individually and had <i>ad libitum</i> access to standard diet (SD) and water. To evaluate binge-like intake, the animals had 1 h of access to PF during 12 baseline binge eating test (BET) sessions. Mice were then randomly assigned to the following treatment groups: 1) vehicle; 2) L-745870; 3) L-745870-HU308, 4) L-745870+AM630 to be evaluated under the effect of treatments for three additionally BET sessions.</p><p><strong>Results: </strong>Our results show that DRD4 antagonist reduced binge-like intake of PF, and that a coadministration with a CB2R agonist induced an even more pronounced reduction of binge-like intake.</p><p><strong>Conclusion: </strong>These findings suggest an interaction between the dopaminergic and endocannabinoid systems in the modulation of binge-like intake of PF in adult mice, where CB2R activation participates in modulating reward pathways and reducing binge-like behavior.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1572374"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}