Frontiers in Behavioral Neuroscience最新文献

{"title":"A critical opinion on adult endogenous neurogenesis as a brain repair mechanism after traumatic brain injury.","authors":"Andrea Aguilar-Arredondo, Angélica Zepeda","doi":"10.3389/fnbeh.2025.1543122","DOIUrl":"https://doi.org/10.3389/fnbeh.2025.1543122","url":null,"abstract":"","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1543122"},"PeriodicalIF":2.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-based differences in the long-term fate of hippocampal neurons born after a traumatic brain injury.","authors":"Hannah C Downing, Ashley B Glover, Jessica E Gebhardt, Katherine L Thompson, Kathryn E Saatman","doi":"10.3389/fnbeh.2025.1523969","DOIUrl":"https://doi.org/10.3389/fnbeh.2025.1523969","url":null,"abstract":"<p><strong>Introduction: </strong>Moderate-to-severe traumatic brain injury (TBI) results in an early loss of immature hippocampal granule cells and the activation of typically quiescent neural stem cells (NSCs) in the dentate gyrus. Activation of NSCs leads to a robust increase in proliferation and generation of neural progenitor cells (NPCs), supporting restoration of the immature neuron population of over a period of 1-2 weeks. However, it is unclear if neurons born early after injury develop normally, survive long-term and functionally integrate into the hippocampal network. Although adult hippocampal neurogenesis is regulated in a sex-dependent manner, the majority of pre-clinical TBI studies lack the inclusion of both sexes. The goal of this study was to examine sex differences in hippocampal neurogenesis in response to a moderate controlled cortical impact brain injury.</p><p><strong>Methods: </strong><i>In-vivo</i> labeling of NPCs and tracking of their morphological development into a granule cell was achieved using an inducible Cre recombinase driven by the Ascl1 promoter in a CAG-floxStopTom reporter mouse. Ascl1 is a basic helix-loop-helix transcription factor transiently expressed in NPCs and activated NSCs in the dentate gyrus of the adult mammalian brain. To specifically label NPCs born acutely after TBI, tamoxifen was delivered to mice on days 2 and 3 postinjury. Mice survived to 6 weeks after TBI to allow for full neuronal maturation of tdTomato-labeled NPCs.</p><p><strong>Results: </strong>At 6 weeks postinjury, numbers of tdTomato-positive granule cells were significantly reduced in the ipsilateral hippocampus of brain-injured mice compared to controls, with a more pronounced decrease in males. Further, posttrauma-born neurons in males, but not females, exhibited impaired dendritic development. Neurons born after injury extended axons which formed synaptic terminals within the CA3 region. Numbers of mossy fiber boutons were significantly decreased in injured males compared to naïve males or to injured females. Potential forms of plasticity were observed in brain-injured females, including increased neurogenesis in the contralateral hippocampus and increased mossy fiber bouton volume. Together these data suggest a neurogenic advantage in females after injury.</p><p><strong>Discussion: </strong>This study is the first to report sex differences in posttraumatic hippocampal neurogenesis and to demonstrate modification of synaptic terminals formed by neurons born after TBI.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1523969"},"PeriodicalIF":2.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling dynamics on the dance floor with directional swarmalators.","authors":"Petri Toiviainen, Joshua S Bamford, Marc R Thompson","doi":"10.3389/fnbeh.2025.1534371","DOIUrl":"https://doi.org/10.3389/fnbeh.2025.1534371","url":null,"abstract":"<p><p>Understanding collective behavior in both biological and social contexts, such as human interactions on dance floors, is a growing field of interest. Spatiotemporal dynamics of collective behavior have previously been modeled, for instance, with swarmalators, which are dynamical units that exhibit both swarming behavior and synchronization, combining spatial movement and entrainment. In our current study, we have expanded the swarmalator concept to encompass gaze direction as a representation of visual attention. We employ the newly developed directional swarmalator model for simulating the complex spatiotemporal dynamics observed on dance floors. Our model aims to reflect the complex dynamics of collective movement, as well as rhythmic synchronization and gaze alignment. It establishes a quantitative framework to dissect how individuals on dance floors self-organize and generate emergent patterns in response to both musical stimuli and visual perception of other dancers. The inclusion of gaze direction allows for the simulation of realistic scenarios on dance floors, mirroring the dynamic interplay of human movement in rhythm-driven environments. The model is initially tested against motion capture recordings of two groups dancing in a silent disco, however, it is theoretically adaptable to a variety of scenarios, including varying group sizes, adjustable degrees of auditory and visual coupling, as well as modifiable interaction ranges, making it a generic tool for exploring collective behavior in musical settings. The development of the directional swarmalator model contributes to understanding social dynamics in shared music and dance experiences.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1534371"},"PeriodicalIF":2.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The visuomotor synchronization immersive virtual reality of a depression avatar in a stigma context experience mobilizes the fronto-parietal cortex and anterior insula.","authors":"Kelssy Hitomi Dos Santos Kawata, Wey Guan Lem, Koki Ono, Hiroshi Oyama","doi":"10.3389/fnbeh.2025.1526684","DOIUrl":"10.3389/fnbeh.2025.1526684","url":null,"abstract":"<p><strong>Introduction: </strong>The gradual synchronization of the movement of one's real hand with a virtual one can effectively induce a sense of embodiment (SoE) with an avatar with depression. Although neuroimaging studies have explored the neural correlates of some SoE subcomponents of visuomotor synchronization, the neural correlates of individual differences in SoE and how humans acquire virtual body representations through SoE subcomponents remain to be investigated.</p><p><strong>Methods: </strong>Here, we used the right hand of a virtual patient with depression in immersive virtual reality (IVR) to induce SoE in participants and measured whole brain activity using functional magnetic resonance imaging (fMRI). Participants were instructed to listen to the audio recording of the IVR experience and visualize movements during the fMRI scan. fMRI data were acquired before and immediately after the visuomotor synchronization IVR experience (target condition) or an asynchronized video experience (control condition), followed by embodiment measures related to the two types of experiences.</p><p><strong>Results: </strong>All five subcomponents of SoE (sense of ownership, sense of agency, sense of localization, appearance, and response to stimuli) were significantly increased during the visuomotor synchronization IVR experience compared with the asynchronized video experience. A significant negative effect of the SoE score was identified in the frontoparietal and anterior insula only for the visuomotor synchronization IVR experience of guiding the virtual right hand of the avatar with depression, implicating interoceptive and multisensory integration.</p><p><strong>Discussion: </strong>We demonstrated that all five subcomponents of the SoE were present, and that decreased activity in the frontoparietal and anterior insula were crucial brain regions for the virtual human body to be perceived as one's own body and promote conscious feelings of embodiment.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1526684"},"PeriodicalIF":2.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved jet lag recovery is associated with a weaker molecular biological clock response around the time of expected activity onset.","authors":"Marie-Claire Boutrin, Melissa E S Richardson, Feyikemi Oriola, Samira Bolo","doi":"10.3389/fnbeh.2025.1535124","DOIUrl":"10.3389/fnbeh.2025.1535124","url":null,"abstract":"<p><strong>Introduction: </strong>Properly timed environmental light input to the suprachiasmatic nucleus (SCN) in the brain is crucial in maintaining the 24-hour biological rhythm (circadian rhythm). However, light exposure at the wrong time of the day-night cycle is disruptive to circadian-regulated behaviors such as the sleep-wake cycle and memory. While factors such as jet lag, variations in day length, and light at night are known disruptors to the timing of activity onset following rest, the molecular consequence of the intersection of multiple disruptions is less understood.</p><p><strong>Methods: </strong>Here, we expose mice to a jet lag paradigm under two light-dark (LD) conditions (12:12 LD and 8:16 LD) coupled with additional light exposure at night during the recovery period (known as negative masking), previously demonstrated to improve jet lag-related memory loss in mice.</p><p><strong>Results: </strong>Our results show that jet lag exposure in both LD cycles (to a greater extent in 8:16 LD) increased the fold-change of circadian gene expression in the SCN relative to the dark onset. The further addition of light during the jet lag recovery period reduced typical changes in circadian gene expression in the SCN to minimal levels under both LD cycles.</p><p><strong>Discussion: </strong>This study uncovers a novel explanation for the impact of multiple disruptive light exposures on gene expression of the molecular SCN clock in the brain.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1535124"},"PeriodicalIF":2.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin as a physiological correlate of dyadic music therapy relationships - a randomized crossover pilot study.","authors":"Paula Kristin Busse, Lutz Neugebauer, Götz Kaschubowski, Dennis Anheyer, Thomas Ostermann","doi":"10.3389/fnbeh.2024.1504229","DOIUrl":"10.3389/fnbeh.2024.1504229","url":null,"abstract":"<p><strong>Rationale: </strong>Music therapy has been in practice for years. However, the mechanism of action of music or music therapy is not well understood. It is only recently that the neuroendocrinological basis of therapeutic relationships has become the subject of growing research interest. The aim of this pilot study (Clinical Trial No: DRKS00035174) is to investigate whether oxytocin is usable and feasible as a biomarker of attachment to demonstrate the development of therapeutic alliance between therapist and patient in a dyadic music therapy setting.</p><p><strong>Methods: </strong>In a single-measure crossover design, children aged 6-12 years from a special school for social and emotional disorders, were randomly with either music therapy followed by a waiting list control group that performed silent work, or vice versa. The respective interventions were conducted on the school premises on different days over a period of 1 month. The primary outcome was salivary oxytocin, with tests performed immediately before and after each 30-min intervention.</p><p><strong>Results: </strong>Thirty-two children were included in the study, resulting in <i>n</i> = 16 children per allocation sequence. During the implementation of the study, difficulties were encountered with protocol adherence both in terms of the duration of the music therapy and the implementation of the silent work in the control group. There were no dropouts, however, only 28 children were included in the final data analysis as two participants in each group were excluded due to large fluctuations in oxytocin levels. Between-group comparison and within-group comparisons showed no significant changes in oxytocin levels. However, the music therapist showed a significant increase in oxytocin levels in the before after measurement. No side effects or adverse events were reported during the trial.</p><p><strong>Conclusion: </strong>The findings indicated a responsiveness of oxytocin to musical stimulation. Although feasibility of oxytocin measurement was clearly demonstrated, evaluation of the results is difficult against the background of many remaining questions regarding individual and contextual factors influencing the oxytocinergic system. Moreover, the clinical significance of changes in oxytocin levels remains a topic for further research to better understand the role of oxytocin in the attachment formation between therapist and patient in music therapy.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1504229"},"PeriodicalIF":2.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in category information processing between areas TEO and TE of the macaque.","authors":"Masaumi Shimizu, Shun Katakami, Masato Okada, Yasuko Sugase-Miyamoto, Kazuko Hayashi, Keiji Matsuda, Kenichiro Miura, Mark A G Eldridge, Richard C Saunders, Barry J Richmond, Narihisa Matsumoto","doi":"10.3389/fnbeh.2024.1449097","DOIUrl":"10.3389/fnbeh.2024.1449097","url":null,"abstract":"<p><p>Object categorization is a fundamental visual function, via which primates group items based on perceptual similarity. Neurons that respond to a class of complex objects, such as faces, can be found in inferior temporal cortex of macaque monkeys, comprising areas TEO and TE. The ability of monkeys to categorize cat/dog images is greatly impaired when both TE and TEO are removed, but is only modestly impaired if either region is left intact. This suggests that both TE and TEO can support object categorization. We investigated what differences exist in category information processing between areas TEO and TE. For cat and dog stimulus images, we found that category decoding performance increased during the initial phase of a stimulus presentation, then remained stable in area TEO for the duration of the presentation in a passive fixation task. In area TE, category decoding performance continued to improve into later in the time window than in TEO. Furthermore, we found that, after cat/dog category training, area TE neuronal populations encode cat and dog category information more strongly than do TEO neurons even in a fixation task (Mann-Whitney U-test, <i>p</i> < 0.05). Together, our results suggest that area TEO processes category information without changing its representation, whereas the category information representation in area TE evolves over time (both within a trial and across category training sessions), indicating that responses in TE may be influenced by top-down feedback.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1449097"},"PeriodicalIF":2.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latencies of conditioned vocal responses to hearing test tones in killer whales (<i>Orcinus orca</i>).","authors":"Jared Stephens, Alyssa W Accomando, Kayla Nease, Brian K Branstetter, Todd R Robeck","doi":"10.3389/fnbeh.2024.1495579","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1495579","url":null,"abstract":"<p><strong>Introduction: </strong>Perceived loudness is challenging to study in non-human animals. However, reaction time to an acoustic stimulus is a useful behavioral proxy for the assessment of perceived loudness. Understanding the effect of sound frequency and level on perceived loudness would improve prediction and modeling of anthropogenic noise impacts on marine mammals.</p><p><strong>Methods: </strong>In this study, behavioral hearing tests conducted with two killer whales were analyzed to capture conditioned vocal response latency, which is the time between the onset of the acoustic signal and the onset of the response (i.e., reaction time).</p><p><strong>Results: </strong>The results showed that vocal reaction times decreased with increasing sensation level (i.e., sound pressure level above the baseline hearing threshold), while the effect of frequency on reaction time varied between the subjects. Reaction time as a function of sound duration is described, and equal-latency contours are presented.</p><p><strong>Discussion: </strong>The data suggest that vocal reaction time decreases with increasing sensation level, therefore supporting the use of reaction time as a proxy for loudness perception in killer whales.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1495579"},"PeriodicalIF":2.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between social networks, messaging apps, addictive behaviors, and sleep problems in adolescents: the EHDLA study.","authors":"María Navalón-González, José Adrián Montenegro-Espinosa, Héctor Gutiérrez-Espinoza, Jorge Olivares-Arancibia, Rodrigo Yañéz-Sepúlveda, Daniel Duclos-Bastías, Miriam Garrido-Miguel, Arthur Eumann Mesas, José Francisco López-Gil, Estela Jiménez-López","doi":"10.3389/fnbeh.2025.1512535","DOIUrl":"10.3389/fnbeh.2025.1512535","url":null,"abstract":"<p><strong>Objective: </strong>The current study aims to provide a comprehensive analysis of the relationships between social network (SN) use, messaging apps use, and addictive behaviors related to SNs, and sleep-related problems in a sample of Spanish adolescents.</p><p><strong>Methods: </strong>This was a cross-sectional study using data from the Eating Healthy and Daily Life Activities (EHDLA) project, which involved adolescents aged 12-17 years from three secondary schools in <i>Valle de Ricote</i> (Region of Murcia, Spain). A sample of 632 adolescents was studied. The use of SN (i.e., Facebook, Twitter, Instagram, Snapchat or TikTok) or messaging applications (i.e., WhatsApp) was assessed via a scale including one item for each SN, in which adolescents were asked what type of SN they used and the usage profile of each SN. The Short Social Networks Addiction Scale-6 Symptoms (SNAddS-6S) was used to determine SN addictive behaviors. Generalized linear regression analyses with a negative binomial distribution were performed to determine the associations of SN use or SN addictive behaviors with sleep-related problems. These analyses were adjusted for age, sex, body mass index, socioeconomic level, physical activity, sedentary behavior, and adherence to the Mediterranean diet.</p><p><strong>Results: </strong>Higher SN use was related to greater presence of sleep-related problems [prevalence ratio (PR) = 1.04; 95% confidence interval (CI) 1.01-1.07; <i>p</i> = 0.015]. Additionally, the higher the score on the addictive behaviors toward SN use scale was, the more sleep-related problems were identified (PR = 1.15; 95% Cl 1.09 to 1.21; <i>p</i> < 0.001). Specifically, only the use of Twitter was significantly associated with sleep-related problems (PR = 1.10; 95% Cl 1.01 to 1.21; <i>p</i> = 0.035). In terms of addictive behaviors related to SN use, mood modification, relapse, withdrawal, and conflict were significantly associated with sleep-related problems (mood modification: PR = 1.58; 95% CI 1.36 to 1.84; <i>p</i> < 0.001; relapse: PR = 1.24; 95% CI 1.07 to 1.43; <i>p</i> = 0.004; withdrawal: PR = 1.28; 95% CI 1.08 to 1.51; <i>p</i> = 0.004; conflict: PR = 1.19; 95% CI 1.01 to 1.39; <i>p</i> = 0.037).</p><p><strong>Conclusion: </strong>Our results suggest a relationship between SN use, SN addictive behaviors, and sleep-related problems in adolescents. These cross-sectional results should be confirmed in longitudinal and intervention studies.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1512535"},"PeriodicalIF":2.6,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11802513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Cognitive stimulants: from caffeine to cannabinoids - current and future perspectives.","authors":"Daniel Moreira-Silva, Marta C Cunha-Rodrigues, Ana Elisa Speck, Pablo Pandolfo","doi":"10.3389/fnbeh.2025.1547970","DOIUrl":"https://doi.org/10.3389/fnbeh.2025.1547970","url":null,"abstract":"","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1547970"},"PeriodicalIF":2.6,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}