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Frontiers in Behavioral Neuroscience最新文献

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Behavioral and neurophysiological effects of buspirone in healthy and depression-like state juvenile salmon 丁螺环酮对健康和抑郁状态幼鲑的行为和神经生理学影响
IF 3 3区 医学
Frontiers in Behavioral Neuroscience Pub Date : 2024-02-12 DOI: 10.3389/fnbeh.2024.1285413
Sheyda Shapouri, Aziz Sharifi, Ole Folkedal, Thomas W. K. Fraser, Marco A. Vindas
{"title":"Behavioral and neurophysiological effects of buspirone in healthy and depression-like state juvenile salmon","authors":"Sheyda Shapouri, Aziz Sharifi, Ole Folkedal, Thomas W. K. Fraser, Marco A. Vindas","doi":"10.3389/fnbeh.2024.1285413","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1285413","url":null,"abstract":"A proportion of farmed salmon in seawater show a behaviorally inhibited, growth stunted profile known as a depression-like state (DLS). These DLS fish are characterized by chronically elevated serotonergic signaling and blood plasma cortisol levels and the inability to react further to acute stress, which is suggestive of chronic stress. In this study, we characterize the neuroendocrine profile of growth stunted freshwater parr and confirm that they show a DLS-like neuroendocrine profile with a blunted cortisol response and no serotonergic increase in response to acute stress. Furthermore, we attempted to reverse this DLS-like profile through pharmacological manipulation of the serotonin (5-HT) system with buspirone, an anxiolytic medication that acts as a serotonin receptor agonist (i.e., decreases serotonergic signaling). We found that while buspirone decreases anxiolytic-type behavior in healthy fish, no quantifiable behavioral change was found in DLS-like fish. However, there was a physiological effect of diminished basal serotonergic signaling. This suggests that at the physiological level, buspirone appears to reverse the neuroendocrine DLS profile. With a deeper understanding of what causes DLS profiles and growth stunting in juvenile fish, steps can be taken in terms of husbandry to prevent repeated stressors and the formation of the DLS profile, potentially reducing losses in aquaculture due to chronic stress.","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139763003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral effects of visual stimuli in adult zebrafish using a novel eight-tank imaging system 利用新型八槽成像系统研究视觉刺激对成年斑马鱼行为的影响
IF 3 3区 医学
Frontiers in Behavioral Neuroscience Pub Date : 2024-02-12 DOI: 10.3389/fnbeh.2024.1320126
Sayali V. Gore, Thaís Del Rosario Hernández, Robbert Creton
{"title":"Behavioral effects of visual stimuli in adult zebrafish using a novel eight-tank imaging system","authors":"Sayali V. Gore, Thaís Del Rosario Hernández, Robbert Creton","doi":"10.3389/fnbeh.2024.1320126","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1320126","url":null,"abstract":"<sec><title>Introduction</title><p>Animals respond to various environmental cues. Animal behavior is complex, and behavior analysis can greatly help to understand brain function. Most of the available behavioral imaging setups are expensive, provide limited options for customization, and allow for behavioral imaging of one animal at a time.</p></sec><sec><title>Methods</title><p>The current study takes advantage of adult zebrafish as a model organism to study behavior in a novel behavioral setup allowing one to concurrently image 8 adult zebrafish.</p></sec><sec><title>Results</title><p>Our results indicate that adult zebrafish show a unique behavioral profile in response to visual stimuli such as moving lines. In the presence of moving lines, the fish spent more time exploring the tank and spent more time toward the edges of the tanks. In addition, the fish moved and oriented themselves against the direction of the moving lines, indicating a negative optomotor response (OMR). With repeated exposure to moving lines, we observed a reduced optomotor response in adult zebrafish.</p></sec><sec><title>Discussion</title><p>Our behavioral setup is relatively inexpensive, provides flexibility in the presentation of various animated visual stimuli, and offers improved throughput for analyzing behavior in adult zebrafish. This behavioral setup shows promising potential to quantify various behavioral measures and opens new avenues to understand complex behaviors.</p></sec>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140099475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Dysfunctional motivation in eating behaviors: a complex gene x environment interplay 社论：饮食行为中的功能失调动机：基因与环境的复杂相互作用
IF 3 3区 医学
Frontiers in Behavioral Neuroscience Pub Date : 2024-02-09 DOI: 10.3389/fnbeh.2024.1367256
Kirrilly M. Pursey, Lucy Babicola, Rossella Ventura, Matteo Di Segni
{"title":"Editorial: Dysfunctional motivation in eating behaviors: a complex gene x environment interplay","authors":"Kirrilly M. Pursey, Lucy Babicola, Rossella Ventura, Matteo Di Segni","doi":"10.3389/fnbeh.2024.1367256","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1367256","url":null,"abstract":"","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Dysfunctional motivation in eating behaviors: a complex gene x environment interplay 社论：饮食行为中的功能失调动机：基因与环境的复杂相互作用
IF 3 3区 医学
Frontiers in Behavioral Neuroscience Pub Date : 2024-02-09 DOI: 10.3389/fnbeh.2024.1367256
Kirrilly M. Pursey, Lucy Babicola, Rossella Ventura, Matteo Di Segni
{"title":"Editorial: Dysfunctional motivation in eating behaviors: a complex gene x environment interplay","authors":"Kirrilly M. Pursey, Lucy Babicola, Rossella Ventura, Matteo Di Segni","doi":"10.3389/fnbeh.2024.1367256","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1367256","url":null,"abstract":"","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139849068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Prey-predator interactions 社论：猎物与捕食者之间的相互作用
IF 3 3区 医学
Frontiers in Behavioral Neuroscience Pub Date : 2024-02-08 DOI: 10.3389/fnbeh.2024.1367484
F. C. Rind, Vincent Bels
{"title":"Editorial: Prey-predator interactions","authors":"F. C. Rind, Vincent Bels","doi":"10.3389/fnbeh.2024.1367484","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1367484","url":null,"abstract":"","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139851567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Prey-predator interactions 社论：猎物与捕食者之间的相互作用
IF 3 3区 医学
Frontiers in Behavioral Neuroscience Pub Date : 2024-02-08 DOI: 10.3389/fnbeh.2024.1367484
F. C. Rind, Vincent Bels
{"title":"Editorial: Prey-predator interactions","authors":"F. C. Rind, Vincent Bels","doi":"10.3389/fnbeh.2024.1367484","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1367484","url":null,"abstract":"","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139791521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The novel peptide LCGM-10 attenuates metabotropic glutamate receptor 5 activity and demonstrates behavioral effects in animal models 新型多肽 LCGM-10 可抑制代谢型谷氨酸受体 5 的活性，并在动物模型中显示出行为效应
IF 3 3区 医学
Frontiers in Behavioral Neuroscience Pub Date : 2024-02-07 DOI: 10.3389/fnbeh.2024.1333258
Anton V. Malyshev, Vsevolod V. Pavshintcev, Nikita A. Mitkin, Iuliia A. Sukhanova, Vasilina R. Gedzun, Alexander S. Zlobin, Igor I. Doronin, Gennady A. Babkin, Tomi K. Sawyer
{"title":"The novel peptide LCGM-10 attenuates metabotropic glutamate receptor 5 activity and demonstrates behavioral effects in animal models","authors":"Anton V. Malyshev, Vsevolod V. Pavshintcev, Nikita A. Mitkin, Iuliia A. Sukhanova, Vasilina R. Gedzun, Alexander S. Zlobin, Igor I. Doronin, Gennady A. Babkin, Tomi K. Sawyer","doi":"10.3389/fnbeh.2024.1333258","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1333258","url":null,"abstract":"We employed a structural bioinformatics approach to develop novel peptides with predicted affinity to the binding site for negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluR5). Primary screening in zebrafish (<jats:italic>Danio rerio</jats:italic>) revealed a stimulatory effect of two peptides, LCGM-10 and LCGM-15. Target validation studies using calcium ion flux imaging and a luciferase reporter assay confirmed mGluR5 as the target. LCGM-10 showed greater potency than LCGM-15; it was comparable to that of the mGluR5 NAM 2-methyl-6-(phenylethynyl) pyridine (MPEP). Rodent behavioral screening in the open field and elevated plus maze revealed increased locomotor activity in both tests after acute LCGM-10 treatment, supported by further analysis of home cage spontaneous locomotor activity (SLA). The stimulating effect of a single LCGM-10 administration on SLA was evident up to 60 min after administration and was not accompanied by hypokinetic rebound observed for caffeine. According to our results, LCGM-10 has therapeutic potential to treat hypo- and dyskinesias of various etiologies. Further investigation of LCGM-10 effects in the delay discounting model of impulsive choice in rats revealed reduced trait impulsivity after single and chronic administrations, suggesting potential implication for attention deficit hyperactivity disorder, obsessive compulsive disorder, and addictions.","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139763002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal and postnatal methamphetamine exposure alters prefrontal cortical gene expression and behavior in mice 产前和产后甲基苯丙胺暴露会改变小鼠前额叶皮质基因表达和行为
IF 3 3区 医学
Frontiers in Behavioral Neuroscience Pub Date : 2024-02-07 DOI: 10.3389/fnbeh.2024.1286872
Philip A. Adeniyi, Tolulope T. Adeyelu, Amita Shrestha, Chin-Chi Liu, Charles C. Lee
{"title":"Prenatal and postnatal methamphetamine exposure alters prefrontal cortical gene expression and behavior in mice","authors":"Philip A. Adeniyi, Tolulope T. Adeyelu, Amita Shrestha, Chin-Chi Liu, Charles C. Lee","doi":"10.3389/fnbeh.2024.1286872","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1286872","url":null,"abstract":"<p>Methamphetamine is a highly abused psychostimulant that substantially impacts public health. Prenatal and postnatal methamphetamine exposure alters gene expression, brain development, and behavior in the offspring, although the underlying mechanisms are not fully defined. To assess these adverse outcomes in the offspring, we employed a mouse model of prenatal and postnatal methamphetamine exposure. Juvenile offspring were behaviorally assessed on the open field, novel object recognition, Y-maze, and forced swim tests. In addition, RNA sequencing was used to explore potential alterations in prefrontal cortical gene expression. We found that methamphetamine-exposed mice exhibited decreased locomotor activity and impaired cognitive performance. In addition, differential expression of genes involved in neurotransmission, synaptic plasticity, and neuroinflammation were found with notable changes in dopaminergic signaling pathways. These data suggest potential neural and molecular mechanisms underlying methamphetamine-exposed behavioral changes. The altered expression of genes involved in dopaminergic signaling and synaptic plasticity highlights potential targets for therapeutic interventions for substance abuse disorders and related psychiatric complications.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140034921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Women in behavioral neuroscience: 2022 社论：行为神经科学领域的女性：2022 年
IF 3 3区 医学
Frontiers in Behavioral Neuroscience Pub Date : 2024-02-07 DOI: 10.3389/fnbeh.2024.1374244
Lisa Y. Maeng, L. Fattore, Marjorie C. Gondré-Lewis
{"title":"Editorial: Women in behavioral neuroscience: 2022","authors":"Lisa Y. Maeng, L. Fattore, Marjorie C. Gondré-Lewis","doi":"10.3389/fnbeh.2024.1374244","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1374244","url":null,"abstract":"","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139854867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Women in behavioral neuroscience: 2022 社论：行为神经科学领域的女性：2022 年
IF 3 3区 医学
Frontiers in Behavioral Neuroscience Pub Date : 2024-02-07 DOI: 10.3389/fnbeh.2024.1374244
Lisa Y. Maeng, L. Fattore, Marjorie C. Gondré-Lewis
{"title":"Editorial: Women in behavioral neuroscience: 2022","authors":"Lisa Y. Maeng, L. Fattore, Marjorie C. Gondré-Lewis","doi":"10.3389/fnbeh.2024.1374244","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1374244","url":null,"abstract":"","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139795064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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