Frontiers in Behavioral Neuroscience最新文献

{"title":"Inverted-U association between daily steps and WHO-5 in university students: non-linear modeling and robustness checks.","authors":"Huakai Zhang, Shiguang Wang, Yongchao Huang, Lei Xiu, Yan Wang","doi":"10.3389/fnbeh.2025.1693386","DOIUrl":"10.3389/fnbeh.2025.1693386","url":null,"abstract":"<p><strong>Background: </strong>Physical activity is linked to mental health, yet the dose-response shape remains debated.</p><p><strong>Methods: </strong>In a cross-sectional sample of Chinese university students, 820 participants (mean age 21.5 years; 51.8% women) wore wrist accelerometers for 7 days. Subjective well-being (SWB) was measured with the WHO-5 (0-100). Restricted cubic spline models adjusted for age, sex, sleep quality, perceived stress, and socioeconomic status. Sensitivity analyses included quadratic and segmented models, trimming/winsorization, and E-value assessment. Peaks/plateaus were estimated via the delta method and bootstrap-BCa confidence intervals.</p><p><strong>Results: </strong>The steps-SWB association was non-linear (overall p<0.05). SWB rose steeply up to ~8,650 steps/day and then leveled off, with a statistical plateau near ~19,300 steps/day (bootstrap-BCa 95% CI: 7,997-17,896; delta-method 95% CI: 9,394-14,462). No contrast versus 4,000 steps/day exceeded the prespecified minimal clinically important difference (MCID=10 points). Findings were consistent across specifications; right-tail precision was limited due to few very high step counts.</p><p><strong>Conclusion: </strong>Among university students, higher daily steps are associated with better SWB up to ~8,000-12,000 steps/day, beyond which benefits plateau with diminishing returns rather than harm. Results support range-based, progressive step guidance for student mental health. Please replace the current abstract with the structured IMRaD version provided above.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1693386"},"PeriodicalIF":2.9,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12592034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divergent effects of pitch feedback on online and offline motor sequence learning.","authors":"Pauline Ploettner, Christoph Muehlberg, Felix Psurek, Christopher Fricke, Jost-Julian Rumpf","doi":"10.3389/fnbeh.2025.1680277","DOIUrl":"10.3389/fnbeh.2025.1680277","url":null,"abstract":"<p><strong>Introduction: </strong>Motor sequence learning - the integration of individual movement elements into coordinated actions - is essential for everyday skills. This process comprises online learning during practice and post-practice offline consolidation. A key mechanism is action-perception coupling, in which motor actions become linked with predictable sensory outcomes. Pitch feedback, which conveys timing and spatial information, may strengthen this coupling and facilitate skill acquisition. Here, we evaluated pitch feedback as a tool to modulate both online and offline motor sequence learning.</p><p><strong>Methods: </strong>We included sixty healthy young non-musicians (mean age: 28.4 ± 4.6 years) who were asked to perform a finger-tapping task on a MIDI keyboard. They were randomly assigned to one of three auditory feedback groups: congruent, fixed, and random pitch feedback. The task involved repeatedly performing an 11-item sequence with the right hand. Pitch feedback was delivered according to group assignment during 14 training blocks of six sequences each. Prior to training, participants completed one block of the task without pitch feedback to assess baseline performance. Retention was tested 6 h later under two conditions: seven blocks without pitch feedback (Retest 1) and seven blocks with pitch feedback (Retest 2).</p><p><strong>Results: </strong>Congruent pitch feedback facilitated online learning across the initial training session compared to fixed or random feedback. This advantage of congruent pitch feedback persisted during retesting in the presence of feedback (Retest 2), but did not generalize to task performance in the absence of pitch feedback (Retest 1). Importantly, while online learning and task performance were facilitated by congruent pitch feedback, between-session performance changes were significantly larger in the group that received random pitch feedback during the initial training session compared to the congruent and fixed feedback groups.</p><p><strong>Conclusion: </strong>These findings highlight a dissociation between feedback types that optimize immediate performance and those that promote lasting motor memory formation. While congruent pitch feedback facilitates online skill acquisition compared to fixed or random pitch feedback, unpredictable auditory input may challenge learners to engage internal monitoring mechanisms, leading to more robust, feedback-independent motor memory consolidation. These insights have implications for optimizing auditory feedback in motor learning and neurorehabilitation contexts.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1680277"},"PeriodicalIF":2.9,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12592037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of ziprasidone and olanzapine on cognitive function in patients with schizophrenia at different stages: a prospective study in Huai'an, China.","authors":"Jingjing Yao, Zeliang Liu, Xiaoming Xiao, Liu Zhang, Shouhui Qi, Yangcheng Ge, Hua Han, Xiuling Wang","doi":"10.3389/fnbeh.2025.1561615","DOIUrl":"10.3389/fnbeh.2025.1561615","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effects of ziprasidone and olanzapine on cognitive function in patients with first-episode schizophrenia and chronic schizophrenia at different stages.</p><p><strong>Methods: </strong>Cognitive function tests were performed on chronic schizophrenic patients who took olanzapine for a long time, first-episode drug-free schizophrenic patients, and healthy controls.</p><p><strong>Results: </strong>There were significant differences in the digit span test, Stroop color and word test, auditory verbal learning test N2, N3, N4, trail-making test, verbal fluency test, and clock drawing test between first-episode drug-free schizophrenic patients and healthy controls (<i>p</i> < 0.05). Compared with patients with chronic schizophrenia, there were significant differences in the digit span test, Stroop color and word test B, auditory verbal learning test, trail making test B, and clock drawing test in patients with first-episode schizophrenia after 4 weeks of olanzapine treatment (<i>p</i> < 0.05). Compared with patients with chronic schizophrenia after 4 weeks of Ziprasidone treatment, patients with first-episode schizophrenia had significant differences in the digit span test, Stroop color, and word test, auditory verbal learning test N3, and clock drawing test after 4 weeks of olanzapine treatment (<i>p</i> < 0.05). Compared with patients with chronic schizophrenia who were treated with Ziprasidone for 12 weeks, there were significant differences in Stroop color and word test A, auditory verbal learning test N3, and clock drawing test in patients with first-episode schizophrenia after 4 weeks of olanzapine treatment (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Patients with schizophrenia have cognitive dysfunction in the early stage of onset. The combination of ziprasidone and olanzapine can effectively improve cognitive dysfunction and promote the recovery of social functions of patients.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1561615"},"PeriodicalIF":2.9,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12592029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroanatomy of hippocampal activity patterns: theta, gamma waves, sharp wave-ripples, and dentate spikes.","authors":"Nicholas Paleologos, Mihály Vöröslakos, Joaquin Gonzalez, Anna Maslarova, Deren Aykan, Anli A Liu, György Buzsáki","doi":"10.3389/fnbeh.2025.1685846","DOIUrl":"10.3389/fnbeh.2025.1685846","url":null,"abstract":"<p><p>Monitoring representative fractions of neurons from multiple brain circuits in behaving animals is necessary for understanding how different brain regions interact. Using multishank, high-density recording silicon probes (up to 1,024 sites), we describe the main characteristic LFP patterns in the hippocampus, including sharp wave-ripples (SPW-Rs), dentate spikes (DSs), theta, and gamma oscillations. Our novel observations primarily relate to the distinction between subclasses of SPW-Rs and DSs, as well as their neuronal spiking correlations. In addition to the classical SPW-Rs, initiated in the CA2-3 recurrent collateral system and characterized by a large negative sharp wave (sink) in the mid-CA1 stratum radiatum (SPW-R^Rad), a small subset of ripples, associated with a sink in CA1 str. lacunosum-moleculare was also observed (SPW-R^LM). The two types of ripple events differed in frequency, magnitude, and neuronal correlates. CA3 pyramidal neurons were strongly active during SPW-R^Rad but not during (SPW-R^LM). DSs could also be grouped further based on their excitatory inputs from the medial and lateral entorhinal cortex (DS^MEC and DS^LEC), by their impact on their physiological targets, and by the brain states into which they were embedded. Overall, our experiments demonstrate the utility and need for high-density recording of both LFP and spiking activity for the appropriate classification of seemingly similar events. These distinctions relate not only to their neurogenesis but also to their behavioral-cognitive contributions.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1685846"},"PeriodicalIF":2.9,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12589087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextual influences on risk-taking in children and adults.","authors":"Penelope Lacombe, Klaus Zuberbühler, Christoph D Dahl","doi":"10.3389/fnbeh.2025.1644777","DOIUrl":"10.3389/fnbeh.2025.1644777","url":null,"abstract":"<p><p>Human risk-taking is well known to be influenced by context-dependent factors. In a previous study, we demonstrated that non-human primates similarly exhibit contextual risk-preference: two species of great apes showed risk-prone or risk-neutral choices depending on the manner in which risk was presented. Here, we applied the same experimental paradigm to human participants across different age groups using a computerized online interface. Consistent with the findings in great apes, we observed shifts in risk preference contingent on the experimental context, with these effects particularly pronounced in children. In a subsequent experiment, we explored potential cognitive mechanisms underlying this preference shift, identifying a general propensity for exploration and framing effects as promising explanatory factors common to both humans and animals.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1644777"},"PeriodicalIF":2.9,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12586073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent male and female rats show enhanced latent inhibition of conditioned fear compared to adult rats.","authors":"Christina J Perry, Ricky John, Han B Trinh, Brandon K Richards, Katherine D Drummond, Chun Hui J Park, Jee Hyun Kim","doi":"10.3389/fnbeh.2025.1636674","DOIUrl":"10.3389/fnbeh.2025.1636674","url":null,"abstract":"<p><strong>Introduction: </strong>Latent inhibition is diminished associative memory because of pre-exposure to the conditioned stimulus without any consequences. Latent inhibition likely plays a significant role in the ontogeny of anxiety disorders, contributing to why anxiety disorders are particularly prevalent in adolescence. Therefore, the present study examined latent inhibition of conditioned fear in adolescent and adult rats of each sex. Given that adolescence is associated with deficits in fear extinction, we hypothesized that latent inhibition will be impaired in adolescents compared to adults and expected females to show age-specific estrous cycle effects.</p><p><strong>Methods: </strong>On day 1, male (Experiment 1) and female (Experiment 2) rats were placed in fear conditioning chambers. Half of the rats received pre-exposure to the tone cue while the other half received nothing. On day 2, all rats were placed back in the same chambers and exposed to three cue-footshock pairings. Latent inhibition was tested on day 3 with 20 presentations of the cue by itself in the same chamber.</p><p><strong>Results: </strong>We unexpectedly observed enhanced latent inhibition in adolescents compared to adults in both male and female rats, indicated by lower levels of freezing due to pre-exposure to the cue. Estrous cycle did not affect latent inhibition at any age.</p><p><strong>Discussion: </strong>These results suggest that benign experience to a cue reduces subsequent conditioning to the cue more potently in adolescence compared to adulthood, which suggests a potential resilience mechanism naturally occurring in adolescence.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1636674"},"PeriodicalIF":2.9,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12586020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for food-related and non-food-related maladaptive preference in a mouse model of binge eating disorder.","authors":"Daniela Vajdová, Janet Ježková, Petra Procházková, Radka Roubalová, Enrico Patrono","doi":"10.3389/fnbeh.2025.1653807","DOIUrl":"10.3389/fnbeh.2025.1653807","url":null,"abstract":"<p><strong>Introduction: </strong>Rising numbers of binge eating disorder (BED) cases and excessive associated economic costs, together with the absence of efficient treatment strategies, highlight the importance of research in this area. To date, numerous studies have investigated the role of aberrant motivation in compulsive, maladaptive feeding behaviors. However, other aspects of maladaptive preference toward foods, possibly involving risk-based decision-making processes, are not yet fully elucidated.</p><p><strong>Methods: </strong>In this research, two types of environmental stressors-food-related and non-food-related-are explored in their ability to model compulsive behavior toward palatable food in mice.</p><p><strong>Results and discussion: </strong>Results from the behavioral experiments suggest that both types of stressors, when paired with the availability of highly palatable food, can produce aberrant motivation toward such food. These findings were subsequently supported by data obtained from cortisol concentration analysis in subjects.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1653807"},"PeriodicalIF":2.9,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12580334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145444426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taylor Swift versus Mozart: music preferences of C57BL/6J mice.","authors":"Dominik Kamionek, Johann G Maass, Claudia Pitzer, Christian P Schaaf","doi":"10.3389/fnbeh.2025.1668278","DOIUrl":"10.3389/fnbeh.2025.1668278","url":null,"abstract":"<p><strong>Introduction: </strong>Music has become an established complementary element of modern medicine, demonstrating beneficial effects towards various diseases such as dementia, hypertension, or chronic pain. Given its low cost and non-invasive nature, music-based interventions have been studied in both healthy mice and disease models over recent decades to examine potential effects in rodents. However, the selection of music in these interventions is based on prior reports and human preferences, without critically evaluating its relevance or perception in mice. Novel experimental approaches are needed to evaluate which type of music is preferred by mice.</p><p><strong>Methods: </strong>In this pilot study, we introduce a new experimental setup that can be used to analyze the music preferences regarding different genres and frequencies. Here, we present the first-ever evaluation of mouse music preferences by examining the behavioral responses of healthy C57BL/6J.</p><p><strong>Results: </strong>When given a choice between different musical conditions, mice spent comparatively less time in a chamber playing <i>Sonata for Two Pianos in D major, K.448</i> by Mozart, a piece regularly used in music-intervention studies of rodents. Further testing revealed that this behavioral response is independent of tone pitch.</p><p><strong>Discussion: </strong>These findings underscore the importance of species-specific tailoring of music selection towards therapeutic approaches. Our assay can be used to further broaden our understanding of murine music preferences and to analyze how mice respond to and perceive different auditory stimuli. Further studies are needed to systematically investigate murine music perception and preference across genres and exposure durations.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1668278"},"PeriodicalIF":2.9,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12568665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different frequencies of human scalp-recorded theta activity may index integration of activity in distinct recurrent cortico-subcortical mnemonic networks.","authors":"Inanna K Haddon, Rohan O C King, Dylan A Taylor, Jodie N Bell, Jasmine E B Murray, Meghan van der Meer, Christopher D Erb, Ian J Kirk","doi":"10.3389/fnbeh.2025.1686252","DOIUrl":"10.3389/fnbeh.2025.1686252","url":null,"abstract":"<p><p>It is now well-accepted that differing frequencies of neuro-oscillations support the selection, quantising, and pacing of information around different circuits in the brain. Another related function of neuro-oscillations, for which the frequency of oscillation is again critical, is to allow for integration of neural activity across differing spatial scales. In this short review, we discuss the degree to which human scalp-recorded EEG occurring in the theta-range (4-8 Hz) can be used to infer activation of mnemonic circuits involving the hippocamps and diencephalon (Papez loops), as well as in the neocortical areas the activity is directly recorded from. We also discuss the potential role of theta-range frequency modulation in the selection of specific mnemonic circuits. In light of the foregoing, we suggest that the frequency at which theta is occurring within and between cognitive tasks should be reported more thoroughly than it generally is. Finally, we suggest that assessing disruptions in frequency modulation of theta-range oscillations is a potentially valuable biomarker for disorders such as Alzheimer's disease.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1686252"},"PeriodicalIF":2.9,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12568603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reward-seeking behaviors moderate the association between early life adversity and anhedonia 12 months later.","authors":"Mai-Lan Tran, Uma Rao, Julienne Bower, Andrew Fuligni, Kate Ryan Kuhlman","doi":"10.3389/fnbeh.2025.1672103","DOIUrl":"10.3389/fnbeh.2025.1672103","url":null,"abstract":"<p><p>Approximately 20% of adolescents report experiencing anhedonia, conferring high risk for the onset of adolescent depression. Early life adversity (ELA) is associated with anhedonia, and individual differences in reward motivation may inform this association. The current study examined whether reward-seeking behaviors moderated the prospective association between ELA and anhedonia 12-months later among adolescents. During a baseline visit, 74 participants, aged 11-17, completed the Balloon Analogue Risk Task (BART) to measure reward-seeking behaviors via adjusted average balloon pumps. Indeed, participation in the BART has been shown to activate the fronto-striatal neural circuits known to subserve reward-seeking. ELA was assessed continuously via parent-report using a 9-item Adverse Childhood Experiences questionnaire, with scores reflecting cumulative exposures to adversity prior to enrollment; interaction effects were subsequently probed at low, average, and high values for interpretation. At baseline and 12-months later, participants completed the anhedonia subscale within the Reynolds Adolescent Depression Scale 2nd Edition. Adolescents with greater ELA reported more anhedonia 12-months later (<i>b</i> = 0.97, <i>SE</i> = 0.46, <i>p</i> = 0.04), suggesting that ELA confers risk for developing anhedonia. Reward-seeking behavior moderated this association, such that adolescents with more experiences of ELA and low (<i>b</i> = 2.35, <i>SE</i> = 0.61, <i>p</i> < 0.01) and average reward seeking-behavior (<i>b</i> = 0.95, <i>SE</i> = 0.43, <i>p</i> = 0.03), but not high reward-seeking behavior (<i>b</i> = -0.45, <i>SE</i> = 0.60, <i>p</i> = 0.45), were at the greatest risk for increasing severity of anhedonia across the subsequent 12-months. Reward-seeking behaviors may aid in distinguishing which youth with ELA are at risk for depression. Additionally, results from this study may help to inform more specific interventions by increasing reward-seeking behaviors to mitigate the risks of developing anhedonia.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"19 ","pages":"1672103"},"PeriodicalIF":2.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12558990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}