Frontiers in Behavioral Neuroscience最新文献

{"title":"Effects of sex and estrous cycle on extended-access oxycodone self-administration and cue-induced drug seeking behavior.","authors":"Bhumiben P Patel, Jessica A Loweth","doi":"10.3389/fnbeh.2024.1473164","DOIUrl":"10.3389/fnbeh.2024.1473164","url":null,"abstract":"<p><strong>Introduction: </strong>Increasing evidence indicates that sex is a factor that impacts the abuse liability and relapse vulnerability of prescription opioids like oxycodone. However, while women are more likely than men to be prescribed and to use these drugs, the impact of sex and ovarian hormones on prescription opioid use and relapse vulnerability remains unclear. Accurately assessing these measures is complicated by the fact that chronic opioid exposure can lower ovarian hormone levels and cause cycle irregularities.</p><p><strong>Methods: </strong>Adult male and female Sprague-Dawley rats self-administered oxycodone (0.1 mg/kg/infusion) under extended-access conditions (6 h/day, 10 days) followed by forced abstinence. Separate groups of animals received cue-induced seeking tests in a drug-free state during early (1-2 days) or later periods of abstinence (43-45 days). To track estrous cycle stage, animals were regularly vaginally swabbed throughout the study.</p><p><strong>Results: </strong>We observed oxycodone-induced estrous cycle dysregulation in the majority (~60%) of the animals during both self-administration and the first month of abstinence. In animals whose cycles were not dysregulated, we found a reduction in oxycodone intake during estrus compared to all other cycle stages (non-estrus). We also found that males but not females showed a time-dependent intensification or incubation of cue-induced oxycodone craving over the first 6 weeks of abstinence. This sex difference was estrous cycle-dependent, driven by a selective reduction in drug seeking during estrus.</p><p><strong>Discussion: </strong>These findings highlight the importance of tracking drug-induced estrous cyclicity and identify a clear impact of ovarian hormones on oxycodone taking and seeking behavior.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1473164"},"PeriodicalIF":2.6,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the dorsolateral prefrontal cortex in processing temporal anomalies retained in working memory.","authors":"Pierandrea Mirino, Alessandro Quaglieri, Gabriele Scozia, Sara Mercuri, Alessandro Alessi, Cecilia Guariglia, Anna Maria Giannini, Fabrizio Doricchi, Anna Pecchinenda","doi":"10.3389/fnbeh.2024.1494227","DOIUrl":"10.3389/fnbeh.2024.1494227","url":null,"abstract":"<p><strong>Introduction: </strong>Time is a crucial abstract construct, allowing us to perceive the duration of events. Working memory (WM) plays an important role in manipulating and storing the different features of environmental stimuli, including temporal features. Different brain structures, including the dorsolateral prefrontal cortex, are involved in time processing.</p><p><strong>Methods: </strong>Here we investigated the functional aspects of time processing by using functional near-infrared spectroscopy (fNIRS) to assess changes in DLPFC activity. A modified version of the \"Times Squares Sequences\" (TSS) task was used, in which participants are required to match sequences of squares that have fixed or variable durations.</p><p><strong>Results: </strong>Findings showed that the DLPFC activates when information necessary for later comparison needs to be maintained online, as is common in visuo-spatial WM tasks. Importantly, the DLPFC deactivates when a temporal anomaly is detected.</p><p><strong>Discussion: </strong>This deactivation occurs because the temporal anomaly does not require ongoing maintenance for later comparison, thus demanding fewer cognitive resources from the DLPFC. This seemingly counterintuitive effect can be attributed to the temporal aspects being irrelevant to the primary task goals. This finding highlights the crucial role of implicit temporal interference and establishes a strong connection between timing and executive cognitive processes.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1494227"},"PeriodicalIF":2.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplementation with inulin reverses cognitive flexibility alterations and modulates the gut microbiota in high-fat-fed mice.","authors":"Gabriela González-Velázquez, José Félix Aguirre-Garrido, Rigoberto Oros-Pantoja, Isidro Daniel Salinas-Velarde, Irazú Contreras, José Antonio Estrada, Alexandra Estela Soto-Piña","doi":"10.3389/fnbeh.2024.1445154","DOIUrl":"10.3389/fnbeh.2024.1445154","url":null,"abstract":"<p><strong>Introduction: </strong>Alterations in cognitive performance are associated with inadequate nutritional states and diet composition. Prebiotics, such as inulin, are substances that can modulate the gut microbiome and, consequently, brain function by producing metabolites such as short-chain fatty acids (SCFAs). This study aimed to evaluate the effect of supplementation with inulin on cognitive flexibility, body composition, and gut microbiota in a murine model exposed to a high-fat (HF) diet.</p><p><strong>Methods: </strong>CD1 mice were divided into five groups: control fed a standard diet (C), high-fat diet (HF), inulin (I), high-fat diet with inulin (HFI), and manipulation control (M). Dietary supplementation was administered for 6 weeks. Cognitive flexibility was assessed using the Attentional Set-Shifting Test (AST). In addition, body composition was measured via electrical bioimpedance and adipose tissue compartments of each mouse were removed and weighed. Finally, gut microbiota metataxonomic was analyzed through metataxonomic bacterial 16S rRNA sequencing.</p><p><strong>Results: </strong>We observed that HF group required more AST trials than the C, HFI, and I groups in the compound discrimination (CD) and extra-dimensional (ED) stages. Notably, the HFI group required fewer trials than the HF group in the ED stage (<i>p</i> = 0.0187). No significant differences in overall body composition were observed between the groups. However, the percentage of gonadal and peritoneal adipose tissue was significantly higher in the HF and I groups compared to the C group. Statistically significant differences in alpha diversity for gut microbiota were observed using the Shannon, Simpson, and Chao1 indices. The I group showed a decrease in bacterial diversity compared to the HF group. While no differences were observed between groups in the phyla Bacillota and Bacteroidotes, <i>Clostridium</i> bacteria represented a lower proportion of sequences in the I group compared to the C group. Additionally, <i>Lactobacillus</i> represented a lower proportion of sequences in the HF group compared to the C and I groups.</p><p><strong>Discussion: </strong>These findings suggest that supplementation with inulin could be a useful approach to mitigate the negative effects of an HF diet on cognitive flexibility and modulate gut microbiota composition.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1445154"},"PeriodicalIF":2.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fully automated social interaction chamber for studying social threat learning in mice.","authors":"Ellora M McTaggart, Noah W Miller, Maria M Ortiz-Juza, Nicolas C Pégard, Jose Rodriguez-Romaguera","doi":"10.3389/fnbeh.2024.1481935","DOIUrl":"10.3389/fnbeh.2024.1481935","url":null,"abstract":"<p><p>Social interactions are fundamental for our survival as a predominately social species. We need and seek positive social interactions to navigate the world. However, when social interactions are negative, and occur in the presence of an aversive event, learning occurs to associate such social interactions as threatening. Gaining insight into the neural circuits that drive social threat learning is crucial for understanding social interactions. Animal models can be leveraged to employ technologies that allow us to track neuronal processes with very high resolution to obtain a better understanding of the neural circuits involved. To accomplish this, we need robust behavioral models that are replicable and high throughput. Here, we present an open-source social interaction chamber that detects social interaction and automatically pairs it with foot shock. The social interaction chamber is designed to easily integrate into modular chambers commonly used for auditory and context threat learning. It contains an array of optical gates that precisely track mouse-to-mouse interactions in real time with digital triggers that can communicate with external devices to deliver a foot shock. We find that pairing social interactions with electric foot shock using our fully automated social interaction chamber is optimal for social threat associations. We further demonstrate that timing of social contact with foot shock produces optimal learning.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1481935"},"PeriodicalIF":2.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential regulation of sleep by blue, green, and red light in <i>Drosophila melanogaster</i>.","authors":"Samuel M Bond, Aaliyah J Peralta, Dilhan Sirtalan, Dominic A Skeele, Haoyang Huang, Debra R Possidente, Christopher G Vecsey","doi":"10.3389/fnbeh.2024.1476501","DOIUrl":"10.3389/fnbeh.2024.1476501","url":null,"abstract":"<p><strong>Introduction: </strong>Exposure to blue-enriched light from electronic devices is an emergent disruptor of human sleep, especially at particular times of day. Further dissection of this phenomenon necessitates modeling in a tractable model organism.</p><p><strong>Methods: </strong>Thus, we investigated the effects of light color on sleep in <i>Drosophila melanogaster</i>. We measured sleep in red-eyed Canton-S (CS) and white-eyed <i>w</i> ¹¹¹⁸ flies in baseline 12:12 light/dark conditions and experimental conditions with light-color (blue, red, or green) exposure for all 12 h of daylight or 3 h in the morning or evening.</p><p><strong>Results: </strong>Blue light reduced daytime and nighttime sleep in CS but not in <i>w</i> ¹¹¹⁸, potentially indicating a role for the compound eye in blue light's effects on fruit fly sleep. Red light, especially in the evening, reduced sleep during exposure in both strains. Green light had minimal effects on sleep in CS flies, but evening exposure reduced sleep in <i>w</i> ¹¹¹⁸ flies, mimicking red light's effects.</p><p><strong>Discussion: </strong>In conclusion, light's effects on sleep in <i>D. melanogaster</i> are dependent on wavelength and time-of-day. Future studies will aim to dissect these mechanisms genetically.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1476501"},"PeriodicalIF":2.6,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical acupuncture at HT7 attenuates alcohol self-administration in rats by modulating neuroinflammation and altering mPFC-habenula-VTA circuit activity.","authors":"Su Yeon Seo, Se Kyun Bang, Suk Yun Kang, Seong Jin Cho, Kwang-Ho Choi, Yeonhee Ryu","doi":"10.3389/fnbeh.2024.1455622","DOIUrl":"10.3389/fnbeh.2024.1455622","url":null,"abstract":"<p><strong>Introduction: </strong>Alcohol use disorder is a chronic disorder with significant limitations in pharmacological treatments, necessitating the exploration of non-pharmacological interventions.</p><p><strong>Methods: </strong>We used a model of alcohol self-administration (10% v/v) to analyze behavioral, neurochemical, and signaling mechanisms.</p><p><strong>Results: </strong>Our findings demonstrate that stimulation of the HT7 acupuncture point significantly decreased the frequency of active lever presses in rats self-administering alcohol (<i>p</i> < 0.05). Alcohol self-administration increased microglial activity and sigma 1 receptor expression in the habenula (Hb), while HT7 stimulation mitigated these effects, decreasing microglial activity and sigma 1 receptor levels (<i>p</i> < 0.05). Additionally, alcohol self-administration reduced brain-derived neurotrophic factor (BDNF) expression in the medial prefrontal cortex (mPFC) and increased tyrosine hydroxylase (TH) levels in the ventral tegmental area (VTA) (<i>p</i> < 0.05). HT7 stimulation reversed these alterations by increasing BDNF expression in the mPFC and decreasing TH levels in the VTA (<i>p</i> < 0.05). Further investigation revealed that BDNF microinjection into the mPFC inhibited sigma 1 receptor activity in the Hb, while microglial inhibition in the Hb decreased TH expression in the VTA (<i>p</i> < 0.05). The administration of the microglial inhibitor MINO to the Hb also reduced alcohol self-administration (<i>p</i> < 0.05).</p><p><strong>Discussion: </strong>These results suggest that HT7 stimulation regulates the mPFC-Hb-VTA circuit, leading to decreased alcohol-seeking behavior. Our study demonstrates that HT7 acupuncture can modulate the mPFC-Hb-VTA circuit, providing a potential non-pharmacological treatment for alcohol-seeking behavior by influencing microglial activity, sigma 1 receptor expression, and TH levels. These findings contribute to a deeper understanding of the neural mechanisms underlying acupuncture's therapeutic effects on alcohol use disorder.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1455622"},"PeriodicalIF":2.6,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reinforcement learning in motor skill acquisition: using the reward positivity to understand the mechanisms underlying short- and long-term behavior adaptation.","authors":"Mariane F B Bacelar, Keith R Lohse, Juliana O Parma, Matthew W Miller","doi":"10.3389/fnbeh.2024.1466970","DOIUrl":"10.3389/fnbeh.2024.1466970","url":null,"abstract":"<p><strong>Introduction: </strong>According to reinforcement learning, humans adjust their behavior based on the difference between actual and anticipated outcomes (i.e., prediction error) with the main goal of maximizing rewards through their actions. Despite offering a strong theoretical framework to understand how we acquire motor skills, very few studies have investigated reinforcement learning predictions and its underlying mechanisms in motor skill acquisition.</p><p><strong>Methods: </strong>In the present study, we explored a 134-person dataset consisting of learners' feedback-evoked brain activity (reward positivity; RewP) and motor accuracy during the practice phase and delayed retention test to investigate whether these variables interacted according to reinforcement learning predictions.</p><p><strong>Results: </strong>Results showed a non-linear relationship between RewP and trial accuracy, which was moderated by the learners' performance level. Specifically, high-performing learners were more sensitive to violations in reward expectations compared to low-performing learners, likely because they developed a stronger representation of the skill and were able to rely on more stable outcome predictions. Furthermore, contrary to our prediction, the average RewP during acquisition did not predict performance on the delayed retention test.</p><p><strong>Discussion: </strong>Together, these findings support the use of reinforcement learning models to understand short-term behavior adaptation and highlight the complexity of the motor skill consolidation process, which would benefit from a multi-mechanistic approach to further our understanding of this phenomenon.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1466970"},"PeriodicalIF":2.6,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social contagion of pain and fear results in opposite social behaviors in rodents: meta- analysis of experimental studies.","authors":"Rui Du, Yang Yu, Xiao-Liang Wang, Guofang Lu, Jun Chen","doi":"10.3389/fnbeh.2024.1478456","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1478456","url":null,"abstract":"<p><strong>Introduction: </strong>The study aimed to explore the key factors influencing emotional valence in rodents, focusing on the critical elements that distinguish the contagion processes of fear and pain.</p><p><strong>Methods: </strong>Through a systematic review and meta-analysis, we examined behavioral outcomes of rodents exposed to painful or fearful catastrophes to see whether they are prosocial or antisocial through three-chamber test and dyadic social interaction paradigm.</p><p><strong>Results: </strong>Fear contagion, particularly when witnessed, leads to social avoidance behavior, unaffected by sex difference but more pronounced with age. In contrast, pain contagion promotes social approach and caring/helping behaviors.</p><p><strong>Discussion: </strong>The present study demonstrates that the emotional valence induced by pain contagion is quite different from fear contagion and this difference may result in different motivations and social behaviors, namely, social contagion of pain is likely to be more associated with prosocial behaviors, however, social contagion of fear is likely to be more associated with antisocial behaviors.</p><p><strong>Systematic review registration: </strong>PROSPERO (CRD42024566326).</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1478456"},"PeriodicalIF":2.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Generalization and discrimination of inhibitory avoidance differentially engage anterior and posterior retrosplenial subregions.","authors":"Erisa Met Hoxha, Payton K Robinson, Kaitlyn M Greer, Sydney Trask","doi":"10.3389/fnbeh.2024.1508609","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1508609","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnbeh.2024.1327858.].</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1508609"},"PeriodicalIF":2.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired maturation of resting-state connectivity in anorexia nervosa from adolescence to adulthood: differential mechanisms of consummatory vs. anticipatory responses through a symptom provocation paradigm.","authors":"Andrea Mendez-Torrijos, Mageshwar Selvakumar, Silke Kreitz, Julie Roesch, Arnd Dörfler, Georgios Paslakis, Johannes Krehbiel, Sabine Steins-Löber, Oliver Kratz, Stefanie Horndasch, Andreas Hess","doi":"10.3389/fnbeh.2024.1451691","DOIUrl":"https://doi.org/10.3389/fnbeh.2024.1451691","url":null,"abstract":"<p><p>This functional magnetic resonance imaging (fMRI) study examined resting-state (RS) connectivity in adolescent and adult patients with anorexia nervosa (AN) using symptom provocation paradigms. Differential food reward mechanisms were investigated through separate assessments of responses to food images and low-caloric/high-caloric food consumption. Thirteen young (≤ 21 years) and seventeen adult (> 21 years) patients with AN and age-matched controls underwent two stimulus-driven fMRI sessions involving RS scans before and after the presentation of food-related stimuli and food consumption. Graph theory and machine learning were used for analyzing the fMRI and clinical data. Healthy controls (HCs) showed widespread developmental changes, while young participants with AN exhibited cerebellum differences for high-calorie food. Young individuals with AN displayed increased connectivity during the consumption of potato chips compared to zucchini, with no differences in adults with AN. Multiparametric machine learning accurately distinguished young individuals with AN from healthy controls based on RS connectivity following food visual stimulation (\"anticipatory\") and consumption (\"consummatory\"). This study highlights the differential food reward mechanisms and minimal developmental changes in RS connectivity from youth to adulthood in individuals with AN compared to healthy controls. Young individuals with AN demonstrated heightened reactivity to high-caloric foods, while adults showed decreased responsiveness, potentially due to desensitization. These findings shed light on aberrant eating behaviors in individuals with AN and contribute to our understanding of the chronicity of the disease.</p>","PeriodicalId":12368,"journal":{"name":"Frontiers in Behavioral Neuroscience","volume":"18 ","pages":"1451691"},"PeriodicalIF":2.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}