Fortschritte Der Neurologie Psychiatrie最新文献

{"title":"[Routine clinical data and innovative therapeutic approaches - implications for the further development of psychiatry and neuropsychiatry].","authors":"Stefan Borgwardt","doi":"10.1055/a-2813-6755","DOIUrl":"10.1055/a-2813-6755","url":null,"abstract":"","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"94 4","pages":"130-131"},"PeriodicalIF":0.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The function of sleep and and the mechanisms of sleep regulation provide the basis for insomnia therapy].","authors":"Wolfgang Freund","doi":"10.1055/a-2664-3170","DOIUrl":"10.1055/a-2664-3170","url":null,"abstract":"<p><p>Considering frequent complaints of patients about insomnia and the manifold therapy proposals, the following questions arise: Is insomnia relevant, what is the function of normal sleep? What are the mechanisms of sleep regulation? In order to correctly assess and adress insomnia, we have to understand the physiology of sleep. In this context, considerable insights have been gained in the last years. Only with these we can aid patients with insomnia and choose the optimal therapy.The presented paper mainly deals with primary insomnia. Secondary insomnia like in sleep apnea or with restless legs syndrome has to be adressed causally and will not be discussed here.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"94 4","pages":"150-167"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Transitional psychiatry in Switzerland: Results of the first-year follow-up of 187 patients after the establishment of the transitional psychiatric department at St. Urban Clinic in Lucerne].","authors":"Sebastian K M Fischer, Laura Iten, Christian Lay, Evgeniy Perlov, Oliver Bilke-Hentsch, Eginhard Koch, Jochen Mutschler","doi":"10.1055/a-2816-4268","DOIUrl":"https://doi.org/10.1055/a-2816-4268","url":null,"abstract":"<p><strong>Introduction: </strong> The structural separation of child and adolescent psychiatric care from adult psychiatric care necessitates a transition between the two systems when patients reach the age of majority. In order to facilitate an orderly transition, St. Urban Clinic in Lucerne opened a department for transitional psychiatry in November 2023. The department provides treatment for patients aged 16 to 25 from the cantons of Lucerne, Nidwalden, and Obwalden. In this study, an analysis was conducted on the treatment courses of the first-year cohort. The results are intended to support quality assurance and provide impetus for the further development of transitional care structures.</p><p><strong>Methods: </strong> Between 1 November 2023 and 1 November 2024, a total of 187 patients received treatment in the transitional psychiatry department at St. Urban Clinic. Patient characteristics were presented using descriptive statistics. The patients' mental state was recorded and examined at admission and discharge using the Brief Symptom Checklist (BSCL) and Health of the Nation Outcome Scales (HoNOS) measurement instruments. Additionally, the primary and secondary psychiatric diagnoses were documented and compared with those in adult psychiatry.</p><p><strong>Results: </strong> The evaluation of patient data revealed a significant reduction in psychiatric symptoms during the period of hospitalization. It was also found that the range of diagnoses differed considerably in some cases from that in adult psychiatry. The most prevalent psychiatric diagnoses among transitional patients were depression, anxiety disorders, cannabis use disorder, borderline personality disorder, post-traumatic stress disorder and attention deficit hyperactivity disorder.</p><p><strong>Conclusions: </strong> Within a year, an inpatient transitional psychiatric care service was successfully established to cover the needs of three Swiss cantons. Moreover, the present study offers exploratory insights into the characteristics of patients in transitional psychiatric settings, including their psychiatric diagnoses and comorbidities.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Psychosomatics in children with severe neurogenetic and complex neurological diseases].","authors":"Thomas Lücke, Daria Tsvetkova, Rainer Georg Siefen","doi":"10.1055/a-2777-2072","DOIUrl":"https://doi.org/10.1055/a-2777-2072","url":null,"abstract":"<p><p>Psychosomatic disorders are reported in approximately 10% of clinical populations of children and adolescents. A burden of psychosomatic symptoms is found in about 25% to 40% in both care-seeking and clinical populations. For some of these symptoms the figure is even higher. In contrast, psychosomatic comorbidities may be underdiagnosed in children and adolescents with neurogenetic and complex neurological disorders. We initially investigated this potential underdiagnosis with a systematic literature search. As only few neuropediatric publications on this specific topic were found, publications from neighboring disciplines were included as well. The failure to record comorbid psychosomatic stress could be due to the complex symptomatology of this patient group. Other possible causes concern communication problems within the family and between parents and experts, or insufficient cooperation between the specialist groups involved. Suggestions include potential further development in diagnostic techniques and strategies of communication. New diagnostic and therapeutic perspectives arise when symptoms are understood as functional attempts at adaptation in a developmental psychopathological treatment model. Affected children must also be seen as unique and creative individuals.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Imaging diagnostics for neurodegenerative dementias - current clinical reality and important new developments].","authors":"Florian Schöberl, Marianne Dieterich","doi":"10.1055/a-2765-8373","DOIUrl":"https://doi.org/10.1055/a-2765-8373","url":null,"abstract":"","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"94 3","pages":"83-84"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Adherence to the Mediterranean diet and anthropometric characteristics in patients with myasthenia gravis: a retrospective cohort study].","authors":"Felix Maximilian Xaver Lorenz, Benjamin Seethaler, Benedikt Schoser","doi":"10.1055/a-2698-6039","DOIUrl":"10.1055/a-2698-6039","url":null,"abstract":"<p><p>Myasthenia gravis (MG) is a chronic neuromuscular autoimmune disease characterized by muscle weakness in which both genetic and environmental factors play a role. A positive influence of the Mediterranean diet (MedD) has been demonstrated for some autoimmune diseases. Whether such a connection also exists in patients with MG has not yet been investigated.In a monocentric, retrospective cohort study, anthropometric data were collected from 200 patients with MG. In addition, adherence to MedD was assessed in a subgroup (n=43) using the validated Mediterranean Diet Adherence Screener (MEDAS) questionnaire. The MG cohort was stratified into a treatment-refractory group (≥3 immunosuppressants in the course; n=23) and a non-refractory group (n=177). Statistical analysis was performed using SPSS.31.6% of patients were obese, with a median BMI of 27.2 kg/m². The median MEDAS score of the overall group was 7.0 points. In the treatment-refractory group, the median score was 8.0 points; in the non-refractory group, 6.0 points. However, no significant difference was found between the groups (p=0.69). The values determined were within the range of previous comparative studies on other autoimmune diseases.MG patients showed moderate adherence to the MedD. The observation of a higher MEDAS score in the refractory group requires further investigation. The results of our study did not show any statistical evidence of a positive effect of a MedD on the course of MG.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":"101-106"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnostic utility of the MTA-Score depending on age and cerebral microangiopathy in times of automated volumetry].","authors":"Pauline Klara Sander, Cathrin Sauer, Arne Grey, Pawel Krukowski, Jennifer Linn, Moritz D Brandt, Robert Haussmann","doi":"10.1055/a-2512-7931","DOIUrl":"10.1055/a-2512-7931","url":null,"abstract":"<p><p>  To investigate the diagnostic value of the MTA score according to age, cerebral small vessel disease and in times of automated volumetry.  Retrospective analysis of patients with subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), Alzheimer's disease (AD) and mixed dementia (MD) who presented to our outpatient dementia clinic between February 2018 and October 2020. Patients underwent cranial magnetic resonance imaging (MRI) including specific MRI sequences needed for automated volumetry. MRI data sets were analyzed regarding MTA score, Fazekas score, hippocampal und temporal lobe percentile and total white matter lesion volume.  Within the study period, 242 patients (100 male, 142 female, mean age 74.7±9.9 years) with SCD (n=20), aMCI (n=110), AD (n=62) and MD (n=50) were analyzed. MTA score strongly correlated with age (ρ=0.545; p<0.001), especially regarding the aMCI and AD group. MTA score differentiated only between prodromal and dementia stages (aMCI vs. AD: p=0.005), whereas hippocampal percentile also showed a trend in differentiating between SCD and aMCI. There was a correlation between MTA score and hippocampal percentile (ρ=-0.385; p<0.001), which, on a single group level, could only be shown for the aMCI and AD group. There was significant correlation between MTA score with hippocampal and temporal lobe percentile. MTA score also correlated with Fazekas score (ρ=0.451; p<0.001) which again could only be detected within the aMCI and AD group. But there was no correlation between hippocampal percentile and total white matter lesion volume.  When interpreting the MTA score, patient's age needs to be taken into consideration. Especially, in early dementia diagnostics, automated volumetric procedures might be advantageous, but due to the strong correlation of MTA score with hippocampal percentile, the MTA score still is a valid diagnostic marker. Whether hippocampal atrophy is modulated by cerebral small vessel disease still needs to be elucidated.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":"95-100"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The Therapy of Anxiety Disorders Around 1900. Hermann Oppenheim (1858-1919) and his Early Innovations].","authors":"Nina C Moenikes, Holger Steinberg","doi":"10.1055/a-2191-2835","DOIUrl":"10.1055/a-2191-2835","url":null,"abstract":"<p><p>As a teacher and textbook author in psychiatry, Oppenheim initially received high national as well as international scientific recognition. In 1892, with his monograph on traumatic neurosis, which he regarded as the result of organic or molecular changes, his views became increasingly controversial and were met with rejection from the specialists of his time. mainly from German colleagues, probably not least because of his Jewish origin. Less historical attention, however, has been paid to Oppenheim's examination of the phenomenon of anxiety, which at his time was still a poorly elaborated pathological disorder. In his work, Oppenheim considered anxiety disorders to be an etiologically multifactorial disease and a syndrome in their own right. Oppenheim not only oriented himself towards common treatment methods such as dietetics or psychoanalysis but also considered the patient with his multi-dimensional problems as an individual deserving respect. What was more, he also applied self-developed psychotherapeutic treatment methods that show similarities with cognitive behavioral therapy that is predominantly used for anxiety disorders today. Oppenheim's work on anxiety disorders can be considered as highly innovative for his time.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":"87-94"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Multimodal treatment for depression in old age].","authors":"Vjera Holthoff-Detto","doi":"10.1055/a-2655-2742","DOIUrl":"10.1055/a-2655-2742","url":null,"abstract":"<p><p>Old age depression can lead to significant functional impairment and severe deterioration in cognitive and physical health. Multimodal, individually tailored treatment for depression in old age should address affective symptoms, functional status, and cognition in the best possible way, as clinical management competes against reduced somatic and psychological reserves in the old patients.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"94 3","pages":"108-119"},"PeriodicalIF":0.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The de jure and de facto working time situation of assistant and senior physicians in Switzerland].","authors":"David Sebastian Weis, Ladina Pfyffer, Jochen Mutschler","doi":"10.1055/a-2778-7720","DOIUrl":"https://doi.org/10.1055/a-2778-7720","url":null,"abstract":"<p><p>The legal stipulation of maximum working hours for assistant doctors of 50 hours per week [1, 2] has raised the question of whether the legal requirements are implemented in reality. This question has been looked at for the overall group of doctors [5], but not for the specific medical specialties. The aim of this study was to analyze the de jure and de facto working time situation and its conformity with regard to the specialties of psychiatry, internal medicine and surgery.A representative online survey of around 3,240 assistant and senior physicians in Switzerland was conducted.The analysis of working hours in medicine showed significant differences within the specialist disciplines and in relation to the de jure and de facto working situation. The implementation of the de jure working hours was largely in accordance with the law. Overall, psychiatry had greater flexibility with regard to employment contracts and a lower actual workload compared to the other specialist areas. Nevertheless, the actual de facto working hours deviatefd considerably from those contractually agreed. In addition, there was a discrepancy between the reported and actual hours worked in all departments. The highest additional workload occurred in surgery, followed by internal medicine and then by psychiatry.There is a general non-compliance with the statutory working time regulations in all specialist areas, which points to a systematic problem in the medical sector. The discrepancy between the hours actually worked and the hours reported or contractually agreed, could indicate structural weaknesses and a possible failure in the system. It is important to improve working conditions and to fulfill the legal requirements.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146226208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}