Fortschritte Der Neurologie Psychiatrie最新文献

{"title":"[The positive Mozart effect on people with epilepsy: Is there some truth in this claim?]","authors":"Johannes Rösche","doi":"10.1055/a-2366-6948","DOIUrl":"https://doi.org/10.1055/a-2366-6948","url":null,"abstract":"<p><p>The positive treatment effect of Mozart's melody on patients with epilepsy, which was propagated in the late 1990s, was investigated in 29 papers. Commonly, the first movement of the sonata for two pianos KV 448 was played with many repetitions. At least a fifth of the patients achieved a reduction of seizure frequency of more than 50%. Patients with epileptic discharges from the occipital lobe responded very rarely. The mechanism of the effect is not clear, but the melodic aspects seem to have a significant role in this context.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Ofatumumab in the treatment of multiple sclerosis - A summary of preclinical and clinical data].","authors":"Juliane Klehmet, Tobias Bopp","doi":"10.1055/a-2365-0966","DOIUrl":"https://doi.org/10.1055/a-2365-0966","url":null,"abstract":"<p><strong>Background: </strong>  B-cell targeted therapies are highly effective in multiple sclerosis (MS). Most of these therapies are administered intravenously at long intervals. Ofatumumab, an anti-CD20 antibody that is administered subcutaneously at low doses on a monthly basis due to its high affinity to the target structure, became available for the treatment of MS in 2021.</p><p><strong>Methods: </strong>  An overview of practice-relevant immunological and clinical data on ofatumumab is provided.</p><p><strong>Results: </strong>  The high affinity of ofatumumab to the target structure allows low dose and low volume administration, with the release and absorption profile after subcutaneous application allowing for high concentrations in the lymph nodes and gradual depletion of B-cells. Rapid onset of action is achieved as well as B-cell repletion within a few months in case of discontinuation of therapy. Long-term data show stable IgG levels over up to four years and high efficacy with respect to relapse rate, progression, and cognition. According to current study data, the effect compared to teriflunomide is greater the earlier therapy is initiated. Ofatumumab has a specific B-cell depletion pattern. CD20 expressing B-cell progenitor cells in the bone marrow are preserved and therefore also the inducibility and differentiation of plasma cells. The formation of a humoral immunological memory is therefore possible. Four-year study data showed no abnormalities in the rate of severe infections or malignancies.</p><p><strong>Conclusions: </strong>  Ofatumumab is an innovative B-cell targeted therapy. It is highly effective with a good safety and tolerability profile, well controllable and maintains immunocompetence against pathogens.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Institutional and patient-related factors influencing the frequency of restraint in a general psychiatric acute care unit].","authors":"Miriam Paetzold, Kathrin Kuhr, Fritz-Georg Lehnhardt","doi":"10.1055/a-2365-0878","DOIUrl":"https://doi.org/10.1055/a-2365-0878","url":null,"abstract":"<p><strong>Objective: </strong>Valid knowledge about risk stratification is essential for the development of preventive approaches to reduce restraints.</p><p><strong>Methods: </strong>  This retrospective, monocentric study examined all 248 restraining measures used on 79 patients of a university psychiatric department in 2015. Eight institutional and seven patient-related factors were statistically calculated using logistic regression analysis and matched pairs.</p><p><strong>Results: </strong>A statistically significant increased probability of fixation was found in connection with a lower number of nurses per patient, a higher number of patients admitted by law, lower professional experience of nurses and in the nursing late shift as well as when admission occurred via emergency medical service.</p><p><strong>Conclusion: </strong>Based on the results, possible preventive organizational measures are elaborated and preconditions for a prospective evaluation of the complex factors influencing coercive measures are discussed.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of (Potentially) Traumatizing Deployments and Posttraumatic Stress in Police Officers: An Exploratory Survey of Early Career Police Officers.","authors":"Lena Posch, Anna-Lena Zube","doi":"10.1055/a-2351-2533","DOIUrl":"https://doi.org/10.1055/a-2351-2533","url":null,"abstract":"<p><strong>Background: </strong>As part of their career, police officers are faced with traumatic events on a regular basis and are at a higher risk of developing post-traumatic-stress disorder (PTSD) compared to the general population. The aim of this study was to examine if and how many early career police officers had already experienced potentially traumatizing situations and how many met either subsyndromal or complete PTSD criteria. A further subject of interest was if the officers knew the concept of psychosocial emergency care for first responders (PSNV-E) and if such support was made use of.</p><p><strong>Method: </strong>Early career police officers (<i>n</i>=221) were assessed via an online survey about their posttraumatic stress symptoms.</p><p><strong>Results: </strong>More than half of the participants (<i>n</i>=121) reported having experienced at least one traumatic deployment. PTSD prevalence in this group was at 1.7%, an additional 14.9% showed partial PTSD. One-fifth did not know about the PSNV-E concept.</p><p><strong>Conclusion: </strong>Police officers are confronted with a range of extremely stressful events early in their career leading to first symptoms of PTSD in some of them. Early prevention strategies as well as the identification of those affected for secondary prevention is of very high relevance for long-term mental health.</p><p><strong>Hintergrund: </strong>Polizeibeamt:innen werden in ihrer beruflichen Karriere oft mit traumatischen Einsätzen konfrontiert und weisen im Vergleich zur Allgemeinbevölkerung ein erhöhtes Risiko eine posttraumatische Belastungsstörung (PTBS) zu entwickeln auf. Ziel der vorliegenden Studie war, zu untersuchen, ob und wie häufig Berufsanfänger:innen der Polizei bereits (potenziell) traumatische Einsätze erlebt haben und wie häufig eine PTBS oder eine subsyndromale Ausprägung der PTBS vorliegt. Ferner war von Interesse, ob ihnen das Konzeptzur psychosozialen Notfallversorgung für Einsatzkräfte (PSNV-E) bekannt ist und ob diese Angebote in Anspruch genommen werden.</p><p><strong>Methode: </strong><i>N</i>=221 Berufsanfänger:innen der Polizei wurden im Rahmen einer Online-Befragung zum Erleben potenziell traumatischer Einsätze befragt. Zudem wurde mit der PCL-5 das Ausmaß posttraumatischer Belastungssymptome erhoben.</p><p><strong>Ergebnisse: </strong>Über die Hälfte der Befragten (<i>n</i>=121) hatte mindestens einen (potenziell) traumatischen Einsatz erlebt. Die PTBS-Prävalenz lag in dieser Gruppe bei 1,7%, weitere 14,9% wiesen eine partielle PTBS auf. Einem Fünftel der Befragten war das PSNV-E Konzept nicht bekannt.</p><p><strong>Schlussfolgerung: </strong>Bereits in den ersten Berufsjahren sind Polizeibeamt:innen mit extrem belastenden Einsätzen konfrontiert, woraufhin ein Teil von ihnen erste Anzeichen einer PTBS aufweist. Frühe Präventionsmaßnahmen sowie Identifikation von Betroffenen zur sekundären Prävention sind von hoher Relevanz für die langfristige Gesunderhaltung.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Intrajejunal levodopa in Parkinson's disease: Optimization of PEG application].","authors":"Karl-Ernst Grund, Annette Zipfel, Wolfgang H Jost","doi":"10.1055/a-2337-3433","DOIUrl":"https://doi.org/10.1055/a-2337-3433","url":null,"abstract":"<p><p>The various forms of Percutaneous Endoscopic Gastrostomy (PEG) are highly relevant in neurology, as pump-administered intrajejunal levodopa application is one of the indispensable forms of therapy in advanced Parkinson's disease. Optimal PEG placement and follow-up are therefore significant for the success of the therapy. However, the standard intrajejunal administration of levodopa gel via a JET-PEG, i. e. a PEG with an internal catheter inserted into the jejunum, is not without problems for various reasons. In particular, the considerable cumulative complication rates demand a reconsideration of the situation. The very limited absorption area of the drug in the region of the flexura duodenojejunalis must also be taken into account. Causes of complications are predominantly a non-optimal application technique of PEG and internal catheter as well as the frequent lack of an adequate follow-up. In this paper, the details of a modified and optimized application technique compared to the conventional techniques are presented. These new methods have proved their usefulness in clinical applications for years, and additionally a new application form, the Hybrid-PEG, is presented. However, many of the details derived from anatomical/physiological, surgical and endoscopic aspects must be strictly observed during the application in order to reduce or avoid minor and major complications. In particular, problems are caused by local infections in the area of the insertion point of the PEG including peritonitis, leaks and buried bumper syndrome (BBS). The relatively frequent dislocations of the internal catheter also prove to be particularly troublesome. These can ultimately be avoided by clip fixation of the catheter tip down in the jejunum. In particular, the use of the newly developed Hybrid-PEG, a combination of endoscopically controlled gastropexy with three sutures and subsequent central thread-pull-through of the PEG tube, can significantly reduce the complication rate and thus achieve a decisive improvement for patients. The aspects discussed here are highly relevant for all those involved in the therapy of advanced Parkinson's disease. Trustful interdisciplinary collaboration between neurology and endoscopy/surgery/gastroenterology is a prerequisite for good clinical outcomes.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women's mental health during late pregnancy: A survey conducted in Shandong Province, China.","authors":"Yijie Li, Huihui Yu, Kaifang Shen, Jing Long","doi":"10.1055/a-2337-4336","DOIUrl":"https://doi.org/10.1055/a-2337-4336","url":null,"abstract":"<p><strong>Background: </strong>  The study aimed to investigate the general mental health status and its associated factors in women during late pregnancy. The objective was to provide a scientific basis for developing psychological interventions tailored to this specific population.</p><p><strong>Methods: </strong>  The research was conducted from May 2021 to July 2022, involving the recruitment of 200 women attending maternal and child health clinics for their late-pregnancy checkups. Data collection was carried out using a comprehensive approach, involving several validated tools. The participants completed a general demographic and sociological questionnaire along with four standardized psychological assessment scales: the 12-item General Health Questionnaire (GHQ-12), the Athens Insomnia Scale (AIS-8), the Generalized Anxiety Disorder 7 (GAD-7), and the 9-question Patient Health Questionnaire (PHQ-9). A total of 200 valid questionnaires were collected for analysis.</p><p><strong>Results: </strong>  The study revealed that the overall prevalence of positive detection of general mental health problems in women during late pregnancy was 11%. Significant differences were observed in the positive detection rate of general mental health status based on various factors such as the quality of relationships with husbands, pregnancy intentions, insomnia, anxiety, and depression (p<0.01). Furthermore, participants with general mental health problems displayed notably higher scores on the AIS-8, PHQ-9, and GAD-7 scales compared to those without such problems (p<0.01). Regression analysis indicated that pregnancy intention and PHQ-9 scores were influential factors affecting the general mental health of women during late pregnancy (p<0.05).</p><p><strong>Conclusion: </strong>  The study highlights high rates of general mental health problems during late pregnancy, with unplanned pregnancy and elevated depression scores as key risk factors. Regular mental health screening and targeted interventions are essential to support women during this critical period and enhance the well-being of both mothers and babies.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Digitalization in Migraine Therapy].","authors":"Diana Lindner, Dagny Holle-Lee, Armin Scheffler","doi":"10.1055/a-2314-2960","DOIUrl":"10.1055/a-2314-2960","url":null,"abstract":"<p><p>Digitalization is a commonly used keyword in medicine and also in the area of migraine and its therapy. However, digitalization should not be an end in itself, but should improve the treatment of patients and make the work of practitioners easier. This article summarizes the use of e-health applications for migraine medicine, today and in the future.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":"289-293"},"PeriodicalIF":0.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Migraine and psychosomatic comorbidity].","authors":"Ruth Ruscheweyh, Nadine Lehnen, Peter Henningsen","doi":"10.1055/a-2331-0840","DOIUrl":"10.1055/a-2331-0840","url":null,"abstract":"<p><p>As a common neurological disorder (10-15% of the population), migraine is associated with numerous comorbidities, particularly other pain syndromes, mental illnesses and functional disorders. These 'psychosomatic' comorbidities increase with migraine severity. Severely affected, comorbid patients also often have a poorer response to specific migraine therapy. Interestingly, migraine and the comorbidities mentioned have a number of common aetiological or facilitating factors, e.g. genetic factors, and show a higher incidence in women and in people with previous traumatic experiences, as well as (in the case of pain syndromes) signs of central sensitization. Another common feature is the association with current or chronic stress. We propose an extended diathesis-stress model that takes into account interrelated but individually different vulnerabilities and, depending on the stress experience, can depict both the occurrence of individual disorders (e.g. an isolated migraine) and the joint occurrence of migraine with other pain syndromes and other psychosomatic comorbidities. In summary, psychosomatic comorbidities should always be kept in mind in migraine therapy and, if necessary, treated early and multimodally.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":"304-309"},"PeriodicalIF":0.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A Lot is Happening in Migraine and Headache Therapy!]","authors":"Dagny Holle-Lee, Claudia Sommer","doi":"10.1055/a-2315-2100","DOIUrl":"https://doi.org/10.1055/a-2315-2100","url":null,"abstract":"","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":"92 7-08","pages":"266"},"PeriodicalIF":0.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Acute Therapy of Migraine: What is new?]","authors":"Axel Heinze, Katja Heinze-Kuhn, Hartmut Göbel, Carl H Göbel","doi":"10.1055/a-2331-0716","DOIUrl":"10.1055/a-2331-0716","url":null,"abstract":"<p><p>The landscape of acute migraine medication has changed fundamentally in recent years. It has been a gradual, often unnoticed process characterized less by spectacular introduction of new substances than by changes in patients' access to medications and individualized selection of treatment adapted to the patients' needs. Four triptans are now available over-the-counter in Germany which has a major influence on self-medication. The main new introduction was the 5HT1F-agonist lasmiditan as an alternative to triptans.</p>","PeriodicalId":12353,"journal":{"name":"Fortschritte Der Neurologie Psychiatrie","volume":" ","pages":"283-288"},"PeriodicalIF":0.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}