FARMACIA最新文献_第3页

THE ANALGESIC PROPERTIES OF THE FLAVONOID GALANGIN IN EXPERIMENTAL ANIMAL MODELS OF NOCICEPTION 黄酮类化合物高良姜素在痛觉实验动物模型中的镇痛特性

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.20

Esam Y QNAIS

{"title":"THE ANALGESIC PROPERTIES OF THE FLAVONOID GALANGIN IN EXPERIMENTAL ANIMAL MODELS OF NOCICEPTION","authors":"Esam Y QNAIS","doi":"10.31925/farmacia.2023.5.20","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.20","url":null,"abstract":"This study aimed to investigate the antinociceptive properties of galangin using various nociception models. Galangin's effects were assessed across different doses (50, 100, 150, and 200 µg/kg bw) in mice through multiple pain tests. The results were compared to those of mice treated with acetylsalicylic acid or morphine, with or without naloxone. In addition to standard pain models, capsaicin-and glutamate-induced tests were employed to explore the involvement of the vanilloid and glutamatergic systems in galangin's pain-relief mechanisms. It was found that galangin exhibited a significant, dose-dependent reduction in pain behaviour during the acetic acid-induced writhing test, with a 72.2% inhibition observed at a 200 µg/kg bw dose. In the hot plate test, it increased latency period, with a 72.0% increase at the same dose. Galangin also significantly inhibited both neurogenic and inflammatory phases in the formalin-induced paw-licking test. These effects were reversed by naloxone treatment, indicating opioid system involvement. Galangin further showed inhibitory effects on neurogenic nociception induced by capsaicin and glutamate. Enzyme-linked immunosorbent assay (ELISA) revealed that galangin, at doses of 100 and 200 µg/kg bw, significantly reduced pro-inflammatory cytokine levels (IL-1β, TNF-α, IFN-γ, and NO) in mouse serum. The study concluded that galangin possesses antinociceptive activity mediated through central and peripheral pathways, modulating vanilloid receptors, opioid receptors","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"67 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE DEVELOPMENT OF A BRAIN TARGETED MUCOADHESIVE AMISULPRIDE LOADED NANOSTRUCTURED LIPID CARRIER 开发出一种脑部靶向粘液黏附性阿米舒必利纳米结构脂质载体

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.18

Manar Adnan Tamer

{"title":"THE DEVELOPMENT OF A BRAIN TARGETED MUCOADHESIVE AMISULPRIDE LOADED NANOSTRUCTURED LIPID CARRIER","authors":"Manar Adnan Tamer","doi":"10.31925/farmacia.2023.5.18","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.18","url":null,"abstract":"This research aimed to create and refine intranasal mucoadhesive amisulpride-loaded nanostructured lipid carriers (AMS-MNLCs) to increase efficacy and safety by increasing nasal-mucosal adhesion and facilitating direct brain targetability. Using HPMC K4M, Carbopol 934, and Hyaluronic acid (HA), AMS-MNLCs were made by applying modified melt-emulsification and ultra-sonication procedures. The results of the pH, osmolarity, and mucoadhesive tests on the optimized formulation were 6.3 ± 0.02, 304.53 ± 2.15, and 26.07 ± 0.37, respectively. Rheological investigation, in-vitro release and ex-vivo permeation study of the optimized formulation revealed a shear-thinning behaviour, significantly higher release, and the flux of the drug from the formula was 975.2 ± 12.45. Based on the pharmacokinetic analyses in rats, intranasal AMS-MNLCs were reported to have a brain C max about 14 times higher than intravenous AMS-solution. In addition, two weeks of intranasal administration of formulation did not affect haematological parameters in the in vivo research. The histopathological investigation showed that there was no disruption of the naso-mucosal membrane structure. Therefore, the created and optimized intranasal MNLCs showed a promised venue for the efficient and secure delivery of AMS as an antiemetic drug for the prevention and treatment of preoperative nausea and vomiting (PONV).","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"11 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IN VITRO ASSESSMENT OF TWO TYPES OF HYALURONIC ACID’S ANTITUMOR POTENTIAL IN OSTEOSARCOMA CELLS 体外评估两种透明质酸在骨肉瘤细胞中的抗肿瘤潜力

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.9

Iosif ILIA

引用次数: 0

RISK FACTORS FOR POSTOPERATIVE INCISIONAL INFECTION AND ANTI-INFECTIVE EFFECTS OF JEFUYIN DECOCTION IN PATIENTS WITH COLORECTAL CANCER 大肠癌患者术后切口感染的危险因素和积雪苷煎剂的抗感染作用

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.22

JINZHI TAN

引用次数: 0

ANTI-INFLAMMATORY EFFECT OF MONOAMMONIUM GLYCYRRHIZINATE ON EXPERIMENTAL COLITIS 甘草酸单铵对实验性结肠炎的抗炎作用

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.6

Plamen KRASTEV

引用次数: 0

META-ANALYSIS ON THE EFFICACY AND SAFETY OF BELIMUMAB FOR LUPUS NEPHRITIS BY USING THE PUBMED DATABASE 利用 Pubmed 数据库对贝利木单抗治疗狼疮肾炎的疗效和安全性进行荟萃分析

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.2

QIYUAN CHEN

{"title":"META-ANALYSIS ON THE EFFICACY AND SAFETY OF BELIMUMAB FOR LUPUS NEPHRITIS BY USING THE PUBMED DATABASE","authors":"QIYUAN CHEN","doi":"10.31925/farmacia.2023.5.2","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.2","url":null,"abstract":"Systemic lupus erythematosus (SLE) is a chronic autoimmune connective tissue disease associated with loss of immunological tolerance (LIT). Lupus nephritis (LN) is a serious manifestation of SLE, affecting the majority of patients and posing a significant threat to the well-being and survival of SLE patients. More research and evidence are needed to determine whether belimumab can be used to treat active LN, as data on the safety and efficacy of belimumab in the treatment of active LN are currently lacking. The search criteria utilised were “belimumab”, “lupus nephritis”, “systemic lupus erythematosus” and “lupus treatment”. The search was limited to articles published between January 2000 and May 2022. The analysis and evaluation were performed using Rev Man 5.3 and Stata, the risk of bias (RoB) of the included articles was assessed, and the heterogeneity was assessed using the Q-test and the I2 statistics. The results showed that in the 6 included references, the OR for efficacy of belimumab in the treatment of LN was 0.30, the OR for safety was 0.22, and no heterogeneity was observed between study groups (I2 = 0.00%; I2 = 0.00%). The OR for renal involvement of belimumab in the treatment of LN was - 0.22, and the OR for complications was -0.37, indicating apparent heterogeneity","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"105 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DEVELOPMENT AND VALIDATION OF A NEW VISIBLE SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF FLUCONAZOLE IN THE PRESENCE OF SOME ESSENTIAL OILS 建立和验证测定某些精油中氟康唑的新可见分光光度法

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.19

Ioana OLARIU

引用次数: 0

MERCURY EXPOSURE IN COSMETICS AND HUMAN HEALTH RISK 化妆品中的汞暴露与人类健康风险

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.7

M. Bîrsan

引用次数: 0

EFFECT OF CARBON DIOXIDE LASER COMBINED WITH ANTI-HPV BIOLOGICAL PROTEIN DRESSING ON HPV LOAD IN PATIENTS WITH CONDYLOMA ACUMINATUM 二氧化碳激光联合抗 HPV 生物蛋白敷料对尖锐湿疣患者 HPV 感染的影响

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.12

Liqin Li

{"title":"EFFECT OF CARBON DIOXIDE LASER COMBINED WITH ANTI-HPV BIOLOGICAL PROTEIN DRESSING ON HPV LOAD IN PATIENTS WITH CONDYLOMA ACUMINATUM","authors":"Liqin Li","doi":"10.31925/farmacia.2023.5.12","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.12","url":null,"abstract":"The aim of this study was to investigate the therapeutic effect of a carbon dioxide (CO 2 ) laser combined with an anti-human papillomavirus (HPV) biological protein dressing on patients with condyloma acuminata (CA). In this study, male CA patients in the hospital were selected as research subjects and enrolled into the control group (30 cases, CO 2 laser treatment) and the observation group (30 cases, CO 2 laser combined with anti-HPV biological protein dressing treatment). The viral DNA load of the two groups was determined and compared before treatment, after treatment and at 18 months of follow-up. The treatment response rate and relapse rate of the two groups were also compared. After 18 months, both control and observation viral DNA loads were significantly lower (p < 0.05). After treatment and 18 months of follow-up, the viral DNA loads in the observation group were significantly lower than the viral DNA loads in the control group (p < 0.05). The efficacy rate (93.33%) of the observation group was significantly higher than that of the control group (63.33%), the long-term recurrence rate (13.33%) was significantly lower than that of the control group (43.33%), and the adverse reaction rate (23.33%) of the observation group was significantly lower than that of the control group (56.67%) (all p < 0.05). Therefore, a CO 2 laser combined with an anti-HPV biologic protein dressing can significantly reduce the HPV load in CA patients, improving the cure rate and reducing the recurrence rate.","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"9 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

POLYPHENOL QUANTIFICATION ON DIPSACUS LACINIATUS AND ARMORACIA RUSTICANA FROM ROMANIAN FLORA 对罗马尼亚植物区系中的 Dipsacus laciniatus 和 armoracia rusticana 进行多酚定量分析

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.5

VALENTIN Nănescu

{"title":"POLYPHENOL QUANTIFICATION ON DIPSACUS LACINIATUS AND ARMORACIA RUSTICANA FROM ROMANIAN FLORA","authors":"VALENTIN Nănescu","doi":"10.31925/farmacia.2023.5.5","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.5","url":null,"abstract":"In recent years, the polyphenolic compounds profile of plants has been intensively studied. These compounds protect the body against oxidative stress and certain diseases such as diabetes and cancer, where the antioxidant efficiency of the defence system is low. The plant material (harvested from Romania) was analysed for polyphenols and flavonoids using thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) coupled with photo diode array and mass spectrometer. The polyphenols/flavonoids (caffeic acid, chlorogenic acid, p -coumaric acid, protocatechuic acid, rutin and quercetin) were identified and quantified in different part of the plants (flower, leaf, stem and roots for Dipsacus laciniatus and both roots and leaves for Armoracia rusticana ). The least amount of polyphenols were found to be as expected in the root part of Dipsacus laciniatus. This was also sustained by the further UHPLC-MS analysis. The results revealed that the flower extract has the highest radical scavenging activity with 87.43% followed by the leaf extract with 86.63%, the stem extract with 83.54% and the root extract with 78.17%. Higher concentrations of p-Coumaric acid and ferulic acid were identified in the Armoracia rusticana samples whereas the Dipsacus laciniatus samples contained higher concentrations of both protocatechuic acid and chlorogenic acid. The results of the present study revealed that the methanolic extracts of both Dipsacus laciniatus and Armoracia rusticana , can be considered an effective source of antioxidant compounds.","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"1 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0