FARMACIA最新文献

{"title":"IMPACT OF EDARAVONE DEXBORNEOL TREATMENT ON NEUROLOGICAL FUNCTION, COGNITIVE FUNCTION, AND INFLAMMATORY-OXIDATIVE STRESS STATUS IN PATIENTS WITH ACUTE PROGRESSIVE CEREBRAL INFARCTION","authors":"ZIJIAN FAN","doi":"10.31925/farmacia.2025.3.10","DOIUrl":"https://doi.org/10.31925/farmacia.2025.3.10","url":null,"abstract":"Acute progressive cerebral infarction (APCI) is marked by worsening symptoms and neurological decline with high mortality.This study aimed to compare the clinical efficacy of edaravone (Eda) and edaravone dexborneol (Eda.B) in APCI treatment.Clinical data from 98 APCI patients were retrospectively analysed: 48 received Eda and 50 received Eda.B intravenously for 2 weeks.Hemorheological parameters, neurological and cognitive function (NIHSS, MoCA, BI), serum inflammatory and oxidative stress markers (IL-6, IL-17, IL-1, MMP-9, MDA, SOD, GSH-Px), and cerebral perfusion (MRI-based) were evaluated.Compared to Eda, Eda.B significantly reduced blood viscosity indices and erythrocyte sedimentation rate, improved NIHSS, MoCA, and BI scores, and favourably modulated inflammatory-oxidative markers.Eda.B also enhanced cerebral blood volume and flow, while reducing mean transit time and time to peak.The clinical efficacy rate was higher in the Eda.B group (96.0% vs. 83.3%,p < 0.05), with similar adverse reaction rates (16.0% vs. 25.0%,p > 0.05).In conclusion, Eda.B showed superior effectiveness in improving neurological and cognitive function, cerebral perfusion, and reducing inflammation and oxidative stress in APCI patients. RezumatInfarctul cerebral acut progresiv (APCI) se caracterizeaz prin agravarea rapid a simptomelor i declin neurologic accentuat, fiind asociat cu o mortalitate ridicat.Acest studiu a comparat eficiena clinic a edaravonei (Eda) i a edaravonei dexborneol (Eda.B) n tratamentul APCI.Au fost analizate retrospectiv datele clinice a 98 de pacieni, dintre care 48 au primit Eda i 50 Eda.B, intravenos, timp de dou sptmni.S-au evaluat parametrii hemoreologici, funciile neurologice i cognitive (NIHSS, MoCA, BI), markerii serici inflamatori i de stres oxidativ (IL-6, IL-17, IL-1, MMP-9, MDA, SOD, GSH-Px), precum i perfuzia cerebral pe baza RMN.Comparativ cu Eda, Eda.B a redus semnificativ vscozitatea sngelui i viteza de sedimentare a hematiilor, a mbuntit scorurile funcionale i a reglat favorabil markerii inflamatori i de stres oxidativ.De asemenea, Eda.B a crescut volumul i fluxul sanguin cerebral, reducnd timpul mediu de tranzit.Rata de eficien clinic a fost mai mare n grupul Eda.B (96,0% vs. 83,3%, p < 0,05), fr diferene semnificative n privina reaciilor adverse.n concluzie, Eda.B s-a dovedit mai eficient n ameliorarea funciilor neurologice i cognitive, a perfuziei cerebrale i n reducerea inflamaiei i stresului oxidativ la pacienii cu APCI.","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"73 3","pages":"637-645"},"PeriodicalIF":0.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://farmaciajournal.com/wp-content/uploads/art-10-Fan_Mao_637-645.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147881747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROTECTIVE EFFECT OF TETRAMETHYLPYRAZINE COMBINED WITH METHYLPREDNISOLONE ON THE SPINAL CORD AFTER SPINAL CORD INJURY IN RATS","authors":"Myeong‐Ki Hong","doi":"10.31925/farmacia.2025.1.14","DOIUrl":"https://doi.org/10.31925/farmacia.2025.1.14","url":null,"abstract":"","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"73 1","pages":"130-139"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://farmaciajournal.com/wp-content/uploads/art-14-Hong_Zhang_Wang_130-139.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICACY OF ST. JOHN’S WORT EXTRACT IN PATIENTS WITH POST-STROKE DEPRESSION","authors":"Yi Tian","doi":"10.31925/farmacia.2025.1.21","DOIUrl":"https://doi.org/10.31925/farmacia.2025.1.21","url":null,"abstract":"","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"73 1","pages":"201-209"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://farmaciajournal.com/wp-content/uploads/art-21-Tian_Hou_201-209.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MECHANISM AND THERAPEUTIC ROLE OF JIANPI JIEDU DECOCTION IN PROMOTING HEALING OF RECURRENT ORAL ULCER LESIONS IN RATS VIA NF-ΚB PATHWAY-MEDIATED OXIDATIVE STRESS AND INFLAMMATORY REBALANCE","authors":"Xu Zhang","doi":"10.31925/farmacia.2024.4.21","DOIUrl":"https://doi.org/10.31925/farmacia.2024.4.21","url":null,"abstract":"This study investigated the effects of Jianpi Jiedu decoction (JJD) on healing recurrent oral ulcers (ROUs) in rats by modulating oxidative stress and inflammation via the NF-B pathway.Seventy-two male Wistar rats were used; 12 were selected to prepare tissue emulsions for ROU modelling, and 60 were randomized into six groups: normal, model (ROU induction), positive control (dexamethasone) and three JJD dose groups (high, medium, low).Treatments were administered daily by intragastric gavage for 8 weeks.Oral ulcer area, healing status, oxidative stress factors, proinflammatory cytokines, growth factors and NF-B pathway-related proteins were assessed post-treatment.The PC and JJD groups showed superior ulcer healing compared to the model group.JJD dose-dependently reduced oxidative stress, inflammatory cytokines, IKK, NF-B and increased p-IB levels.In conclusion, JJD promotes oral ulcer healing by modulating the NF-B pathway, reducing oxidative stress and inflammatory responses. RezumatAcest studiu a investigat efectele decoctului Jianpi Jiedu (JJD) asupra vindecrii ulcerelor orale recurente (ROU) la obolani prin modularea stresului oxidativ i a inflamaiei prin intermediul cii NF-B.Au fost utilizai 72 de obolani Wistar masculi; 12 au fost utilizati pentru prepararea emulsiilor de esut pentru inducerea modelului murin ROU, iar 60 au fost randomizai n ase grupuri: normal, model (inducerea ROU), control pozitiv (dexametazon) i trei grupuri de doze JJD (mare, mediu, sczut).Tratamentele au fost administrate zilnic prin gavaj intragastric timp de 8 sptmni.Zona ulcerului oral, starea de vindecare, factorii de stres oxidativ, citokinele proinflamatorii, factorii de cretere i proteinele legate de calea NF-B au fost evaluate dup tratament.Grupurile PC i JJD au prezentat o vindecare superioar a ulcerului comparativ cu grupul model.JJD a redus, n funcie de doz, stresul oxidativ, citokinele inflamatorii, IKK, NF-B i a crescut nivelul p-IB.n concluzie, JJD favorizeaz vindecarea ulcerului prin modularea cii NF-B, reducerea stresului oxidativ i a rspunsurilor inflamatorii.","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"72 4","pages":"924-933"},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://farmaciajournal.com/wp-content/uploads/art-21-Zhang_Zhang_924-933.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147887842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF MAGNETIC RESONANCE PROBE-BASED OXALIPLATIN-RESVERATROL DRUG RELEASE-CONTROLLED NANOPARTICLE THERAPY FOR COLORECTAL CANCER","authors":"Xiaoyang Bi","doi":"10.31925/farmacia.2024.2.21","DOIUrl":"https://doi.org/10.31925/farmacia.2024.2.21","url":null,"abstract":"","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"72 2","pages":"436-447"},"PeriodicalIF":0.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://farmaciajournal.com/wp-content/uploads/art-21-Bi_Song_436-447.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147913730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEVELOPING THE ROLE OF THE ROMANIAN COMMUNITY PHARMACY IN ENVIRONMENTAL PROTECTION","authors":"ALEXANDRA  TOMA","doi":"10.31925/farmacia.2023.5.25","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.25","url":null,"abstract":"Environmental pollution with medicines is a major problem against which the best solutions are sought, in the context of a risk of contamination present in all activities relating to medicines, including those specific to the community pharmacy. The objective of the paper was to identify the best ways for developing the role of the Romanian community pharmacy in environmental protection. We performed documentary research on the websites of professional associations and pharmacies in Romania to find relevant documents, which we submitted to a thematic analysis. The community pharmacy can contribute to the protection of the environment in many ways, from reducing the waste of medicines, by promoting rational use practices and providing appropriate services for patient adherence to treatment, to collecting waste medicines from the population. In Romania, the community pharmacy is too little involved in environmental protection, therefore proper regulation of its role is necessary, combined with the will of pharmacy owners and professional associations to develop it. The most accessible ways to involve the Romanian community pharmacy include adopting institutional green policies and providing information to the population regarding the best practices for environmental protection. Rezumat","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"3 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QUANTITATIVE ANALYSIS OF SORAFENIB AND NILOTINIB IN HUMAN PLASMA BY SPE-LC-MS","authors":"Monica Denisa Elena POPESCU","doi":"10.31925/farmacia.2023.5.17","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.17","url":null,"abstract":"Sorafenib and nilotinib are two tyrosine kinase inhibitors (TKIs) used in the treatment of cancer. Plasmatic levels of the drugs show an important variability, so determining plasma concentration of the drugs, benefits in cancer treatment can be improved. Most papers published so far in the literature use protein precipitation followed by liquid chromatography - tandem mass-spectrometry (LC-MS/MS) as separation and detection method. With this work, we propose an alternative method for the analysis of both TKIs in human plasma. Solid phase extraction (SPE) involving Oasis PRiME HLB ® cartridges was our choice for plasma “clean-up” procedure. Extraction recoveries were at least 85%. Chromatography was performed by an ultra-high-performance liquid chromatographic system (UHPLC), using a C18 (4.6 x 50 mm) column and a mobile phase consisting of ammonium acetate/acetic acid-acetonitrile gradient elution. Detector was a simple mass spectrometer (MS) in Single Ion Recording (SIR) mode. Intra-and inter-day precision data for both TKIs were 3.8 - 7.6% and 4.5 - 8.8% for sorafenib and nilotinib, respectively. Sorafenib and nilotinib calibration curves were linear between 500 and 20000 ng/mL and 5 and 5000 ng/mL respectively, with correlation coefficients higher than 0.998. Analytes were determined in a 15 min run-time. The validated LC-MS method was applied in real human plasma routine analysis. This method may improve dose adjustment of the drugs in patients involved in cancer therapy","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"27 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INCISION-WOUND HEALING ACTIVITY OF SUNFLOWER SEED OIL (HELIANTHUS ANNUUS L.: IN VIVO AND IN SILICO STUDY","authors":"Rita MALIZA","doi":"10.31925/farmacia.2023.5.15","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.15","url":null,"abstract":"Sunflower seed oil (SFO) ( Helianthus annuus L.) is rich in oleic acid and unsaturated fatty acids and can potentially treat various ailments. To validate the ethno-therapeutic claims of the SFO in skin diseases, the incision wound healing activity was studied. The objectives of this study were to evaluate the chemical content and incision wound-healing activities of SFO. Twenty-seven adult male Wistar rats were used, and a 2 cm length and 2 mm depth incision was made on the back of the rat. The rats were administered SFO, povidone iodine (PI), or were left untreated as a control group. Histological evaluations were conducted on postoperative wound tissue biopsies on days 0, 5 and 10. The SFO compounds were assessed using GC/MS analysis, and a subsequent in silico investigation was conducted based on the GC/MS findings. The binding affinity of these compounds to TNF-α, VEGFR1, IGFR1 and TGF-β1 was evaluated. On day 10, sunflower seed oil topical application accelerated wound healing by decreasing wound area and increasing wound contraction compared to untreated and PI-treated wounds. Moreover, granulation tissue expanded more, and the epidermis fully recovered. Twenty-four active compounds were detected using GC/MS, and six are responsible for lipid metabolism regulation and anti-inflammatory activity. The in silico study showed that 9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol (3ß,5Z,7E) had a high affinity of - 8.5 kcal/mol for TNF-α. The conclusion of this study shows that SFO has incision wound healing activity in vivo and in silico by controlling the inflammatory phase and proangiogenic factors with a high affinity to bind to TNF-α in the skin tissue","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"112 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A PILOT STUDY ON FORMALDEHYDE EXPOSURE RISKS OF BAKERY WORKERS","authors":"ANA-MARIA VLĂSCEANU","doi":"10.31925/farmacia.2023.5.4","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.4","url":null,"abstract":"This study is intended to explore the impacts of formaldehyde (FA) on human health, the use and sources of FA exposure, and the regulations governing acceptable levels of FA in various products across various regions globally. The objective of this pilot study is to evaluate the risk of human FA exposure in traditional bakery units. The study group consisted of 46 subjects working in various areas: the production area (leavening, baking area, storage area), the area where bakery products are sold to customers and the delivery area to stores. The control group consists of 8 non-exposed, non-smokers subjects. Demographic, medical and anthropometric data were collected based on a questionary and the urinary levels of FA were evaluated as a biomarker of exposure. No statistically significant differences regarding the anthropometric and medical parameters of exposed workers and control group were obtained. The highest levels of FA were recorded in smokers working in the fermentation area. The results indicate statistically significant differences of FA levels between the workers in the","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"169 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIVIRAL ACTIVITY OF ORIGINAL FLAVONOIDS-CONTAINING PHYTOPREPARATION AGAINST HUMAN ALPHAHERPESVIRUS 2, HEPATITIS C SURROGATE VIRUS AND TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS","authors":"Alexander GALKIN","doi":"10.31925/farmacia.2023.5.14","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.14","url":null,"abstract":"This study evaluates the antiviral activity of a complex phytopreparation consisting of alcohol tinctures of Filipendula vulgaris , Petroselinum crispum , Apium graveolens radices, Galium verum , Linaria vulgaris herbs and Calendula officinalis flowers. The phytopreparation was tested on in vitro models of human alphaherpesvirus 2 (HHV-2), hepatitis C surrogate virus (bovine viral diarrhoea virus, BVDV) and transmissible gastroenteritis virus (TGEV). The phytopreparation solution demonstrated antiviral activity against all three viruses. The phytopreparation solution is an active inhibitor of HHV-2, BVDV and coronavirus (TGEV) replication with a selectivity index of 80, 320 and 160, respectively. Animal studies showed that the phytopreparation solution (1:100 dilution), when used as a combined treatment regimen ( per os + application), delayed the onset of guinea pig genital herpes first symptoms and reduced the time of disease in vivo . The phytopreparation solution had an antiherpetic therapeutic action similar to that of acyclovir (a reference antiherpetic drug). The induction of αIFN and inhibition of RNA and DNA synthesis were suggested mechanisms of the antiviral action of the phytopreparation complex.","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"17 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}