IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.25

ALEXANDRA TOMA

{"title":"DEVELOPING THE ROLE OF THE ROMANIAN COMMUNITY PHARMACY IN ENVIRONMENTAL PROTECTION","authors":"ALEXANDRA TOMA","doi":"10.31925/farmacia.2023.5.25","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.25","url":null,"abstract":"Environmental pollution with medicines is a major problem against which the best solutions are sought, in the context of a risk of contamination present in all activities relating to medicines, including those specific to the community pharmacy. The objective of the paper was to identify the best ways for developing the role of the Romanian community pharmacy in environmental protection. We performed documentary research on the websites of professional associations and pharmacies in Romania to find relevant documents, which we submitted to a thematic analysis. The community pharmacy can contribute to the protection of the environment in many ways, from reducing the waste of medicines, by promoting rational use practices and providing appropriate services for patient adherence to treatment, to collecting waste medicines from the population. In Romania, the community pharmacy is too little involved in environmental protection, therefore proper regulation of its role is necessary, combined with the will of pharmacy owners and professional associations to develop it. The most accessible ways to involve the Romanian community pharmacy include adopting institutional green policies and providing information to the population regarding the best practices for environmental protection. Rezumat","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

QUANTITATIVE ANALYSIS OF SORAFENIB AND NILOTINIB IN HUMAN PLASMA BY SPE-LC-MS 利用SPE-LC-MS对人体血浆中的索拉非尼和尼洛替尼进行定量分析

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.17

Monica Denisa Elena POPESCU

{"title":"QUANTITATIVE ANALYSIS OF SORAFENIB AND NILOTINIB IN HUMAN PLASMA BY SPE-LC-MS","authors":"Monica Denisa Elena POPESCU","doi":"10.31925/farmacia.2023.5.17","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.17","url":null,"abstract":"Sorafenib and nilotinib are two tyrosine kinase inhibitors (TKIs) used in the treatment of cancer. Plasmatic levels of the drugs show an important variability, so determining plasma concentration of the drugs, benefits in cancer treatment can be improved. Most papers published so far in the literature use protein precipitation followed by liquid chromatography - tandem mass-spectrometry (LC-MS/MS) as separation and detection method. With this work, we propose an alternative method for the analysis of both TKIs in human plasma. Solid phase extraction (SPE) involving Oasis PRiME HLB ® cartridges was our choice for plasma “clean-up” procedure. Extraction recoveries were at least 85%. Chromatography was performed by an ultra-high-performance liquid chromatographic system (UHPLC), using a C18 (4.6 x 50 mm) column and a mobile phase consisting of ammonium acetate/acetic acid-acetonitrile gradient elution. Detector was a simple mass spectrometer (MS) in Single Ion Recording (SIR) mode. Intra-and inter-day precision data for both TKIs were 3.8 - 7.6% and 4.5 - 8.8% for sorafenib and nilotinib, respectively. Sorafenib and nilotinib calibration curves were linear between 500 and 20000 ng/mL and 5 and 5000 ng/mL respectively, with correlation coefficients higher than 0.998. Analytes were determined in a 15 min run-time. The validated LC-MS method was applied in real human plasma routine analysis. This method may improve dose adjustment of the drugs in patients involved in cancer therapy","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

INCISION-WOUND HEALING ACTIVITY OF SUNFLOWER SEED OIL (HELIANTHUS ANNUUS L.: IN VIVO AND IN SILICO STUDY 向日葵籽油的切口愈合活性：体内和硅学研究

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.15

Rita MALIZA

{"title":"INCISION-WOUND HEALING ACTIVITY OF SUNFLOWER SEED OIL (HELIANTHUS ANNUUS L.: IN VIVO AND IN SILICO STUDY","authors":"Rita MALIZA","doi":"10.31925/farmacia.2023.5.15","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.15","url":null,"abstract":"Sunflower seed oil (SFO) ( Helianthus annuus L.) is rich in oleic acid and unsaturated fatty acids and can potentially treat various ailments. To validate the ethno-therapeutic claims of the SFO in skin diseases, the incision wound healing activity was studied. The objectives of this study were to evaluate the chemical content and incision wound-healing activities of SFO. Twenty-seven adult male Wistar rats were used, and a 2 cm length and 2 mm depth incision was made on the back of the rat. The rats were administered SFO, povidone iodine (PI), or were left untreated as a control group. Histological evaluations were conducted on postoperative wound tissue biopsies on days 0, 5 and 10. The SFO compounds were assessed using GC/MS analysis, and a subsequent in silico investigation was conducted based on the GC/MS findings. The binding affinity of these compounds to TNF-α, VEGFR1, IGFR1 and TGF-β1 was evaluated. On day 10, sunflower seed oil topical application accelerated wound healing by decreasing wound area and increasing wound contraction compared to untreated and PI-treated wounds. Moreover, granulation tissue expanded more, and the epidermis fully recovered. Twenty-four active compounds were detected using GC/MS, and six are responsible for lipid metabolism regulation and anti-inflammatory activity. The in silico study showed that 9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol (3ß,5Z,7E) had a high affinity of - 8.5 kcal/mol for TNF-α. The conclusion of this study shows that SFO has incision wound healing activity in vivo and in silico by controlling the inflammatory phase and proangiogenic factors with a high affinity to bind to TNF-α in the skin tissue","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A PILOT STUDY ON FORMALDEHYDE EXPOSURE RISKS OF BAKERY WORKERS 面包房工人接触甲醛风险的试点研究

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.4

ANA-MARIA VLĂSCEANU

引用次数: 0

ANTIVIRAL ACTIVITY OF ORIGINAL FLAVONOIDS-CONTAINING PHYTOPREPARATION AGAINST HUMAN ALPHAHERPESVIRUS 2, HEPATITIS C SURROGATE VIRUS AND TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS 含黄酮类化合物的原始植物制剂对人类阿尔法疱疹病毒 2、代丙型肝炎病毒和传染性胃肠炎冠状病毒的抗病毒活性

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.14

Alexander GALKIN

{"title":"ANTIVIRAL ACTIVITY OF ORIGINAL FLAVONOIDS-CONTAINING PHYTOPREPARATION AGAINST HUMAN ALPHAHERPESVIRUS 2, HEPATITIS C SURROGATE VIRUS AND TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS","authors":"Alexander GALKIN","doi":"10.31925/farmacia.2023.5.14","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.14","url":null,"abstract":"This study evaluates the antiviral activity of a complex phytopreparation consisting of alcohol tinctures of Filipendula vulgaris , Petroselinum crispum , Apium graveolens radices, Galium verum , Linaria vulgaris herbs and Calendula officinalis flowers. The phytopreparation was tested on in vitro models of human alphaherpesvirus 2 (HHV-2), hepatitis C surrogate virus (bovine viral diarrhoea virus, BVDV) and transmissible gastroenteritis virus (TGEV). The phytopreparation solution demonstrated antiviral activity against all three viruses. The phytopreparation solution is an active inhibitor of HHV-2, BVDV and coronavirus (TGEV) replication with a selectivity index of 80, 320 and 160, respectively. Animal studies showed that the phytopreparation solution (1:100 dilution), when used as a combined treatment regimen ( per os + application), delayed the onset of guinea pig genital herpes first symptoms and reduced the time of disease in vivo . The phytopreparation solution had an antiherpetic therapeutic action similar to that of acyclovir (a reference antiherpetic drug). The induction of αIFN and inhibition of RNA and DNA synthesis were suggested mechanisms of the antiviral action of the phytopreparation complex.","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PERCEPTIONS OF PEOPLES TOWARDS HEALTH CARE SEEKING BEHAVIOUR FROM HEALTH CARE PROFESSIONALS – FINDINGS FROM SAUDI COMMUNITY PERSPECTIVE 人们对医护人员提供的医疗服务的看法--从沙特社区的角度得出的结论

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.24

Adel S. BASHATAH

{"title":"PERCEPTIONS OF PEOPLES TOWARDS HEALTH CARE SEEKING BEHAVIOUR FROM HEALTH CARE PROFESSIONALS – FINDINGS FROM SAUDI COMMUNITY PERSPECTIVE","authors":"Adel S. BASHATAH","doi":"10.31925/farmacia.2023.5.24","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.24","url":null,"abstract":"The purpose of this study was to analyse the individuals' attitudes about seeking medical care from healthcare professionals in the Riyadh Region of Saudi Arabia (SA). Between November 2022 and January 2023, a cross-sectional, web-based study was performed among residents of Riyadh in SA. In this study, 19-items questionnaires with three sections were employed. IBM Statistic SPSS was used to evaluate the data, and the level of statistical significance was set at p < 0.05. Among the participants, 77.7% (n = 411) agreed that Saudi rules prohibit pharmacists from prescribing drugs without a prescription, while 45% (n = 193) had an unsatisfactory event with a medical doctor. The most common reason for people seeking pharmacist consultation was a common cold 79% (n = 343) followed by cough 64.5% (n = 280), headache 57.1% (n = 248), diarrhoea 38.5% (n = 176), constipation 34.6% (n = 150), fever 45.9% (n = 199). As the insurance status increased, there was a significant decrease in the unsatisfactory event associated with a medical doctor (B = 0.138; t = -2.901; p = 0.004), respectively. A multiple regression predictor analysis revealed that education and health insurance statistically","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMOKING CESSATION – WHAT’S NEW? 戒烟--有什么新变化？

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.1

ANCUȚA-ALINA CONSTANTIN

{"title":"SMOKING CESSATION – WHAT’S NEW?","authors":"ANCUȚA-ALINA CONSTANTIN","doi":"10.31925/farmacia.2023.5.1","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.1","url":null,"abstract":"Tobacco cessation represents a multifaceted approach involving patients who often don't neatly fit into classic prototypes. Researchers found that current smokers experience a more than 10-year reduction in life expectancy compared to non-smokers, and more than half make an attempt each year, but less than 10% manage to stay smoke-free for at least 6 months. Therefore, it's recommended to employ a combination of methods and strategies, ranging from questionnaires to established medications. The role of the medical staff is and remains vital in this context. Nicotine is a potent drug due to its rapid absorption and swift diffusion into the central nervous system, and quitting nicotine leads to important consequences, such as craving, drug-seeking behaviour and withdrawal symptoms. Negative affective states also emerge, characterized by symptoms like depressed mood, anxiety, irritability and insomnia. Hierarchical multiple regression models have revealed that extraversion, neuroticism, conscientiousness and age are among the predictors of daily cigarette consumption. The authors discuss both traditional and innovative opportunities to expedite this process, while analysing the potential to enhance the compliance of healthcare providers and patients. Smoking cessation, the process of quitting smoking, can be approached through both pharmacological (medication-based) and non-pharmacological (behavioural and supportive) methods. The choice of approach or combination of approaches depends on individual preferences and needs. Rezumat","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STUDY OF THE CHEMICAL COMPOSITION, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF VARIOUS EXTRACTS OF THE AERIAL PART OF LEONURUS CARDIACA 研究蝎尾草气生部分各种提取物的化学成分、抗菌和抗氧化活性

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.21

L. Stepanyan

引用次数: 0

THE PHARMACIST’S ROLE IN PROMOTING FOOD SUPPLEMENTS: CONSUMPTION OF MAGNESIUM SUPPLEMENTS IN WESTERN ROMANIA 药剂师在促进食品补充剂方面的作用：罗马尼亚西部的镁补充剂消费情况

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.23

Corina MOISA

引用次数: 0

ASSESSMENT OF THE ANTI-ARTHRITIC AND IMMUNOSUPPRESSIVE POTENTIAL OF ENALAPRIL BY USING NETWORK PHARMACOLOGY, MOLECULAR DOCKING AND EXPERIMENTAL PHARMACOLOGY APPROACHES 利用网络药理学、分子对接和实验药理学方法评估依那普利的抗关节炎和免疫抑制潜力

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.16

SUMERA QASIM

{"title":"ASSESSMENT OF THE ANTI-ARTHRITIC AND IMMUNOSUPPRESSIVE POTENTIAL OF ENALAPRIL BY USING NETWORK PHARMACOLOGY, MOLECULAR DOCKING AND EXPERIMENTAL PHARMACOLOGY APPROACHES","authors":"SUMERA QASIM","doi":"10.31925/farmacia.2023.5.16","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.16","url":null,"abstract":"The present study validates the anti-arthritic and immunosuppressive attributes of enalapril, an angiotensin-converting enzyme inhibitor (ACEI) with a potential role in major inflammatory pathways. A network pharmacology-based prediction approach was utilised to reveal the possible target genes that can be targeted by enalapril for managing arthritis. In vitro anti-arthritic efficacy of enalapril was assessed using an assay that measures the denaturation of proteins in bovine serum albumin (BSA), egg albumin and the stability of the human red blood cell (HRBC) membrane at a dosage ranging from 100 to 6400 µg/mL. In vivo anti-arthritic efficacy of enalapril at doses of 2, 4 and 8 mg/kg bw was assessed in formaldehyde-induced arthritis model. Dinitrochlorobenzene (DNCB)-provoked delayed type hypersensitivity (DTH) and cyclophosphamide-provoked myelosuppression were employed to assess the immunosuppressant capacity of enalapril. Network pharmacology outcomes revealed that the anti-arthritic effects of enalapril targets include tumour necrosis factor (TNF), matrix metalloproteinase 9 (MMP-9) and caspase 3 (CASP3). Molecular docking of enalapril with these three targets also validates the strong interaction between them. Enalapril markedly inhibited protein denaturation in egg albumin and bovine serum albumin (BSA) assays and stabilised RBC haemolysis exposed to hypotonic media. Likewise, enalapril demonstrated a dose-dependent inhibition of paw oedema provoked by formaldehyde. In the DTH assay, enalapril significantly reduced skin thickness compared to the negative control group and exhibited potent immunosuppressant potential in cyclophosphamide-induced myelosuppression. Based on the outcomes of the current study, it can be predicted that enalapril has anti-arthritic attributes that might be due to its immunosuppressive potential","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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