FARMACIA最新文献_第2页

PERCEPTIONS OF PEOPLES TOWARDS HEALTH CARE SEEKING BEHAVIOUR FROM HEALTH CARE PROFESSIONALS – FINDINGS FROM SAUDI COMMUNITY PERSPECTIVE 人们对医护人员提供的医疗服务的看法--从沙特社区的角度得出的结论

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.24

Adel S. BASHATAH

{"title":"PERCEPTIONS OF PEOPLES TOWARDS HEALTH CARE SEEKING BEHAVIOUR FROM HEALTH CARE PROFESSIONALS – FINDINGS FROM SAUDI COMMUNITY PERSPECTIVE","authors":"Adel S. BASHATAH","doi":"10.31925/farmacia.2023.5.24","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.24","url":null,"abstract":"The purpose of this study was to analyse the individuals' attitudes about seeking medical care from healthcare professionals in the Riyadh Region of Saudi Arabia (SA). Between November 2022 and January 2023, a cross-sectional, web-based study was performed among residents of Riyadh in SA. In this study, 19-items questionnaires with three sections were employed. IBM Statistic SPSS was used to evaluate the data, and the level of statistical significance was set at p < 0.05. Among the participants, 77.7% (n = 411) agreed that Saudi rules prohibit pharmacists from prescribing drugs without a prescription, while 45% (n = 193) had an unsatisfactory event with a medical doctor. The most common reason for people seeking pharmacist consultation was a common cold 79% (n = 343) followed by cough 64.5% (n = 280), headache 57.1% (n = 248), diarrhoea 38.5% (n = 176), constipation 34.6% (n = 150), fever 45.9% (n = 199). As the insurance status increased, there was a significant decrease in the unsatisfactory event associated with a medical doctor (B = 0.138; t = -2.901; p = 0.004), respectively. A multiple regression predictor analysis revealed that education and health insurance statistically","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"143 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMOKING CESSATION – WHAT’S NEW? 戒烟--有什么新变化？

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.1

ANCUȚA-ALINA CONSTANTIN

{"title":"SMOKING CESSATION – WHAT’S NEW?","authors":"ANCUȚA-ALINA CONSTANTIN","doi":"10.31925/farmacia.2023.5.1","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.1","url":null,"abstract":"Tobacco cessation represents a multifaceted approach involving patients who often don't neatly fit into classic prototypes. Researchers found that current smokers experience a more than 10-year reduction in life expectancy compared to non-smokers, and more than half make an attempt each year, but less than 10% manage to stay smoke-free for at least 6 months. Therefore, it's recommended to employ a combination of methods and strategies, ranging from questionnaires to established medications. The role of the medical staff is and remains vital in this context. Nicotine is a potent drug due to its rapid absorption and swift diffusion into the central nervous system, and quitting nicotine leads to important consequences, such as craving, drug-seeking behaviour and withdrawal symptoms. Negative affective states also emerge, characterized by symptoms like depressed mood, anxiety, irritability and insomnia. Hierarchical multiple regression models have revealed that extraversion, neuroticism, conscientiousness and age are among the predictors of daily cigarette consumption. The authors discuss both traditional and innovative opportunities to expedite this process, while analysing the potential to enhance the compliance of healthcare providers and patients. Smoking cessation, the process of quitting smoking, can be approached through both pharmacological (medication-based) and non-pharmacological (behavioural and supportive) methods. The choice of approach or combination of approaches depends on individual preferences and needs. Rezumat","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"1 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STUDY OF THE CHEMICAL COMPOSITION, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF VARIOUS EXTRACTS OF THE AERIAL PART OF LEONURUS CARDIACA 研究蝎尾草气生部分各种提取物的化学成分、抗菌和抗氧化活性

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.21

L. Stepanyan

引用次数: 0

THE PHARMACIST’S ROLE IN PROMOTING FOOD SUPPLEMENTS: CONSUMPTION OF MAGNESIUM SUPPLEMENTS IN WESTERN ROMANIA 药剂师在促进食品补充剂方面的作用：罗马尼亚西部的镁补充剂消费情况

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.23

Corina MOISA

引用次数: 0

ASSESSMENT OF THE ANTI-ARTHRITIC AND IMMUNOSUPPRESSIVE POTENTIAL OF ENALAPRIL BY USING NETWORK PHARMACOLOGY, MOLECULAR DOCKING AND EXPERIMENTAL PHARMACOLOGY APPROACHES 利用网络药理学、分子对接和实验药理学方法评估依那普利的抗关节炎和免疫抑制潜力

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.16

SUMERA QASIM

{"title":"ASSESSMENT OF THE ANTI-ARTHRITIC AND IMMUNOSUPPRESSIVE POTENTIAL OF ENALAPRIL BY USING NETWORK PHARMACOLOGY, MOLECULAR DOCKING AND EXPERIMENTAL PHARMACOLOGY APPROACHES","authors":"SUMERA QASIM","doi":"10.31925/farmacia.2023.5.16","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.16","url":null,"abstract":"The present study validates the anti-arthritic and immunosuppressive attributes of enalapril, an angiotensin-converting enzyme inhibitor (ACEI) with a potential role in major inflammatory pathways. A network pharmacology-based prediction approach was utilised to reveal the possible target genes that can be targeted by enalapril for managing arthritis. In vitro anti-arthritic efficacy of enalapril was assessed using an assay that measures the denaturation of proteins in bovine serum albumin (BSA), egg albumin and the stability of the human red blood cell (HRBC) membrane at a dosage ranging from 100 to 6400 µg/mL. In vivo anti-arthritic efficacy of enalapril at doses of 2, 4 and 8 mg/kg bw was assessed in formaldehyde-induced arthritis model. Dinitrochlorobenzene (DNCB)-provoked delayed type hypersensitivity (DTH) and cyclophosphamide-provoked myelosuppression were employed to assess the immunosuppressant capacity of enalapril. Network pharmacology outcomes revealed that the anti-arthritic effects of enalapril targets include tumour necrosis factor (TNF), matrix metalloproteinase 9 (MMP-9) and caspase 3 (CASP3). Molecular docking of enalapril with these three targets also validates the strong interaction between them. Enalapril markedly inhibited protein denaturation in egg albumin and bovine serum albumin (BSA) assays and stabilised RBC haemolysis exposed to hypotonic media. Likewise, enalapril demonstrated a dose-dependent inhibition of paw oedema provoked by formaldehyde. In the DTH assay, enalapril significantly reduced skin thickness compared to the negative control group and exhibited potent immunosuppressant potential in cyclophosphamide-induced myelosuppression. Based on the outcomes of the current study, it can be predicted that enalapril has anti-arthritic attributes that might be due to its immunosuppressive potential","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"23 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EVALUATION OF NUTRITIONAL STATUS AND ADHERENCE TO A HEALTHY DIET AMONG THE ROMANIAN POPULATION 评估罗马尼亚人口的营养状况和健康饮食坚持情况

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.13

Magdalena Mititelu

引用次数: 0

A BOX-BEHNKEN DESIGN FOR OPTIMIZATION OF ULTRASOUND-ASSISTED EXTRACTION OF SINAPIC ACID FROM FRAGARIA ANANASSA 优化超声波辅助提取山奈酸的箱式贝肯设计

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.8

Ajaz AHMAD

{"title":"A BOX-BEHNKEN DESIGN FOR OPTIMIZATION OF ULTRASOUND-ASSISTED EXTRACTION OF SINAPIC ACID FROM FRAGARIA ANANASSA","authors":"Ajaz AHMAD","doi":"10.31925/farmacia.2023.5.8","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.8","url":null,"abstract":"The present study focuses on optimizing the extraction process of sinapic acid from Fragaria ananassa using ultrasonic-assisted extraction (UAE). The extraction process study variables were: temperature in the range of 20 to 60°C, extraction time between 20 and 90 minutes and the solid-to-liquid ratio ranging from 10 to 30 mL/g. Response surface analysis determined that the most favourable conditions for sinapic acid extraction were at a temperature of 60°C, extraction time of 55 minutes and at a liquid-to-solid ratio of 30 mL/g. Under these conditions, the extraction yield of sinapic acid was measured at 23.56 mg/g. The experimental results closely aligned with the predicted values, affirming the reliability of the proposed model. Furthermore, UAE proved to be a highly effective method, exhibiting significantly reduced extraction time and producing higher levels of sinapic acid compared to traditional extraction techniques. HPLC analysis confirmed the presence of substantial amounts of sinapic acid in Fragaria ananassa . In conclusion, the optimized UAE method, in conjunction with HPLC-UV analysis, presents a valuable approach for the efficient extraction and estimation of sinapic acid from Fragaria ananassa . These results have the potential to greatly benefit industrial applications that need for extremely high extraction yields of these organic molecules.","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"198 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EFFECT OF STIRRING SPEED AND STIRRING TIME ON CHARACTERIZATION OF CLINDAMYCIN HCL ETHOSOMAL AND ICH Q1A (R2) STABILITY TEST 搅拌速度和搅拌时间对克林霉素 Hcl 乙硫异烟肼和 ich Q1a (r2) 稳定性试验表征的影响

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.10

E. F. Apriani

{"title":"EFFECT OF STIRRING SPEED AND STIRRING TIME ON CHARACTERIZATION OF CLINDAMYCIN HCL ETHOSOMAL AND ICH Q1A (R2) STABILITY TEST","authors":"E. F. Apriani","doi":"10.31925/farmacia.2023.5.10","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.10","url":null,"abstract":"Clindamycin HCl is an antibiotic with limited bioavailability ranging from 0.7% to 12.9% of the applied dose. The ethosomal delivery system can increase the bioavailability of clindamycin HCl. However, in the manufacturing process, the speed and time of stirring are essential factors that affect the characterization of the resulting ethosomes. This study aims to optimize the clindamycin HCl ethosomal formula by varying the stirring speed (7,600 and 15,000 rpm) and stirring time (15 and 30 minutes) using ultra-turrax with a 2 2 factorial design method. The ethosomal formula was characterized including entrapment efficiency, particle size, polydispersity index and potential zeta. The optimum formula was tested for stability according to the ICH Q1A (R2) standard. The optimum formula was obtained at a stirring speed of 7,600 rpm and a stirring time of 15 minutes with an entrapment efficiency percentage of 72.38 ± 0.36%, a particle size of 270.80 ± 8.69 nm, a polydispersity index of 0.111 ± 0.032 and a potential zeta of -31.21 ± 0.82 mV. The results of the ICH Q1A (R2) stability test showed that the release model of the active substance followed order 0, the activation energy was 4.232 cal/mol, the kinetic constant was 9.897/day with a shelf life of 7.293 days at 25 ± 2°C/60 ± 5% RH and 8.247 days at","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"1 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OPTIMIZING MILK PRODUCTION, QUALITY AND SAFETY THROUGH ESSENTIAL OIL APPLICATIONS 通过精油应用优化牛奶生产、质量和安全

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.3

LAURENȚIU TUDOR

{"title":"OPTIMIZING MILK PRODUCTION, QUALITY AND SAFETY THROUGH ESSENTIAL OIL APPLICATIONS","authors":"LAURENȚIU TUDOR","doi":"10.31925/farmacia.2023.5.3","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.3","url":null,"abstract":"This study comprehensively explores the integration of essential oils (EOs) into dairy livestock nutrition and milk production, focusing on optimising various facets of dairy farming. Food safety and biosecurity are paramount when introducing EOs into dairy farming practices. Rigorous safety assessments, including toxicity, allergenicity and potential adverse effects on animal health, are essential for the welfare of both livestock and consumers. Additionally, managing EO residues is challenging due to their potential impact on dairy product composition. Moreover, the variable effects of EOs on dairy animals` performance add complexity. While EOs show potential for inhibiting oxidative reactions and microbial spoilage, their influence on nutrient utilisation, ruminal fermentation and milk performance varies. Extensive research is required to optimise EO dosage and formulation for consistent performance benefits. Sustainability is a critical concern, requiring the alignment of EO utilisation with sustainable agricultural practices to address environmental and resource constraints. Lastly, consumer perception and acceptance are vital, necessitating transparent communication and an understanding of consumer preferences to maintain trust in dairy products. Addressing these challenges enables the dairy industry to harness the full potential of EOs, ensuring ongoing safety, quality and sustainability in dairy product production. This study provides practical insights and outlines future research directions to advance dairy production, quality and safety. Rezumat","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"46 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE IMPORTANCE OF ANALGO-SEDATION IN THE PATIENT WITH SERIOUS PELVIC AND SPINE TRAUMA DURING TRANSPORT 在转运过程中对骨盆和脊柱有严重创伤的病人进行肛门镇静的重要性

IF 1.6 4区医学

FARMACIA Pub Date : 2023-10-26 DOI: 10.31925/farmacia.2023.5.11

Florica BĂGESCU-DRUGĂ POP

{"title":"THE IMPORTANCE OF ANALGO-SEDATION IN THE PATIENT WITH SERIOUS PELVIC AND SPINE TRAUMA DURING TRANSPORT","authors":"Florica BĂGESCU-DRUGĂ POP","doi":"10.31925/farmacia.2023.5.11","DOIUrl":"https://doi.org/10.31925/farmacia.2023.5.11","url":null,"abstract":"This prospective, randomised study aimed to assess the efficacy of ketamine/propofol (K/P) compared to the commonly used fentanyl/midazolam (F/M) combination in providing analgesia for patients with severe pelvic and spinal trauma. The study, conducted over 30 months on 154 patients, found that the K/P group experienced significantly lower perceived pain levels, as measured on the numerical pain scale, when compared to the F/M group (p < 0.0001). Additionally, patients in the K/P group achieved adequate sedation with an average Ramsay scale score of 3.1, while the F/M group had a more profound sedation with a score of 5.5 (p < 0.0001). Furthermore, the study demonstrated that analgesia with K/P significantly improved the physiological severity score (PSS) (p < 0.0001) and resulted in a notably lower incidence of oxygen desaturation, with only one patient experiencing this in the K/P group compared to 16 patients in the F/M group (p = 0.0003). These findings suggest that co-administration of low-dose ketamine and propofol provides safe and effective sedation and analgesia, both in the emergency department and pre-hospital settings. The study highlights the importance of adequate pain management in severe trauma cases and emphasizes the potential advantages of using the K/P combination over F/M, particularly due to the reduced risk of oxygen desaturation and the more moderate level of sedation achieved with K/P. These results underscore the potential clinical utility of this approach in improving the overall care and outcomes of patients with severe pelvic and spinal trauma","PeriodicalId":12344,"journal":{"name":"FARMACIA","volume":"60 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0