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3D dental similarity quantification in forensic odontology identification
IF 2.2 3区 医学
Forensic science international Pub Date : 2025-04-02 DOI: 10.1016/j.forsciint.2025.112462
Anika Kofod Petersen , Andrew Forgie , Palle Villesen , Line Staun Larsen
{"title":"3D dental similarity quantification in forensic odontology identification","authors":"Anika Kofod Petersen ,&nbsp;Andrew Forgie ,&nbsp;Palle Villesen ,&nbsp;Line Staun Larsen","doi":"10.1016/j.forsciint.2025.112462","DOIUrl":"10.1016/j.forsciint.2025.112462","url":null,"abstract":"<div><div>Forensic odontology identification largely depends on comparing dental work like fillings and crowns with the dental records of potential victims. This process can be challenging, especially regarding victims with minimal or no dental work. Alternatively, 3D tooth morphology can be used for identification by automated dental surface similarity scoring. However, high-resolution 3D intraoral photo scans contain hundreds of thousands of datapoints from each individual jaw, making database searches difficult and slow. Here, we reduce full 3D scans to keypoints, which are small points located in areas of high curvature on tooth surfaces. We use Difference of Curvature (DoC) for robust keypoint detection and evaluate different keypoint representation methods to distinguish between scans of the same individual and scans of different individuals, assigning them a similarity score.The results demonstrate that combining DoC with the Signature of Histograms of OrienTations (SHOT) representation method effectively separates matches from mismatches. This indicates the potential for automatic scoring of dental surface similarity. This can be valuable for forensic odontology identification, especially in cases where traditional methods are limited by the lack of dental work.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"370 ","pages":"Article 112462"},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhalation and oral administration of HHC products – Quantification of (9R)-, (9S)-Hexahydrocannabinol and metabolites in plasma and detectability in on-site drug tests for urine and oral fluid
IF 2.2 3区 医学
Forensic science international Pub Date : 2025-03-28 DOI: 10.1016/j.forsciint.2025.112437
L. Lucuta , L. Schwarz , J. Liut , J. Hose , L. Nauroth , M. Juebner , H. Andresen-Streichert
{"title":"Inhalation and oral administration of HHC products – Quantification of (9R)-, (9S)-Hexahydrocannabinol and metabolites in plasma and detectability in on-site drug tests for urine and oral fluid","authors":"L. Lucuta ,&nbsp;L. Schwarz ,&nbsp;J. Liut ,&nbsp;J. Hose ,&nbsp;L. Nauroth ,&nbsp;M. Juebner ,&nbsp;H. Andresen-Streichert","doi":"10.1016/j.forsciint.2025.112437","DOIUrl":"10.1016/j.forsciint.2025.112437","url":null,"abstract":"<div><div>The semisynthetic cannabinoid Hexahydrocannabinol (HHC) has gained recognition among drug users. A GC-MS/MS method for the detection of (9R)- and (9S)-HHC and their respective carboxy- and hydroxy-metabolites in plasma has been developed and validated. The method was applied to authentic plasma samples obtained from a self-administration experiment. HHC was either inhaled (Vapes, 95 % HHC) or ingested (Jellys, 25 mg HHC). Maximum plasma (9R)-HHC and (9S)-HHC concentrations of 3.8 ng/mL and 2.5 ng/mL were detected 1.16 h after ingestion and approx. 65 ng/mL (9R)-HHC and 21 ng/mL (9S)-HHC were measured 0.08 h after inhalation. (9 R)-OH-HHC concentrations ranged from approx. 0.3–1.4 ng/mL after ingestion, and approx. 0.2–1.8 ng/mL after inhalation. (9R)-COOH-HHC was detectable in concentrations of 0.8–17 ng/mL (ingestion) and 0.6–8.7 ng/mL (inhalation). Corresponding S-Hydroxy- and Carboxy-metabolites were detectable after ingestion ((9S)-OH-HHC: approx. 0.1–0.7 ng/mL, (9S)-COOH-HHC: approx. 0.2–0.4 ng/mL), but mainly not after inhalation. Cannabimimetic effects and respective psychomotor impairments such as (slight) vertigo as well as slight headache and dizziness, and mouth dryness could be observed after ingestion. After inhalation, one participant showed distinct impairments. On-site drug tests for cannabinoids in urine (DrugScreen®) and oral fluid (DrugWipe® 5S) were performed. DrugScreen® (cut-off: 25 ng/mL THC-COOH) gave positive results up to 10 h after ingestion and inhalation. Cross-reactivity with DrugWipe® 5S (cut-off: 5 ng/mL THC) was not observed. An immunological CEDIA™ cannabinoid assay showed good cross-reactivity with the plasma samples and gave positive results up to 6.16 h after ingestion and 4.16 h after inhalation.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"370 ","pages":"Article 112437"},"PeriodicalIF":2.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential human bone remodeling rates and implications for the temporal resolution of geoprofiling isotopes
IF 2.2 3区 医学
Forensic science international Pub Date : 2025-03-25 DOI: 10.1016/j.forsciint.2025.112454
Rhonda L. Quinn , Melanie M. Beasley , Timothy P. Gocha , Sophia R. Mavroudas
{"title":"Differential human bone remodeling rates and implications for the temporal resolution of geoprofiling isotopes","authors":"Rhonda L. Quinn ,&nbsp;Melanie M. Beasley ,&nbsp;Timothy P. Gocha ,&nbsp;Sophia R. Mavroudas","doi":"10.1016/j.forsciint.2025.112454","DOIUrl":"10.1016/j.forsciint.2025.112454","url":null,"abstract":"<div><div>Isotopic analysis of human skeletal remains helps individuate decedents in forensic contexts by providing diet and residence information during life. The time represented (adolescence, middle adulthood) and the amount of time averaged (years, decades) depends on a bone’s remodeling rate (RMR). Measuring isotopic values of multiple bones with different RMRs has been used to detect an individual’s residential mobility and major changes in dietary practices. However, RMRs for the majority of human bones have not been adequately quantified, so the temporal resolution of bone isotopes is not well known. Here we utilized reported fraction modern radiocarbon (F<sup>14</sup>C) values of known decedents to estimate RMRs for the following elements, structures, and phases: cortical and trabecular femoral collagen, cortical tibial collagen and bioapatite, cortical and trabecular rib collagen, cortical occipital and parietal collagen, and trabecular vertebral collagen. Non-parametric comparisons yielded several significant RMR differences; the largest between the collagen phase of femoral cortex (3.3 %/year) and vertebral trabeculae (14.3 %/year). Tibial collagen and bioapatite also yielded different RMRs, 3.7 %/year and 5.0 %/year, respectively. As a result, dietary models that combine bioapatite and collagen phases may mix temporal scales. Turnover intervals exceeded 20 years for all cortical structures, potentially indicating that isotopic values represent much younger periods in an individual’s life than previously thought. Additional studies are warranted that integrate histomorphometry and bomb pulse <sup>14</sup>C dating of multiple elements, structures, and phases from known decedents to improve the temporal resolution of bone isotopes.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"370 ","pages":"Article 112454"},"PeriodicalIF":2.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of non-thermal plasma for DNA decontamination in a forensic vacuum metal deposition chamber: A proof of concept study 在法医真空金属沉积室中使用非热等离子体进行 DNA 净化:概念验证研究
IF 2.2 3区 医学
Forensic science international Pub Date : 2025-03-25 DOI: 10.1016/j.forsciint.2025.112453
Katie Hussain , Roberto S.P. King , Raymond N. Allan , Kevin Farrugia , Urszula Krzeminska-Ahmadzai
{"title":"The use of non-thermal plasma for DNA decontamination in a forensic vacuum metal deposition chamber: A proof of concept study","authors":"Katie Hussain ,&nbsp;Roberto S.P. King ,&nbsp;Raymond N. Allan ,&nbsp;Kevin Farrugia ,&nbsp;Urszula Krzeminska-Ahmadzai","doi":"10.1016/j.forsciint.2025.112453","DOIUrl":"10.1016/j.forsciint.2025.112453","url":null,"abstract":"<div><div>Vacuum Metal Deposition (VMD) is routinely deployed for fingermark development on various types of evidence. In efforts to implement a sequential forensic workflow where fingermarks are processed before DNA collection to maximise evidential value, it is essential to prevent cross-contamination between analysed items. Non-thermal plasma (NTP) presents a potential advantage in DNA decontamination as it can reach areas that are inaccessible to conventional UV-C light and eliminates the need for solvents that might interfere with the vacuum-based systems. In this study, different NTP conditions generated within a VMD chamber were tested on human cells with known DNA concentrations, and cell-free DNA. This included variations in power (maximum and medium), exposure times (0.5 h, 1 h, 2 h), and pressures (1.68, 2, 4.27 ×10<sup>−1</sup> mbar). Overall, a reduction of approximately 100-fold in DNA concentration was observed after plasma treatment. Out of the tested conditions 1 h, 2 × 10<sup>−1</sup> mbar and maximum power proved to be the most stable plasma for the DNA removal. While UV-C light was more efficient at degrading cell-free DNA in direct line of sight by reducing DNA levels below the limit of detection and showing significant degradation, NTP was more effective at eliminating DNA out of the line of sight. These findings suggest that NTP could be a promising tool for DNA decontamination of forensic instruments like VMD. Future research should focus on optimizing NTP settings, including power output and vacuum conditions, to ensure complete DNA removal.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"370 ","pages":"Article 112453"},"PeriodicalIF":2.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular identification of fungi associated with advanced decomposition at a human taphonomy facility in Canada 在加拿大的一个人类粪便处理设施中,对与晚期腐烂有关的真菌进行分子鉴定
IF 2.2 3区 医学
Forensic science international Pub Date : 2025-03-24 DOI: 10.1016/j.forsciint.2025.112451
Steven Richard Beaulieu , Agathe Ribéreau-Gayon , Theo Devèze , Shari L. Forbes , Hugo Germain
{"title":"Molecular identification of fungi associated with advanced decomposition at a human taphonomy facility in Canada","authors":"Steven Richard Beaulieu ,&nbsp;Agathe Ribéreau-Gayon ,&nbsp;Theo Devèze ,&nbsp;Shari L. Forbes ,&nbsp;Hugo Germain","doi":"10.1016/j.forsciint.2025.112451","DOIUrl":"10.1016/j.forsciint.2025.112451","url":null,"abstract":"<div><div>Forensic taphonomy investigates the postmortem processes of human remains, focusing on the environmental factors that influence decomposition. Recent studies have highlighted the potential forensic relevance of fungi in this context, but the knowledge base remains limited. This study explored fungal communities associated with outdoor human decomposition at the REST[ES] facility in Quebec. Nested PCR amplification and Illumina MiSeq sequencing were used to identify fungal species on discolored patches of twelve samples of desiccated soft tissues from three donors. Twelve fungal species were putatively identified, some of which were previously unknown on human remains, including <em>Leucosporidium yakuticum</em>, <em>Tausania pullulans</em>, and Fusicolla species. These fungi may contribute to tissue discoloration and following longitudinal investigation, could serve as biomarkers for forensic reconstructions, including place and time of death. This study emphasizes the need for further research into the role of fungi in human decomposition processes and their applications in forensic science.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"370 ","pages":"Article 112451"},"PeriodicalIF":2.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiothoracic injuries and mechanical cardiopulmonary resuscitation – A forensic autopsy convenience control study on 436 cases 心胸损伤与机械心肺复苏术 - 436 例法医尸检方便对照研究
IF 2.2 3区 医学
Forensic science international Pub Date : 2025-03-23 DOI: 10.1016/j.forsciint.2025.112452
Johanne Ejby Bidstrup, Lars Löchte, Johannes Rødbro Busch, Jytte Banner
{"title":"Cardiothoracic injuries and mechanical cardiopulmonary resuscitation – A forensic autopsy convenience control study on 436 cases","authors":"Johanne Ejby Bidstrup,&nbsp;Lars Löchte,&nbsp;Johannes Rødbro Busch,&nbsp;Jytte Banner","doi":"10.1016/j.forsciint.2025.112452","DOIUrl":"10.1016/j.forsciint.2025.112452","url":null,"abstract":"<div><div>This study documents the types and frequencies of injuries related to chest compressions during resuscitation attempts in a cohort of 436 non-traumatic, forensic autopsy cases from Eastern Denmark. We hypothesized that there would be a difference in types and frequencies of injuries seen after mechanical cardiopulmonary resuscitation (mCPR) compared to manual basic life support (BLS). We included all non-traumatic deaths referred for a forensic autopsy in eastern Denmark in the period 2015–2017, for a total of 436 cases (females, <em>n</em> = 146; males, <em>n</em> = 290), of which 75 cases had mCPR performed. Data on injuries were obtained from forensic autopsy reports. The mCPR group was characterized by a statistically significantly higher incidence of myocardial rupture (4 % vs. 0 %, p &lt; 0.0001). We found no other statistically significant differences in the incidence of visceral trauma (e.g. haemothorax, pericardial haemorrhage, pulmonary contusions, liver or spleen injuries) between the two groups. In addition, characteristic injuries recorded in both groups included a high frequency of multiple rib fractures in the upper and middle parts of the rib cage, primarily located anteriorly, as well as sternum fractures, but these findings occurred almost twice as much in the mCPR group (77.3 % vs. 46.8 %, p &lt; 0.0001).</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"370 ","pages":"Article 112452"},"PeriodicalIF":2.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143696098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HNO3-PCF: A new lossless light microscopy method for forensic diatom drowning analysis
IF 2.2 3区 医学
Forensic science international Pub Date : 2025-03-22 DOI: 10.1016/j.forsciint.2025.112449
Tomáš Bešta , Hana Hamrová , Petr Tomášek , Petra Dohnalová , Jana Markvartová , Tomáš Hauer , Tereza Švejdová , Kateřina Zubíčková , Iva Zagatová , Radek Lefnar , Eva Tomášková , Kateřina Čapková , Jan Kaštovský
{"title":"HNO3-PCF: A new lossless light microscopy method for forensic diatom drowning analysis","authors":"Tomáš Bešta ,&nbsp;Hana Hamrová ,&nbsp;Petr Tomášek ,&nbsp;Petra Dohnalová ,&nbsp;Jana Markvartová ,&nbsp;Tomáš Hauer ,&nbsp;Tereza Švejdová ,&nbsp;Kateřina Zubíčková ,&nbsp;Iva Zagatová ,&nbsp;Radek Lefnar ,&nbsp;Eva Tomášková ,&nbsp;Kateřina Čapková ,&nbsp;Jan Kaštovský","doi":"10.1016/j.forsciint.2025.112449","DOIUrl":"10.1016/j.forsciint.2025.112449","url":null,"abstract":"<div><div>Five simple methods for diatom drowning analysis, including three newly developed ones, were compared for diatom yield and species composition consistency. Saponification of fats using sodium hydroxide solution significantly improved the yield of the extraction step, as well as the use of filtration instead of centrifugation. The combination of nitric acid digestion, vacuum filtration, and polycarbonate filter melting led to the development of the lossless light microscopy diatom forensic method (HNO3-PCF), with no detectable alteration in diatom community composition. When applied to 4-week submerged pig cadavers and six confirmed drowned human cases, the method exhibited unprecedented sensitivity. Among eight tissue types, lung diatom concentration was found to be the only reliable indicator for distinguishing between non-drowned and drowned cases. To minimize false positives from systematic contamination of the thoracic cavity, subtraction of heart diatom concentration from lung values was recommended. Provisional diatom concentration thresholds for drowning determination were set. The method’s low equipment requirements (simple vacuum filtration, light microscope, hot plate) and high efficiency make it a promising tool for widespread use in forensic practice.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"370 ","pages":"Article 112449"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interlaboratory study to evaluate background databases for the calculation of likelihood ratios in the interpretation of vehicle glass evidence using LA-ICP-MS data
IF 2.2 3区 医学
Forensic science international Pub Date : 2025-03-21 DOI: 10.1016/j.forsciint.2025.112450
Katelyn Lambert , Anuradha Akmeemana , David Almendro , Ruthmara Corzo , Sandrine Le Franc , Gwyneth Gordon , Seongshin Gwak , Ping Jiang , Shirly Montero , Oriana Ovide , Katrin Prasch , Masataka Sakayanagi , Enrique Santillana , Thomas Scholz , Tatiana Trejos , Peter Weis , Huifang Xie , Peter Zoon , Pablo Ramirez-Hereza , Daniel Ramos Castro , Jose Almirall
{"title":"Interlaboratory study to evaluate background databases for the calculation of likelihood ratios in the interpretation of vehicle glass evidence using LA-ICP-MS data","authors":"Katelyn Lambert ,&nbsp;Anuradha Akmeemana ,&nbsp;David Almendro ,&nbsp;Ruthmara Corzo ,&nbsp;Sandrine Le Franc ,&nbsp;Gwyneth Gordon ,&nbsp;Seongshin Gwak ,&nbsp;Ping Jiang ,&nbsp;Shirly Montero ,&nbsp;Oriana Ovide ,&nbsp;Katrin Prasch ,&nbsp;Masataka Sakayanagi ,&nbsp;Enrique Santillana ,&nbsp;Thomas Scholz ,&nbsp;Tatiana Trejos ,&nbsp;Peter Weis ,&nbsp;Huifang Xie ,&nbsp;Peter Zoon ,&nbsp;Pablo Ramirez-Hereza ,&nbsp;Daniel Ramos Castro ,&nbsp;Jose Almirall","doi":"10.1016/j.forsciint.2025.112450","DOIUrl":"10.1016/j.forsciint.2025.112450","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Glass samples were analyzed by 13 laboratories participating in an interlaboratory study that used laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) with a standard test method (ASTM E2927–23) for the forensic analysis and comparison of vehicle glass. The aim of this study was to explore the performance of the application of a match criterion described in the standard test method and from likelihood ratio (LR) calculations when reporting the significance of glass evidence comparisons. Five (5) databases populated in different countries and combinations of the databases were used as background data to calculate LRs for two (2) casework scenarios involving vehicle glass comparisons. When the ASTM E2927–23 was used to compare vehicle glass samples that originated from the same source, all laboratories (except one) correctly reported the samples to be indistinguishable thus concluding that the possibility that the glass originated from the same source could not be eliminated. When the LR was calculated for the same comparison, most laboratories obtained large LR values (≈ 10,000) interpreted as “strong support” for same-source proposition. The LR rate of misleading evidence for the same-source (ROME-ss) comparisons was &lt; 2 % for scenario 1. Comparing vehicle glass samples known to originate from different sources resulted in most laboratories reporting the glass to be “distinguishable” when using the ASTM standard method criterion or produced very small LR values (≈ 0.0001) when using the LR comparison criteria, interpreted as “strong (or very strong) support” for different-source proposition. The LR rate of misleading evidence for different-source (ROME-ds) comparisons for scenario 1 was &lt; 21 %, which was due to the number of comparisons of glass samples that are chemically similar (different vehicles but same source of manufacturing). If the chemically similar glass comparisons from the same manufacturer were not treated as “different source”, the ROME-ds was reduced to zero. Glass samples that were chemically similar (those that originated from different vehicles but were collected from the same make, model, and year or originated from the same vehicle but a different pane of glass) sometimes resulted in an LR value (≈ 1) interpreted as no support of either proposition or that the possibility that the glass originated from the same source could not be eliminated when using the ASTM match criterion. The laboratories reported approximately 20 % false support for same-source proposition (or “false inclusion”) and 7 % false support for different-source proposition (or “false exclusion”) when using the ASTM match criterion in the first scenario. All “false inclusions” were derived from the comparison of chemically similar samples, such as inner and outer panes from the same windshield, thus “error rates” on this dataset should not be generalized outside of the context of this study. A database composed of about 200","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"370 ","pages":"Article 112450"},"PeriodicalIF":2.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143696914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technical note: N-Isopropylbutylone unveiled – Differentiating the new synthetic cathinone in ecstasy from its close analogues with GC-MS and NMR spectroscopy
IF 2.2 3区 医学
Forensic science international Pub Date : 2025-03-16 DOI: 10.1016/j.forsciint.2025.112448
Hui Zhi Shirley Lee, Mei Ching Ong, Jong Lee Wendy Lim, Tiong Whei Angeline Yap
{"title":"Technical note: N-Isopropylbutylone unveiled – Differentiating the new synthetic cathinone in ecstasy from its close analogues with GC-MS and NMR spectroscopy","authors":"Hui Zhi Shirley Lee,&nbsp;Mei Ching Ong,&nbsp;Jong Lee Wendy Lim,&nbsp;Tiong Whei Angeline Yap","doi":"10.1016/j.forsciint.2025.112448","DOIUrl":"10.1016/j.forsciint.2025.112448","url":null,"abstract":"<div><div><em>N</em>-Isopropylbutylone, a novel synthetic cathinone, was identified in an ecstasy tablet bearing a \"SUPERMAN\" logo imprint, alongside methamphetamine and ketamine. The laboratory employed two orthogonal analytical techniques – gas chromatography with electron ionisation mass spectrometry (GC-EI-MS) and nuclear magnetic resonance (NMR) spectroscopy to determine the identity of the novel drug present. The identification of <em>N</em>-isopropylbutylone was challenging due to its mass spectral similarities with structural isomers, particularly <em>N</em>-propylbutylone. Multiple NMR experiments such as correlation spectroscopy (COSY), distortionless enhancement by polarisation transfer (DEPT), heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple bond correlation (HMBC) were utilised to unequivocally confirm the structure. The findings highlight the importance of orthogonal analytical techniques in identifying new psychoactive substances and underscore the ongoing challenges in forensic drug analysis.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"370 ","pages":"Article 112448"},"PeriodicalIF":2.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The assessment of Solstice® PF as a carrier solvent for amino acid sensitive fingermark development techniques
IF 2.2 3区 医学
Forensic science international Pub Date : 2025-03-12 DOI: 10.1016/j.forsciint.2025.112447
Sarah Yergeau , Rolanda Lam , Daniel Hockey , Sebastien Moret
{"title":"The assessment of Solstice® PF as a carrier solvent for amino acid sensitive fingermark development techniques","authors":"Sarah Yergeau ,&nbsp;Rolanda Lam ,&nbsp;Daniel Hockey ,&nbsp;Sebastien Moret","doi":"10.1016/j.forsciint.2025.112447","DOIUrl":"10.1016/j.forsciint.2025.112447","url":null,"abstract":"<div><div>Amino acid sensitive fingermark detection techniques like 1,8-diazafluoren-9-one (DFO), 1,2-indanedione/zinc chloride (IND-Zn), and ninhydrin (NIN) commonly contain 1-methoxynonafluorobutane (HFE7100) as a carrier solvent for the visualization of latent fingermarks. As a result of the cessation of manufacturing by the end of 2025, and potential environmental regulations, an alternative carrier solvent must be validated to replace HFE7100. In this study, the relative performance of Solstice® Performance Fluid (PF) (trans-1-chloro-3,3,3-trifluoropropene) was compared to that of HFE7100 using 6000 natural fingermarks, aged for either one week or eight weeks, from five donors on five substrates (white copy paper, brown kraft paper, bubble envelope, lined notebook, magazine). Split fingermarks were treated with DFO or IND-Zn followed by NIN (DFO/NIN and IND-Zn/NIN, respectively) or NIN alone. All fingermarks were evaluated using a modified University of Canberra comparative scale by three assessors and, for differences in identification rates, by a former forensic identification practitioner. Results from this study showed comparable fingermark enhancement between the two carrier solvents after each treatment within the three technique sequences. There are some limitations with Solstice® PF, notably, an increase in ink diffusion and the need to store working solutions in a refrigerator or freezer.</div></div>","PeriodicalId":12341,"journal":{"name":"Forensic science international","volume":"370 ","pages":"Article 112447"},"PeriodicalIF":2.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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