Expert Review of Hematology最新文献_第3页

Association between sickle cell disease and autoimmune diseases in Saudi population: a single center study. 沙特人群镰状细胞病与自身免疫性疾病之间的关系：一项单中心研究

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2025-10-01 Epub Date: 2025-07-18 DOI: 10.1080/17474086.2025.2534713

Rehab Y Al-Ansari, Alexander Woodman, Hana Ibrahim Al Daajani, Mohammad Ibrahim Aljamily, Tawasoul Fadoul, Elham Hamid Alfallaj, Khaled Abdullah Hassan, Nada Rajab Al Zahrani, Zechariah Jebakumar Arulanantham, Mohammed Al Ghamdi

{"title":"Association between sickle cell disease and autoimmune diseases in Saudi population: a single center study.","authors":"Rehab Y Al-Ansari, Alexander Woodman, Hana Ibrahim Al Daajani, Mohammad Ibrahim Aljamily, Tawasoul Fadoul, Elham Hamid Alfallaj, Khaled Abdullah Hassan, Nada Rajab Al Zahrani, Zechariah Jebakumar Arulanantham, Mohammed Al Ghamdi","doi":"10.1080/17474086.2025.2534713","DOIUrl":"10.1080/17474086.2025.2534713","url":null,"abstract":"Background: The association between sickle cell disease (SCD) and autoimmune diseases (AID) is not well understood. This retrospective study aims to investigate the frequency of coexistence of AIDS with SCD.Research design and methods: This study was conducted in a tertiary care hospital. Data of n = 168 SCD patients between January 2016 and March 2023 were extracted and analyzed. Data included demographics, medications, hospitalization, phenotypes, presence of AIDs, and laboratory data.Results: The mean age of n = 168 SCD patients was 30.66 (SD ± 11.27), with 54.2% of cases being female. Overall, 88.56% of patients had HGBSS phenotyping. The incidence of SCD cases with negative AID was 84.52%, while incidence of SCD cases with positive AID was 15.47% (p = 0.00001). Systemic lupus erythematosus (SLE, 4.2%), hypothyroidism (3.6%), and antiphospholipid syndrome (APS, 3.6%) were the most common SCD-associated AIDs. In addition, 69.2% of AIDs-positive patients used hydroxyurea. A strong correlation was found between hospitalization rate and a positive AID (p = 0.03).Conclusions: The result of this study represents the significant rate of AID and SCD coexistence. The findings require further study to substantiate the need to develop recommendations for screening and early detection of the SCD-associated AIDs.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"837-846"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factor first! Emergency department management of persons with hemophilia: a single-center study. 第一个因素!血友病患者的急诊管理：一项单中心研究

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2025-10-01 Epub Date: 2025-07-15 DOI: 10.1080/17474086.2025.2534704

Kelsey Uminski, Natalia Rydz, Dawn Goodyear

{"title":"Factor first! Emergency department management of persons with hemophilia: a single-center study.","authors":"Kelsey Uminski, Natalia Rydz, Dawn Goodyear","doi":"10.1080/17474086.2025.2534704","DOIUrl":"10.1080/17474086.2025.2534704","url":null,"abstract":"Background: Timely hemostatic therapy is essential when persons with hemophilia (PwH) present to the emergency department (ED), with guidelines recommending treatment at the time a bleed is suspected ('Factor First' strategy).Research design and methods: This study examined ED management of PwH in Southern Alberta from 2014 to 2022, focusing on adherence to guidelines.Results: A total of 393 ED visits from 191 adults with hemophilia A or B were identified. Most visits (86%) required emergent or urgent care. Median times from ED registration to ordering and administering hemostatic therapy were 2.9 and 4.2 hours, respectively, with treatment given within 2 hours in a minority of cases. Laboratory tests were ordered in nearly half of visits, with a median ordering time of 65 minutes. Use of individualized emergency management protocols increased over time, reaching 91.4% in 2022. Median ED stay was 3.4 hours, and approximately 25% of visits had a hemophilia-related admission diagnosis.Conclusions: These findings highlight persistent delays and nonadherence to best practice recommendations, emphasizing the need for targeted quality improvement interventions to ensure timely, guideline-concordant care for PwH in emergency settings.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"829-835"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive strategies for poor outcomes after allotransplantation in patients with acute myeloid leukemia: what are the options and when should clinicians use them? 急性髓系白血病患者异体移植后不良预后的预测策略：有哪些选择？临床医生应该何时使用它们？

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2025-10-01 Epub Date: 2025-07-04 DOI: 10.1080/17474086.2025.2528887

Xiao-Su Zhao, Ying-Jun Chang

{"title":"Predictive strategies for poor outcomes after allotransplantation in patients with acute myeloid leukemia: what are the options and when should clinicians use them?","authors":"Xiao-Su Zhao, Ying-Jun Chang","doi":"10.1080/17474086.2025.2528887","DOIUrl":"10.1080/17474086.2025.2528887","url":null,"abstract":"Introduction: Allotransplantation can provide a curative option for many AML patients. Over the past decade, an expanding array of predictive tools has been effectively used to identify high-risk patients with poor outcomes, enabling personalized treatment strategies. These advances have made precision medicine a reality for AML patients undergoing allogeneic transplantation, ultimately improving survival outcomes. The published articles were searched from Web of science with the keywords of 'stem cell transplantation' or 'bone marrow transplantation' (subject) and 'acute myeloid leukemia.'Areas covered: We first discussed the predictive biomarkers for poor outcomes in AML patients after allotransplantation. We also summarized the clinical utility of biomarkers in guiding optimal donor selection, conditioning regimen optimization, as well as prophylaxis, maintenance, and preemptive therapy for transplantation complications in AML patients, with a primary focus on leukemia relapse and GVHD. we highlighted the challenges and future directions in the field of biomarker-directed transplantation complication prediction and therapy.Expert opinion: Advances in biomarker-based prediction of transplant complications, prophylactic strategies, and preemptive therapy have made precision medicine a reality for AML patients. Future efforts should focus on identifying novel biomarkers to develop new techniques for predicting poor outcomes and guiding personalized prophylaxis and therapy.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"803-815"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of histological characteristics in arterial and venous thrombi. 动脉和静脉血栓组织学特征的系统综述。

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2025-10-01 Epub Date: 2025-07-17 DOI: 10.1080/17474086.2025.2533237

Gurtej Singh, Shiffoni Sukhlal, Isha Joshi, Shang Lee, Nicholas Sikalas, Jose A Diaz, Nicos Labropoulos

{"title":"A systematic review of histological characteristics in arterial and venous thrombi.","authors":"Gurtej Singh, Shiffoni Sukhlal, Isha Joshi, Shang Lee, Nicholas Sikalas, Jose A Diaz, Nicos Labropoulos","doi":"10.1080/17474086.2025.2533237","DOIUrl":"10.1080/17474086.2025.2533237","url":null,"abstract":"Introduction: Despite being the leading causes of morbidity and mortality worldwide, very little is known about the similarities and differences between venous and arterial thrombi. This review is focused on comparing their structural, molecular, and temporal characteristics.Methods: A systematic review following PRISMA guidelines and focusing on arterial and venous thrombi was conducted. Only studies having histological images in vivo from animal studies and humans were included. Data on structural components and temporal changes of thrombi were collected and analyzed.Results: There were 76 articles found eligible from the full-text review. Only two studies had simultaneous temporal and spatial comparisons and did not attempt to compare the two types of thrombi: arterial and venous. Therefore, comparative insights were additionally drawn from studies analyzing one thrombus type in isolation. Four common factors were identified: red blood cells (RBCs), white blood cells (WBCs), platelets, and fibrin. Platelet concentration was higher in arterial thrombi, while more red blood cells (RBCs) were found in the venous thrombi.Conclusions: There is a clear lack of direct comparison between arterial and venous thrombi, with limited information on their evaluations. Most available findings are derived from independently conducted analyses.Registration: The protocol was registered on PROSPERO (registration ID: CRD420251003712).","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"817-828"},"PeriodicalIF":2.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of weight status on risk of venous thromboembolism associated with GLP-1 receptor agonists. 体重状况对GLP-1受体激动剂相关静脉血栓栓塞风险的影响

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2025-09-17 DOI: 10.1080/17474086.2025.2562077

Cho-Han Chiang, Rushad Patell

引用次数: 0

Lower rates of maternal morbidities among pregnant women suffering from sickle cell disease who are exposed to hydroxyurea, a retrospective study from tribal area of Western India. 来自印度西部部落地区的一项回顾性研究：暴露于羟基脲的镰状细胞病孕妇的产妇发病率较低。

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2025-09-17 DOI: 10.1080/17474086.2025.2562080

Gayatri Desai, Hasmukh Balar, Kapilkumar Dave, Shrey Desai

{"title":"Lower rates of maternal morbidities among pregnant women suffering from sickle cell disease who are exposed to hydroxyurea, a retrospective study from tribal area of Western India.","authors":"Gayatri Desai, Hasmukh Balar, Kapilkumar Dave, Shrey Desai","doi":"10.1080/17474086.2025.2562080","DOIUrl":"10.1080/17474086.2025.2562080","url":null,"abstract":"Background: Sickle cell disease (SCD) is a common inherited blood disorder causing high maternal and fetal morbidity during pregnancy. Hydroxyurea (HU) is a standard SCD therapy, but its safety in pregnancy remains uncertain due to concerns about congenital anomalies. This study evaluates maternal-fetal outcomes in pregnant women with SCD who received HU versus those who did not.Research design and methods: A retrospective review was conducted at Kasturba Hospital, Gujarat, India. Pregnant women with SCD who received HU were compared with a historic control group. Maternal morbidities, fetal outcomes, and congenital anomalies were assessed. Poisson regression was done.Results: Among a total of 235 pregnant women with SCD, 154 received HU (440.5 person-months), while 81 did not (269.6 person-months). The HU group had a lower adverse maternal event score (91.2 vs. 109.8 per 100 person-months, adjusted IRR 0.82, 95% CI 0.71-0.96, p = 0.01) and reduced maternal morbidity, blood transfusion needs, complications, and deaths. No significant increase in congenital anomalies was observed. Fetal-outcomes, including live-birth, stillbirth, low birth weight, and prematurity, were comparable between groups, with no statistically significant differences.Conclusions: HU use in pregnancy lowered maternal morbidity without increasing congenital anomalies. Further prospective studies are needed in resource-limited settings.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"1-7"},"PeriodicalIF":2.1,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood clot prevention in patients with lower limb immobilisation: should low-risk patients receive medication? 下肢固定患者的血栓预防：低危患者是否应该接受药物治疗？

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2025-09-16 DOI: 10.1080/17474086.2025.2562078

Daniel Horner, Xavier L Griffin, Beverley J Hunt

引用次数: 0

Subclinical myocardial dysfunction in essential thrombocythemia: role of global longitudinal strain. 原发性血小板增多症的亚临床心肌功能障碍：全球纵向应变的作用。

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2025-09-16 DOI: 10.1080/17474086.2025.2562073

Aykut Demirkıran, Cihan Aydın, Hüseyin Orta, Nurullah Uslu, Damla Öztürk, Seval Akpınar, Şeref Alpsoy

{"title":"Subclinical myocardial dysfunction in essential thrombocythemia: role of global longitudinal strain.","authors":"Aykut Demirkıran, Cihan Aydın, Hüseyin Orta, Nurullah Uslu, Damla Öztürk, Seval Akpınar, Şeref Alpsoy","doi":"10.1080/17474086.2025.2562073","DOIUrl":"10.1080/17474086.2025.2562073","url":null,"abstract":"Background: The present study aimed to evaluate cardiac global longitudinal strain (GLS) in patients diagnosed with essential thrombocytosis (ET).Research design and methods: Patients diagnosed with ET were consecutively screened in the hematology department of our institution. Patients who underwent transthoracic echocardiography within 1 year of diagnosis were included in the study. A control group of healthy individuals matched for demographic characteristics was established. Second echocardiographic evaluation was performed during the follow-up period. The routine echocardiographic and strain parameters of both groups were compared.Results: A total of 92 participants were included, consisting of 60 patients with ET and 32 healthy volunteers. GLS values were reduced in the ET group compared to the control group (16.5 ± 2.4% vs. 22.5 ± 2.2%; p = 0.024). Among ET patients, those with GLS values ≤ 18% had a higher prevalence of the JAK2 mutation (81.1% vs. 21.7%; p < 0.001). In univariate logistic regression analysis, presence of the JAK2 mutation (OR: 4.6; 95% CI: 1.01-21; p = 0.04) was independently associated with reduced GLS.Conclusions: ET may reduce GLS, especially in the presence of JAK2 mutation.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"1-6"},"PeriodicalIF":2.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global, regional, and national burden of Hodgkin lymphoma, 1990-2021, and predictions for 2050: an analysis of the global burden of disease study 2021. 1990-2021年全球、地区和国家霍奇金淋巴瘤负担及2050年预测：2021年全球疾病负担研究分析

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2025-09-09 DOI: 10.1080/17474086.2025.2558710

Dongnan Li, Yunjie Li, Yue Chen, Qiuni Chen, Jingjing Ma, Chuanyang Lu, Yuye Shi, Chunling Wang, Liang Yu

{"title":"Global, regional, and national burden of Hodgkin lymphoma, 1990-2021, and predictions for 2050: an analysis of the global burden of disease study 2021.","authors":"Dongnan Li, Yunjie Li, Yue Chen, Qiuni Chen, Jingjing Ma, Chuanyang Lu, Yuye Shi, Chunling Wang, Liang Yu","doi":"10.1080/17474086.2025.2558710","DOIUrl":"10.1080/17474086.2025.2558710","url":null,"abstract":"Background: Hodgkin lymphoma (HL), a lymphoid malignancy with bimodal age incidence, was analyzed across 204 countries (1990-2021) using data from the global burden of disease (GBD) 2021, with projections till 2050.Research design and methods: Using GBD 2021 data, we assessed HL burden via incidence, mortality, and disability-adjusted life years (DALYs), with age-standardized rates/100,000. Trends were evaluated using frontier analysis, age-period-cohort modeling and Bayesian APC methods.Results: From 1990-2021, global HL cases increased 19.2%, while age-standardized incidence rate (ASIR) fell 29.5%. Mortality declined 46.0%, with males showing higher ASIR (0.95 vs. 0.64) and mortality rates (0.43 vs. 0.26). High Socio-demographic Index (SDI) regions had the highest ASIR (1.42) but fastest mortality declines (estimated annual percentage change(EAPC): -3.38), whereas low SDI areas exhibited the highest age-standardized mortality rate (ASMR: 0.7) and minimal improvement. Eastern Sub-Saharan Africa recorded peak ASMR (0.85) and DALY rates (ASDR: 36.96). Bayesian Age-Period-Cohort(BAPC) projections predict sustained ASIR, ASMR, and ASDR reductions until 2050, with persistent gender/age disparities.Conclusions: Despite rising HL cases due to demographic changes, age-standardized incidence, mortality, and DALYs declined substantially over three decades and are projected to continue declining through 2050, indicating improved treatments. Persistent disparities across SDI tiers underscore the need for region-tailored strategies.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of HLA eplets mismatch load on outcomes of outpatient haploidentical-related stem cell transplantation from peripheral blood after reduced intensity conditioning. HLA小体错配负荷对门诊单倍体相关外周血干细胞移植低强度调理后结果的影响

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2025-09-01 Epub Date: 2025-06-29 DOI: 10.1080/17474086.2025.2524522

José Carlos Jaime-Pérez, Magali Irais Ureño Segura, Adriana Domínguez-Villanueva, Nidia Karina Moncada-Saucedo, Sandra Iveth Mendoza-Ibarra, David Gómez-Almaguer

{"title":"Impact of HLA eplets mismatch load on outcomes of outpatient haploidentical-related stem cell transplantation from peripheral blood after reduced intensity conditioning.","authors":"José Carlos Jaime-Pérez, Magali Irais Ureño Segura, Adriana Domínguez-Villanueva, Nidia Karina Moncada-Saucedo, Sandra Iveth Mendoza-Ibarra, David Gómez-Almaguer","doi":"10.1080/17474086.2025.2524522","DOIUrl":"10.1080/17474086.2025.2524522","url":null,"abstract":"Background: Molecular typing before hematopoietic stem cell transplantation (HSCT) at the eplet level is an emerging method to optimize HLA matching.Materials and methods: Patients who received outpatient haploidentical HSCT (Haplo-HSCT) from a sibling after reduced intensity conditioning (RIC) were studied. HLA class I and II mismatched eplets (MEs) load was determined using HLAMatchmaker software. A cutoff > or < 10 MEs was used to assess outcomes.Results: 114 patients were studied. A locus B MEs load > 10 was associated with decreased overall survival (OS), (p = 0.049), and increased graft failure (GF) (p = 0.004). Mortality was higher with > 10 MEs in HLA-I locus B (p = 0.025), and HLA-II DRB1 (p = 0.026); chronic GVHD was higher with > 10 MEs in DRB1 (p = 0.009). Anti-HLA donor-specific antibodies (DSA) were more frequent in recipients with > 10 MEs load at locus C (p = 0.021) and DRB1 (p = 0.002). MEs load > 10 at locus C and DRB1 were associated with anti-HLA DSA. Infection (p = 0.012), DSA (p = 0.014), and relapse (p = 0.001) were associated with lower OS, while multitransfusion (p = 0.035), aGVHD (p = 0.035) and infection (p = 0.021) with reduced event-free survival (EFS).Conclusion: HLA MEs load > 10 in locus B was associated with reduced OS, and in locus DRB1 with higher death rate and cGVHD after outpatient sibling haplo-HSCT using RIC.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"761-769"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0