原发性血小板增多症的亚临床心肌功能障碍：全球纵向应变的作用。

IF 2.1 4区医学 Q2 HEMATOLOGY

Expert Review of Hematology Pub Date : 2025-09-16 DOI:10.1080/17474086.2025.2562073

Aykut Demirkıran, Cihan Aydın, Hüseyin Orta, Nurullah Uslu, Damla Öztürk, Seval Akpınar, Şeref Alpsoy

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引用次数: 0

摘要

背景：本研究旨在评估诊断为原发性血小板增多症（ET）患者的心脏整体纵向应变（GLS）。研究设计与方法：对我院血液科诊断为ET的患者进行连续筛选。在诊断1年内接受经胸超声心动图检查的患者被纳入研究。建立符合人口统计学特征的健康个体对照组。随访期间进行第二次超声心动图评价。比较两组常规超声心动图及应变参数。结果：共纳入92名参与者，包括60名ET患者和32名健康志愿者。与对照组相比，ET组GLS值降低（16.5±2.4%比22.5±2.2%;p = 0.024）。在ET患者中，GLS值≤18%的患者JAK2突变患病率较高（81.1% vs. 21.7%; p p = 0.04）与GLS降低独立相关。结论：ET可能降低GLS，特别是在JAK2突变的情况下。

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Subclinical myocardial dysfunction in essential thrombocythemia: role of global longitudinal strain.

Background: The present study aimed to evaluate cardiac global longitudinal strain (GLS) in patients diagnosed with essential thrombocytosis (ET).

Research design and methods: Patients diagnosed with ET were consecutively screened in the hematology department of our institution. Patients who underwent transthoracic echocardiography within 1 year of diagnosis were included in the study. A control group of healthy individuals matched for demographic characteristics was established. Second echocardiographic evaluation was performed during the follow-up period. The routine echocardiographic and strain parameters of both groups were compared.

Results: A total of 92 participants were included, consisting of 60 patients with ET and 32 healthy volunteers. GLS values were reduced in the ET group compared to the control group (16.5 ± 2.4% vs. 22.5 ± 2.2%; p = 0.024). Among ET patients, those with GLS values ≤ 18% had a higher prevalence of the JAK2 mutation (81.1% vs. 21.7%; p < 0.001). In univariate logistic regression analysis, presence of the JAK2 mutation (OR: 4.6; 95% CI: 1.01-21; p = 0.04) was independently associated with reduced GLS.

Conclusions: ET may reduce GLS, especially in the presence of JAK2 mutation.

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来源期刊

Expert Review of Hematology HEMATOLOGY-

CiteScore

4.70

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Advanced molecular research techniques have transformed hematology in recent years. With improved understanding of hematologic diseases, we now have the opportunity to research and evaluate new biological therapies, new drugs and drug combinations, new treatment schedules and novel approaches including stem cell transplantation. We can also expect proteomics, molecular genetics and biomarker research to facilitate new diagnostic approaches and the identification of appropriate therapies. Further advances in our knowledge regarding the formation and function of blood cells and blood-forming tissues should ensue, and it will be a major challenge for hematologists to adopt these new paradigms and develop integrated strategies to define the best possible patient care. Expert Review of Hematology (1747-4086) puts these advances in context and explores how they will translate directly into clinical practice.