Expert Review of Hematology最新文献

Rilzabrutinib for persistent or chronic immune thrombocytopenia (ITP): a Bruton tyrosine kinase inhibitor that can target multiple pathophysiological pathways. 利扎布替尼治疗持续性或慢性免疫性血小板减少症（ITP）：一种布鲁顿酪氨酸激酶抑制剂，可靶向多种病理生理途径。

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2026-05-10 DOI: 10.1080/17474086.2026.2672113

Ahmed Mjali, Sylvain Audia, Yoshitaka Miyakawa, Waleed Ghanima

{"title":"Rilzabrutinib for persistent or chronic immune thrombocytopenia (ITP): a Bruton tyrosine kinase inhibitor that can target multiple pathophysiological pathways.","authors":"Ahmed Mjali, Sylvain Audia, Yoshitaka Miyakawa, Waleed Ghanima","doi":"10.1080/17474086.2026.2672113","DOIUrl":"https://doi.org/10.1080/17474086.2026.2672113","url":null,"abstract":"Introduction: Immune thrombocytopenia (ITP) is characterized by reduced platelet production and platelet destruction. Despite the availability of numerous treatments, many patients develop treatment resistance, experience relapse, or suffer from persistent symptoms such as fatigue, highlighting the need for innovative immune-modulating techniques. This review highlights the chemical properties, clinical efficacy and safety evidence for rilzabrutinib.Areas covered: Bruton tyrosine kinase (BTK) is a promising therapeutic target in ITP as it is essential for B-cell receptor signaling, Fcγ receptor-mediated platelet clearance, and inflammatory amplification. Rilzabrutinib is a reversible, covalent oral BTK inhibitor developed to treat immune-mediated disorders. It targets several pathogenic immunological pathways. In the phase 2 LUNA 2 trial and the subsequent randomized, placebo-controlled, phase 3 LUNA 3 study, rilzabrutinib was clinically evaluated in patients with persistent or chronic ITP. The treatment resulted in durable platelet responses in extensively pretreated patients, decreased bleeding episodes, and led to significant improvements in patient-reported fatigue. The safety profile was generally good with adverse events considered mild to moderate.Expert opinion: The approval of rilzabrutinib for persistent and chronic ITP represents an important addition to the therapeutic armamentarium for the disease. The drug's full potential will be further defined in future studies.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in circular RNA expression in acute chest syndrome and vaso-occlusive crisis in sickle cell disease: analysis of a public RNA-seq cohort. 镰状细胞病急性胸综合征和血管闭塞危象中环状RNA表达的变化：一项公开RNA序列队列分析

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2026-05-09 DOI: 10.1080/17474086.2026.2671173

Alawi Habara

{"title":"Changes in circular RNA expression in acute chest syndrome and vaso-occlusive crisis in sickle cell disease: analysis of a public RNA-seq cohort.","authors":"Alawi Habara","doi":"10.1080/17474086.2026.2671173","DOIUrl":"10.1080/17474086.2026.2671173","url":null,"abstract":"Background: Sickle cell disease (SCD) is a monogenic hemoglobinopathy characterized by recurrent vaso-occlusive crises (VOCs) that affect any organ and progress to multi-organ failure. Acute chest syndrome (ACS) is a major complication and leading cause of death. This study explored whole-blood circRNA signatures as candidate molecular markers for VOC and ACS and examined their functional relevance through miRNA mapping and pathway enrichment.Research design and methods: A publicly available total RNA-seq dataset (GSE139912) was analyzed for circRNA expression at baseline (n = 12), VOC (n = 10), and ACS (n = 11).Results: Significant circRNA dysregulation was identified in ACS vs. baseline and VOC vs. baseline. An exploratory panel of the top 20 upregulated and 16 downregulated circRNAs in ACS was summarized as a composite circRNA score. The unchanged score increased stepwise across clinical states, with mean differences of 1.60 for VOC vs. baseline and 1.08 for ACS vs. VOC. Standardized effect sizes were Cohen's d = 2.89 and 1.61, respectively. VOC showed intermediate scores between baseline and ACS. Enrichment analyses suggested immune and inflammatory involvement, including interleukin signaling and PI3K/AKT/MAPK-related cascades.Conclusions: These findings support circRNA expression as a source of candidate biomarkers for ACS and VOC, although validation in independent multicenter cohorts is required.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"1-13"},"PeriodicalIF":2.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges faced by women and girls with hemophilia or are carriers: an expert call for closing the diagnosis gap. 患有血友病或携带血友病的妇女和女童面临的挑战：专家呼吁缩小诊断差距。

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2026-05-08 DOI: 10.1080/17474086.2026.2672096

Ramya Ramakrishnan, Miguel A Escobar, Lakshmi V Srivaths

{"title":"Challenges faced by women and girls with hemophilia or are carriers: an expert call for closing the diagnosis gap.","authors":"Ramya Ramakrishnan, Miguel A Escobar, Lakshmi V Srivaths","doi":"10.1080/17474086.2026.2672096","DOIUrl":"https://doi.org/10.1080/17474086.2026.2672096","url":null,"abstract":"Introduction: Women and girls (WG) carrying factor 8/9 gene variant can present with hemophilia with low factor VIII/IX levels and bleeding phenotype similar to men and boys with additional gynecological bleeding, or as Hemophilia carriers (HC) with normal factor levels with/without bleeding. This review aims to address the gender gap in diagnosing WG with hemophilia (WGwH)/HC and discusses ways to improve diagnosis for appropriate and timely management of their unique challenges.Areas covered: This review summarizes available evidence published in Pubmed, regarding the various challenges in WGwH/HC screening and diagnosis. Patient-related challenges in recognizing their bleeding manifestations and provider-related factors causing delay in diagnosis are outlined. Barriers encountered by providers in screening, evaluation and diagnosis including utilization of screening tools, laboratory diagnosis with factor assays and genetic testing are discussed.Expert opinion: The diagnosis gap in WGwH/HC can be narrowed by improving patient and provider knowledge, and by developing expert recommendations for uniform screening, laboratory and genetic testing. Creating international WGwH/HC registries, outreach, twinning programs with developing countries or centers of excellence can further help improve understanding of the unique global challenges in diagnosing these patients. Research efforts can further help mitigate existing gaps and improve overall care in WGwH/HC.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early pharmacological intervention in acute promyelocytic leukemia: can we still improve outcomes? 急性早幼粒细胞白血病的早期药物干预：我们还能改善预后吗？

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2026-05-07 DOI: 10.1080/17474086.2026.2672111

Håkon Reikvam, Sona Vardanyan, Tor Henrik Andersson Tvedt

引用次数: 0

Apparent plateaus during iron chelation in transfusion-dependent β-thalassemia: interpretation and clinical implications. 输血依赖性β-地中海贫血铁螯合过程中的明显高原：解释和临床意义。

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2026-05-07 DOI: 10.1080/17474086.2026.2672115

Sophia Delicou, Constantina Aggeli, Iliana Mani, Christos Savvidis, Aikaterini Xydaki, Maria Moraki, Ioannis Koskinas

{"title":"Apparent plateaus during iron chelation in transfusion-dependent β-thalassemia: interpretation and clinical implications.","authors":"Sophia Delicou, Constantina Aggeli, Iliana Mani, Christos Savvidis, Aikaterini Xydaki, Maria Moraki, Ioannis Koskinas","doi":"10.1080/17474086.2026.2672115","DOIUrl":"https://doi.org/10.1080/17474086.2026.2672115","url":null,"abstract":"Introduction: Transfusion-dependent β-thalassemia (TDT) has become a chronic, survivable condition, but transfusional iron overload remains a central driver of cardiac, hepatic, and endocrine morbidity. Clinicians increasingly encounter patients whose iron indices 'stall' despite seemingly appropriate chelation, creating uncertainty about whether the problem is correctable (iron balance, adherence, dosing) or reflects a harder biological limitation in iron mobilization.Areas covered: A narrative review of pivotal randomized trials, prospective cohorts, and major observational MRI datasets evaluating deferoxamine, deferiprone, deferasirox, and combination regimens in TDT was performed. Literature was identified via structured searches of PubMed and key hematology/cardiometabolic journals (2000-February 2026), prioritizing primary studies with MRI liver iron concentration (LIC) and cardiac T2* endpoints, and supplemented by regulatory prescribing information for safety monitoring.Expert opinion/commentary: Many 'plateaus' are predictable steady-state iron balance-ongoing transfusional iron input matches achievable chelator-mediated excretion-and can be addressed by quantifying iron intake, verifying adherence, and rationally intensifying therapy. A second category, a hypothesized 'biological ceiling,' may arise when stored iron becomes less accessible (slow-turnover pools, tissue remodeling, altered export). Clinicians can disentangle these mechanisms by integrating transfusion iron input calculations with serial multi-organ MRI trajectories, then tailoring chelator strategy to the dominant iron compartment and organ risk.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of mental health conditions among individuals with sickle cell disease in Texas Medicaid. 德克萨斯州医疗补助中镰状细胞病患者精神健康状况的患病率

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2026-05-01 Epub Date: 2026-02-27 DOI: 10.1080/17474086.2026.2634988

Blessing I Okoye, Ananya Bhalla, Ayobami A Aiyeolemi, Gloria N Odonkor, Jamie C Barner, Samantha M Catanzano

{"title":"Prevalence of mental health conditions among individuals with sickle cell disease in Texas Medicaid.","authors":"Blessing I Okoye, Ananya Bhalla, Ayobami A Aiyeolemi, Gloria N Odonkor, Jamie C Barner, Samantha M Catanzano","doi":"10.1080/17474086.2026.2634988","DOIUrl":"10.1080/17474086.2026.2634988","url":null,"abstract":"Background: While individuals with sickle cell disease (SCD) experience mental health conditions (MHCs) that may negatively impact health outcomes, studies estimating the prevalence of MHCs in this population are limited.Research design and methods: A retrospective analysis of Texas Medicaid data from 01/01/2016-05/31/2021 included individuals aged 3-63 years with SCD and continuously enrolled for one year. Study objectives were addressed using descriptive and bivariate analyses.Results: Of the 2,878 (mean age = 23.1 ± 14.0) individuals included, 29.9% had at least one MHC. The most common MHCs were substance use disorders (15.4%), depressive disorders (8.4%), anxiety (8.3%), and suicidal ideation (6.1%). While no significant difference in age, those with SCD+MHCs had a significantly higher proportion of males (37.1% vs 27.7%, p < 0.0001). Also, compared to those without MHCs, those with MHCs had a significantly (p < 0.0001) higher mean number and proportion, respectively, of vaso-occlusive crises (5.8 ± 5.8 vs. 1.8 ± 3.1; 82.9% vs. 51.9%), SCD-related complications (3.3 ± 2.3 vs. 1.9 ± 1.8; 92.2% vs. 75.5%), and comorbid medical conditions (1.2 ± 1.2 vs. 0.5 ± 0.9; 65.5% vs. 35.7%).Conclusions: Individuals with SCD+MHCs had poorer health outcomes. Timely screening and treatment of MHCs and incorporating mental health specialists into the care team may improve patient outcomes. Interpretation should consider limitations inherent to claims data.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"555-562"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longer time to response in hemato-oncological patients with immune thrombocytopenia (ITP): a pilot study. 免疫血小板减少症（ITP）的血液肿瘤患者反应时间较长：一项初步研究。

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2026-05-01 Epub Date: 2026-03-11 DOI: 10.1080/17474086.2026.2641490

Tessa Hattenhauer, Rebekka Mispelbaum, Peter Brossart, Carmen Kuehn, Annkristin Heine

{"title":"Longer time to response in hemato-oncological patients with immune thrombocytopenia (ITP): a pilot study.","authors":"Tessa Hattenhauer, Rebekka Mispelbaum, Peter Brossart, Carmen Kuehn, Annkristin Heine","doi":"10.1080/17474086.2026.2641490","DOIUrl":"10.1080/17474086.2026.2641490","url":null,"abstract":"Background: Hemato-oncological diseases have been described as a common cause of secondary immune thrombocytopenia (ITP). So far, studies on patients with active hemato-oncological disease and concurrent ITP are limited, making it difficult to provide clear treatment recommendations. Due to the underlying disease and cancer treatment, this patient population is especially vulnerable.Research design and methods: This retrospective, single-center pilot study investigated treatment response and time-to-treatment response in patients with newly diagnosed ITP, comparing those with active hemato-oncological disease, those in remission after malignancy, to those without any underlying malignancy.Results: Comparable response rates to ITP treatment were observed across these groups, including the achievement of platelet counts above 30 G/L and complete response (platelet counts ≥100 G/L). However, patients with an active hematologic-oncological malignancy exhibited a significantly longer time to platelet recovery after initiating steroid therapy.Conclusion: Our preliminary data suggest that standard treatment recommendations for primary ITP may be effective in patients with an active hematologic - oncologic malignancy. However, therapy responses could be significantly delayed, warranting closer monitoring. Given the pilot nature of this study and the limited sample size, these findings should be considered hypothesis-generating and require confirmation in larger studies.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"547-553"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The linkage between hemoglobin-to-red blood cell distribution width ratio and osteoarthritis: a study based on the national health and nutrition examination survey. 血红蛋白与红细胞分布宽度比与骨关节炎的关系：基于全国健康与营养检查调查的研究。

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2026-05-01 Epub Date: 2026-02-24 DOI: 10.1080/17474086.2026.2634991

Wuyang Zhou, Guanfeng Lu, Jing Wang, Shujuan Fan, Gang Fang

{"title":"The linkage between hemoglobin-to-red blood cell distribution width ratio and osteoarthritis: a study based on the national health and nutrition examination survey.","authors":"Wuyang Zhou, Guanfeng Lu, Jing Wang, Shujuan Fan, Gang Fang","doi":"10.1080/17474086.2026.2634991","DOIUrl":"10.1080/17474086.2026.2634991","url":null,"abstract":"Background: Inflammation is crucial in osteoarthritis (OA) pathogenesis. The hemoglobin-to-red cell distribution width ratio (HRR), an emerging inflammatory marker, remains unclear regarding its connection with OA.Research design and methods: This study was based on National Health and Nutrition Examination Survey (NHANES) data spanning 2003-2016, covering 13,453 participants. Weighted logistic regression assessed the HRR-OA association. Subgroup and interaction analyses evaluated differences across populations.Results: After adjusting for all confounders in the model, a negative association between HRR and OA (Odds Ratio (OR) = 0.56, 95% Confidence Interval (CI): 0.34-0.93) was detected. Compared to the lowest quartile, the third and highest HRR quartiles were associated with 23% (OR = 0.77) and 34% (OR = 0.66) lower OA odds, respectively. This inverse association was stronger in subgroups including individuals ≥65 years, males, and those widowed/divorced/separated. Marital status showed a significant interaction effect.Conclusions: HRR is negatively correlated with the risk of OA and may serve as a potential relevant biological marker. Future studies could further confirm the linkage between HRR and OA by integrating imaging assessments with clinical evaluations.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"571-577"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond linearity and static risk: re-evaluating core prognostic factors in diffuse large B-cell lymphoma. 超越线性和静态风险：重新评估弥漫性大b细胞淋巴瘤的核心预后因素。

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2026-05-01 Epub Date: 2026-03-12 DOI: 10.1080/17474086.2026.2643330

Rashad Ismayilov, Murat Ozdede, Yahya Buyukasik

{"title":"Beyond linearity and static risk: re-evaluating core prognostic factors in diffuse large B-cell lymphoma.","authors":"Rashad Ismayilov, Murat Ozdede, Yahya Buyukasik","doi":"10.1080/17474086.2026.2643330","DOIUrl":"10.1080/17474086.2026.2643330","url":null,"abstract":"Background: This study challenges the static and linear assumptions of traditional prognostic models for diffuse large B-cell lymphoma (DLBCL), such as the International Prognostic Index (IPI).Research design and methods: Analyzing 664 DLBCL patients treated with R-CHOP, the research explored the time-dependent and nonlinear effects of established risk factors.Results: While the IPI maintained strong overall prognostic stability, its individual components exhibited dynamic behavior. ECOG performance score, beta-2 microglobulin (β2 M), and lactate dehydrogenase (LDH) were key predictors of early mortality, with their influence diminishing over time. Conversely, the importance of Ann Arbor stage and extranodal involvement grew, identifying them as markers of later risk. Notably, the study found a resurgence in the predictive power of β2 M after two years. Furthermore, restricted cubic spline modeling revealed significant nonlinear relationships between overall survival and age, LDH, and β2 M (all p < 0.001 for nonlinearity).Conclusions: The prognostic impact of baseline factors in DLBCL follows dynamic and nonlinear trajectories, challenging the one-size-fits-all approach of current risk scores. Future models should incorporate these temporal dynamics to provide a more accurate, personalized risk assessment.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"563-570"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the impact of air pollution on anemia: a comprehensive review and meta-analysis. 评估空气污染对贫血的影响：一项综合综述和荟萃分析。

IF 2.1 4区医学

Expert Review of Hematology Pub Date : 2026-05-01 Epub Date: 2026-03-13 DOI: 10.1080/17474086.2026.2643325

Chi-Thien Dinh, Yueh-Lun Lee, Li-Te Chang, Ta-Yuan Chang, Kian Fan Chung, Kang-Yun Lee, Jer-Hwa Chang, Hsiao-Chi Chuang

{"title":"Assessing the impact of air pollution on anemia: a comprehensive review and meta-analysis.","authors":"Chi-Thien Dinh, Yueh-Lun Lee, Li-Te Chang, Ta-Yuan Chang, Kian Fan Chung, Kang-Yun Lee, Jer-Hwa Chang, Hsiao-Chi Chuang","doi":"10.1080/17474086.2026.2643325","DOIUrl":"10.1080/17474086.2026.2643325","url":null,"abstract":"Introduction: Air pollution and household fuel use may impair hematologic health through inflammation and oxidative stress. We synthesized evidence on associations of ambient/household air pollution with anemia risk and erythrocyte indices.Methods: We searched PubMed, Embase, and Web of Science (inception-27 September 2025). Two reviewers independently screened and extracted data, and assessed risk of bias using Joanna Briggs Institute checklists. Random-effects meta-analyses pooled risk ratios (RRs) per 10 µg/m3 for particulate matter with aerodynamic diameter ≤10 µm (PM10), ≤2.5 µm (PM2.5), and nitrogen dioxide (NO2), and by household fuel type.Results: Thirty-six studies were included. Each 10 µg/m3 increase in PM2.5 and NO2 was associated with higher anemia risk (RR 1.200, 95% CI 1.041-1.384, I2 98.2%; RR 1.127, 95% CI 1.025-1.241, I2 98.0%). Solid and biomass fuel increased anemia risk (RR 1.143, 95% CI 1.027-1.274, I2 82.9%; RR 1.271, 95% CI 1.050-1.539, I2 91.7%). PM10 was associated with lower hemoglobin (0.074 g/dL, 95% CI -0.124 to -0.023, I2 90.7%). Effects were generally stronger in males and in low- and middle-income countries.Conclusions: Ambient and household air pollution are associated with increased anemia risk and reductions in hemoglobin; high heterogeneity and observational designs limit causal inference.","PeriodicalId":12325,"journal":{"name":"Expert Review of Hematology","volume":" ","pages":"529-538"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0