A systematic review of histological characteristics in arterial and venous thrombi.

IF 2.1 4区医学 Q2 HEMATOLOGY

Expert Review of Hematology Pub Date : 2025-10-01 Epub Date: 2025-07-17 DOI:10.1080/17474086.2025.2533237

Gurtej Singh, Shiffoni Sukhlal, Isha Joshi, Shang Lee, Nicholas Sikalas, Jose A Diaz, Nicos Labropoulos

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引用次数: 0

Abstract

Introduction: Despite being the leading causes of morbidity and mortality worldwide, very little is known about the similarities and differences between venous and arterial thrombi. This review is focused on comparing their structural, molecular, and temporal characteristics.

Methods: A systematic review following PRISMA guidelines and focusing on arterial and venous thrombi was conducted. Only studies having histological images in vivo from animal studies and humans were included. Data on structural components and temporal changes of thrombi were collected and analyzed.

Results: There were 76 articles found eligible from the full-text review. Only two studies had simultaneous temporal and spatial comparisons and did not attempt to compare the two types of thrombi: arterial and venous. Therefore, comparative insights were additionally drawn from studies analyzing one thrombus type in isolation. Four common factors were identified: red blood cells (RBCs), white blood cells (WBCs), platelets, and fibrin. Platelet concentration was higher in arterial thrombi, while more red blood cells (RBCs) were found in the venous thrombi.

Conclusions: There is a clear lack of direct comparison between arterial and venous thrombi, with limited information on their evaluations. Most available findings are derived from independently conducted analyses.

Registration: The protocol was registered on PROSPERO (registration ID: CRD420251003712).

查看原文本刊更多论文

动脉和静脉血栓组织学特征的系统综述。

导论：尽管静脉血栓和动脉血栓是世界范围内发病率和死亡率的主要原因，但人们对静脉血栓和动脉血栓的异同之处知之甚少。本文综述了它们的结构、分子和时间特征的比较。方法：根据PRISMA指南，以动脉血栓和静脉血栓为重点进行系统综述。仅包括具有动物和人类体内组织学图像的研究。收集和分析血栓的结构成分和时间变化数据。结果：从全文综述中找到76篇符合条件的文章。只有两项研究同时进行了时间和空间比较，并没有试图比较两种类型的血栓：动脉血栓和静脉血栓。因此，从单独分析一种血栓类型的研究中也获得了比较的见解。比较了两种血栓中常见的成分。确定了四个常见因素：红细胞（rbc）、白细胞（wbc）、血小板和纤维蛋白。动脉血栓中血小板浓度较高，而静脉血栓中红细胞浓度较高。白细胞数量和纤维蛋白浓度随时间变化。在两种类型的血栓中都发现了新生血管和溶解，后者在静脉血栓中更常见。一些因素，如血流速度、隐蔽性血栓、红色和白色血栓共存，使这种描述复杂化。精确的分子和细胞量化以及更详细的分析动脉和静脉血栓的时间和空间分布，以及标准化的方法，没有报道。结论：动脉血栓和静脉血栓之间明显缺乏直接比较，其评估信息有限。大多数可用的发现来自独立进行的分析。需要进一步的工作来更好地定义这些血栓，并加强我们对其短期和长期重塑的理解，以改善预后。注册：协议在PROSPERO上注册（注册ID: CRD420251003712）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Hematology HEMATOLOGY-

CiteScore

4.70

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Advanced molecular research techniques have transformed hematology in recent years. With improved understanding of hematologic diseases, we now have the opportunity to research and evaluate new biological therapies, new drugs and drug combinations, new treatment schedules and novel approaches including stem cell transplantation. We can also expect proteomics, molecular genetics and biomarker research to facilitate new diagnostic approaches and the identification of appropriate therapies. Further advances in our knowledge regarding the formation and function of blood cells and blood-forming tissues should ensue, and it will be a major challenge for hematologists to adopt these new paradigms and develop integrated strategies to define the best possible patient care. Expert Review of Hematology (1747-4086) puts these advances in context and explores how they will translate directly into clinical practice.