Experimental and therapeutic medicine最新文献

{"title":"Effects of dexmedetomidine on postoperative pain and early cognitive impairment in older male patients undergoing laparoscopic cholecystectomy","authors":"Yanlong Fu, Qiang Wei, Zhenliang Wang, Qingtao Zhao, Wenxin Shi","doi":"10.3892/etm.2024.12477","DOIUrl":"https://doi.org/10.3892/etm.2024.12477","url":null,"abstract":". The primary aim of the present study was to inves‑ tigate the effect of dexmedetomidine (DEX) on postoperative pain and early cognitive impairment in old male patients, who underwent laparoscopic cholecystectomy (LC). A total of 97 old patients, subjected to LC at the 980 Hospital of the Joint Service Support Force of the People's Liberation Army of China, were randomly divided into two groups, namely the DEX and normal saline groups. Patients in the DEX group received an intravenous infusion of 0.8 µg/kg DEX within 10 min following general anesthesia, followed by a mainte‑ nance infusion of 0.5 µg/(kg/h). Furthermore, patients in the normal saline group were treated with an equivalent volume of normal saline. Cognitive function was assessed using the Mini‑Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) tests at 6 h, 1, 2 and 3 days, postoperatively. The incidence of postoperative cognitive dysfunction (POCD) and postoperative adverse events were recorded for both groups. In addition, the Visual Analogue Scale (VAS) pain score was utilized to assess the pain level of all patients, while the Quality of Recovery‑15 (QoR‑15) scale was employed to analyze the postoperative recovery results. Therefore, the MoCA score was higher in the DEX group compared with the normal saline group at 6 h and day 1 postoperatively. Additionally, the MMSE score was higher at 6 h postoperatively in the DEX group compared with the normal saline group. Correspondingly, the incidence of POCD was lower in the DEX group compared with the normal saline group at 6 h and day 1, after LC (P<0.05). VAS score in resting state for patients in the DEX group was significantly lower compared with the normal‑saline group (P<0.05). Furthermore, the QoR‑15 scale score in patients in the DEX group was notably increased compared with the normal saline group on the first and second days after the operation (P<0.05). Overall, the present study verified that the continuous infusion of DEX at a rate of","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140257517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum cell division cycle 42 reflects the development and progression of diabetic nephropathy in patients with diabetes mellitus","authors":"Hongyu Yu, Jian Ma, Yueru Gu, Wei Zou, Na Zhao","doi":"10.3892/etm.2024.12473","DOIUrl":"https://doi.org/10.3892/etm.2024.12473","url":null,"abstract":". Cell division cycle 42 (CDC42) regulates podocyte apoptosis to take part in the development and progression of diabetic nephropathy (DN), but currently the clinical evidence is limited. The aim of the present study was to investigate the capability of serum CDC42 expression level to estimate the development and progression of DN in patients with diabetes mellitus (DM). Patients with type 2 DM (n=306) were enrolled and divided into normoalbuminuria (n=185), microalbumin‑ uria (n=72) and macroalbuminuria (n=49) groups based on the urinary albumin‑to‑creatinine ratio. Serum CDC42 was measured in all subjects using enzyme‑linked immunosorbent assay. The median (interquartile range) CDC42 in patients with DM was 0.461 (0.314‑0.690) ng/ml (range, 0.087‑1.728 ng/ml). CDC42 was positively associated with the estimated glomerular filtration rate (P<0.001), but negatively correlated with body mass index, systolic blood pressure, hemoglobin A1c, serum creatine, serum uric acid and C reactive protein (all P<0.050). CDC42 levels were lowest in the macroalbuminuria group, followed by the microalbuminuria group, and were highest in the normoalbuminuria group (P<0.001). CDC42 indicated that it was a favorable estimator for the presence of albuminuria [area under the curve (AUC), 0.792; 95% confidence interval (CI), 0.736‑0.848] and macroalbuminuria (AUC, 0.845; 95% CI, 0.775‑0.915). By analyses in four different multivariate logistic regression models, increased CDC42 was indepen‑ dently associated with the presence of microalbuminuria (all P<0.001), macroalbuminuria (most P<0.001) and microalbu‑ minuria + macroalbuminuria (all P<0.001). Serum CDC42 level negatively correlated with microalbuminuria and macro‑ albuminuria in patients with DM, suggesting its","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140261017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotinamide ribose ameliorates myocardial ischemia/reperfusion injury by regulating autophagy and regulating oxidative stress","authors":"Chen Yuan, Heng Yang, Wanqi Lan, Juesheng Yang, Yanhua Tang","doi":"10.3892/etm.2024.12475","DOIUrl":"https://doi.org/10.3892/etm.2024.12475","url":null,"abstract":". Nicotinamide riboside (NR) has been reported to play a protective role in myocardial ischemia‑reperfusion","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140259059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A large gastric splenosis mimicking gastrointestinal stromal tumor: A case report and literature review","authors":"Xiaotian Li, Xianwen Hu, Pan Wang, Guiyun Hu, Bin Zhou, Jiong Cai","doi":"10.3892/etm.2024.12474","DOIUrl":"https://doi.org/10.3892/etm.2024.12474","url":null,"abstract":". Splenosis pertains to the phenomenon wherein a segment of the spleen undergoes detachment and becomes embedded in other anatomical regions subsequent to traumatic rupture or therapeutic resection, and then progressively estab‑ lishing blood circulation to foster the regeneration of splenic tissue. Existing literature posits that splenosis predominantly manifests within the confines of the abdominal and pelvic cavities. The objective of the current study was to present an uncommon case involving the occurrence of splenosis within the gastric myometrium, thereby contributing to the current knowledge regarding splenosis. A 16‑year‑old female sought medical assistance owing to recurrent abdominal pain persisting for a duration of six months, and had a history of splenectomy two years prior. Gastroscopy, endoscopic ultrasound and computed tomography (CT) examination collectively identified a lesion in the submucosal prominence of the fundus of the stomach. Initial considerations based on imaging examinations leaned towards a gastrointestinal stromal tumor. Consequently, an endoscopic resection was undertaken. Remarkably, the pathological findings and histochemistry concurred with the alterations associated with ectopic spleen implantation, leading to a stable postoperative course. In conclusion, splenosis denotes the implantation of a segment of the spleen into extraneous anatomical sites, attributable to traumatic rupture or therapeutic resection. The preoperative diagnosis of splenosis can pose a chal‑ lenge, potentially culminating in unnecessary radical clinical interventions. Therefore, the acquisition of a comprehensive medical history, with a particular focus on surgical and trauma events, emerges as pivotal for an accurate diagnosis. In light of novel diagnostic modalities, the non‑invasive technology of nuclear medicine can efficaciously visualize ectopic splenic tissue, thereby averting superfluous surgical procedures. It is both feasible and imperative to implement individualized treatment strategies for patients afflicted with splenosis.","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140259967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial calcium uniporter promotes mitophagy by regulating the PINK1/Parkin pathway in caerulein‑treated pancreatic ductal epithelial cells in vitro","authors":"Yu Lei, Hui-Ying Yang, Nuo Meng, Ying-Ying Qin, Meng-Tao Xu, Xue-Lian Xiang, Li Liu, Guo-Du Tang","doi":"10.3892/etm.2024.12435","DOIUrl":"https://doi.org/10.3892/etm.2024.12435","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139958719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic immune inflammation index and gastric cancer prognosis: A systematic review and meta‑analysis","authors":"Xiaomao Yang, Chen Wu","doi":"10.3892/etm.2024.12410","DOIUrl":"https://doi.org/10.3892/etm.2024.12410","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139685813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonorchis sinensis infection in a non‑endemic area: A case report","authors":"Xingqi Chen, Jixin He, Chong Tan, Yaxuan Xu, Lijin Zhao","doi":"10.3892/etm.2024.12394","DOIUrl":"https://doi.org/10.3892/etm.2024.12394","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139527194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Retracted] MicroRNA‑93 promotes cell proliferation by directly targeting P21 in osteosarcoma cells","authors":"Yunjing He, Boxiao Yu","doi":"10.3892/etm.2024.12389","DOIUrl":"https://doi.org/10.3892/etm.2024.12389","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139530470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Corrigendum] Changes in expression of p53 and inflammatory factors in patients with ulcerative colitis","authors":"Hui Su, Qian Kang, Haihong Wang, Hui Yin, Linghui Duan, Yuli Liu, Ruying Fan","doi":"10.3892/etm.2024.12384","DOIUrl":"https://doi.org/10.3892/etm.2024.12384","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139440058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockdown of FOXO4 protects against OGD/R‑induced cerebral microvascular endothelial cell injury and regulates the AMPK/Nrf2/HO‑1 pathway through transcriptional activation of CTRP6","authors":"Xiangting Cui, Zhili Li, Yuhua Yuan","doi":"10.3892/etm.2024.12382","DOIUrl":"https://doi.org/10.3892/etm.2024.12382","url":null,"abstract":"","PeriodicalId":12285,"journal":{"name":"Experimental and therapeutic medicine","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139441358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}