肺损伤预测评分与晚期糖基化终产物受体联合对急性呼吸窘迫综合征发生的预测价值

IF 2.4 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Jun Yang, Ai Wei, Bing Wu, Jialin Deng
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引用次数: 0

摘要

本研究评价肺损伤预测评分(LIPS)与晚期糖基化终产物受体(RAGE)联合应用对危重患者急性呼吸窘迫综合征(ARDS)发生的预测价值。将551例有ARDS危险因素的患者分为ARDS组和非ARDS组。入院后6 h内计算LIPS,入院后24 h内检测血浆RAGE浓度。进行多因素分析以确定独立相关性,并采用受试者工作特征(ROC)曲线评估ARDS发生的预测值。入院后7 d内发生ARDS 176例(31.9%)。多因素分析表明,lip[比值比(OR), 1.282;95%置信区间(CI), 1.108‑1.604),RAGE水平(OR, 2.359;95% CI, 1.351 - 4.813)和急性生理和慢性健康评估II评分(OR, 1.167;95% CI, 1.074 - 1.485)与ARDS发生独立相关。ROC曲线显示,LIPS、RAGE水平及其组合的曲线下面积(AUC)为0.714[标准误差(SE), 0.023;95% ci, 0.670 - 0.759], 0.709 (se, 0.025;95% CI, 0.660 - 0.758)和0.889 (SE, 0.014;95% CI, 0.861 - 0.917)。LIPS联合RAGE水平的AUC显著高于LIPS (0.889 vs. 0.714;Z = 6.499;P<0.001)和RAGE (0.889 vs. 0.709;Z = 6.282;P<0.001)水平。综上所述,在具有ARDS危险因素的危重患者中,LIPS和RAGE水平与ARDS发生独立相关,对ARDS发生具有中等预测价值。LIPS联合RAGE水平提高了ARDS发生的预测值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictive value of combination of lung injury prediction score and receptor for advanced glycation end‑products for the occurrence of acute respiratory distress syndrome
The present study evaluated the predictive value of the combination of the lung injury prediction score (LIPS) and receptor for advanced glycation end‑products (RAGE) for the occurrence of acute respiratory distress syndrome (ARDS) in critically ill patients with ARDS risk factors. A total of 551 patients with risk factors of ARDS were divided into an ARDS group and a non‑ARDS group. LIPS was computed within 6 h of admission into the ICU, and the plasma concentration of RAGE was detected within 24 h of admission. Multivariate analysis was performed to identify independent associations, and the predictive values for ARDS occurrence were assessed with receiver operating characteristic (ROC) curve. Within 7 days after admission into the ICU, ARDS occurred in 176 patients (31.9%). Multivariate analysis demonstrated that LIPS [odds ratio (OR), 1.282; 95% confidence interval (CI), 1.108‑1.604], RAGE levels (OR, 2.359; 95% CI, 1.351‑4.813) and Acute Physiology and Chronic Health Evaluation II score (OR, 1.167; 95% CI, 1.074‑1.485) were independently associated with ARDS occurrence. ROC curves demonstrated that the area under curve (AUC) of LIPS, RAGE levels and their combination was 0.714 [standard error (SE), 0.023; 95% CI, 0.670‑0.759], 0.709 (SE, 0.025; 95% CI, 0.660‑0.758) and 0.889 (SE, 0.014; 95% CI, 0.861‑0.917), respectively. The AUC of LIPS combined with RAGE levels was significantly higher compared with those of LIPS (0.889 vs. 0.714; Z=6.499; P<0.001) and RAGE (0.889 vs. 0.709; Z=6.282; P<0.001) levels alone. In conclusion, both LIPS and RAGE levels were independently associated with ARDS occurrence in critically ill patients with ARDS risk factors, and had medium predictive values for ARDS occurrence. Combination of LIPS with RAGE levels increased the predictive value for ARDS occurrence.
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来源期刊
Experimental and therapeutic medicine
Experimental and therapeutic medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.50
自引率
0.00%
发文量
570
审稿时长
1 months
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