Experimental Neurobiology最新文献_第9页

Visuosocial Preference Memory, but Not Avoidance Memory, Requires PLCγ1 in the CA2 Hippocampus. 视觉社会偏好记忆，而非回避记忆，需要CA2海马中的plc γ - 1。

IF 2.4 4区医学

Experimental Neurobiology Pub Date : 2022-10-31 DOI: 10.5607/en22033

Sunpil Kim, Jeongyeon Kim, Yongmin Mason Park, Pann-Ghill Suh, C Justin Lee

{"title":"Visuosocial Preference Memory, but Not Avoidance Memory, Requires PLCγ1 in the CA2 Hippocampus.","authors":"Sunpil Kim, Jeongyeon Kim, Yongmin Mason Park, Pann-Ghill Suh, C Justin Lee","doi":"10.5607/en22033","DOIUrl":"https://doi.org/10.5607/en22033","url":null,"abstract":"Visuosocial memory is defined as stored visual information containing social context. Primates have a powerful ability to associate visuosocial memory with episodic memory. However, the existence of visuosocial memory in mice remains unclear. Here, we design a novel vision-specific social memory test using a portrait picture or mirrored self-image and demonstrate that mice can distinguish conspecific from other species by forming a visuosocial memory. Because CA2 hippocampus has been reported as a critical brain region for social memory, we develop CA2-specific blockade of memory formation through deletion of phospholipase C gamma 1 (PLCγ1), which is a key molecule in the brain-derived neurotrophic factor (BDNF) signaling pathway. Interestingly, these mice have intact sociability but impaired social memory in three chamber test and five-trial social memory test, which is highly dependent on visual information. Finally, PLCγ1 deletion in CA2 impairs visuosocial preference memory, but not avoidance memory, whereas non-social object recognition is intact. Our study proposes that mice have visuosocial memory, just as primates and humans.","PeriodicalId":12263,"journal":{"name":"Experimental Neurobiology","volume":"31 5","pages":"332-342"},"PeriodicalIF":2.4,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/5b/en-31-5-332.PMC9659492.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40674444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Association of White Matter Tracts with Alexithymia among Individuals with Major Depressive Disorder. 重度抑郁症患者述情障碍与白质束的关系。

IF 2.4 4区医学

Experimental Neurobiology Pub Date : 2022-10-31 DOI: 10.5607/en22030

Youbin Kang, Aram Kim, Wooyoung Kang, Kyu-Man Han, Byoungjoo Ham

{"title":"The Association of White Matter Tracts with Alexithymia among Individuals with Major Depressive Disorder.","authors":"Youbin Kang, Aram Kim, Wooyoung Kang, Kyu-Man Han, Byoungjoo Ham","doi":"10.5607/en22030","DOIUrl":"https://doi.org/10.5607/en22030","url":null,"abstract":"Alexithymia is characterized by impairments in the processing of emotions. Although the disruptions in the white matter (WM) integrity in Major depressive disorder (MDD) has frequently been reported, the underlying relationship with alexithymia remains unclear. In the present study, we investigated WM tracts with Tracts Constrained by UnderLying Anatomy approach to discover potential associations between alexithymia and WM integrity to identify the neural basis of impaired emotional self-awareness in MDD. 101 patients with MDD and 99 healthy sex- and age-matched individuals underwent diffusion-weighted imaging. All participants were assessed with the 20-item Toronto Alexithymia Scale (TAS). TAS scores were significantly higher in MDD patients than in controls. Patients with MDD exhibited significantly lower FA values in the left inferior longitudinal fasciculus and it also showed negative associations with TAS. These results contribute to the neurobiological evidence on the association between MDD and alexithymia. Additionally, they suggest that reduced white matter integrity in the regions constitutes a principal pathophysiology underlying impaired emotional recognition and description in MDD.","PeriodicalId":12263,"journal":{"name":"Experimental Neurobiology","volume":"31 5","pages":"343-352"},"PeriodicalIF":2.4,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/f6/en-31-5-343.PMC9659491.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40689190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced Sulcal Depth in Central Sulcus of Major Depressive Disorder. 重度抑郁症的中央沟深度减少。

IF 2.4 4区医学

Experimental Neurobiology Pub Date : 2022-10-31 DOI: 10.5607/en22031

Seung-Joon Shin, Aram Kim, Kyu-Man Han, Woo-Suk Tae, Byung-Joo Ham

{"title":"Reduced Sulcal Depth in Central Sulcus of Major Depressive Disorder.","authors":"Seung-Joon Shin, Aram Kim, Kyu-Man Han, Woo-Suk Tae, Byung-Joo Ham","doi":"10.5607/en22031","DOIUrl":"https://doi.org/10.5607/en22031","url":null,"abstract":"Major depressive disorder (MDD) is one of the most common psychiatric disorders, and present various symptoms such as the dysregulation of mood, cognition, and behavior. The purpose of the present study was to investigate the morphometric change in MDD patients by voxel-based morphometry (VBM) and sulcal depth analyses. Forty-six MDD patients (mean age, SD; 36.07±14.34), and 23 age- and sex-matched normal controls (NML) (mean age, SD; 36.78±14.42) were included. Coronal 3D T1 magnetic resonance imaging (MRI) was obtained with the resolution of isotropic 1.0 mm. To check morphological changes of brain, T1 MRIs were objectively processed by VBM and sulcal depth methods. In sulcal depth analysis, depressed patients showed reduced sulcal depth in the areas of left posterior ramus of the lateral sulcus, superior frontal sulcus, supramarginal gyrus, central sulcus (Rolando's fissure), and Heschl's gyrus. And right posterior ramus of the lateral sulcus, temporal plane of the superior temporal gyrus, anterior transverse collateral sulcus, and central sulcus (Rolando's fissure) were also reduced compared to NML. But, VBM analyses did not showed significant finding. Reduced sulcal depth in the motor and emotion related areas were found in patients with MDD. Especially reduced sulcal depth in bilateral central sulci which are connecting between primary motor cortex and primary sensory cortex seems to be related with social and physical anhedonia in MDD.","PeriodicalId":12263,"journal":{"name":"Experimental Neurobiology","volume":"31 5","pages":"353-360"},"PeriodicalIF":2.4,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e2/21/en-31-5-353.PMC9659494.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40689191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Multiplexed Representation of Itch and Pain and Their Interaction in the Primary Somatosensory Cortex. 瘙痒和疼痛的多重表征及其在初级体感觉皮层中的相互作用。

IF 2.4 4区医学

Experimental Neurobiology Pub Date : 2022-10-31 DOI: 10.5607/en22029

Seunghui Woo, Yoo Rim Kim, Myeong Seong Bak, Geehoon Chung, Sang Jeong Kim, Sun Kwang Kim

{"title":"Multiplexed Representation of Itch and Pain and Their Interaction in the Primary Somatosensory Cortex.","authors":"Seunghui Woo, Yoo Rim Kim, Myeong Seong Bak, Geehoon Chung, Sang Jeong Kim, Sun Kwang Kim","doi":"10.5607/en22029","DOIUrl":"https://doi.org/10.5607/en22029","url":null,"abstract":"Itch and pain are distinct sensations that share anatomically similar pathways: from the periphery to the brain. Over the last decades, several itch-specific neural pathways and molecular markers have been identified at the peripheral and spinal cord levels. Although the perception of sensation is ultimately generated at the brain level, how the brain separately processes the signals is unclear. The primary somatosensory cortex (S1) plays a crucial role in the perception of somatosensory information, including touch, itch, and pain. In this study, we investigated how S1 neurons represent itch and pain differently. First, we established a spontaneous itch and pain mouse model. Spontaneous itch or pain was induced by intradermal treatment with 5-HT or capsaicin on the lateral neck and confirmed by a selective increase in scratching or wiping-like behavior, respectively. Next, in vivo two-photon calcium imaging was performed in awake mice after four different treatments, including 5-HT, capsaicin, and each vehicle. By comparing the calcium activity acquired during different sessions, we distinguished the cells responsive to itch or pain sensations. Of the total responsive cells, 11% were both responsive, and their activity in the pain session was slightly higher than that in the itch session. Itch- and painpreferred cells accounted for 28.4% and 60.6%, respectively, and the preferred cells showed the lowest activity in their counter sessions. Therefore, our results suggest that S1 uses a multiplexed coding strategy to encode itch and pain, and S1 neurons represent the interaction between itch and pain.","PeriodicalId":12263,"journal":{"name":"Experimental Neurobiology","volume":"31 5","pages":"324-331"},"PeriodicalIF":2.4,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/c7/en-31-5-324.PMC9659493.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40674443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutamate Permeability of Chicken Best1. 鸡对谷氨酸的渗透性研究

IF 2.4 4区医学

Experimental Neurobiology Pub Date : 2022-10-31 DOI: 10.5607/en22038

Jung Moo Lee, Changdev Gorakshnath Gadhe, Hyunji Kang, Ae Nim Pae, C Justin Lee

{"title":"Glutamate Permeability of Chicken Best1.","authors":"Jung Moo Lee, Changdev Gorakshnath Gadhe, Hyunji Kang, Ae Nim Pae, C Justin Lee","doi":"10.5607/en22038","DOIUrl":"https://doi.org/10.5607/en22038","url":null,"abstract":"Bestrophin-1 (Best1) is a calcium (Ca2+)-activated chloride (Cl-) channel which has a phylogenetically conserved channel structure with an aperture and neck in the ion-conducting pathway. Mammalian mouse Best1 (mBest1) has been known to have a permeability for large organic anions including gluconate, glutamate, and D-serine, in addition to several small monovalent anions, such as Cl‑, bromine (Br-), iodine (I-), and thiocyanate (SCN-). However, it is still unclear whether non-mammalian Best1 has a glutamate permeability through the ion-conducting pathway. Here, we report that chicken Best1 (cBest1) is permeable to glutamate in a Ca2+-dependent manner. The molecular docking and molecular dynamics simulation showed a glutamate binding at the aperture and neck of cBest1 and a glutamate permeation through the ion-conducting pore, respectively. Moreover, through electrophysiological recordings, we calculated the permeability ratio of glutamate to Cl- (PGlutamate/PCl) as 0.28 based on the reversal potential shift by ion substitution from Cl- to glutamate in the internal solution. Finally, we directly detected the Ca2+-dependent glutamate release through cBest1 using the ultrasensitive two-cell sniffer patch technique. Our results propose that Best1 homologs from non-mammalian (cBest1) to mammalian (mBest1) have a conserved permeability for glutamate.","PeriodicalId":12263,"journal":{"name":"Experimental Neurobiology","volume":"31 5","pages":"277-288"},"PeriodicalIF":2.4,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/a1/en-31-5-277.PMC9659495.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40674439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal Plasticity. 双侧失明后听觉皮层突触重构:交叉模态可塑性的证据。

IF 2.4 4区医学

Experimental Neurobiology Pub Date : 2022-10-31 DOI: 10.5607/en22020

Jae Joon Han, Tae-Soo Noh, Myung-Whan Suh, Seung Ha Kim, Doo Hee Kim, Sang Jeong Kim, Seung Ha Oh

{"title":"Synaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal Plasticity.","authors":"Jae Joon Han, Tae-Soo Noh, Myung-Whan Suh, Seung Ha Kim, Doo Hee Kim, Sang Jeong Kim, Seung Ha Oh","doi":"10.5607/en22020","DOIUrl":"https://doi.org/10.5607/en22020","url":null,"abstract":"We aimed to evaluate structural dynamic changes of neurons in the auditory cortex after visual deprivation. We longitudinally tracked dendritic spines for 3 weeks after visual deprivation in vivo using a two-photon microscope. GFP-labeled dendritic spines in the auditory cortex were serially followed after bilateral enucleation. The turnover rate, density, and size of the spines in the dendrites were evaluated 1, 2, and 3 weeks after visual deprivation. The turnover rate of the dendritic spines in the auditory cortex increased at 1 week (20.1±7.3%) after bilateral enucleation compared to baseline (12.5±7.9%); the increase persisted for up to 3 weeks (20.9±11.0%). The spine loss rate was slightly higher than the spine gain rate. The average spine density (number of spines per 1 μm of dendrite) was significantly lower at 2 weeks (2W; 0.22±0.06 1/μm) and 3 W (0.22±0.08 1/μm) post-nucleation compared to baseline (0.026±0.09 1/μm). We evaluated the change of synaptic strength in the stable spines at each time point. The normalized spine size in the auditory cortex was significantly increased after bilateral blindness at 1 W postoperatively (1.36±0.92), 2 W postoperatively (1.40±1.18), and 3 W postoperatively (1.36±0.88) compared to baseline. Sensory deprivation resulted in remodeling of the neural circuitry in the spared cortex, via cross-modal plasticity in the direction of partial breakdown of synapses, and enhanced strength of the remaining synapses.","PeriodicalId":12263,"journal":{"name":"Experimental Neurobiology","volume":"31 5","pages":"299-306"},"PeriodicalIF":2.4,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/24/en-31-5-299.PMC9659489.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40674441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Three Musketeers in the Medial Prefrontal Cortex: Subregion-specific Structural and Functional Plasticity Underlying Fear Memory Stages. 内侧前额叶皮层的三个火枪手:恐惧记忆阶段的亚区域特异性结构和功能可塑性。

IF 2.4 4区医学

Experimental Neurobiology Pub Date : 2022-08-31 DOI: 10.5607/en22012

Yongmin Sung, Bong-Kiun Kaang

{"title":"The Three Musketeers in the Medial Prefrontal Cortex: Subregion-specific Structural and Functional Plasticity Underlying Fear Memory Stages.","authors":"Yongmin Sung, Bong-Kiun Kaang","doi":"10.5607/en22012","DOIUrl":"https://doi.org/10.5607/en22012","url":null,"abstract":"Fear memory recruits various brain regions with long-lasting brain-wide subcellular events. The medial prefrontal cortex processes the emotional and cognitive functions required for adequately handling fear memory. Several studies have indicated that subdivisions within the medial prefrontal cortex, namely the prelimbic, infralimbic, and anterior cingulate cortices, may play different roles across fear memory states. Through a dedicated cytoarchitecture and connectivity, the three different regions of the medial prefrontal cortex play a specific role in maintaining and extinguishing fear memory. Furthermore, synaptic plasticity and maturation of neural circuits within the medial prefrontal cortex suggest that remote memories undergo structural and functional reorganization. Finally, recent technical advances have enabled genetic access to transiently activated neuronal ensembles within these regions, suggesting that memory trace cells in these regions may preferentially contribute to processing specific fear memory. We reviewed recently published reports and summarize the molecular, synaptic and cellular events occurring within the medial prefrontal cortex during various memory stages.","PeriodicalId":12263,"journal":{"name":"Experimental Neurobiology","volume":"31 4","pages":"221-231"},"PeriodicalIF":2.4,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c3/38/en-31-4-221.PMC9471411.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40340900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Anti-stress Effect of Octopus Cephalotocin in Rats. 章鱼催产素对大鼠的抗应激作用。

IF 2.4 4区医学

Experimental Neurobiology Pub Date : 2022-08-31 DOI: 10.5607/en22010

Ye-Ji Kim, Seonmi Jo, Seung-Hyun Jung, Dong Ho Woo

{"title":"Anti-stress Effect of Octopus Cephalotocin in Rats.","authors":"Ye-Ji Kim, Seonmi Jo, Seung-Hyun Jung, Dong Ho Woo","doi":"10.5607/en22010","DOIUrl":"https://doi.org/10.5607/en22010","url":null,"abstract":"Cephalotocin is a bioactivity-regulating peptide expressed in octopus (Octopus vulgaris). The peptide sequence of cephalotocin is very similar to the peptide sequence of mammalian vasopressin, and cephalotocin has been proposed to mainly activate arginine vasopressin 1b receptor (Avpr1b) in the brain. However, the effects of cephalotocin on mammalian behavior have not been studied. In the current study, cephalotocin significantly reduced both the frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs) recorded from not only cultured neuronal cells from postnatal Sprague-Dawley (SD) rats but also hippocampal slices from 4-week-old male C57BL/6 mice. Intraperitoneal (IP) injection did not affect the open field behaviors of C57BL/6 mice. Cephalotocin was directly infused into the hippocampus because the normalized Avpr1b staining intensity divided by the DAPI staining intensity indicated that Avpr1b expression tended to be high in the hippocampus. A hippocampal infusion of 1 mg/kg cephalotocin via an implanted cannula exerted an anti-stress effect, significantly reducing the immobility time in the tail suspension test (TST). The present results provide evidence that the effects of cephalotocin on the activity of hippocampal neurons are related to ameliorating stress, suggesting that cephalotocin may be developed as an anti-stress biomodulator that functions by affecting the brain.","PeriodicalId":12263,"journal":{"name":"Experimental Neurobiology","volume":"31 4","pages":"260-269"},"PeriodicalIF":2.4,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/67/03/en-31-4-260.PMC9471412.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40340903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Peripheral Tinnitus, Causes, and Treatments from the Perspective of Autophagy. 从自噬的角度综述外周性耳鸣、病因及治疗。

IF 2.4 4区医学

Experimental Neurobiology Pub Date : 2022-08-31 DOI: 10.5607/en22002

Karthikeyan A Vijayakumar, Gwang-Won Cho, Nagarajan Maharajan, Chul Ho Jang

{"title":"A Review on Peripheral Tinnitus, Causes, and Treatments from the Perspective of Autophagy.","authors":"Karthikeyan A Vijayakumar, Gwang-Won Cho, Nagarajan Maharajan, Chul Ho Jang","doi":"10.5607/en22002","DOIUrl":"https://doi.org/10.5607/en22002","url":null,"abstract":"Tinnitus is the perception of phantom noise without any external auditory sources. The degeneration of the function or activity of the peripheral or central auditory nervous systems is one of the causes of tinnitus. This damage has numerous causes, such as loud noise, aging, and ototoxicity. All these sources excite the cells of the auditory pathway, producing reactive oxygen species that leads to the death of sensory neural hair cells. This causes involuntary movement of the tectorial membrane, resulting in the buzzing noise characteristic of tinnitus. Autophagy is an evolutionarily conserved catabolic scavenging activity inside a cell that has evolved as a cell survival mechanism. Numerous studies have demonstrated the effect of autophagy against oxidative stress, which is one of the reasons for cell excitation. This review compiles several studies that highlight the role of autophagy in protecting sensory neural hair cells against oxidative stress-induced damage. This could facilitate the development of strategies to treat tinnitus by activating autophagy.","PeriodicalId":12263,"journal":{"name":"Experimental Neurobiology","volume":"31 4","pages":"232-242"},"PeriodicalIF":2.4,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/6b/en-31-4-232.PMC9471415.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40340901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System. 血脑屏障损伤是SARS-CoV-2感染中枢神经系统的关键。

IF 2.4 4区医学

Experimental Neurobiology Pub Date : 2022-08-31 DOI: 10.5607/en21049

Jahir Rodríguez-Morales, Sebastián Guartazaca-Guerrero, Salma A Rizo-Téllez, Rebeca Viurcos-Sanabria, Eira Valeria Barrón, Aldo F Hernández-Valencia, Porfirio Nava, Galileo Escobedo, José Damián Carrillo-Ruiz, Lucía A Méndez-García

{"title":"Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System.","authors":"Jahir Rodríguez-Morales, Sebastián Guartazaca-Guerrero, Salma A Rizo-Téllez, Rebeca Viurcos-Sanabria, Eira Valeria Barrón, Aldo F Hernández-Valencia, Porfirio Nava, Galileo Escobedo, José Damián Carrillo-Ruiz, Lucía A Méndez-García","doi":"10.5607/en21049","DOIUrl":"https://doi.org/10.5607/en21049","url":null,"abstract":"Transsynaptic transport is the most accepted proposal to explain the SARS-CoV-2 infection of the CNS. Nevertheless, emerging evidence shows that neurons do not express the SARS-CoV-2 receptor ACE2, which highlights the importance of the blood-brain barrier (BBB) in preventing virus entry to the brain. In this study, we examine the presence of SARS-CoV-2 messenger ribonucleic acid (mRNA) and the cytokine profile in cerebrospinal fluids (CSF) from two patients with a brain tumor and COVID-19. To determine the BBB damage, we evaluate the Q- albumin index, which is an indirect parameter to assess the permeability of this structure. The Q-albumin index of the patient with an intraventricular brain tumor suggests that the BBB is undamaged, preventing the passage of SARS-CoV-2 and pro-inflammatory molecules. The development of brain tumors that disrupt the BBB (measured by the Q-albumin index), in this case, a petroclival meningioma (Case 1), allows the free passage of the SARS-CoV-2 virus and probably lets the free transit of pro-inflammatory molecules to the CNS, which leads to a possible activation of the microglia (astrogliosis) and an exacerbated immune response represented by IL-13, IFN-γ, and IL-2 trying to inhibit both the infection and the carcinogenic process.","PeriodicalId":12263,"journal":{"name":"Experimental Neurobiology","volume":"31 4","pages":"270-276"},"PeriodicalIF":2.4,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/78/en-31-4-270.PMC9471413.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40340904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4