Experimental and Clinical Gastroenterology最新文献_第4页

Gastric accommodation: pathogenetic role and clinical significance 胃容积：致病作用和临床意义

Experimental and Clinical Gastroenterology Pub Date : 2024-03-26 DOI: 10.31146/1682-8658-ecg-219-11-120-129

A. E. Shklyaev

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Malnutrition, dysfunction of the gastrointestinal tract and sarcopenia - features of combined pathology 营养不良、胃肠道功能障碍和肌肉疏松症--综合病症的特征

Experimental and Clinical Gastroenterology Pub Date : 2024-03-26 DOI: 10.31146/1682-8658-ecg-222-2-111-119

D. P. Kurmaev, S. Bulgakova, E. Treneva, N. Pervyshin, L. A. Sharonova, Y. Dolgikh

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Threshold values of anthropometric indicators of obesity for screening of low muscle mass in elderly women as a method for early diagnosis of sarcopenia 筛查老年妇女低肌肉质量的肥胖人体测量指标阈值，作为早期诊断肌肉疏松症的一种方法

Experimental and Clinical Gastroenterology Pub Date : 2024-03-26 DOI: 10.31146/1682-8658-ecg-222-2-15-21

S. Bulgakova, D. P. Kurmaev, E. Treneva, N. Pervyshin, K. R. Kiseleva

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In memory of Professor Vyacheslav Yurievich Golofeevsky 纪念维亚切斯拉夫-尤里耶维奇-戈洛费耶夫斯基教授

Experimental and Clinical Gastroenterology Pub Date : 2024-03-26 DOI: 10.31146/1682-8658-ecg-219-11-167-168

A. V. Yazenok, A. S. Parcernyak, A. N. Vlasenko, I. M. Pavlovich

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Anti-inflammatory and antimicrobial properties of some licorice metabolites 一些甘草代谢物的抗炎和抗菌特性

Experimental and Clinical Gastroenterology Pub Date : 2024-03-26 DOI: 10.31146/1682-8658-ecg-222-2-75-88

A. I. Khavkin, K. Nikolaychuk, E. V. Shreiner, M. F. Novikova, A. S. Veremenko, I. D. Levchenko, E. E. Vergunova, A. S. Tumas, P. Y. Platonova, A. Ponomarenko, I. A. Pak, E. Pokushalov

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Does proximal gastrectomy work better versus total gastrectomy in proximal gastric cancers? A Comparative analytic study 近端胃切除术与全胃切除术在近端胃癌中效果更好吗？比较分析研究

Experimental and Clinical Gastroenterology Pub Date : 2024-03-26 DOI: 10.31146/1682-8658-ecg-219-11-40-46

Wadji M. Baghai, A. .. Kashanizadeh, S. .. Sabouri, S. .. Ahmadi, M. .. Moradi, M. .. Kashanizadeh, A. .. Madankan

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Dynamics of the level of hormones-regulators of gastric motility when drinking low-mineralized water 饮用低矿物质水时胃动力调节激素水平的动态变化

Experimental and Clinical Gastroenterology Pub Date : 2024-03-26 DOI: 10.31146/1682-8658-ecg-219-11-12-18

A. E. Shklyaev, D. Kazarin, E. Y. Benderskaya, O. A. Grigorieva, Yu. S. Merzlyakova

{"title":"Dynamics of the level of hormones-regulators of gastric motility when drinking low-mineralized water","authors":"A. E. Shklyaev, D. Kazarin, E. Y. Benderskaya, O. A. Grigorieva, Yu. S. Merzlyakova","doi":"10.31146/1682-8658-ecg-219-11-12-18","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-219-11-12-18","url":null,"abstract":"Purpose of the study: To assess the effect of low-mineralized sulfate-chloride-sodium mineral water (MW) on the level of motilin and cholecystokinin in the blood in functional dyspepsia and in healthy people. Materials and methods. 180 people aged 22.3±0.21 years were examined, divided into 3 groups: patients with postprandial distress syndrome (PDS) (62 people), patients with epigastric pain syndrome (EPS) (62 people), practically healthy (56 people). The severity of gastroenterological symptoms was determined using the GSRS questionnaire. In all examined patients, the concentrations of motilin and cholecystokinin in the blood were determined initially and after a single dose of 200 ml of MW. Results. The initial concentration of motilin in the blood of patients with EPS (8584,0 [7951,0; 9807,0] pg/ml) was lower than in patients with PDS (9876,0 [9340,0; 10219,0] pg/ml, p=0,000) and healthy (9779,5 [9230,0; 10027,0] pg/ml, p=0,000). The intake of MW in healthy people did not cause changes in the concentration of motilin in the blood (p=0,352), in patients with PDS it led to a decrease in its level (p=0,000), and to an increase in EPS (p=0,000). The initial level of cholecystokinin in the blood of patients with EPS (187,7 [124,0; 230,1] pg/ml) was higher (p=0,008), and in those examined with PDS (123,3 [83,5; 143,2 ] pg/ml) is lower (p=0,000) than in healthy people (145,3 [107,1; 186,2] pg/ml). MW intake led to an increase in its concentration in all three groups: healthy (p=0,014), patients with PDS (p=0,000) and EPS (p=0,000). Conclusion. Peculiarities of the dynamics of the level of motilin and cholecystokinin in the blood of patients with PDS, EPS and healthy people when taking low-mineralized sulfate-chloride-sodium MW, which must be taken into account when developing schemes for drinking balneotherapy for functional pathology of the stomach, were revealed.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"52 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possibilities of a new assessment scale for prediction of chronic liver disease “CLivD” 预测慢性肝病的新评估量表 "CLivD "的可能性

Experimental and Clinical Gastroenterology Pub Date : 2024-03-26 DOI: 10.31146/1682-8658-ecg-219-11-62-66

L. B. Lazebnik, S. Turkina

引用次数: 0

Matrix metalloproteinases and morphological features in chronic liver diseases 基质金属蛋白酶与慢性肝病的形态特征

Experimental and Clinical Gastroenterology Pub Date : 2024-03-15 DOI: 10.31146/1682-8658-ecg-218-10-153-159

A. Yagoda, P. Koroy, T. R. Dudov

{"title":"Matrix metalloproteinases and morphological features in chronic liver diseases","authors":"A. Yagoda, P. Koroy, T. R. Dudov","doi":"10.31146/1682-8658-ecg-218-10-153-159","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-218-10-153-159","url":null,"abstract":"Aim of investigation. To study the relationship of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) with a morphological features of chronic liver diseases (CLD). Materials and methods. 76 patients with CLD of viral or alcoholic etiology aged from 18 to 64 years were examined. Chronic hepatitis was diagnosed in 59 patients, liver cirrhosis (class A according Child-Pugh score) was detected in 17 cases. The control group consisted of 72 practically healthy people. The blood levels of MMP-1, MMP-9, TIMP-1 were determined by enzyme immunoassay, and the ratio of TIMP-1/MMP-1, TIMP-1/MMP-9 was calculated. Results. There was an increase in the concentration of TIMP-1 and MMP-1 in the blood, the ratio of TIMP-1/MMP-9, a decrease in the ratio of TIMP-1/MMP-1 in CLD. In moderate and severe histological activity of CLD the levels of TIMP-1 and MMP-9 were higher, and the ratio of TIMP-1/MMP-9 was lower than in patients with histological activity index values less than 9 points. In patients with liver cirrhosis (fibrosis F4), the maximum values of TIMP-1, TIMP-1/MMP-1 and TIMP-1/MMP-9 were determined, which differed from the corresponding values for fibrosis F0-1 and F2. The blood levels of MMP-9 more than 410 ng/ml predicted severe inflammation in CLD with an accuracy of 82.9 %. The blood levels of TIMP-1 above 624 ng/ml, TIMP-1/MMP-1 more than 37.1, TIMP-1/MMP-9 more than 7.33 had high accuracy (82.9, 80.3, 80.3 %, respectively) in the prediction of liver cirrhosis (fibrosis F4). Conclusion. The imbalance in the matrix metalloproteinase system is associated with the morphological features of CLD and is characterized by hyperexpression of MMP-9 in cases of severe inflammation and increased activity of TIMP-1 in severe stages of liver fibrosis.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"45 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic analysis of the relationship between non-alcoholic fatty liver disease and tissue iron overload: promising areas for the use of polypeptide therapy 非酒精性脂肪肝与组织铁超载之间关系的系统分析：使用多肽疗法的前景广阔领域

Experimental and Clinical Gastroenterology Pub Date : 2024-03-15 DOI: 10.31146/1682-8658-ecg-218-10-139-152

I. Torshin, O. Gromova, T. E. Bogacheva

引用次数: 0