Experimental and Clinical Gastroenterology最新文献

{"title":"Improvement of quality of life indicators in patients with metabolic syndrome after correction of hemodynamically significant coronary stenoses and dyslipidemia","authors":"Y. Vukolova, I. V. Gubareva, O. Germanova, N. V. Savelyeva, A. V. Pashentseva","doi":"10.31146/1682-8658-ecg-222-2-37-43","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-222-2-37-43","url":null,"abstract":"It is known that metabolic syndrome is currently the leading cause of the development of cardiovascular pathology, which occupies a leading position in the structure of mortality not only in the Russian population, but also in the world. The prevalence of MS is growing, which is associated with stressful professions, eating disorders. The presence of MS is associated with arterial hypertension and atherosclerosis of the arteries of any localization. In this regard, the purpose of our study was to study the quality of life in patients with MS, depending on the severity of coronary atherosclerosis. Materials and methods: The study included 239 patients (142 men, 97 women) with MS with atherosclerosis of the coronary and carotid arteries. The number of subjects in group 1 (n=141), of which 101 were men and 40 were women. The second group consisted of 84 male and 14 female patients (n=98). The control group consisted of 70 people (27 men, 43 women) with grade 1-3 hypertension. The age of the subjects was 31-56 years. All patients underwent: collection of complaints and anamnesis, assessment of body mass index (BMI); determination of the lipid spectrum, blood glucose, glycated hemoglobin. Microalbuminuria and glomerular filtration rate were determined. Instrumental studies were carried out: ultrasound examination of brachiocephalic vessels with determination of the thickness of the intima-media complex and the percentage of carotid artery stenosis; coronary angiography on the General Electric Innova 3100 angiographic complex. Based on the results of coronary angiography, the patients were divided into two subgroups: group 1 - with coronary artery stenosis of less than 50% (n=141), group 2 - with stenosis of 50% or more (n=98), group 3 (control) without stenotic lesions of the coronary arteries. A non-specific questionnaire “SF-36 Health Status Survey” was used to assess the quality of life. Results: assessing physical functioning and mental health, there was a significant decrease in these indicators in patients of group 2, in whom, according to coronary angiography, hemodynamically significant coronary artery stenoses were diagnosed, a strong correlation (r=0.730; p=0.005) was revealed between deterioration in quality of life and hemodynamically significant stenosis of the carotid and coronary arteries. Restriction of physical activity and reduction of daily activities were more significant in group 2 compared to groups 1 and 3. The feeling of uncertainty with restless expectation and fears, as well as a feeling of depression prevailed in men. However, patients after percutaneous coronary intervention, as well as with lipidogram correction, assessed the quality of life with some restriction of physical activity, but with significant social functioning. Conclusions: hemodynamically significant atherosclerosis of the carotid and coronary arteries is a predictor of deterioration in the quality of life, especially in men. The use of the international que","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"117 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia and non-alcoholic fatty liver disease","authors":"R. Myazin","doi":"10.31146/1682-8658-ecg-222-2-120-130","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-222-2-120-130","url":null,"abstract":"The literature review examines the role of nutrition in the development of skeletal muscles. The pathogenesis of the development of sarcopenia and modern aspects of its diagnosis are outlined. Possible options for the influence of drugs on the state of skeletal muscles and its functional activity are presented. The relationship between sarcopenia and non-alcoholic fatty liver disease with proposed approaches to the treatment of these comorbid diseases is considered.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"103 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140380635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperuricemia, gout and digestive system pathology: common links of pathogenesis","authors":"N. A. Konyshko, T. Morozova, V. V. Tsurko, G. S. Konyshko","doi":"10.31146/1682-8658-ecg-219-11-130-137","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-219-11-130-137","url":null,"abstract":"The aim: to study and present scientists opinions on the direct and indirect clinical and pathogenetic purine compounds metabolism relationships with the digestive system physiological and pathological processes in normal uric acid levels conditions and in hyperuricemia and gout cases. Material and methods. A comprehensive analysis of available modern scientific official sources and regulatory documents for the last decade in the Scopus, PubMed.com, E-library databases. Conclusion. Based on the modern scientific literature data and numerous studies, we can say that there is a pathogenetic relationship between the level of uric acid and the digestive organs defeat.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"38 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic esophagitis and comorbid pathology: current state of the problem","authors":"I. V. Zaikova-Khelimskaya, M. Y. Bank, A. A. Khelimskiy","doi":"10.31146/1682-8658-ecg-219-11-138-145","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-219-11-138-145","url":null,"abstract":"Eosinophilic esophagitis and asthma are often found as part of comorbid pathology in children and adults, along with other manifestations of atopy. The two diseases share similar pathophysiology due to T-helper type 2 responses, common treatment approaches such as the use of glucocorticosteroids and targeted anti-cytokine biologic therapy. Patients with eosinophilic esophagitis, as with asthma, often have elevated serum markers of atopy, including IgE levels, peripheral eosinophil counts, and T-helper type 2-associated cytokines. A review of the literature shows that the true incidence of eosinophilic esophagitis remains poorly understood due to the difficulty of diagnosing this pathology, which has a mask of gastroesophageal reflux disease. Gastroesophageal reflux disease has been shown to influence asthma through microaspiration, airway hyperresponsiveness, and increased vagal tone. Understanding the relationship between gastroesophageal reflux and eosinophilic esophagitis is also being actively explored. Many works show the high efficacy of PPIs in the initial treatment of eosinophilic esophagitis and gastroesophageal reflux disease. The development of new clinical diagnostic criteria for eosinophilic esophagitis will improve the differential diagnosis of this disease and the improvement of therapeutic strategies for managing this pathology, especially in combination with asthma.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"120 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin resistance, type 2 diabetes mellitus and sarcopenia","authors":"D. P. Kurmaev, S. Bulgakova, E. Treneva","doi":"10.31146/1682-8658-ecg-222-2-141-148","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-222-2-141-148","url":null,"abstract":"Sarcopenia is a chronic age-associated disease, the prevalence of which increases with aging. The primary form is associated with aging, when no other causes have been identified, the cause of secondary sarcopenia may be various diseases, including type 2 diabetes mellitus (DM2). One of the common links in the pathogenesis of DM2 and sarcopenia is insulin resistance. A combination of sarcopenia and obesity is often observed. The interrelation of these pathological processes, etiology and pathogenesis are presented in this literature review.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"115 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polypill as a means of population pharmacological prevention of cardiovascular diseases","authors":"P. A. Lebedev, I. K. Petruhina, E. V. Paranina","doi":"10.31146/1682-8658-ecg-222-2-64-74","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-222-2-64-74","url":null,"abstract":"Non-communicable diseases, among which arterial hypertension and ischemic heart disease are the predominant contributors to disability and mortality, have long been identified as a strategic target of preventive intervention in our country. The situation is aggravated by covid-19 associated mortality, which is characterized by delayed dynamics and is largely related to cardiovascular. Excess mortality, in the structure of which cardiovascular diseases are leading, requires new solutions. One of them is population pharmacoprevention, based on the use of complex fixed combinations of drugs targeting different risk factors, as arterial hypertension and dyslipidemia, as most important. This concept, which logically follows from modern realities, is in contradiction with the existing approach of personalized therapy in high/very high risk groups, because of its complexity, leading to patients noncompliance. The new system of cardiovascular risk stratification SCORE 2 introduced in the Russian Federation significantly contributes to the spread of the concept of polypills as a unified approach primarily in the most vulnerable population of males 50 years and older.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"10 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for choosing combination therapy for hypertension in metabolic syndrome - focus on inflammation","authors":"I. V. Gubareva, A. V. Pashentseva, Y. Vukolova, N. V. Savelyeva, L. Y. Shvan","doi":"10.31146/1682-8658-ecg-222-2-31-36","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-222-2-31-36","url":null,"abstract":"The article substantiates the need for adequate fixed combination therapy for metabolic syndrome and arterial hypertension (AH). The issues of inflammation in the initiation and stabilization of arterial hypertension in patients with metabolic syndrome (MS) are considered. Taking into account the results of international and Russian studies, a differentiated approach is proposed to select a fixed combination of antihypertensive drugs for the treatment of hypertension and prevention of cardiovascular complications in patients with MS.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polycystic ovary syndrome and metabolic syndrome: possible ways to correct metabolic disorders","authors":"Y. Dolgikh, S. Bulgakova, L. A. Sharonova, E. Treneva, O. Kosareva, D. P. Kurmaev","doi":"10.31146/1682-8658-ecg-222-2-5-14","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-222-2-5-14","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a common endocrine disease in women of reproductive age. The prevalence of this pathology is approximately 15-20%. PCOS is characterized by hyperandrogenism, hirsutism, menstrual irregularities, and polycystic ovaries. More than half of patients with PCOS have a metabolic syndrome, the main component of which is visceral obesity and insulin resistance, which play an important role in the pathophysiology of PCOS. Insulin resistance is a marker of cardiometabolic risk and can lead to cardiovascular disease and carbohydrate metabolism disorders up to type 2 diabetes mellitus (DM2). Therefore, in the treatment of patients with PCOS, an important aspect is the impact on insulin sensitivity and body weight. This review focuses on various groups of drugs that can potentially have a positive effect on metabolic disorders in PCOS. Among them are metformin, drugs with an incretin effect, as well as drugs for weight loss. Given the similarity of the metabolic and pathological features of PCOS and DM2, as well as the diversity of therapeutic options, there is a potential for expanding the strategy for the treatment of metabolic disorders in PCOS, including through antidiabetic drugs, which, however, requires further study. It should be noted that surgical treatment of obesity also has a beneficial effect and contributes to the normalization of the menstrual cycle and the normalization of the hormonal and metabolic profile in patients with PCOS and severe obesity.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"110 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical improvement of some indicators of the activity of non-alcoholic fatty liver disease after correction of intestinal dysbiosis with dietary fiber","authors":"I. A. Krylova, A. Lyamin, V. I. Kupaev","doi":"10.31146/1682-8658-ecg-222-2-44-49","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-222-2-44-49","url":null,"abstract":"","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"121 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the new coronavirus infection on the human pancreas","authors":"S. V. Tarasenko, D. A. Glotov, O. D. Peskov, S. N. Sokolova, U. V. Zhuchkova, T. S. Rakhmaev, I. Bakonina, A. Bogomolov, D. O. Tyulenev, S. N. Brovkina, S. G. Bykova, S. V. Gurov","doi":"10.31146/1682-8658-ecg-219-11-153-159","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-219-11-153-159","url":null,"abstract":"The aim of the study - is to study the effect of a new coronavirus infection on the human pancreas. Research materials. An analysis for blood α-amylase, as well as ultrasound of the abdominal cavity, namely the pancreas, was carried out. This study involved 20 patients, 10 had a concomitant disease in the form of diabetes mellitus and 10 without it. The results of the research. During the research, all patients had relatively the same dynamics of pancreatic lesions, without any pronounced manifestations of pancreatitis. The shift of analyses in favor of this pathology indicates more to the glucocorticosteroid therapy that patients received in the treatment of covid-19 coronavirus infection. Only one of the 20 patients studied had a classic manifestation of pancreatitis. Conclusions. Acute pancreatitis is a rare complication of COVID-19, and it is not often associated with this infection. Nevertheless, acute pancreatitis with SARS-CoV-2 infection is considered to have a higher risk of severe course and poor clinical outcomes, including the risk of organ dysfunction and higher inpatient mortality compared to patients with acute pancreatitis negative for SARS-CoV-2.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"113 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140380261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}