Expert Review of Gastroenterology & Hepatology最新文献_第9页

Multidetector computed tomography angiography in non-variceal upper gastrointestinal bleeding: when, why and how? 多检测器计算机断层血管造影诊断非静脉曲张上消化道出血：何时、为何及如何诊断？

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-12-01 Epub Date: 2025-11-28 DOI: 10.1080/17474124.2025.2596080

Alberto Martino, Marco Di Serafino, Francesco Manguso, Francesco Paolo Zito, Raffaele Bennato, Luigi Orsini, Francesco Lisanti, Silvana Di Bello, Rossana Martino, Marianna Guardascione, Lucio Amitrano, Gianluca Paternoster, Giovanni Lombardi

{"title":"Multidetector computed tomography angiography in non-variceal upper gastrointestinal bleeding: when, why and how?","authors":"Alberto Martino, Marco Di Serafino, Francesco Manguso, Francesco Paolo Zito, Raffaele Bennato, Luigi Orsini, Francesco Lisanti, Silvana Di Bello, Rossana Martino, Marianna Guardascione, Lucio Amitrano, Gianluca Paternoster, Giovanni Lombardi","doi":"10.1080/17474124.2025.2596080","DOIUrl":"10.1080/17474124.2025.2596080","url":null,"abstract":"Introduction: Non-variceal upper gastrointestinal bleeding (NVUGIB) is a common gastroenterological emergency associated with significant morbidity and mortality. According to current gastroenterological guidelines, esophagogastroduodenoscopy (EGD) represents the first-line modality for both diagnosis and treatment of NVUGIB. As opposed to lower gastrointestinal bleeding, multidetector-row computed tomography angiography (MDCTA) has a limited and no well-established role in the diagnostic process of NVUGIB. However, gastroenterological guidelines mainly focus on peptic-related NVUGIB only. Moreover, the adoption of MDCTA in NVUGIB has recently been encountered in radiological guidelines for special situations.Areas covered: The aim of our study was to comprehensively review and discuss the current and potential indications of MDCTA and its technical aspects in the diagnostic process of NVUGIB. A comprehensive literature search of PubMed, EMBASE, and Google Scholar databases was conducted through May 2025 to identify pertinent studies.Expert opinion: Although EGD undoubtedly represents the cornerstone in both diagnosis and treatment of most NVUGIB cases, MDCTA has emerged as a promising adjunct diagnostic tool, especially among clinically severe cases and those due to rare, non-peptic sources. However, evidence is still scarce, and further studies are needed to clarify its role in this scenario.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"1309-1317"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145603264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mistakes in the utilization of vibration-controlled transient elastography in the evaluation of liver fibrosis: a narrative review. 应用振动控制瞬时弹性成像评价肝纤维化的错误：述评。

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-12-01 Epub Date: 2025-11-07 DOI: 10.1080/17474124.2025.2586690

Madunil Anuk Niriella, Uditha Bandara Dassanayake, Charith Priyanga Madurapperuma, Indeewari Prathibha Wijesingha, Arjuna Priyadarshin De Silva, Hithnadura Janaka de Silva

{"title":"Mistakes in the utilization of vibration-controlled transient elastography in the evaluation of liver fibrosis: a narrative review.","authors":"Madunil Anuk Niriella, Uditha Bandara Dassanayake, Charith Priyanga Madurapperuma, Indeewari Prathibha Wijesingha, Arjuna Priyadarshin De Silva, Hithnadura Janaka de Silva","doi":"10.1080/17474124.2025.2586690","DOIUrl":"10.1080/17474124.2025.2586690","url":null,"abstract":"Introduction: The degree of fibrosis is the most significant indicator of clinical prognosis in chronic liver disease (CLD). While liver biopsy remains the gold standard for assessing liver disease activity and fibrosis, its invasive nature, potential complications, and high cost have spurred the development of alternative diagnostic methods. This has led to significant interest in noninvasive, cost-effective, and easily replicable techniques for evaluating liver fibrosis. Among these noninvasive tests, vibration-controlled transient elastography (VCTE) has emerged as the most extensively researched and validated imaging-based method for staging liver fibrosis.Areas covered: A selective literature search was conducted across electronic databases (PubMed, MEDLINE, Embase, and Cochrane Library) to identify relevant publications on VCTE. Randomized controlled trials, meta-analyses, systematic reviews, evidence-based clinical practice guidelines and selected expert consensus statements and narrative reviews were included.Given its increasing use, clinicians must know common pitfalls in VCTE applications when evaluating CLD. This review aims to outline these potential errors and provide evidence-based guidelines to help clinicians avoid them, thereby improving the accuracy and utility of VCTE in clinical practice.Expert opinion: The future of VCTE involves improved accuracy, accessibility, and integration, leading to earlier detection and personalized management of CLD.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"1299-1307"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145451440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current treatment strategy for asymptomatic bile duct stones. 无症状胆管结石的当前治疗策略。

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-12-01 Epub Date: 2025-11-12 DOI: 10.1080/17474124.2025.2588611

Ryunosuke Hakuta, Ryota Nakabayashi, Yutaka Shimamatsu, Nao Otsuka, Yukiko Takayama, Masataka Kikuyama, Yousuke Nakai

{"title":"Current treatment strategy for asymptomatic bile duct stones.","authors":"Ryunosuke Hakuta, Ryota Nakabayashi, Yutaka Shimamatsu, Nao Otsuka, Yukiko Takayama, Masataka Kikuyama, Yousuke Nakai","doi":"10.1080/17474124.2025.2588611","DOIUrl":"10.1080/17474124.2025.2588611","url":null,"abstract":"Introduction: Asymptomatic bile duct stones are increasingly diagnosed by imaging studies. Guidelines recommend endoscopic retrograde cholangiopancreatography (ERCP) for the treatment of bile duct stones, but evidence regarding short- and long-term outcomes of asymptomatic bile duct stones remains inadequate.Area covered: This review summarized evidence about clinical outcomes and technical tips of ERCP for asymptomatic bile duct stones through a literature search of PubMed until March 2025. Long-term outcomes including cholangitis, cholecystitis, biliary pancreatitis, and spontaneous passage of bile duct stones among patients who selected the wait-and-see strategy were also summarized. According to the recent evidence of short- and long-term outcomes, we discussed the pros and cons of each treatment option and proposed a treatment strategy for asymptomatic bile duct stones.Expert opinion: Despite guideline recommendations for endoscopic removal, ERCP for asymptomatic bile duct stones is associated with a high incidence of post-ERCP pancreatitis (PEP) and clinicians need to mitigate the risk of PEP by including administration of non-steroidal anti-inflammatory drugs, prophylactic pancreatic stent, or peri-procedural aggressive hydration. Considering the probability of spontaneous stone passage, the wait-and-see strategy might be a treatment option.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"1231-1239"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the regenerative and immunomodulatory potential of adipose-derived mesenchymal stem cells in gastroenterology and beyond. 探索脂肪来源的间充质干细胞在胃肠病学和其他领域的再生和免疫调节潜力。

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-12-01 Epub Date: 2025-12-14 DOI: 10.1080/17474124.2025.2591247

Helena Pelanda, Giulia Fargnoli, Maria Valeria Matteo, Yousef Amiri, Valerio Pontecorvi, Vincenzo Bove, Loredana Gualtieri, Martina De Siena, Anna Amelia Caretto, Massimiliano Papi, Stefano Gentileschi, Cristiano Spada, Ivo Boskoski

{"title":"Exploring the regenerative and immunomodulatory potential of adipose-derived mesenchymal stem cells in gastroenterology and beyond.","authors":"Helena Pelanda, Giulia Fargnoli, Maria Valeria Matteo, Yousef Amiri, Valerio Pontecorvi, Vincenzo Bove, Loredana Gualtieri, Martina De Siena, Anna Amelia Caretto, Massimiliano Papi, Stefano Gentileschi, Cristiano Spada, Ivo Boskoski","doi":"10.1080/17474124.2025.2591247","DOIUrl":"10.1080/17474124.2025.2591247","url":null,"abstract":"Introduction: Adipose-derived mesenchymal stem cells (ADMSCs) are being increasingly explored in regenerative medicine because of their accessibility and potent immunomodulatory properties. Their application is gaining traction in gastroenterology, where inflammation and tissue degeneration are central to disease progression.Areas covered: This review aims to provide an in-depth overview of the biological mechanisms, therapeutic effects, and clinical applications of ADMSCs, focusing on gastrointestinal disorders. We conducted a narrative literature review of relevant studies in PubMed, Google Scholar, and Scopus, covering key findings from gastroenterology, cardiology, neurology, orthopedics, and plastic surgery (editor comment#4b). Original studies evaluating ADMSCs use in gastroenterology and related medical fields were included. Data were organized to illustrate the cellular pathways, cytokine profiles, and paracrine signaling mechanisms through which ADMSCs exert therapeutic effects. ADMSCs consistently reduced inflammation, enhanced tissue repair, and modulated immune responses.Expert opinion: In gastroenterology, ADMSCs have demonstrated potential in the treatment of inflammatory bowel disease and liver disorders by promoting mucosal healing and limiting fibrosis. They hold significant promise because of their robust immunomodulatory and regenerative properties. Future studies should focus on refining the isolation methods, validating therapeutic protocols, and establishing safety and efficacy through controlled trials to bring ADMSCs into clinical practice.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"1319-1327"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145721539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A contemporary review of care gaps in hepatocellular carcinoma surveillance. 肝细胞癌监测中护理缺口的当代回顾。

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-12-01 Epub Date: 2025-11-22 DOI: 10.1080/17474124.2025.2592105

Nikki Duong, Veronica Nguyen, Mindie Nguyen

{"title":"A contemporary review of care gaps in hepatocellular carcinoma surveillance.","authors":"Nikki Duong, Veronica Nguyen, Mindie Nguyen","doi":"10.1080/17474124.2025.2592105","DOIUrl":"10.1080/17474124.2025.2592105","url":null,"abstract":"Introduction: Hepatocellular carcinoma (HCC) is a leading cause of morbidity and mortality in patients with cirrhosis and carries a substantial public health burden. Primary liver cancer is the sixth most common cancer worldwide. Despite guideline recommendations for HCC surveillance, pooled surveillance rates are around 18%. Further, racial, ethnic, and socioeconomic disparities exist. Along the HCC care continuum, care gaps exist from access to care, to surveillance, and ultimately in linkage to treatment.Areas covered: A literature search was performed utilizing PubMed to review peer-reviewed articles published from 2000 to present. Key landmark studies are reviewed highlighting the care gaps in cirrhosis management, HCC surveillance, and treatment. These studies underscore the complex interplay of systems, provider, and patient level factors that influence care gaps experienced by patients with HCC.Expert opinion: Despite low adherence to HCC surveillance and care gaps, there are several opportunities to ensure equitable access to care while achieving personalized, precision medicine. Future efforts will need to focus on multi-disciplinary care while ensuring that providers are knowledgeable and able to provider culturally competent care.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"1273-1284"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145548945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatocellular carcinoma: new insights into prevention and surveillance. 肝细胞癌：预防和监测的新见解。

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-11-01 Epub Date: 2025-11-07 DOI: 10.1080/17474124.2025.2584018

Mohammad Jarrah, Samantha Bourque, Ashok Choudhury, Amit G Singal

{"title":"Hepatocellular carcinoma: new insights into prevention and surveillance.","authors":"Mohammad Jarrah, Samantha Bourque, Ashok Choudhury, Amit G Singal","doi":"10.1080/17474124.2025.2584018","DOIUrl":"10.1080/17474124.2025.2584018","url":null,"abstract":"Introduction: Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is one of the few cancers with a 5-year survival below 25%, largely driven by frequent late-stage diagnoses. Historically, viral etiologies have been the leading causes of HCC; however, the rising prevalence of metabolic risk factors including obesity and diabetes, in parallel with increasing alcohol misuse, has resulted in increasing proportions of HCC due to non-viral etiologies.Areas covered: This review summarizes HCC prevention, including established approaches such as hepatitis B vaccination and antiviral therapies, as well as emerging strategies tailored to non-viral etiologies. The review also discusses existing surveillance modalities and highlights emerging strategies including blood-based biomarkers, imaging modalities, and artificial intelligence (AI) models.Expert opinion: Traditional prevention strategies face challenges with the shifting liver disease patterns. Emerging approaches, including lifestyle modifications and pharmacological therapies, show promise but require further evaluation in contemporary populations. Advances in surveillance may help overcome underutilization, improve early-HCC detection, and increase curative treatment receipt.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"1167-1179"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extra-pancreatic malignancies in patients with intraductal papillary mucinous neoplasms. 导管内乳头状黏液性肿瘤患者的胰外恶性肿瘤。

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-11-01 DOI: 10.1080/17474124.2025.2584021

Rares Ilie Orzan, Tawfik Khoury

{"title":"Extra-pancreatic malignancies in patients with intraductal papillary mucinous neoplasms.","authors":"Rares Ilie Orzan, Tawfik Khoury","doi":"10.1080/17474124.2025.2584021","DOIUrl":"10.1080/17474124.2025.2584021","url":null,"abstract":"Introduction: Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic ductal adenocarcinoma, and clinical markers of increased risk of extra-pancreatic malignancies (EPMs). However, the true burden, organ-specific risks, and optimal screening strategies for EPMs in this population remain unclear.Areas covered: This review summarizes current evidence on the association between IPMNs and EPMs, focusing on colorectal, gastric, breast, lung, and renal cancers. Geographic and ethnic differences in cancer distribution are examined, with gastric cancer predominating in East Asian populations and breast or renal cancer more common in Western cohorts. Potential mechanisms linking IPMNs to systemic carcinogenic susceptibility are discussed. A structured literature search was conducted in PubMed, Embase, Web of Science, and Cochrane Library databases for studies published up to June 2025.Expert opinion: Twenty-three studies (n = 9899 IPMN patients) revealed a consistently increased risk of colorectal cancer (SIRs 1.5-3.0), followed by gastric, breast, lung, and renal cancers. Gastric cancer was notably overrepresented in East Asian cohorts, while breast and renal cancers were more frequent in Western populations. Screening colonoscopy at IPMN diagnosis and upper endoscopy in East Asians are strongly supported. Broader, risk-adapted EPM surveillance integrating genetic and demographic factors is warranted.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"1197-1208"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune gastritis: an organ-specific disease or a model of systemic autoimmunity? Parallels, divergences, and emerging insights. 自身免疫性胃炎：器官特异性疾病还是全身性自身免疫模型？相似之处、分歧和新见解。

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-11-01 Epub Date: 2025-07-07 DOI: 10.1080/17474124.2025.2522284

Sara Massironi

{"title":"Autoimmune gastritis: an organ-specific disease or a model of systemic autoimmunity? Parallels, divergences, and emerging insights.","authors":"Sara Massironi","doi":"10.1080/17474124.2025.2522284","DOIUrl":"10.1080/17474124.2025.2522284","url":null,"abstract":"Introduction: Autoimmune gastritis (AIG) is traditionally classified as an organ-specific autoimmune disease; however, emerging evidence highlights its immunological overlap with systemic autoimmunity, warranting a reevaluation of its pathophysiological framework.Areas covered: This review delineates the immunopathogenic basis of AIG, with particular emphasis on the breakdown of central and peripheral tolerance, the predominance of autoreactive CD4+ T-cell subsets, and the contributions of Th1 and Th17 cytokine profiles. The role of humoral immunity, including autoantibodies as potential biomarkers, is critically appraised. Literature was selected through a targeted search of PubMed and Scopus, prioritizing mechanistic studies, translational research, and recent therapeutic advances, covering the period from January 2000 to March 2025.Expert opinion: AIG represents a paradigm of localized autoimmunity with systemic immunological features, including cytokine dysregulation and epitope spreading. Although serologic markers are valuable for screening, their prognostic utility remains limited. Therapeutic approaches currently focus on complication prevention rather than immune modulation. Future research should prioritize the identification of predictive biomarkers of disease progression and the development of targeted immunotherapies aimed at restoring immune tolerance and preserving gastric mucosal integrity.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"1209-1217"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The eternal dichotomy between early biologic therapy and early surgery in Crohn's disease: which should truly take precedence? 克罗恩病的早期生物治疗和早期手术之间永恒的二分法：哪个应该真正优先？

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-11-01 Epub Date: 2025-10-18 DOI: 10.1080/17474124.2025.2577983

Raffaele Pellegrino, Antonietta Gerarda Gravina, Alessandro Federico

引用次数: 0

Clinical management of inflammatory bowel disease from preconception to postpartum. 从孕前到产后炎症性肠病的临床处理。

IF 2.5 3区医学

Expert Review of Gastroenterology & Hepatology Pub Date : 2025-11-01 Epub Date: 2025-10-22 DOI: 10.1080/17474124.2025.2577985

Loren G Rabinowitz, Ajay Gade, Tina Deyhim, Alessandra Saraga, Joseph D Feuerstein

{"title":"Clinical management of inflammatory bowel disease from preconception to postpartum.","authors":"Loren G Rabinowitz, Ajay Gade, Tina Deyhim, Alessandra Saraga, Joseph D Feuerstein","doi":"10.1080/17474124.2025.2577985","DOIUrl":"10.1080/17474124.2025.2577985","url":null,"abstract":"Introduction: Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, often affects individuals during their peak reproductive years. Female patients with IBD face unique challenges across the reproductive years, from fertility and conception to delivery and lactation. Despite increasing awareness, knowledge gaps remain regarding optimal management during pregnancy and postpartum. This review outlines these challenges and provides a practical, evidence-based approach across reproductive stages.Areas covered: This review summarizes care for IBD in reproductive years, including preconception counseling, pregnancy management, delivery planning, surgical, and perianal disease considerations, postpartum care, breastfeeding, and infant vaccination after biologic exposure.Expert opinion: Managing IBD from preconception through the postpartum period requires early planning, multidisciplinary coordination, and patient-centered care. Disease remission is the strongest predictor of maternal and fetal outcomes. Most IBD therapies, including biologics, are safe in pregnancy and lactation and should continue, except small molecules, which remain contraindicated due to teratogenic risk or limited safety data. Rotavirus and other vaccinations can generally be administered on schedule in infants exposed to biologics in utero. A proactive, treat-to-target strategy throughout pregnancy, combined with close postpartum monitoring, can prevent disease flares and support optimal outcomes for both mother and child.","PeriodicalId":12257,"journal":{"name":"Expert Review of Gastroenterology & Hepatology","volume":" ","pages":"1219-1230"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0