Implications of the microbiome after pancreatic cancer resection with regards to morbidity & mortality.

IF 3.8 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Expert Review of Gastroenterology & Hepatology Pub Date : 2024-11-22 DOI:10.1080/17474124.2024.2427648

Nabeel Merali, Tarak Chouari, Su Junjun, Timothy A Rockall, Elisa Giovannetti, Nicola Annels, Adam E Frampton

引用次数: 0

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with an extremely poor prognosis. The most common complications after a pancreaticoduodenectomy (PD) include surgical site infection (SSI), postoperative pancreatic fistula (POPF), and delayed gastric emptying (DGE). The potential role and mechanisms of microbial colonization of key surgical sites resulting in perioperative complications after PD remain to be fully elucidated. In this key paper evaluation, the role of different microbiota in perioperative morbidity and mortality following PD are discussed, and key microbial signatures are identified that may shape the future management of post-operative surgical care.

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胰腺癌切除术后微生物组对发病率和死亡率的影响。

胰腺导管腺癌（PDAC）是一种侵袭性疾病，预后极差。胰十二指肠切除术（PD）后最常见的并发症包括手术部位感染（SSI）、术后胰瘘（POPF）和胃排空延迟（DGE）。关键手术部位微生物定植导致腹腔镜手术后围手术期并发症的潜在作用和机制仍有待全面阐明。在这篇关键论文评估中，讨论了不同微生物群在腹腔镜手术后围手术期发病率和死亡率中的作用，并确定了可能影响未来手术后护理管理的关键微生物特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Gastroenterology & Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

6.80

自引率

2.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The enormous health and economic burden of gastrointestinal disease worldwide warrants a sharp focus on the etiology, epidemiology, prevention, diagnosis, treatment and development of new therapies. By the end of the last century we had seen enormous advances, both in technologies to visualize disease and in curative therapies in areas such as gastric ulcer, with the advent first of the H2-antagonists and then the proton pump inhibitors - clear examples of how advances in medicine can massively benefit the patient. Nevertheless, specialists face ongoing challenges from a wide array of diseases of diverse etiology.