Expert Review of Pharmacoeconomics & Outcomes Research最新文献_第10页

The value of cycleways to improve population physical activity levels: a systematic review of economic evaluations. 自行车道对提高人口体育活动水平的价值：经济评估的系统回顾。

IF 1.5 4区医学

Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1080/14737167.2025.2542289

Luiz F Andrade, Bisola Osifowora, Emma Frew

{"title":"The value of cycleways to improve population physical activity levels: a systematic review of economic evaluations.","authors":"Luiz F Andrade, Bisola Osifowora, Emma Frew","doi":"10.1080/14737167.2025.2542289","DOIUrl":"10.1080/14737167.2025.2542289","url":null,"abstract":"Background: Active travel (AT), particularly cycling, is increasingly recognized as a public health strategy to promote physical activity and prevent non-communicable diseases (NCDs). Given the substantial investments required to build cycling infrastructure, economic evaluations are essential to inform policy and efficient funding decisions. This systematic review aims to identify and assess economic evaluations of cycleway infrastructure, with particular emphasis on the methodological approaches employed.Methods: A systematic review was conducted using databases including PubMed, EconLit, Business Source Premier, CINAHL Plus, and MEDLINE. Eligible studies focused on cycling-specific infrastructure, reported both costs and benefits, and included a comparator. Data were extracted on evaluation type, costs, benefits, perspective, and time horizon. Study quality was assessed using the Drummond checklist, and findings were synthesized narratively, following PRISMA guidelines.Results: Eight studies met the inclusion criteria, using cost-benefit analysis or cost-effectiveness analysis. Interventions ranged from single cycle tracks to complex networks. Most studies were hypothetical and relied on secondary data and modeling assumptions. All reported positive economic returns. Equity impacts were rarely considered, and substantial methodological variability was observed.Conclusion: Cycling infrastructure appears to demonstrate economic value for society. However, methodological inconsistencies and data limitations remain considerable and limit comparability and generalizability of findings.Registration: PROSPERO Protocol:(CRD420251005334).","PeriodicalId":12244,"journal":{"name":"Expert Review of Pharmacoeconomics & Outcomes Research","volume":" ","pages":"1183-1194"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TearCare system versus cyclosporine ophthalmic emulsion for the treatment of moderate-to-severe meibomian gland disease associated dry eye disease in the United States: a cost-utility analysis. 在美国，TearCare系统与环孢素眼用乳剂治疗中重度睑板腺病相关干眼病：成本效用分析

IF 1.5 4区医学

Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2025-10-01 Epub Date: 2025-07-31 DOI: 10.1080/14737167.2025.2537850

Nathan Lighthizer, Bonnie-Kim Schwertz, Thomas Chester, Roberta Longo, Phoenix Riley, Lorie Mody, Chad Patel

{"title":"TearCare system versus cyclosporine ophthalmic emulsion for the treatment of moderate-to-severe meibomian gland disease associated dry eye disease in the United States: a cost-utility analysis.","authors":"Nathan Lighthizer, Bonnie-Kim Schwertz, Thomas Chester, Roberta Longo, Phoenix Riley, Lorie Mody, Chad Patel","doi":"10.1080/14737167.2025.2537850","DOIUrl":"10.1080/14737167.2025.2537850","url":null,"abstract":"Background: Meibomian gland disease (MGD) is a leading cause of dry eye disease (DED), yet current treatments like over-the-counter and prescription drops do not address this root cause. TearCare is an FDA-cleared, in-office procedure that directly targets MGD, but its cost-effectiveness has not been previously evaluated.Research design and methods: We conducted a cost-utility analysis (CUA) comparing TearCare with topical cyclosporine 0.05% (CsA) for moderate-to-severe MGD-related DED. A U.S. payer perspective and 1-year time horizon were used. A Markov model with 3-month cycles evaluated transitions across four Ocular Surface Disease Index (OSDI)-defined health states. Transition probabilities and persistence rates were derived from the SAHARA trial and literature.Results: TearCare provided better outcomes (e.g. more patients improving to mild/no symptoms) and was less costly ($4,916 vs $5,819), with a quality-adjusted life year (QALY) gain of 0.014. This corresponds to approximately 5.1 additional days in perfect health over 1 year. The incremental cost-effectiveness ratio (ICER) showed TearCare to be dominant (more effective and less costly).Conclusions: TearCare is a cost-effective treatment for MGD-related DED, offering both clinical benefits and cost savings over CsA.","PeriodicalId":12244,"journal":{"name":"Expert Review of Pharmacoeconomics & Outcomes Research","volume":" ","pages":"1239-1247"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The economics of prevention and quality of care: policy insights from the EU's COVID-19 response. 预防经济学和护理质量：来自欧盟应对COVID-19的政策见解。

IF 1.5 4区医学

Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2025-10-01 Epub Date: 2025-08-13 DOI: 10.1080/14737167.2025.2542294

John Yfantopoulos, Athanasios Chantzaras

{"title":"The economics of prevention and quality of care: policy insights from the EU's COVID-19 response.","authors":"John Yfantopoulos, Athanasios Chantzaras","doi":"10.1080/14737167.2025.2542294","DOIUrl":"10.1080/14737167.2025.2542294","url":null,"abstract":"Introduction: Prevention and quality of care are increasingly recognized as fundamental drivers of sustainable, high-performing health systems. Both have demonstrated cost-effectiveness and long-term benefits, yet remain underfunded and fragmented across many European Union Member States. The COVID-19 pandemic offered a natural stress test, revealing significant variation in investment patterns, system responsiveness, and outcome efficiency.Areas covered: This article integrates economic theory, empirical evidence, and policy analysis to explore how prevention and quality jointly shape system value. It includes analyses of prevention expenditure trends, elasticity to GDP and health spending, and cross-country efficiency indicators across EU Member States (2019-2022). The findings draw from Eurostat data and a targeted review of economic literature on cost-effectiveness and value-based care.Expert opinion: Empirical results confirm that prevention is income- and budget-elastic, but efficiency and impact depend on institutional capacity and governance. The underuse of economic tools in quality planning and prevention prioritization hampers performance. Embedding efficiency metrics, dynamic modeling, and performance-based allocation into policy frameworks is essential to enhance value and resilience. In the coming years, prevention and quality should be better embedded in fiscal planning and system performance, not just as public health imperatives - but as economic necessities.","PeriodicalId":12244,"journal":{"name":"Expert Review of Pharmacoeconomics & Outcomes Research","volume":" ","pages":"1129-1142"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges with integrating early-stage cancer trial endpoints into economic models: review of health technology recommendations for adjuvant or neoadjuvant therapies in Canada. 将早期癌症试验终点纳入经济模型的挑战：加拿大辅助或新辅助治疗的卫生技术建议综述

IF 1.5 4区医学

Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2025-10-01 Epub Date: 2025-07-14 DOI: 10.1080/14737167.2025.2525224

Jaclyn M Beca, Stephanie Gosselin, Don Husereau, Eon Ting

{"title":"Challenges with integrating early-stage cancer trial endpoints into economic models: review of health technology recommendations for adjuvant or neoadjuvant therapies in Canada.","authors":"Jaclyn M Beca, Stephanie Gosselin, Don Husereau, Eon Ting","doi":"10.1080/14737167.2025.2525224","DOIUrl":"10.1080/14737167.2025.2525224","url":null,"abstract":"Objectives: Adjuvant and neoadjuvant therapies for early-stage cancers demonstrate early clinical benefit in delaying disease recurrence. Health technology assessments require economic evaluations modeling lifetime disease trajectories. We examined modeling approaches used in Canadian health technology reviews to understand relevant challenges and identify opportunities for methodological improvements.Methods: From CDA-AMC reimbursement recommendations for adjuvant/neo-adjuvant treatment of solid tumors, we collected outcomes and details of submitted clinical and economic evidence. We classified issues raised during economic review related to data maturity, surrogacy, treatment pathways, and assumptions surrounding extrapolation, duration of benefit and cure.Results: Reviews from Jul/2015-Mar/2023 were identified. Reimbursement was recommended in 14/18 (78%) reviews. All assessments described OS as immature. Most (9/10, 90%) reviews with interim comparative OS data recommended reimbursement, while several (3/8, 38%) without OS data were not recommended. CDA-AMC revisions changed implications for cost-effectiveness ($50,000/QALY threshold) in 10/18 (56%) reviews. Duration of benefit assumptions was inconsistent among both submitters and reviewers. Cure-time was consistently revised to ≥5 years from initiation.Conclusions: Despite surrogate endpoints and immature survival data, positive reimbursement recommendations were common. CDA-AMC re-analyses frequently had modest impacts on cost-effectiveness. Further guidance is needed to capture benefits and assess uncertainties with more consistency for early-stage cancers.","PeriodicalId":12244,"journal":{"name":"Expert Review of Pharmacoeconomics & Outcomes Research","volume":" ","pages":"1219-1229"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Qualitative research on the acceptance of evolving evidence for HTA body approval of innovative health technologies in selected European countries. 在选定的欧洲国家对卫生和技术机构批准创新卫生技术的不断演变的证据的接受程度进行定性研究。

IF 1.5 4区医学

Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2025-10-01 Epub Date: 2025-07-09 DOI: 10.1080/14737167.2025.2530622

E Reith, L Maas, A Joos, I Heikkinen, M De Iaco, M Hiligsmann

{"title":"Qualitative research on the acceptance of evolving evidence for HTA body approval of innovative health technologies in selected European countries.","authors":"E Reith, L Maas, A Joos, I Heikkinen, M De Iaco, M Hiligsmann","doi":"10.1080/14737167.2025.2530622","DOIUrl":"10.1080/14737167.2025.2530622","url":null,"abstract":"Objective: With increasing efforts of streamlining market access of innovative drugs, the current acceptance of health technology assessment (HTA) bodies on non-traditional trial designs is still unclear. The aim of this study was to assess the perspective of drug developers on the acceptance of non-traditional trial designs by HTA bodies in Europe.Methods: Eleven semi-structured interviews were conducted with experts to gain insights on their perception of non-traditional trial design acceptance by HTA bodies from the Netherlands, Germany, United Kingdom, Sweden, and France. Future perspectives on and recommendations for facilitating the acceptance of non-traditional trials were provided.Results: All experts highlighted the HTA bodies' preference for randomized controlled trials over non-traditional trial designs. The degree of acceptance varied between countries. Experts recommended multistakeholder discussions between drug developers and HTA bodies for early scientific advice and reevaluation of evidence requirements. The EU-HTA regulation was viewed as both a potential opportunity for harmonization and limiting innovative approach.Conclusion: The results of this study highlighted significant variations in the acceptance of non-traditional trial designs by HTA bodies across Europe. Actions are needed to facilitate a more progressive view on non-traditional clinical trial designs to ensure fast patient access to highly innovative treatments.","PeriodicalId":12244,"journal":{"name":"Expert Review of Pharmacoeconomics & Outcomes Research","volume":" ","pages":"1211-1218"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost effectiveness of non-pharmacological interventions for fatigue in patients with long-term conditions: a systematic literature review. 长期疲劳患者非药物干预的成本效益：系统文献综述。

IF 1.5 4区医学

Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2025-10-01 Epub Date: 2025-08-03 DOI: 10.1080/14737167.2025.2537194

Sarah Davis, Mon Mon-Yee, Anthea Sutton, Joanna Leaviss, Jessica E Forsyth, Christopher Burton

{"title":"Cost effectiveness of non-pharmacological interventions for fatigue in patients with long-term conditions: a systematic literature review.","authors":"Sarah Davis, Mon Mon-Yee, Anthea Sutton, Joanna Leaviss, Jessica E Forsyth, Christopher Burton","doi":"10.1080/14737167.2025.2537194","DOIUrl":"10.1080/14737167.2025.2537194","url":null,"abstract":"Introduction: We aimed to assess the cost-effectiveness of non-pharmacological interventions for fatigue in patients with chronic conditions in the UK.Methods: This systematic review of cost-effectiveness studies aligns with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 statement. Data sources: Electronic databases and citation searches. Inclusion criteria: Studies including adults with one or more long-term health condition, either physical or mental. Exclusion criteria: Studies associated with cancer, long-COVID, post-viral fatigue, medically unexplained conditions, developmental disorders and injuries. Assessment: A single reviewer completed a two-stage sifting process.Results: Four studies met the inclusion criteria. They included patients with either multiple sclerosis or inflammatory rheumatic conditions, and assessed either cognitive behavioral therapy (CBT) or a personalized exercise program (PEP). CBT was either dominated by usual care or had an incremental cost-effectiveness ratio (ICER) over £30,000. PEP dominated CBT, with the ICER for PEP versus usual care ranging from £13,159 to £35,424.Conclusions: The economic literature on this topic is much more limited than the clinical effectiveness literature, both in terms of interventions and populations covered. Future research should focus on a de novo economic evaluation to identify interventions with a high potential to be cost-effective across multiple conditions.Registration: PROSPERO (CRD42023440141).","PeriodicalId":12244,"journal":{"name":"Expert Review of Pharmacoeconomics & Outcomes Research","volume":" ","pages":"1159-1166"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robot-assisted medication management in home care and long-term care settings: a mixed-method systematic review. 家庭护理和长期护理环境中的机器人辅助药物管理：混合方法系统综述。

IF 1.5 4区医学

Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2025-10-01 Epub Date: 2025-07-24 DOI: 10.1080/14737167.2025.2537190

Maryam Maleki, Abbas Mardani, Edris Kakemam, Ariadna Huertas-Zurriaga, Mojtaba Vaismoradi

{"title":"Robot-assisted medication management in home care and long-term care settings: a mixed-method systematic review.","authors":"Maryam Maleki, Abbas Mardani, Edris Kakemam, Ariadna Huertas-Zurriaga, Mojtaba Vaismoradi","doi":"10.1080/14737167.2025.2537190","DOIUrl":"10.1080/14737167.2025.2537190","url":null,"abstract":"Introduction: Medication errors and non-adherence in older adults are major issues linked to polypharmacy, cognitive decline, and caregiver burden. Medication management robots offer promise in improving patient care but require thorough evaluation . This review synthesizes the experiences of patients and caregivers, assesses the effectiveness of MMR in enhancing medication safety and minimizing errors, and offers insights into its broader implications for elderly home care.Methods: A mixed-methods systematic review was conducted using PRISMA guidelines. Searches were performed across six databases - PubMed, Scopus, Web of Science, Embase, CINAHL, and ProQuest - without publication date limits. Studies were appraised using the Mixed Methods Appraisal Tool (MMAT), and findings were synthesized through a convergent approach.Results: Six studies (3 qualitative, 2 quantitative, 1 mixed-methods) from Sweden, Finland, and the U.S.A. were included. MMRs improved adherence, reduced medication errors, enhanced coordination among healthcare providers, and supported patient autonomy. Key challenges involved technical issues, such as incompatibility with liquid medications, concerns about privacy, and reluctance from users due to diminished human contact.Conclusion: MMRs show promise in elderly care, but successful adoption depends on structured training, ethical safeguards, and user-centered design. Further research is required to validate their long-term impact and optimize implementation strategies.Registration: The protocol for this review was registered with PROSPERO (registration number: CRD42024611310): https://www.crd.york.ac.uk/PROSPERO/view/CRD42024611310.","PeriodicalId":12244,"journal":{"name":"Expert Review of Pharmacoeconomics & Outcomes Research","volume":" ","pages":"1167-1182"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timely access to new drugs in a single-payer system: policy analysis from South Korea's reimbursement framework. 在单一付款人制度下及时获得新药：来自韩国报销框架的政策分析。

IF 1.5 4区医学

Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2025-09-18 DOI: 10.1080/14737167.2025.2561020

Yoo Seung-Lai

{"title":"Timely access to new drugs in a single-payer system: policy analysis from South Korea's reimbursement framework.","authors":"Yoo Seung-Lai","doi":"10.1080/14737167.2025.2561020","DOIUrl":"10.1080/14737167.2025.2561020","url":null,"abstract":"Background: Timely access to innovative medicines remains a policy challenge in single-payer systems. South Korea has introduced mechanisms such as economic evaluation exemptions and risk-sharing agreements (RSAs) to improve access while maintaining expenditure controls. However, empirical evidence on their real-world impact remains limited.Research design and methods: A retrospective observational analysis was conducted using data on 85 new drugs assessed by the Health Insurance Review and Assessment Service (HIRA) between 2022 and 2024. Publicly available HTA datasets were categorized by evaluation outcome, pricing ratios, and projected budget impact. Statistical analyses included descriptive analysis, correlation testing, and multivariable linear regression.Results: Eighty-two percent of assessed drugs were reimbursed. A full recommendation from HIRA strongly predicted listing outcomes. Drugs with moderate budget impact (1.5-10 billion Korean Won) experienced shorter timelines. International price ratios - averaging 64% of the mean level across reference countries - were the only consistent predictors across settings.Conclusion: Evaluation outcomes, assessment complexity, and budget forecasts are key determinants of reimbursement in Korea. Refinement of HTA processes and adaptive use of RSAs may enhance access efficiency while preserving budgetary sustainability.","PeriodicalId":12244,"journal":{"name":"Expert Review of Pharmacoeconomics & Outcomes Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The direct and indirect costs of osteoporosis in the Iranian population: an economic analysis from a social perspective. 伊朗人口骨质疏松症的直接和间接成本：从社会角度的经济分析。

IF 1.5 4区医学

Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2025-09-16 DOI: 10.1080/14737167.2025.2561022

Ramin Ravangard, Mohsen Izadi, Mohammad Hossein Dabbaghmanesh, Zahra Goudarzi, Mehdi Rezaee, Khosro Keshavarz

{"title":"The direct and indirect costs of osteoporosis in the Iranian population: an economic analysis from a social perspective.","authors":"Ramin Ravangard, Mohsen Izadi, Mohammad Hossein Dabbaghmanesh, Zahra Goudarzi, Mehdi Rezaee, Khosro Keshavarz","doi":"10.1080/14737167.2025.2561022","DOIUrl":"10.1080/14737167.2025.2561022","url":null,"abstract":"Background: Osteoporosis is a systemic skeletal disease and has a high prevalence in Iran. This study aimed to calculate the economic burden of osteoporosis in patients referred to the Shahid Motahari Clini in 2023.Research design and methods: This was a cost-of-illness study conducted cross-sectionally from a societal perspective in Shiraz in 2023. Overall, 252 patients were examined through a census approach. Prevalence-based and bottom-up approach were employed. Cost data were obtained using information from patient record, as well as based on the patients' self-reports. The human capital approach was used to calculate the indirect costs.Results: The annual cost of this disease per patient was $5,223 PPP. The largest share was attributed to direct medical costs (42.75%), with hospitalization costs accounting for the highest proportion of these expenses (53.93%). The shares of direct non-medical costs and indirect costs were 38.51% and 18.74%, respectively. Furthermore, the economic burden of the disease in the country for this year was estimated at $15,749,838,044 PPP.Conclusions: According to the results, osteoporosis can impose a significant economic burden on society, the patients, and their families. It is recommended to manage treatment strategies, implement preventive measures, and use better insurance coverage for osteoporosis medications to reduce the costs.","PeriodicalId":12244,"journal":{"name":"Expert Review of Pharmacoeconomics & Outcomes Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential public health impact of new immunization strategies for the prevention of RSV in children in Panama. 预防巴拿马儿童呼吸道合胞病毒的新免疫策略的潜在公共卫生影响

IF 1.5 4区医学

Expert Review of Pharmacoeconomics & Outcomes Research Pub Date : 2025-09-01 Epub Date: 2025-06-04 DOI: 10.1080/14737167.2025.2514530

Xavier Sáez-Llorens, Pieralessandro Lasalvia, Paola Jaramillo, Rodrigo DeAntonio

{"title":"The potential public health impact of new immunization strategies for the prevention of RSV in children in Panama.","authors":"Xavier Sáez-Llorens, Pieralessandro Lasalvia, Paola Jaramillo, Rodrigo DeAntonio","doi":"10.1080/14737167.2025.2514530","DOIUrl":"10.1080/14737167.2025.2514530","url":null,"abstract":"Objective: New prophylaxis to reduce the burden of respiratory syncytial virus (RSV) disease are available, including a long-acting monoclonal antibody (nirsevimab) and maternal immunization with an RSV prefusion F protein vaccine (RSVpreF). We compared the potential public health impact of these strategies when implemented in Panama from the payer perspective.Methods: A static model evaluated the use of year-round nirsevimab with/without catch-up, seasonal nirsevimab with catch-up, and RSVpreF in a birth cohort. Health, cost, quality-of-life outcomes, and the number needed to immunize (NNI) were compared to the current standard of care, followed by an indirect comparison of nirsevimab and RSVpreF.Results: Seasonal nirsevimab with catch-up would be the most effective strategy as it would prevent 62% RSV-associated lower respiratory tract disease cases compared to RSVpreF, followed by year-round nirsevimab with catch-up that would prevent 46% of cases. Each of the nirsevimab strategies would have a greater impact on all outcomes compared to RSVpreF. The NNI to prevent an RSV infection and death was lower for the nirsevimab strategies compared to RSVpreF.Conclusion: RSV immunization strategies would significantly reduce the disease burden in Panama. Nirsevimab would have a greater public health impact than RSVpreF due to its sustained efficacy and protection regardless of gestational age.","PeriodicalId":12244,"journal":{"name":"Expert Review of Pharmacoeconomics & Outcomes Research","volume":" ","pages":"1073-1086"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0