Evidence-based dentistry最新文献

{"title":"Biologic complications in short implant-assisted versus conventional partial dentures.","authors":"Nidhi Parmar","doi":"10.1038/s41432-025-01140-9","DOIUrl":"10.1038/s41432-025-01140-9","url":null,"abstract":"<p><strong>A commentary on: </strong>Benzaquen S I, Ardakani M T, Tsigarida A et al. Biologic complications with removable partial dentures assisted by short implants: A 34-month pilot randomized controlled clinical trial. J Prosthet Dent 2025; https://doi.org/10.1016/j.prosdent.2025.01.026 .</p><p><strong>Design: </strong>This single-centre, parallel-arm, pilot randomised controlled clinical trial (RCT) was conducted in accordance with CONSORT guidelines. The primary objective was to compare the incidence of biologic complications between conventional removable partial dentures (CRPDs) and short implant-assisted removable partial dentures (IARPDs) in patients with Kennedy Class I bilateral distal-extension edentulism. A secondary objective was to evaluate implant survival and peri-implant outcomes over a mean follow-up period of 34 months.</p><p><strong>Case selection: </strong>Thirty-three partially edentulous adult participants (aged 36-87 years) were recruited. Included participants had sufficient bone height to accommodate 6 mm implants without the need for bone augmentation. A strict exclusion criteria included current smoking, uncontrolled diabetes, pregnancy or lactation, and use of immunosuppressive or antiresorptive medications. Random allocation to receive either CRPDs (n = 19) or IARPDs supported by two short implants (n = 14) was conducted after initial CRPD fabrication.</p><p><strong>Data analysis: </strong>Both implant- and non-implant-related biologic complications were recorded at baseline and annual follow-up visits up to four years. Parameters included caries, gingival inflammation, abutment tooth loss, peri-implant mucositis, peri-implantitis, and marginal bone level (MBL) changes. Statistical analyses were performed using chi-square tests, Fisher's exact test and paired and unpaired t-tests, with significance set at p = 0.05.</p><p><strong>Results: </strong>Non-implant biologic complications affected 44.7% of abutment teeth in the CRPD group and 21.4% in the IARPD group; however, this difference was not statistically significant (p > 0.05). The most common complications were gingival inflammation and caries. One abutment tooth was lost in the CRPD group versus none in the IARPD group. Peri-implant mucositis and peri-implantitis were observed in 42.9% and 10.7% of implants, respectively. Implant survival was 81.2%. Most MBL occurred prior to prosthetic loading, with minimal loss thereafter.</p><p><strong>Conclusions: </strong>Both CRPDs and IARPDs are viable treatment options for patients with Kennedy Class I edentulism, with no significant difference in the incidence of biologic complications between groups.</p>","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":" ","pages":"83-84"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do clinical consequences of pulp involvement due to dental caries cause impact on quality of life of children and adolescents?","authors":"C Albert Yeung","doi":"10.1038/s41432-025-01154-3","DOIUrl":"10.1038/s41432-025-01154-3","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;A commentary on: &lt;/strong&gt;Reis P P G, Jorge R C, Marañón-Vásquez G A, Fidalgo T K D S, Maia L C, Soviero V M. Impact of clinical consequences of pulp involvement due to caries on oral health-related quality of life in children and adolescents: a systematic review and meta-analysis. Caries Res 2025; 59: 71-83.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data sources: &lt;/strong&gt;Six electronic databases (PubMed, Scopus, Web of Science, Embase, BBO/VHL and Cochrane Library) and Google Scholar were searched in August 2022. Handsearching of the reference lists in the included studies were also carried out.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study selection: &lt;/strong&gt;Observational studies that assessed children/adolescents with clinical consequences of pulp involvement due to dental caries compared with those without them and its impact on their oral health-related quality of life (OHRQoL) were included. Pulp involvement should have been clinically assessed as pulp exposure (both vital and necrotic), abscess or fistula. Two review authors independently scanned the titles and available abstracts of all the articles identified through the electronic searches. The full text of studies that appeared to meet the inclusion criteria or for which there were insufficient data in the title and abstract were obtained to make a definitive decision. A third review author was consulted in cases of disagreement. All rejected studies and reasons for excluding them were recorded in the table for the list of excluded publications.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data extraction and synthesis: &lt;/strong&gt;Data were independently extracted from the included studies by two review authors using data extraction tables. The methodological quality assessment was conducted using the JBI critical appraisal checklist for analytical cross-sectional studies. The studies were grouped according to participants' age range (preschoolers, schoolchildren and adolescents) and instruments used to measure OHRQoL. To be included in the meta-analyses, the studies should have used PUFA index. The mean differences (MD) or the standardised mean differences (SMD) were calculated for numerical outcome and odds ratio (OR) was calculated for dichotomous outcome. Robustness, heterogeneity, certainty of evidence and publication bias were assessed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;All 29 included studies were cross-sectional and the sample sizes ranged from 30 to 1794 participants. Fourteen studies assessed preschoolers, nine assessed schoolchildren, four assessed adolescents and two assessed children and adolescents. Most studies used PUFA index to assess the exposure. ECOHIS (preschoolers) and CPQ (children/adolescents) were the main tools used to assess the outcome. Only five articles fully adhered to the quality criteria. The meta-analyses revealed the following main results: (a) preschoolers: MD -10.79 (95% CI -16.50 to -5.09); (b) schoolchildren: MD -5.12 (95% CI -7.51 to -2.72); (c) adolescents: MD -1.86 (95% CI -4.59 to 0.87); (d) overall impact: SMD -2.18 ","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":" ","pages":"95-96"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of different adhesive systems in bonding direct resin composite restorations: a systematic review and meta-analysis.","authors":"Ravinder S Saini, Rajesh Vyas, Sunil Kumar Vaddamanu, Syed Altafuddin Quadri, Seyed Ali Mosaddad, Artak Heboyan","doi":"10.1038/s41432-024-01095-3","DOIUrl":"10.1038/s41432-024-01095-3","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to identify and evaluate scholarly research on the efficacy, durability, and long-term stability of various adhesive systems used for bonding direct resin composite restorations and to identify factors influencing bonding performance, such as adhesive composition, application protocol, substrate type, and etching technique.</p><p><strong>Materials and methods: </strong>An all-inclusive electronic database search for peer-reviewed scholarly journal articles was conducted using PubMed, ScienceDirect, Google Scholar, Dimensions, and the Cochrane Library for research articles investigating the effectiveness of different adhesive systems in direct resin composite restorations, excluding reviews, meta-analyses, opinion pieces, and case reports. The risk of bias was assessed using the Cochrane tool (Robvis 2.0). Data were extracted and thematically analyzed, and quantitative data were statistically analyzed using Review Manager software. Dichotomous data were evaluated using the Mantel-Haenszel method, applying a random effects model and 95% confidence interval.</p><p><strong>Results: </strong>The database search yielded 1632 potential articles, of which 14 were included in this study. Several adhesive systems exhibit excellent tensile bond strength. In addition, the type of resin composite, adhesive system, and artificial aging significantly influenced the bonding performance of resin composite restorations. However, the failure rates were low in the different adhesive systems, showing comparable results between the two-step etch-and-rinse and one-step self-etch adhesive systems (p = 0.71). The results showed an overall trend of high bonding effectiveness with a low incidence of adverse events, such as postoperative sensitivity, adhesive failure, and fractures.</p><p><strong>Conclusion: </strong>The study results emphasize the importance of selecting appropriate adhesive systems based on clinical case requirements, restoration characteristics, and patient factors to enhance bonding efficacy, durability, and long-term stability.</p>","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":" ","pages":"115"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between restoration of missing teeth with dentures and cognitive function.","authors":"Lata Goyal, Komal Kaur Saroya, Shipra Gupta, Shubham Sareen","doi":"10.1038/s41432-025-01150-7","DOIUrl":"10.1038/s41432-025-01150-7","url":null,"abstract":"<p><strong>A commentary on: </strong>Ma X, Zhang Y, Wang J et al. Association between denture restoration for tooth loss and cognitive impairment: a systematic review and meta-analysis. J Prosthodont Res 2025; https://doi.org/10.2186/jpr.JPR_D_24_00060 .</p><p><strong>Data sources: </strong>A search was conducted across five electronic databases, including PubMed, EMBASE, Cochrane Library, MEDLINE, and CNKI, from January 2000 to January 2024. The search strategy included keywords related to tooth loss, dentures, cognitive function, memory loss and dementia. Reference lists of relevant studies were also screened to identify additional articles. The search was limited to the English language only.</p><p><strong>Study selection: </strong>Observational studies examining the association between denture restoration and cognitive impairment were included. Eligible studies had to report cognitive impairment or dementia as the outcome and denture restoration as the exposure factor. Six studies with a total of 24,252 participants met the inclusion criteria.</p><p><strong>Data extraction and synthesis: </strong>Two independent reviewers extracted relevant data, including study design, participant characteristics, dental status, cognitive assessment methods, and statistical results. Meta-analysis was conducted using risk ratios (RR) with 95% confidence intervals (CI), applying a random-effects model due to clinical and methodological variations. Newcastle-Ottawa Scale and the Agency for Healthcare research and quality scale were used for quality assessment of included studies. Beg- Mazumdar and Egger regression tests were used to assess the publication bias.</p><p><strong>Results: </strong>The meta-analysis revealed that participants with tooth loss without dentures had a 1.27-fold higher odds of having cognitive impairment, whereas those with dentures had only a 1.02-fold odds. A dose-response analysis showed that each additional missing tooth increased the cognitive impairment risk by 1.009 times in the non-denture group, while the denture group exhibited a lower risk increase of 1.003 times. Heterogeneity was influenced by follow-up duration and cognitive assessment tools. There was significant evidence of publication bias in non denture group as compared to the denture restoration group which showed nonsignificant evidence of publication bias.</p><p><strong>Conclusions: </strong>This study suggests denture restoration is associated with a reduced risk of cognitive impairment in individuals with tooth loss. The findings highlight the potential protective role of timely denture rehabilitation in mitigating cognitive decline. Future research should focus on longitudinal and interventional studies to establish causality.</p>","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":" ","pages":"85-86"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should clinicians recommend oscillating-rotating toothbrushes over sonic models for superior plaque and gingivitis control?","authors":"A Selva Arockiam, P Nithya Nandhini, Praveen Chandrashekaraiah, Reshma Benzigar, Ramya Shivananjan","doi":"10.1038/s41432-025-01143-6","DOIUrl":"10.1038/s41432-025-01143-6","url":null,"abstract":"<p><strong>A commentary on: </strong>Adam R, Grender J, Timm H, Qaqish J, Goyal C R. A randomized controlled trial evaluating a novel oscillating-rotating electric toothbrush versus a sonic toothbrush for plaque and gingivitis. Am J Dent 2025; 38: 3-8.</p><p><strong>Data sources: </strong>The study was a rigorously designed, single-center, examiner-blinded, randomized controlled trial. It included adult participants presenting with clinical signs of gingivitis and visible plaque. Subjects were randomly assigned to use either an oscillating-rotating electric toothbrush or a high-end sonic electric toothbrush. Both groups brushed twice daily for four weeks using a standard sodium fluoride toothpaste. Gingival inflammation was evaluated using the Modified Gingival Index and the Gingival Bleeding Index. Plaque accumulation was assessed via the Rustogi Modification of the Navy Plaque Index. Data were collected at baseline, immediately after a single brushing session and after four weeks of consistent use.</p><p><strong>Study selection: </strong>Participants were adults diagnosed with plaque-induced gingivitis. They were randomized into two arms: one group used the Oral-B iO2 toothbrush with the Ultimate Clean brush head in Daily Clean mode while the other group used the usmile Marble-Art toothbrush with the Advanced Whitening brush head in high-intensity clean mode. All participants followed a standardized brushing regimen. Examiner blinding was implemented to reduce observational bias and enhance objectivity.</p><p><strong>Data extraction and synthesis: </strong>Gingival inflammation and plaque levels were assessed at three distinct intervals. The percentage of participants achieving gingival health defined as fewer than ten percent of bleeding sites was also measured. Comparisons were performed within and between groups. The threshold for statistical significance was set at a probability value less than 0.05.</p><p><strong>Results: </strong>Both devices led to statistically significant reductions in plaque accumulation and gingival inflammation. However, the oscillating-rotating toothbrush demonstrated superior performance across all parameters. Participants using this toothbrush exhibited a significantly greater reduction in Modified Gingival Index scores and a marked decrease in the number of bleeding sites. A higher proportion of users in this group attained gingival health status. Plaque removal was more effective following a single brushing session with notable improvements observed throughout the entire mouth, interproximal surfaces and along the gingival margins. These benefits were maintained at the four-week follow-up.</p><p><strong>Conclusion: </strong>The oscillating-rotating toothbrush achieved superior clinical outcomes in the reduction of plaque and gingival inflammation when compared to the sonic toothbrush. Its efficacy was observed both immediately and after consistent use over a four-week period.</p>","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":" ","pages":"99-100"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition and oral health-related quality of life (OHRQoL) in older adults: a systematic review and meta-analysis.","authors":"Neha Chauhan, Sarah Paul, Bharathi M Purohit, Ritu Duggal, Harsh Priya, Sasidharan S","doi":"10.1038/s41432-024-01088-2","DOIUrl":"10.1038/s41432-024-01088-2","url":null,"abstract":"<p><strong>Background: </strong>Understanding the interplay between nutrition and oral health-related quality of life (OHRQoL) in older adults is crucial amidst the global aging population. This systematic review and meta-analysis aimed to explore this association, recognizing the growing prevalence of older individuals and the imperative of addressing their health needs for enhanced well-being.</p><p><strong>Materials and methodology: </strong>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, relevant studies were identified through electronic database searches and manual screening. Included were studies investigating the relationship between nutritional status, assessed via the Geriatric Oral Health Assessment Index (GOHAI), and OHRQoL in individuals aged 60 years and older. Quality assessment adhered to Joanna Briggs Institute (JBI) criteria, and statistical analysis was conducted using Comprehensive Meta-Analysis Software Version 3.</p><p><strong>Results: </strong>Out of 566 initial records, 14 full-text articles were assessed, with 4 studies meeting the inclusion criteria for meta-analysis. A consistent association emerged between lower nutritional assessment scores and poor OHRQoL among the older adults. Significant relationships were identified between poor oral health indicators, as measured by GOHAI, and an elevated risk of malnutrition. Particularly noteworthy was the role of negative self-perception of oral health as a significant predictor of nutritional deficits, emphasizing the importance of OHRQoL instruments in complementing clinical measurements.</p><p><strong>Discussion: </strong>The findings underscore the predictive capacity of oral health indicators in assessing nutritional well-being in older individuals. Despite previous studies reporting mixed findings, this review contributes to a comprehensive understanding of the association between nutrition and OHRQoL, highlighting the significance of addressing oral health concerns to enhance overall nutritional outcomes in the older adult population.</p><p><strong>Conclusion: </strong>This systematic review and meta-analysis emphasize the significant association between nutrition and OHRQoL among older adults. Highlighting the importance OHRQoL instruments that can complement objective clinical measurements and serve as predictors of malnutrition, particularly among this population. Offering vital insights for stakeholders, policymakers, and public health officials to promote the overall well-being and quality of life of older adults.</p>","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":" ","pages":"109"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is smoking cessation the key to better oral health outcomes for type 2 diabetic patients with periodontal disease?","authors":"Chris Grumley","doi":"10.1038/s41432-025-01161-4","DOIUrl":"10.1038/s41432-025-01161-4","url":null,"abstract":"<p><strong>A commentary on: </strong>La Rosa G R M, Pedulla E, Chapple I et al. A systematic review of oral health outcomes following smoking cessation in type 2 diabetes: clinical and research implications. J Dent 2025; https://doi.org/10.1016/j.jdent.2025.105665 .</p><p><strong>Objective: </strong>This systematic review investigated the impact of smoking cessation in patients with type 2 diabetes.</p><p><strong>Methodology: </strong>The review utilised multiple online academic publication search engines and highly cited journals to compile articles for review in accordance with PRISMA guidelines. A combination of human clinical studies, ranging from randomised control trials to cross-sectional studies involving type 2 diabetic patients with a current or past history of smoking, was employed. These studies were analysed to evaluate oral health outcomes related to periodontal disease and caries.</p><p><strong>Results: </strong>Four of the 549 studies analysed met the inclusion criteria (n = 926 participants). Two were cross-sectional analyses of cohort studies, another was a cohort study, and the last was a report. Each assessed a person's smoking status and its effects on the progression of periodontal disease and response to treatment in the type 2 diabetes subgroup. Overall, smoking cessation does not appear to improve the outcomes of periodontal disease or treatment for type 2 diabetics, but the area lacks robust research to draw any significant conclusions.</p><p><strong>Conclusion: </strong>Evidence that smoking cessation improves the outcomes of periodontal treatment in type 2 diabetics remains inconclusive. Smoking cessation is an important method of preventing health problems in the general population, but its effects related to diabetes are still unknown, and more research is necessary.</p>","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":" ","pages":"93-94"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using flavour in your favour: does giving children an element of control help them engage more positively with the dental experience?","authors":"Beth Cunningham, John Linden","doi":"10.1038/s41432-025-01162-3","DOIUrl":"10.1038/s41432-025-01162-3","url":null,"abstract":"<p><strong>A commentary on: </strong>Karim R, Splieth C H, Schmoeckel J. Effect of choice of flavour of fluoride varnish on behaviour in dental visits in schoolchildren. Clin Exp Dent Res. 2025; https://doi.org/10.1002/cre2.70069 .</p><p><strong>Aim: </strong>To assess the efficacy of giving children choice within the dental surgery to improve behaviour outcomes, investigated by letting them choose the flavour of fluoride varnish (FV). This single-blinded, randomised control trial recruited children attending the specialised paediatric dental service within the Greifswald University Hospital for a dental check-up and preventative FV application. Upon attendance, children were randomly assigned to one of two groups: the control group, where the flavour of FV was predetermined, or the test group, where the children selected their preferred flavour. A blinded observer used Frankl behaviour rating scale (FBRS) to assess behaviour during the appointment, and taste acceptance was assessed using the Facial image scale (FIS).</p><p><strong>Case selection: </strong>70 participants were recruited at the time of their appointment. These were healthy (ASA I or ASA II) German children aged 5 to 10. Exclusion criteria included their first dental experience, experiencing dental pain or an allergy to FV. 35 children were randomly allocated to both groups.</p><p><strong>Results: </strong>Most children, regardless of their allocation, were assessed as positive, or definitely positive according to FBRS (n = 58, 82.8%), though results on behaviour outcomes were statistically insignificant (p = 0.376). There were no significant differences between the control group or the test group on flavour ratings of the FV, with most children (n = 53, 75.7%) scoring happy, or very happy according to FIS. History of negative dental behaviour was also taken into consideration (n = 27), and whilst it appeared children with history of negative experience displayed more positive behaviour in the test group vs the control group (75% vs 54.5%), results were not statistically significant (p = 0.244).</p><p><strong>Conclusion: </strong>This study shows that allowing children a sense of control by permitting them to choose their flavour of FV may be a useful behaviour management tool, though the results are not statistically significant.</p>","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":" ","pages":"97-98"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ozone therapy as a complementary approach in periodontal therapeutics.","authors":"Shubham Sareen, Shipra Gupta, Lata Goyal","doi":"10.1038/s41432-025-01151-6","DOIUrl":"10.1038/s41432-025-01151-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;A commentary on: &lt;/strong&gt;Liu J, Huang Y, Huang J, Yang W, Tao R. Effects of ozone therapy as an adjuvant in the treatment of periodontitis: a systematic review and meta-analysis. BMC Oral Health 2025; 25: 335.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data sources: &lt;/strong&gt;The authors conducted a systematic search across: 1. PubMed (MEDLINE); 2. Embase; 3. Cochrane Central Register of Controlled Trials (CENTRAL). Key question Does adjunctive ozone therapy improve periodontal clinical parameters (probing depth, gingival inflammation, bleeding, plaque levels, and attachment loss) in patients with chronic periodontitis compared to conventional scaling and root planing (SRP) alone? The study follows the PICO framework: 1.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Population: &lt;/strong&gt;Patients with chronic periodontitis; 2.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Intervention: &lt;/strong&gt;SRP + ozone therapy (ozonated water or gaseous ozone); 3. Comparison: SRP + placebo (e.g., saline, distilled water) or no adjunct; 4.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Probing depth (PD), gingival index (GI), bleeding on probing (BOP), plaque index (PI), and clinical attachment level (CAL).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Search strategy: &lt;/strong&gt;Combined Medical Subject Headings (MeSH) terms and free-text keywords related to ozone (\"Ozone,\" \"Ozonated water,\" \"Gaseous ozone\") and periodontitis (\"Chronic periodontitis,\" \"Periodontal therapy\").&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study selection: &lt;/strong&gt;Inclusion criteria: Study Design: 1. Only randomized controlled trials (RCTs); 2.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Participants: &lt;/strong&gt;Adults with chronic periodontitis (no systemic diseases or pregnancy). 3.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Intervention: &lt;/strong&gt;SRP + ozone therapy (either ozonated water irrigation or gaseous ozone insufflation). 4.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Control: &lt;/strong&gt;SRP + placebo (e.g., saline, distilled water) or no adjunct. 5.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;At least one of the following-PD, GI, BOP, PI, or CAL.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exclusion criteria: &lt;/strong&gt;1. Animal/in vitro studies; 2. Studies involving antibiotics, lasers, or other adjuncts; 3. Incomplete data or non-RCT designs. Screening process: 1. Initial Search: 99 records identified; 2. After Duplicate Removal: 62 studies screened; 3. Full-Text Review: 22 articles assessed, 13 met inclusion criteria. Final included studies: 1. 8 used ozonated water (concentration range: 2-85 μg/mL); 2. 5 used gaseous ozone (varying exposure times); 3. Follow-up periods: 4 weeks to 3 months.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Data extraction and synthesis: &lt;/strong&gt;Data collection: 1. Two independent reviewers extracted data to minimize bias; 2. Extracted variables: study design, sample size, ozone concentration, application method, follow-up duration, and clinical outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Statistical analysis: &lt;/strong&gt;1. Primary effect measure: weighted mean difference (WMD) with 95% confidence intervals (CI). 2. Heterogeneity assessed via I&lt;sup&gt;2&lt;/sup&gt; statistic: (a) For Low (0-50%): Fixed-effects model was used. (b) For High (&gt;50%): Random-effects model was applied. 3. Se","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":" ","pages":"91-92"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond statistical significance: when statistically significant post operative endodontic procedures might reduce pain affecting a minority of patients seen clinically.","authors":"Larry Z Lockerman","doi":"10.1038/s41432-025-01158-z","DOIUrl":"10.1038/s41432-025-01158-z","url":null,"abstract":"<p><strong>A commentary on: </strong>Fatima S, Taneja S, Aggarwal V, Dheer A, Taneja P. Effect of cryotherapy, laser therapy and intraligamentary dexamethasone injection on post-treatment pain after single visit RCT-A double-blinded, randomized placebo-controlled trial. J Oral Biol Craniofac Res. 2025; https://doi.org/10.1016/j.jobcr.2025.01.005 .</p><p><strong>Design: </strong>Patients were allocated to 4 groups or 25 subjects, Group-1: placebo, Group-2: Intraligamentary injection of dexamethasone, Group-3: cryotherapy (saline at a temperature of 2.5 °C was used as an irrigant in the canals prior to obturation), Group-4: cold laser therapy. Patients were instructed to record postoperative pain intensity and intake of analgesics after 6, 12, 24, 48, and 72 h.</p><p><strong>Data source: </strong>Researchgate.net, Google Scholar, pmc.ncbi.nlm.nih.gov STUDY SELECTION: Individuals diagnosed with molar necrotic pulps and symptomatic apical periodontitis.</p><p><strong>Inclusion criteria: </strong>Systemically healthy patients, aged 18-65 years, diagnosed with symptomatic apical periodontitis in a mandibular molar requiring a primary endodontic procedure, with a preoperative VAS score of ≥7.3.2.</p><p><strong>Exclusion criteria: </strong>Included patients with a history of allergy to any of the experimental drugs or local anesthetic solutions, patients who were medically compromised, and patients who had taken steroids, antibiotics, or analgesics within the previous 24 h.</p><p><strong>Results: </strong>The study reported that patients in the placebo group exhibited statistically significantly higher intensity. Group 3 (cryotherapy) showed less pain at all time intervals.</p><p><strong>Study conclusions: </strong>The study reported that the adjuvant pain management therapies reduced the intensity of postoperative pain and the frequency of analgesic intake.</p>","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":" ","pages":"107-108"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}