Evidence-based dentistry最新文献

{"title":"Can systemic resveratrol improve periodontal treatment outcomes in smokers?","authors":"Malik Alkabazi","doi":"10.1038/s41432-026-01232-0","DOIUrl":"10.1038/s41432-026-01232-0","url":null,"abstract":"Lucchesi, VH, Giorgetti, APO, Corrêa, MG. et al. Impact of systemic resveratrol on non-surgical periodontal treatment of smokers: A 12-month randomized clinical trial. Clin Oral Invest 2025;29:428. https://doi.org/10.1007/s00784-025-06517-9 This double-blind, placebo-controlled randomized clinical trial evaluated whether systemic resveratrol (500 mg/day for 180 days) improves outcomes of non-surgical periodontal therapy in smokers with Stage III or IV, Grade C periodontitis. Thirty-eight adult smokers were recruited from a university periodontal clinic and randomly assigned to receive full-mouth ultrasonic debridement combined with either systemic resveratrol or placebo (n = 19 per group). Eligible participants had at least 20 teeth, smoked a minimum of 10 cigarettes daily for at least five years, and presented with multiple periodontal sites exhibiting probing depth (PD) and clinical attachment loss ≥5 mm; patients with recent periodontal therapy, systemic diseases, pregnancy, or recent use of antibiotics or anti-inflammatory medications were excluded. Clinical parameters, including PD, clinical attachment level (CAL), position of gingival margin (PGM), full-mouth plaque score (FMPS), and full-mouth bleeding score (FMBS), were assessed at baseline and at 3-, 6-, and 12-month follow-up, alongside microbiological and immunoinflammatory markers. The primary outcome was CAL, while secondary outcomes included PD, PGM, FMPS, subgingival microbiological profiles, and inflammatory cytokine concentrations. Data distribution was assessed using exploratory and normality testing, with appropriate transformations applied where necessary. Repeated clinical measures were analyzed using restricted maximum likelihood models and generalized estimating equations, while microbiological and immunological outcomes were compared using non-parametric tests. Missing data were addressed using multiple imputation, and statistical significance was set at p < 0.05. Compared with placebo, the resveratrol group demonstrated significantly lower PD and improved CAL throughout follow-up. At 12 months, PD was 2.80 mm in the resveratrol group versus 3.02 mm in controls, while CAL was 3.87 mm versus 4.39 mm, respectively. Resveratrol was also associated with lower levels of Aggregatibacter actinomycetemcomitans, reduced IL-1β at 3 months, and reduced IL-6 at 3 and 12 months. Both groups showed substantial improvements following therapy, and no major adverse effects were reported. Systemic resveratrol may improve clinical, microbiological, and inflammatory outcomes when used as an adjunct to non-surgical periodontal therapy in smokers with Stage III or IV, Grade C periodontitis.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"27 3","pages":"58-60"},"PeriodicalIF":2.9,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is tooth loss associated with subsequent cognitive decline and dementia in ageing populations?","authors":"C. Albert Yeung","doi":"10.1038/s41432-026-01231-1","DOIUrl":"10.1038/s41432-026-01231-1","url":null,"abstract":"Chen H, Ji L, Wang Y, Klineberg I, Chen H. Dentition-Cognition Relationship in Aging Populations: A Meta-Analysis of Longitudinal Data. J Oral Rehabil 2026; 53: 924–38. Systematic review and meta-analysis of longitudinal observational studies. Longitudinal cohort and case-control studies assessing dentition status (tooth loss or edentulism) and cognitive outcomes (dementia or mild cognitive impairment [MCI]) were included. Twenty-one studies with approximately 35.7 million participants and a mean follow-up of 8.9 years were analysed. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random- or fixed-effects models depending on heterogeneity. Study quality was assessed using the Newcastle-Ottawa Scale. Tooth loss was associated with an increased risk of both dementia (OR 1.26, 95% CI 1.07–1.49) and MCI (OR 1.40, 95% CI 1.14–1.71), with stronger associations observed in individuals with edentulism, particularly for MCI (OR 1.90, 95% CI 1.07–3.35) and to a lesser extent dementia (OR 1.16, 95% CI 1.09–1.23). Findings also suggested a dose-response relationship, whereby increasing severity of tooth loss corresponded to greater cognitive risk. Subgroup analyses indicated higher risks in women and Western populations. Limited evidence also suggested that denture use attenuated this association, showing no significant increased dementia risk among denture wearers (OR 1.03, 95% CI 0.82–1.28). Tooth loss is associated with an increased risk of cognitive decline and dementia, with more severe tooth loss conferring greater risk. Prosthodontic rehabilitation may mitigate this association, suggesting a potential role for oral health in supporting cognitive ageing.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"27 3","pages":"54-55"},"PeriodicalIF":2.9,"publicationDate":"2026-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148294106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do sleep bruxism patients experience higher complication or failure rates with monolithic lithium disilicate or zirconia molar crowns?","authors":"Afrida Khalid, Thikriat Al-Jewair","doi":"10.1038/s41432-026-01230-2","DOIUrl":"10.1038/s41432-026-01230-2","url":null,"abstract":"Bomicke W, Schmitter M, Waldecker M, et al. Ceramic crowns and sleep bruxism: 3-year results of a randomized controlled trial. J Dent 2026;170:106691. https://doi.org/10.1016/j.jdent.2026.106691 . Prospective randomized controlled clinical trial with a 3-year follow-up evaluating the influence of Sleep Bruxism (SB) on the clinical performance of monolithic ceramic molar crowns. A total of 109 patients requiring a single molar crown were enrolled. SB diagnosis included a structured questionnaire, clinical examination, and portable electromyography device (BruxOFF). Participants were allocated into four groups: lithium disilicate with SB, lithium disilicate without SB, zirconia with SB, and zirconia without SB. Standardized crown preparation, fabrication, and cementation protocols were used. Outcomes assessed were technical complications, survival, and success rates. The study time points were 1 week, 6 months, and 1, 2, and 3 years. Survival was defined as restoration remaining in situ without replacement. Success is defined as restoration without biological or technical complications. Fisher’s exact test was used to compare outcomes between SB and non-SB groups, with statistical significance set at $$alpha $$ = 0.05. No technical complications occurred during the 3-year observation period. Survival rates remained high across all groups (95.2–100%), while success rates ranged from 81.5% to 95.8% for both ceramic materials. No statistically significant differences were observed between SB and non-SB patients or between lithium disilicate and zirconia crowns. Monolithic lithium disilicate and zirconia molar crowns demonstrated favorable clinical performance over three years, and SB was not associated with increased failure or complication risk.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"27 3","pages":"56-57"},"PeriodicalIF":2.9,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41432-026-01230-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148294094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Spin” in randomized controlled trials of digital implant surgery: a meta-epidemiologic study","authors":"Ming Yang, Liandi Cheng, Tiqian Liu, Tianqi Wang, Shiwen Zhang, Xin Xiong","doi":"10.1038/s41432-026-01229-9","DOIUrl":"10.1038/s41432-026-01229-9","url":null,"abstract":"“Spin” refers to the manipulation of language to suggest benefits when none exist, commonly observed in randomized controlled trials (RCTs). This study investigates the extent, strategies, and reporting quality of spin in digital dental implant RCT abstracts, and explores study characteristics associated with spin. RCTs related to digital dental implants were retrieved from PubMed, Web of Science, Embase, Scopus, and the Cochrane Library. Spin was identified using predefined strategies, and logistic regression was performed to assess factors associated with its occurrence. Reporting quality was evaluated with the original 16-item CONSORT checklist for abstracts. We analyzed 19,795 articles, and a total of 127 abstracts were finally included in the reporting quality analyses, with spin identified in 51 abstracts (40.2%), where 24 abstracts (18.9%) exhibited spin in both “Results and conclusions” sections. A significantly lower presence of spin was observed in studies reporting exact p-values (OR: 0.317; 95% CI: 0.134–0.727; p = 0.007) and shorter abstract word limits for journal submission (moderate: OR = 0.185, p = 0.01; low: OR = 0.138, p = 0.02). The prevalence of spin in digital implant surgery RCTs is concerning. Given that busy clinicians often rely solely on abstracts for clinical interpretation, such distorted reporting may mislead practitioners into adopting expensive or complex digital technologies without robust evidence of superiority. It is essential for all stakeholders to prioritize transparent reporting to prevent biased clinical decision-making and safeguard the integrity of evidence-based dentistry.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"27 3","pages":"84-84"},"PeriodicalIF":2.9,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maxillary implant-retained overdentures: telescopic versus LOCATOR attachments","authors":"Nidhi Parmar","doi":"10.1038/s41432-026-01228-w","DOIUrl":"10.1038/s41432-026-01228-w","url":null,"abstract":"Ibrahim WI, Abdeen RM, Denewar MM, Kortam SA. Retention of telescopic versus LOCATOR attachments and marginal bone loss surrounding implant-retained maxillary overdentures: A 2-year randomized clinical trial. J Prosthet Dent. 2026;135:778–786. Prospective two-arm parallel randomised controlled trial (RCT) comparing telescopic and LOCATOR attachments for four-implant retained maxillary overdentures over 24 months. 40 patients with complete edentulism received four maxillary implants to retain a maxillary overdenture and two mandibular implants to retain an opposing mandibular overdenture. Patients were randomly allocated to telescopic or LOCATOR maxillary attachment groups. Inclusion criteria included adequate maxillary bone volume and quality, suitable inter-arch space, acceptable systemic health and absence of parafunctional habits or conditions affecting osseointegration. Retention was measured using a digital force gauge at R0, one month after prosthesis delivery, and at 12 and 24 months. Vertical and horizontal marginal bone loss were assessed using standardised periapical radiographs and digital software. Between- and within-group comparisons were performed using t tests with Bonferroni correction. Telescopic attachments showed significantly greater retention than LOCATOR attachments at all time points. Telescopic retention decreased from 28.59 N to 15.63 N over 24 months, while LOCATOR retention increased slightly at 12 months before decreasing to 9.44 N. Marginal bone loss was significantly greater in the telescopic group at 12 and 24 months. One implant failed in the telescopic group. Telescopic attachments provided greater retention, whereas LOCATOR attachments were associated with less marginal bone loss. Both systems remained within accepted implant success thresholds over two years.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"27 3","pages":"51-53"},"PeriodicalIF":2.9,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41432-026-01228-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI in peer review: the elephant in the editorial room","authors":"Giusy Rita Maria La Rosa, Mona Nasser","doi":"10.1038/s41432-026-01227-x","DOIUrl":"10.1038/s41432-026-01227-x","url":null,"abstract":"","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"27 2","pages":"23-24"},"PeriodicalIF":2.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41432-026-01227-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of medication-related osteonecrosis of the jaws (MRONJ) in osteoporotic patients treated with antiresorptive drug therapy and dental implants","authors":"Gunjan Pruthi","doi":"10.1038/s41432-026-01225-z","DOIUrl":"10.1038/s41432-026-01225-z","url":null,"abstract":"Pereira Santos RM, Ottaviani G, Di Lenarda R, Biasotto M, Rupel K. MRONJ Risk Related to Dental Implants in Osteoporosis Treated with Denosumab: A Systematic Review. Oral Dis. 2026 Jan 8. https://doi.org/10.1111/odi.70181 . A literature search using a combination of MeSH terms and specific keywords like osteoporosis, dental implants, jaws, osteoradionecrosis, MRONJ, Denosumab, and Bisphosphonates was conducted using Boolean operators in PubMed and Scopus, until October 2025, following PRISMA guidelines and a predefined PICO framework. Randomized clinical trials, retrospective studies, and case series (reporting a minimum of 4 patients) were included according to the following research question: “What will be the impact of dental implant in osteoporotic patients undergoing treatment with DEN on MRONJ development, considering both implant surgery-triggered osteonecrosis (ISTO) and implant presence-triggered osteonecrosis (IPTO). Only human studies published in English and evaluating osteoporotic patients treated with antiresorptive therapy (ART), including Bisphosphonates (BP’s) and/ or Denosumab (DEN), and dental implants were considered eligible. Relevant data, such as type of ART, dose and duration of therapy, timing of implant placement to differentiate between implant surgery-triggered osteonecrosis (ISTO) and implant presence-triggered osteonecrosis (IPTO), and stage of MRONJ, were extracted independently by two reviewers. The quality assessment of included studies was reported using appropriate tools according to the study design. Ten studies met the inclusion criteria, comprising one randomized controlled trial, two retrospective studies, one case–control study, and six case series, involving a total of 1823 implants placed in 8220 patients. Most patients were postmenopausal females (mean age = 71.45 years). Four studies reported implants placed prior to initiation of ART, whereas three studies analysed the implants positioned after therapy initiation. Implants were identified as a trigger for MRONJ in 8 studies, with 24 implants associated with MRONJ. Patients developed MRONJ after receiving several doses of DEN (two to nine); however, data related to dose and duration of monotherapy or after transitioning from BP’s were inconclusive. The risk of bias ranged from moderate to high. Large variations in the study design, dose, and duration of ART, type of therapy (DEN alone or following transition from BP’s), and follow-up periods produced highly heterogeneous data, restricting comparability. Current evidence suggests that MRONJ related to dental implants in osteoporotic patients treated with DEN is uncommon but clinically relevant, particularly in patients with prior bisphosphonate exposure or peri-implant inflammation. Most of the studies reported MRONJ associated with implants already in position, followed by antiresorptive therapy (IPTO). However, the results should be interpreted with caution, as there is a lack of homogeneous evidence r","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"27 3","pages":"46-48"},"PeriodicalIF":2.9,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147987069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering the hidden mutational landscape of the oral epithelium","authors":"Manas Dave","doi":"10.1038/s41432-026-01224-0","DOIUrl":"10.1038/s41432-026-01224-0","url":null,"abstract":"Lawson ARJ, et al. Somatic mutation and selection at the population scale. Nature. 2025;647(8089):411–420. https://doi.org/10.1038/s41586-025-09584-w . A cross-sectional observational cohort study using advanced genomic sequencing to map somatic mutations and clonal selection in normal human tissues at the population level1. The authors used targeted NanoSeq, a duplex sequencing method achieving exceptionally low error rates (fewer than five errors per billion base pairs). The technique was applied to targeted capture of a 239-gene panel (0.9 Mb) in 1042 non-invasive buccal swab samples (median donor age 68 years, 79% female, 37% smokers) and 371 blood samples from the TwinsUK registry. Mutation calling required strict duplex consensus filters. Gene-level selection was quantified using dNdScv, while site-level dN/dS analyses were used to identify recurrent hotspots and selected sites. Mutational signatures were deconvolved with sigfit, and multivariate mixed-effects regression modelled associations with age, smoking (pack-years), alcohol (drink-years), missing teeth, and other covariates. In the oral epithelium, single nucleotide variants (SNVs) accumulated at 18.0 per cell per year and indels (insertions or deletions in the genome) at 2.0 per cell per year. Across all 1,042 participants, the authors detected 341,682 somatic mutations, including approximately 62,000 estimated driver mutations across 46 positively selected genes (e.g., NOTCH1 mutant cells reaching approximately 10% by ages 65–85 years, TP53 ~ 3%). Nine genes showed negative selection. Two dominant mutational signatures emerged: a clock-like signature A (resembling SBS1 and SBS5) and an alcohol associated signature B (resembling SBS16). The authors reported that smoking and alcohol were associated with higher mutation burdens, and that some effects on clonal selection were inferred from regression analyses; missing teeth (a marker of poor oral health) were independently associated with higher overall driver density. Driver frequencies for NOTCH1 were similar in normal epithelium and head and neck squamous cell carcinoma (HNSCC), whereas TP53 was enriched in cancer. The authors concluded that optimised NanoSeq enables population-scale mutational epidemiology in polyclonal tissues, revealing an extraordinarily rich landscape of positive and negative selection in normal oral epithelium. Environmental exposures shape mutagenesis and may also influence clonal selection, supporting a plausible mechanistic link between smoking, alcohol, and oral cancer risk.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"27 3","pages":"49-50"},"PeriodicalIF":2.9,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41432-026-01224-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147987009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the scope and applications of digital twin technologies in dentistry: a scoping review","authors":"Isha Duggal, Tulika Tripathi, Vandana Gupta","doi":"10.1038/s41432-026-01204-4","DOIUrl":"10.1038/s41432-026-01204-4","url":null,"abstract":"Digital Twin (DT) technology creates a dynamic virtual representation of a physical system using real-time data and computational modeling. While DTs have demonstrated profound impact in several medical disciplines, their translation into dentistry is still emerging and has not been comprehensively mapped. To systematically review and delineate the current applications, technological advancements, and prospective opportunities of digital twin (DT) technology in dentistry. A scoping review was conducted following the Joanna Briggs Institute (JBI) methodology and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. A systematic search of MEDLINE (PubMed), EMBASE, Scopus, and Web of Science identified English-language publications from January 2000 to April 2025. All empirical and conceptual studies describing DT development, validation, and/or application in dental contexts were eligible. Two reviewers independently conducted screening and study selection, with a third reviewer resolving discrepancies. No automation tools were used. A total of 5989 records were retrieved, and 7 studies met the inclusion criteria. Included studies represented orthodontics, prosthodontics, endodontics, and dental education. DT applications primarily involved: patient-specific virtual modeling for diagnosis and treatment simulation, predictive or performance-monitoring frameworks using biomechanical/algorithmic analysis, and simulation-based skill training. Most were conceptual or prototype studies with small samples and limited clinical validation. DT technology has substantial potential to enhance precision, simulation, monitoring, and personalization in dentistry. However, current evidence remains constrained by fragmented research, methodological inconsistency and insufficient clinical validation. Future adoption of DT requires standardized data pipelines, robust ethical and regulatory frameworks and interdisciplinary collaboration to achieve clinically meaningful and widely adoptable DT integration in dental care.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"27 2","pages":"41-41"},"PeriodicalIF":2.9,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of curcumin in the management of oral submucous fibrosis: an umbrella review","authors":"Namrata Suresh, Mahati Bhadania, Ankita Mathur, Nandita Suresh, Toufiq Noor, Vini Mehta","doi":"10.1038/s41432-026-01221-3","DOIUrl":"10.1038/s41432-026-01221-3","url":null,"abstract":"This umbrella review was planned to synthesize pooled evidence on the efficacy of curcumin in alleviating clinical manifestations of OSMF. The protocol of this review was registered at the Prospective Register of Systematic Reviews (PROSPERO) and the Joanna Briggs Institute (JBI) guidelines were extensively followed. Multiple databases, including PubMed, Scopus, and Embase, were searched to retrieve relevant literature. Data was extracted using a systematically designed data extraction form. An overlap assessment was performed using the GROOVE Tool. A meta-analysis (using a random effects model) was performed to estimate the overall efficacy of curcumin in managing OSMF conditions. Quality assessment for included studies was also carried out using the Assessment of Multiple Systematic Reviews-2 (AMSTAR 2) tool. A total of six SR (n = 1) and SRMAs (n = 5) were included in this review. Overlap assessment found a higher level of overlap (19.39%) of primary studies across included studies. Meta-analysis revealed statistically significant results in improving burning sensation within intervention group [standardized mean difference (SMD = −2.66 (95% CI: −3.56 to −1.77); Z-score = 5.83, p-value < 0.001]. However, for other clinical symptoms, results remained statistically non-significant with variable heterogeneity (0% to 95%). A critical appraisal of the included studies demonstrated a high to moderate level (66.66%) of confidence in the overall evidence presented by the included studies. Findings suggest that curcumin offers limited benefits while managing OSMF conditions, especially in the early stages. Its optimal role may be as an adjunct in multimodal management strategies rather than a standalone therapy.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"27 2","pages":"44-44"},"PeriodicalIF":2.9,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}