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Expert Opinion on Drug Delivery最新文献

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Drug delivery systems for wound healing treatment of upper airway injury 用于上呼吸道损伤伤口愈合治疗的给药系统
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-04-08 DOI: 10.1080/17425247.2024.2340653
Denzel Ryan D. Cruz, Avery Zheng, Tilahun Debele, Peter Larson, Gregory R. Dion, Yoonjee C. Park
{"title":"Drug delivery systems for wound healing treatment of upper airway injury","authors":"Denzel Ryan D. Cruz, Avery Zheng, Tilahun Debele, Peter Larson, Gregory R. Dion, Yoonjee C. Park","doi":"10.1080/17425247.2024.2340653","DOIUrl":"https://doi.org/10.1080/17425247.2024.2340653","url":null,"abstract":"Endotracheal intubation is a common procedure to maintain an open airway with risks for traumatic injury. Pathological changes resulting from intubation can cause upper airway complications, includ...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"10 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Essential considerations toward development of effective nasal antibiotic formulation: features, strategies, and future directions 开发有效鼻腔抗生素制剂的基本考虑因素：特点、策略和未来方向
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-04-08 DOI: 10.1080/17425247.2024.2341184
Sandra Aulia Mardikasari, Gábor Katona, Bence Sipos, Ildikó Csóka
{"title":"Essential considerations toward development of effective nasal antibiotic formulation: features, strategies, and future directions","authors":"Sandra Aulia Mardikasari, Gábor Katona, Bence Sipos, Ildikó Csóka","doi":"10.1080/17425247.2024.2341184","DOIUrl":"https://doi.org/10.1080/17425247.2024.2341184","url":null,"abstract":"Intranasal antibiotic products are gaining popularity as a promising method of administering antibiotics, which provide numerous benefits, e.g. enhancing drug bioavailability, reducing adverse effe...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"100 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing regional drug delivery within the nasal airways 描述鼻腔气道内的区域给药特征
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-04-03 DOI: 10.1080/17425247.2024.2336494
John Chen, Warren H. Finlay, Reinhard Vehring, Andrew R. Martin
{"title":"Characterizing regional drug delivery within the nasal airways","authors":"John Chen, Warren H. Finlay, Reinhard Vehring, Andrew R. Martin","doi":"10.1080/17425247.2024.2336494","DOIUrl":"https://doi.org/10.1080/17425247.2024.2336494","url":null,"abstract":"The nose has been receiving increased attention as a route for drug delivery. As the site of deposition constitutes the first point of contact of the body with the drug, characterization of the reg...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"70 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conjugates of amphotericin B to resolve challenges associated with its delivery 解决两性霉素 B 给药难题的共轭物
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-01-20 DOI: 10.1080/17425247.2024.2308073
Vineet Kumar Jain, Keerti Jain, Harvinder Popli
{"title":"Conjugates of amphotericin B to resolve challenges associated with its delivery","authors":"Vineet Kumar Jain, Keerti Jain, Harvinder Popli","doi":"10.1080/17425247.2024.2308073","DOIUrl":"https://doi.org/10.1080/17425247.2024.2308073","url":null,"abstract":"Amphotericin B (AmB), a promising antifungal and antileishmanial drug, acts on the membrane of microorganisms. The clinical use of AmB is limited due to issues associated with its delivery includin...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"18 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139507395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood-brain barrier transporters: a translational consideration for CNS delivery of neurotherapeutics 血脑屏障转运体：中枢神经系统输送神经治疗药物的转化考量
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-01-13 DOI: 10.1080/17425247.2024.2306138
Patrick T. Ronaldson, Thomas P. Davis
{"title":"Blood-brain barrier transporters: a translational consideration for CNS delivery of neurotherapeutics","authors":"Patrick T. Ronaldson, Thomas P. Davis","doi":"10.1080/17425247.2024.2306138","DOIUrl":"https://doi.org/10.1080/17425247.2024.2306138","url":null,"abstract":"Successful neuropharmacology requires optimization of CNS drug delivery and, by extension, free drug concentrations at brain molecular targets. Detailed assessment of blood-brain barrier (BBB) phys...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"38 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139463668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polypeptides as alternatives to PEGylation of therapeutic agents 多肽作为治疗剂聚乙二醇化的替代品
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2023-12-20 DOI: 10.1080/17425247.2023.2297937
Huali Chen, Qianyu Zhang
{"title":"Polypeptides as alternatives to PEGylation of therapeutic agents","authors":"Huali Chen, Qianyu Zhang","doi":"10.1080/17425247.2023.2297937","DOIUrl":"https://doi.org/10.1080/17425247.2023.2297937","url":null,"abstract":"Due to the concerns raised by the extensive application of PEGylation, polypeptides have stood out as excellent candidates with adequate biocompatibility and biodegradability with tunable hydrophil...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"123 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138816456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advancements on in vitro blood-brain barrier model: a reliable and efficient screening approach for preclinical and clinical investigation 体外血脑屏障模型的最新进展：用于临床前和临床研究的可靠高效筛选方法
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2023-12-15 DOI: 10.1080/17425247.2023.2295940
Snigdha Singh, Mukta Agrawal, Rajat Vashist, Rohit K Patel, Sanchita Dhanchandra Sangave, Amit Alexander
{"title":"Recent advancements on in vitro blood-brain barrier model: a reliable and efficient screening approach for preclinical and clinical investigation","authors":"Snigdha Singh, Mukta Agrawal, Rajat Vashist, Rohit K Patel, Sanchita Dhanchandra Sangave, Amit Alexander","doi":"10.1080/17425247.2023.2295940","DOIUrl":"https://doi.org/10.1080/17425247.2023.2295940","url":null,"abstract":"The efficiency of brain therapeutics is greatly hindered by the blood-brain barrier (BBB). BBB’s protective function, selective permeability, and dynamic functionality maintain the harmony between ...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"52 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138689163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin 开发用于二甲双胍个性化给药的多组分胃网膜可扩张给药系统（GREDDS）
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2023-12-13 DOI: 10.1080/17425247.2023.2294884
Marco Uboldi, Arianna Chiappa, Margherita Rossi, Francesco Briatico-Vangosa, Alice Melocchi, Lucia Zema
{"title":"Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin","authors":"Marco Uboldi, Arianna Chiappa, Margherita Rossi, Francesco Briatico-Vangosa, Alice Melocchi, Lucia Zema","doi":"10.1080/17425247.2023.2294884","DOIUrl":"https://doi.org/10.1080/17425247.2023.2294884","url":null,"abstract":"Efficacy and compliance of type II diabetes treatment would greatly benefit from dosage forms providing controlled release of metformin in the upper gastrointestinal tract. In this respect, the fea...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"2 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138689502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives 用于精神和神经疾病的 3D 打印固体口服剂型：最新进展与未来展望
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2023-12-11 DOI: 10.1080/17425247.2023.2292692
Monika Wojtyłko, Dimitrios A. Lamprou, Anna Froelich, Wiesław Kuczko, Radosław Wichniarek, Tomasz Osmałek
{"title":"3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives","authors":"Monika Wojtyłko, Dimitrios A. Lamprou, Anna Froelich, Wiesław Kuczko, Radosław Wichniarek, Tomasz Osmałek","doi":"10.1080/17425247.2023.2292692","DOIUrl":"https://doi.org/10.1080/17425247.2023.2292692","url":null,"abstract":"3D printing (3DP) applications in medicine are intensively investigated, creating an opportunity to provide patient-tailored therapy by delivering a drug with an accurate dose and release profile. ...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":"19 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138574885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cedrol-loaded dissolvable microneedles based on flexible backing for promoting hair growth. 基于弹性背衬的雪松负载可溶性微针，可促进头发生长。
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2023-07-01 Epub Date: 2023-08-08 DOI: 10.1080/17425247.2023.2244413
Yanjun Zhou, Luan Jia, Guangshuai Zhang, Gang Chen, Di Zhou, Xianbao Shi, Qiang Fu, Ning Li
{"title":"Cedrol-loaded dissolvable microneedles based on flexible backing for promoting hair growth.","authors":"Yanjun Zhou,&nbsp;Luan Jia,&nbsp;Guangshuai Zhang,&nbsp;Gang Chen,&nbsp;Di Zhou,&nbsp;Xianbao Shi,&nbsp;Qiang Fu,&nbsp;Ning Li","doi":"10.1080/17425247.2023.2244413","DOIUrl":"10.1080/17425247.2023.2244413","url":null,"abstract":"<p><strong>Objectives: </strong>The dissolvable microneedles loaded with cedrol based on flexible backing were developed to deliver cedrol directly and continuously to the dermis, where the drug concentration in the hair follicle can be increased locally.</p><p><strong>Methods: </strong>The tip-layer matrix solution was prepared by mixing cedrol and polyvinylpyrrolidone K25 (PVP K25), and the pedestal matrix solution was prepared with aqueous hyaluronic acid. The cedrol-loaded dissolvable microneedles (cedrol-DMNs) were prepared under vacuum conditions. The mechanical properties, pig skin penetration efficiency, in vitro cutaneous permeation test, and the amount of drug in the skin and receptor chamber were evaluated. Pharmacodynamical studies were performed with C57BL/6 mice.</p><p><strong>Results: </strong>The mechanical properties of cedrol-DMNs were good. In vitro cutaneous permeation tests and pharmacodynamical studies demonstrated that cedrol-DMN could efficiently deliver the drug to the deep dermis and effectively promote hair growth.</p><p><strong>Conclusions: </strong>The cedrol-DMNs offer a promising strategy for treating patients suffering from hair loss.</p>","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":" ","pages":"1267-1276"},"PeriodicalIF":6.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10316608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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