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Expert Opinion on Drug Delivery最新文献

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Redefining drug therapy: innovative approaches using catalytic compartments. 重新定义药物疗法：利用催化区的创新方法。
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-09-11 DOI: 10.1080/17425247.2024.2403476
Yasemin Leyla Mustafa,Arianna Balestri,Xinan Huang,Cornelia Palivan
{"title":"Redefining drug therapy: innovative approaches using catalytic compartments.","authors":"Yasemin Leyla Mustafa,Arianna Balestri,Xinan Huang,Cornelia Palivan","doi":"10.1080/17425247.2024.2403476","DOIUrl":"https://doi.org/10.1080/17425247.2024.2403476","url":null,"abstract":"INTRODUCTIONRapid excretion of drug derivatives often results in short drug half-lives, necessitating frequent administrations. Catalytic compartments, also known as nano- and micro-reactors, offer a solution by providing confined environments for in situ production of therapeutic agents. Inspired by natural compartments, polymer-based catalytic compartments have been developed to improve reaction efficiency and enable site-specific therapeutic applications.AREAS COVEREDPolymer-based compartments provide stability, permeability control, and responsiveness to stimuli, making them ideal for generating localized compounds/signals. These sophisticated systems, engineered to carry active compounds and enable selective molecular release, represent a significant advancement in pharmaceutical research. They mimic cellular functions, creating controlled catalytic environments for bio-relevant processes. This review explores the latest advancements in synthetic catalytic compartments, focusing on design approaches, building blocks, active molecules, and key bio-applications.EXPERT OPINIONCatalytic compartments hold transformative potential in precision medicine by improving therapeutic outcomes through precise, on-site production of therapeutic agents. While promising, challenges like scalable manufacturing, biodegradability, and regulatory hurdles must be addressed to realize their full potential. Addressing these will be crucial for their successful application in healthcare.","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aerosol delivery in interstitial lung diseases - breakthrough or lost cause? 间质性肺病的气溶胶输送--突破还是迷途？
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-04-29 DOI: 10.1080/17425247.2024.2348659
Carsten Ehrhardt
{"title":"Aerosol delivery in interstitial lung diseases - breakthrough or lost cause?","authors":"Carsten Ehrhardt","doi":"10.1080/17425247.2024.2348659","DOIUrl":"https://doi.org/10.1080/17425247.2024.2348659","url":null,"abstract":"Published in Expert Opinion on Drug Delivery (Ahead of Print, 2024)","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140810369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-functional nanomedicines for combinational cancer immunotherapy that transform cold tumors to hot tumors 用于组合癌症免疫疗法的多功能纳米药物，将冷肿瘤转化为热肿瘤
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-04-29 DOI: 10.1080/17425247.2024.2348656
Hanhee Cho, Kwangmeyung Kim
{"title":"Multi-functional nanomedicines for combinational cancer immunotherapy that transform cold tumors to hot tumors","authors":"Hanhee Cho, Kwangmeyung Kim","doi":"10.1080/17425247.2024.2348656","DOIUrl":"https://doi.org/10.1080/17425247.2024.2348656","url":null,"abstract":"Currently, cancer immunotherapy is widely used as a groundbreaking method that can completely cure advanced cancers. However, this new immunotherapy has the challenge of low patient response, which...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140842547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design of dry powder inhalers to improve patient outcomes: it’s not just about the device 设计干粉吸入器以改善患者疗效：这不仅仅是设备的问题
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-04-17 DOI: 10.1080/17425247.2024.2343894
Jeffry G. Weers
{"title":"Design of dry powder inhalers to improve patient outcomes: it’s not just about the device","authors":"Jeffry G. Weers","doi":"10.1080/17425247.2024.2343894","DOIUrl":"https://doi.org/10.1080/17425247.2024.2343894","url":null,"abstract":"Up to 50% of asthma/COPD patients make critical errors in dose preparation and dose inhalation with current marketed DPIs which negatively impact clinical outcomes. Others fail to adhere to their c...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140617362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Doxorubicin conjugates: a practical approach for its cardiotoxicity alleviation 多柔比星共轭物：减轻心脏毒性的实用方法
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-04-16 DOI: 10.1080/17425247.2024.2343882
Abed Alqader Ibrahim, Hamdi Nsairat, Mazen Al-Sulaibi, Mohamed El-Tanani, Areej M. Jaber, Zainab Lafi, Rahmeh Barakat, Duaa Azmi Abuarqoub, Ismail Sami Mahmoud, Sherine O Obare, Alaa A. A. Aljabali, Alaaldin M. Alkilany, Walhan Alshaer
{"title":"Doxorubicin conjugates: a practical approach for its cardiotoxicity alleviation","authors":"Abed Alqader Ibrahim, Hamdi Nsairat, Mazen Al-Sulaibi, Mohamed El-Tanani, Areej M. Jaber, Zainab Lafi, Rahmeh Barakat, Duaa Azmi Abuarqoub, Ismail Sami Mahmoud, Sherine O Obare, Alaa A. A. Aljabali, Alaaldin M. Alkilany, Walhan Alshaer","doi":"10.1080/17425247.2024.2343882","DOIUrl":"https://doi.org/10.1080/17425247.2024.2343882","url":null,"abstract":"Doxorubicin (DOX) emerges as a cornerstone in the arsenal of potent chemotherapeutic agents. Yet, the clinical deployment of DOX is tarnished by its proclivity to induce severe cardiotoxic effects,...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expert opinion on antimicrobial therapies: is there enough scientific evidence to state that targeted therapies outperform non-targeted ones? 关于抗菌疗法的专家意见：是否有足够的科学证据表明靶向疗法优于非靶向疗法？
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-04-15 DOI: 10.1080/17425247.2024.2340661
Cristina Yus, Enrique Gámez, Manuel Arruebo
{"title":"Expert opinion on antimicrobial therapies: is there enough scientific evidence to state that targeted therapies outperform non-targeted ones?","authors":"Cristina Yus, Enrique Gámez, Manuel Arruebo","doi":"10.1080/17425247.2024.2340661","DOIUrl":"https://doi.org/10.1080/17425247.2024.2340661","url":null,"abstract":"Different active and passive strategies have been developed to fight against pathogenic bacteria. Those actions are undertaken to reduce the bacterial burden while minimizing the possibilities to d...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug delivery systems for wound healing treatment of upper airway injury 用于上呼吸道损伤伤口愈合治疗的给药系统
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-04-08 DOI: 10.1080/17425247.2024.2340653
Denzel Ryan D. Cruz, Avery Zheng, Tilahun Debele, Peter Larson, Gregory R. Dion, Yoonjee C. Park
{"title":"Drug delivery systems for wound healing treatment of upper airway injury","authors":"Denzel Ryan D. Cruz, Avery Zheng, Tilahun Debele, Peter Larson, Gregory R. Dion, Yoonjee C. Park","doi":"10.1080/17425247.2024.2340653","DOIUrl":"https://doi.org/10.1080/17425247.2024.2340653","url":null,"abstract":"Endotracheal intubation is a common procedure to maintain an open airway with risks for traumatic injury. Pathological changes resulting from intubation can cause upper airway complications, includ...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Essential considerations toward development of effective nasal antibiotic formulation: features, strategies, and future directions 开发有效鼻腔抗生素制剂的基本考虑因素：特点、策略和未来方向
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-04-08 DOI: 10.1080/17425247.2024.2341184
Sandra Aulia Mardikasari, Gábor Katona, Bence Sipos, Ildikó Csóka
{"title":"Essential considerations toward development of effective nasal antibiotic formulation: features, strategies, and future directions","authors":"Sandra Aulia Mardikasari, Gábor Katona, Bence Sipos, Ildikó Csóka","doi":"10.1080/17425247.2024.2341184","DOIUrl":"https://doi.org/10.1080/17425247.2024.2341184","url":null,"abstract":"Intranasal antibiotic products are gaining popularity as a promising method of administering antibiotics, which provide numerous benefits, e.g. enhancing drug bioavailability, reducing adverse effe...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing regional drug delivery within the nasal airways 描述鼻腔气道内的区域给药特征
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-04-03 DOI: 10.1080/17425247.2024.2336494
John Chen, Warren H. Finlay, Reinhard Vehring, Andrew R. Martin
{"title":"Characterizing regional drug delivery within the nasal airways","authors":"John Chen, Warren H. Finlay, Reinhard Vehring, Andrew R. Martin","doi":"10.1080/17425247.2024.2336494","DOIUrl":"https://doi.org/10.1080/17425247.2024.2336494","url":null,"abstract":"The nose has been receiving increased attention as a route for drug delivery. As the site of deposition constitutes the first point of contact of the body with the drug, characterization of the reg...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conjugates of amphotericin B to resolve challenges associated with its delivery 解决两性霉素 B 给药难题的共轭物
IF 6.6 2区 医学
Expert Opinion on Drug Delivery Pub Date : 2024-01-20 DOI: 10.1080/17425247.2024.2308073
Vineet Kumar Jain, Keerti Jain, Harvinder Popli
{"title":"Conjugates of amphotericin B to resolve challenges associated with its delivery","authors":"Vineet Kumar Jain, Keerti Jain, Harvinder Popli","doi":"10.1080/17425247.2024.2308073","DOIUrl":"https://doi.org/10.1080/17425247.2024.2308073","url":null,"abstract":"Amphotericin B (AmB), a promising antifungal and antileishmanial drug, acts on the membrane of microorganisms. The clinical use of AmB is limited due to issues associated with its delivery includin...","PeriodicalId":12229,"journal":{"name":"Expert Opinion on Drug Delivery","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139507395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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